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  1. Article ; Conference proceedings: Spike-beads as a model to investigate the effect of immune complexes on platelet aggregation in Covid-19

    Petry, Julie / Griesbaum, Lena / Verschoor, Admar / Wollenberg, Barbara

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language English
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1767142
    Database Thieme publisher's database

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  2. Article ; Conference proceedings: Spike-Beads als Modell zur Untersuchung der Plättchenaggregation durch Immunkomplexe in Covid-19

    Petry, Julie / Griesbaum, Lena / Verschoor, Admar / Wollenberg, Barbara

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1766546
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  3. Article ; Conference proceedings: Study of eosinophil-platelet interactions in vitro using a standardized eosinophilic cell line

    Griesbaum, Lena / Petry, Julie / Verschoor, Admar / Wollenberg, Barbara

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language English
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1767030
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  4. Article ; Conference proceedings: Untersuchung der Eosinophil Plättchen Interaktionen in vitro mittels einer standardisierten Eosinophil artigen Zelllinie

    Griesbaum, Lena / Petry, Julie / Verschoor, Admar / Wollenberg, Barbara

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1766443
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  5. Article ; Online: Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation.

    Aguiar Bucsai, Martina / Idel, Christian / Wollenberg, Barbara / Mannhalter, Christine / Verschoor, Admar

    Platelets

    2022  Volume 33, Issue 8, Page(s) 1192–1198

    Abstract: We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use to analyze activated but non-complexed platelets via flow cytometry. To do so, we used washed ... ...

    Abstract We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use to analyze activated but non-complexed platelets via flow cytometry. To do so, we used washed platelets from healthy human donors. We combined aggregometry, an assay of platelet functionality, with flow cytometry and ELISA to detect and correlate, respectively, platelet aggregation, activation, and granule release. While tirofiban effectively inhibited agonist-induced platelet aggregation (thrombin receptor-activating peptide 6 (TRAP), convulxin (CVX), U46619 and IV.3), the surface expression of P-selectin and CD63 and granule release of RANTES were significantly increased, indicating that tirofiban enhances degranulation, uncoupled from aggregation. The results show that tirofiban alters the activation phenotype of platelets, something that should be considered when using tirofiban to enable flow cytometric analysis of activated but unaggregated platelet suspensions.
    MeSH term(s) 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology ; Blood Platelets/metabolism ; Chemokine CCL5/metabolism ; Chemokine CCL5/pharmacology ; Humans ; P-Selectin/metabolism ; Platelet Activation ; Platelet Aggregation ; Platelet Aggregation Inhibitors/metabolism ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism ; Receptors, Thrombin/metabolism ; Tirofiban/pharmacology ; Tyrosine/metabolism ; Tyrosine/pharmacology
    Chemical Substances Chemokine CCL5 ; P-Selectin ; Platelet Aggregation Inhibitors ; Platelet Glycoprotein GPIIb-IIIa Complex ; Receptors, Thrombin ; Tyrosine (42HK56048U) ; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid (76898-47-0) ; Tirofiban (GGX234SI5H)
    Language English
    Publishing date 2022-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2022.2078489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Complement and coagulation: so close, yet so far.

    Schmidt, Christoph Q / Verschoor, Admar

    Blood

    2017  Volume 130, Issue 24, Page(s) 2581–2582

    MeSH term(s) Blood Coagulation ; Complement Activation ; Complement System Proteins ; Humans
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2017-12-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-10-811943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Host-Specific Serum Factors Control the Development and Survival of

    Anisuzzaman / Frahm, Sören / Prodjinotho, Ulrich Fabien / Bhattacharjee, Sonakshi / Verschoor, Admar / Prazeres da Costa, Clarissa

    Frontiers in immunology

    2021  Volume 12, Page(s) 635622

    Abstract: Introduction: Schistosomiasis is a neglected tropical disease (NTD) caused by blood-dwelling flatworms which develop from skin-penetrating cercariae, the freely swimming water-borne infective stage of : Materials and methods: Using our recently ... ...

    Abstract Introduction: Schistosomiasis is a neglected tropical disease (NTD) caused by blood-dwelling flatworms which develop from skin-penetrating cercariae, the freely swimming water-borne infective stage of
    Materials and methods: Using our recently developed novel serum- and cell-free
    Results: In contrast to sera from humans and a broad variety of mammalian species, serum from mice, surprisingly, killed parasites already at skin stage
    Conclusion: This study reveals that not yet identified heat-labile serum factors are major selective determinants of the host-specificity of schistosomiasis, by directly controlling schistosomal development and survival.
    MeSH term(s) Animals ; Complement C1q/genetics ; Complement C1q/metabolism ; Complement C3/genetics ; Complement C3/metabolism ; Complement C4/genetics ; Complement C4/metabolism ; Complement System Proteins/genetics ; Complement System Proteins/metabolism ; Disease Models, Animal ; Female ; Host-Parasite Interactions ; Humans ; Immunoglobulin M/blood ; Macaca mulatta ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Schistosoma mansoni/growth & development ; Schistosoma mansoni/immunology ; Schistosomiasis mansoni/blood ; Schistosomiasis mansoni/immunology ; Schistosomiasis mansoni/parasitology ; Species Specificity ; Mice
    Chemical Substances C3 protein, mouse ; C4b protein, mouse ; Complement C3 ; Complement C4 ; Immunoglobulin M ; Complement C1q (80295-33-6) ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2021-04-23
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.635622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pathogen clearance and immune adherence "revisited": Immuno-regulatory roles for CRIg.

    van Lookeren Campagne, Menno / Verschoor, Admar

    Seminars in immunology

    2018  Volume 37, Page(s) 4–11

    Abstract: Rapid elimination of microbes from the bloodstream, along with the ability to mount an adaptive immune response, are essential for optimal host-defense. Kupffer cells are strategically positioned in the liver sinusoids and efficiently capture circulating ...

