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  1. Article ; Online: Partner-choice genetics in Japan.

    Verweij, Karin J H / Abdellaoui, Abdel

    Nature human behaviour

    2022  Volume 7, Issue 1, Page(s) 13–14

    MeSH term(s) Humans ; Japan ; Cooperative Behavior ; Marriage
    Language English
    Publishing date 2022-09-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-022-01439-y
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  2. Article ; Online: Commentary on Carrasquilla et al.: Smoking and obesity; uncovering causal mechanisms through triangulation of different methods.

    van de Weijer, Margot P / Verweij, Karin J H / Treur, Jorien L

    Addiction (Abingdon, England)

    2024  Volume 119, Issue 6, Page(s) 1035–1036

    MeSH term(s) Humans ; Obesity ; Smoking/epidemiology ; Causality ; Research Design
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1141051-6
    ISSN 1360-0443 ; 0965-2140
    ISSN (online) 1360-0443
    ISSN 0965-2140
    DOI 10.1111/add.16506
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    Zs.B 551: Show issues Location:
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  3. Article ; Online: Burt uses a fallacious motte-and-bailey argument to dispute the value of genetics for social science.

    Zietsch, Brendan P / Abdellaoui, Abdel / Verweij, Karin J H

    The Behavioral and brain sciences

    2023  Volume 46, Page(s) e231

    Abstract: Burt's argument relies on a motte-and-bailey fallacy. Burt aims to argue against the value of genetics for social science; instead she argues against certain interpretations of a specific kind of genetics tool, polygenic scores (PGSs). The limitations, ... ...

    Abstract Burt's argument relies on a motte-and-bailey fallacy. Burt aims to argue against the value of genetics for social science; instead she argues against certain interpretations of a specific kind of genetics tool, polygenic scores (PGSs). The limitations, previously identified by behavioural geneticists including ourselves, do not negate the value of PGSs, let alone genetics in general, for social science.
    MeSH term(s) Female ; Humans ; Dissent and Disputes ; Social Sciences
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 423721-3
    ISSN 1469-1825 ; 0140-525X
    ISSN (online) 1469-1825
    ISSN 0140-525X
    DOI 10.1017/S0140525X22002394
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    Zs.A 1470: Show issues Location:
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  4. Article ; Online: Dissecting polygenic signals from genome-wide association studies on human behaviour.

    Abdellaoui, Abdel / Verweij, Karin J H

    Nature human behaviour

    2021  Volume 5, Issue 6, Page(s) 686–694

    Abstract: Genome-wide association studies on human behavioural traits are producing large amounts of polygenic signals with significant predictive power and potentially useful biological clues. Behavioural traits are more distal and are less directly under ... ...

    Abstract Genome-wide association studies on human behavioural traits are producing large amounts of polygenic signals with significant predictive power and potentially useful biological clues. Behavioural traits are more distal and are less directly under biological control compared with physical characteristics, which makes the associated genetic effects harder to interpret. The results of genome-wide association studies for human behaviour are likely made up of a composite of signals from different sources. While sample sizes continue to increase, we outline additional steps that need to be taken to better delineate the origin of the increasingly stronger polygenic signals. In addition to genetic effects on the traits themselves, the major sources of polygenic signals are those that are associated with correlated traits, environmental effects and ascertainment bias. Advances in statistical approaches that disentangle polygenic effects from different traits as well as extending data collection to families and social circles with better geographical coverage will probably contribute to filling the gap of knowledge between genetic effects and behavioural outcomes.
    MeSH term(s) Behavior ; Gene-Environment Interaction ; Genetics, Behavioral ; Genome-Wide Association Study ; Humans ; Multifactorial Inheritance ; Polymorphism, Single Nucleotide ; Selection Bias ; Twin Studies as Topic
    Language English
    Publishing date 2021-05-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-021-01110-y
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  5. Article ; Online: 15 years of GWAS discovery: Realizing the promise.

    Abdellaoui, Abdel / Yengo, Loic / Verweij, Karin J H / Visscher, Peter M

    American journal of human genetics

    2023  Volume 110, Issue 2, Page(s) 179–194

    Abstract: It has been 15 years since the advent of the genome-wide association study (GWAS) era. Here, we review how this experimental design has realized its promise by facilitating an impressive range of discoveries with remarkable impact on multiple fields, ... ...

    Abstract It has been 15 years since the advent of the genome-wide association study (GWAS) era. Here, we review how this experimental design has realized its promise by facilitating an impressive range of discoveries with remarkable impact on multiple fields, including population genetics, complex trait genetics, epidemiology, social science, and medicine. We predict that the emergence of large-scale biobanks will continue to expand to more diverse populations and capture more of the allele frequency spectrum through whole-genome sequencing, which will further improve our ability to investigate the causes and consequences of human genetic variation for complex traits and diseases.
    MeSH term(s) Humans ; Genome-Wide Association Study ; Gene Frequency ; Genetics, Population ; Multifactorial Inheritance ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 219384-x
    ISSN 1537-6605 ; 0002-9297
    ISSN (online) 1537-6605
    ISSN 0002-9297
    DOI 10.1016/j.ajhg.2022.12.011
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    Zs.A 107: Show issues Location:
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  6. Article ; Online: A broader cultural view is necessary to study the evolution of sexual orientation.