    Abstract Rapid elimination of microbes from the bloodstream, along with the ability to mount an adaptive immune response, are essential for optimal host-defense. Kupffer cells are strategically positioned in the liver sinusoids and efficiently capture circulating microbes from the hepatic artery and portal vein, thus preventing bacterial dissemination. In vivo and in vitro studies have probed how complement receptor of the immunoglobulin superfamily (CRIg), also referred to as Z39Ig and V-set and Ig domain-containing 4 (VSIG4), acts as a critical player in pathogen recognition and clearance. While recent data suggested that CRIg may bind bacterial cell wall components directly, the single transmembrane receptor is best known for its interaction with complement C3 opsonization products on the microbial surface. On Kupffer cells, CRIg must capture opsonized microbes against the shear forces of the blood flow. In vivo work reveals how immune adherence (IA), a process in which blood platelets or erythrocytes associate with circulating bacteria, plays a critical role in regulating pathogen capture by CRIg under flow conditions. In addition to its typical innate immune functions, CRIg was shown to directly and indirectly influence adaptive immune responses. Here, we review our current understanding of the diverse roles of CRIg in pathogen elimination, anti-microbial immunity and autoimmunity. In particular, we will explore how, through selective capturing by CRIg, an important balance is achieved between the immunological and clearance functions of liver and spleen.
    MeSH term(s) Agglutination ; Animals ; Bacterial Infections/immunology ; Complement C3/metabolism ; Host-Pathogen Interactions ; Humans ; Immunomodulation ; Kupffer Cells/physiology ; Opsonin Proteins/metabolism ; Pathogen-Associated Molecular Pattern Molecules/immunology ; Receptors, Complement/metabolism ; Receptors, Pattern Recognition/metabolism
    Chemical Substances Complement C3 ; Opsonin Proteins ; Pathogen-Associated Molecular Pattern Molecules ; Receptors, Complement ; Receptors, Pattern Recognition ; VSIG4 protein, human
    Language English
    Publishing date 2018-03-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2018.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2843: Show issues Location:
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  9. Article ; Online: Correction: A novel cell-free method to culture Schistosoma mansoni from cercariae to juvenile worm stages for in vitro drug testing.

    Frahm, Sören / Anisuzzaman, Anisuzzaman / Prodjinotho, Ulrich Fabien / Vejzagić, Nermina / Verschoor, Admar / Prazeres da Costa, Clarissa

    PLoS neglected tropical diseases

    2022  Volume 16, Issue 6, Page(s) e0010513

    Abstract: This corrects the article DOI: 10.1371/journal.pntd.0006590.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pntd.0006590.].
    Language English
    Publishing date 2022-06-02
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0010513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Purified complement C3b triggers phagocytosis and activation of human neutrophils via complement receptor 1.

    Boero, Elena / Gorham, Ronald D / Francis, Emmet A / Brand, Jonathan / Teng, Lay Heng / Doorduijn, Dennis J / Ruyken, Maartje / Muts, Remy M / Lehmann, Christian / Verschoor, Admar / van Kessel, Kok P M / Heinrich, Volkmar / Rooijakkers, Suzan H M

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 274

    Abstract: The complement system provides vital immune protection against infectious agents by labeling them with complement fragments that enhance phagocytosis by immune cells. Many details of complement-mediated phagocytosis remain elusive, partly because it is ... ...

    Abstract The complement system provides vital immune protection against infectious agents by labeling them with complement fragments that enhance phagocytosis by immune cells. Many details of complement-mediated phagocytosis remain elusive, partly because it is difficult to study the role of individual complement proteins on target surfaces. Here, we employ serum-free methods to couple purified complement C3b onto E. coli bacteria and beads and then expose human neutrophils to these C3b-coated targets. We examine the neutrophil response using a combination of flow cytometry, confocal microscopy, luminometry, single-live-cell/single-target manipulation, and dynamic analysis of neutrophil spreading on opsonin-coated surfaces. We show that purified C3b can potently trigger phagocytosis and killing of bacterial cells via Complement receptor 1. Comparison of neutrophil phagocytosis of C3b- versus antibody-coated beads with single-bead/single-target analysis exposes a similar cell morphology during engulfment. However, bulk phagocytosis assays of C3b-beads combined with DNA-based quenching reveal that these are poorly internalized compared to their IgG1 counterparts. Similarly, neutrophils spread slower on C3b-coated compared to IgG-coated surfaces. These observations support the requirement of multiple stimulations for efficient C3b-mediated uptake. Together, our results establish the existence of a direct pathway of phagocytic uptake of C3b-coated targets and present methodologies to study this process.
    MeSH term(s) Humans ; Neutrophils/metabolism ; Complement C3b/metabolism ; Escherichia coli/metabolism ; Phagocytosis ; Receptors, Complement 3b/metabolism ; Complement System Proteins/metabolism ; Immunoglobulin G ; Receptors, Complement/metabolism
    Chemical Substances Complement C3b (80295-43-8) ; Receptors, Complement 3b ; Complement System Proteins (9007-36-7) ; Immunoglobulin G ; Receptors, Complement
    Language English
    Publishing date 2023-01-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-27279-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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