    Savolainen, Vincent / Bailey, Nathan W / Diamond, Lisa / Swift-Gallant, Ashlyn / Gavrilets, Sergey / Raymond, Michel / Verweij, Karin J H

    Nature ecology & evolution

    2024  Volume 8, Issue 2, Page(s) 181–183

    MeSH term(s) Humans ; Female ; Male ; Sexual Behavior
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ISSN 2397-334X
    ISSN (online) 2397-334X
    DOI 10.1038/s41559-023-02273-9
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  7. Article ; Online: Gene-environment correlations across geographic regions affect genome-wide association studies.

    Abdellaoui, Abdel / Dolan, Conor V / Verweij, Karin J H / Nivard, Michel G

    Nature genetics

    2022  Volume 54, Issue 9, Page(s) 1345–1354

    Abstract: Gene-environment correlations affect associations between genetic variants and complex traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British siblings that educational attainment polygenic scores capture gene- ... ...

    Abstract Gene-environment correlations affect associations between genetic variants and complex traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British siblings that educational attainment polygenic scores capture gene-environment correlations, and that migration extends these gene-environment correlations beyond the family to broader geographic regions. We then ran GWASs on 56 complex traits in up to 254,387 British individuals. Controlling for geographic regions significantly decreased the heritability for socioeconomic status (SES)-related traits, most strongly for educational attainment and income. For most traits, controlling for regions significantly reduced genetic correlations with educational attainment and income, most significantly for body mass index/body fat, sedentary behavior and substance use, consistent with gene-environment correlations related to regional socio-economic differences. The effects of controlling for birthplace and current address suggest both passive and active sources of gene-environment correlations. Our results show that the geographic clustering of DNA and SES introduces gene-environment correlations that affect GWAS results.
    MeSH term(s) Educational Status ; Gene-Environment Interaction ; Genome-Wide Association Study ; Humans ; Multifactorial Inheritance/genetics ; Social Class
    Language English
    Publishing date 2022-08-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-022-01158-0
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    Zs.A 3613: Show issues Location:
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    Zs.MG 46: Show issues

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  8. Article ; Online: Unravelling the relation between mental illness and cardiovascular disease by triangulating evidence from different methods.

    Treur, Jorien L / Veeneman, Rada R / Vermeulen, Jentien M / Verweij, Karin J H

    European heart journal

    2023  Volume 44, Issue 21, Page(s) 1851–1854

    MeSH term(s) Humans ; Cardiovascular Diseases ; Mental Disorders ; Anastomosis, Surgical
    Language English
    Publishing date 2023-02-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad049
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  9. Article ; Online: Replicable brain-phenotype associations require large-scale neuroimaging data.

    Liu, Shu / Abdellaoui, Abdel / Verweij, Karin J H / van Wingen, Guido A

    Nature human behaviour

    2023  Volume 7, Issue 8, Page(s) 1344–1356

    Abstract: Numerous neuroimaging studies have investigated the neural basis of interindividual differences but the replicability of brain-phenotype associations remains largely unknown. We used the UK Biobank neuroimaging dataset (N = 37,447) to examine ... ...

    Abstract Numerous neuroimaging studies have investigated the neural basis of interindividual differences but the replicability of brain-phenotype associations remains largely unknown. We used the UK Biobank neuroimaging dataset (N = 37,447) to examine associations with six variables related to physical and mental health: age, body mass index, intelligence, memory, neuroticism and alcohol consumption, and assessed the improvement of replicability for brain-phenotype associations with increasing sampling sizes. Age may require only 300 individuals to provide highly replicable associations but other phenotypes required 1,500 to 3,900 individuals. The required sample size showed a negative power law relation with the estimated effect size. When only comparing the upper and lower quarters, the minimally required sample sizes for imaging decreased by 15-75%. Our findings demonstrate that large-scale neuroimaging data are required for replicable brain-phenotype associations, that this can be mitigated by preselection of individuals and that small-scale studies may have reported false positive findings.
    MeSH term(s) Brain/diagnostic imaging ; Neuroimaging/methods ; Alcohol Drinking ; Phenotype
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-023-01642-5
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  10. Article ; Online: Gene Expression has Distinct Associations with Brain Structure and Function in Major Depressive Disorder.

    Liu, Shu / Abdellaoui, Abdel / Verweij, Karin J H / van Wingen, Guido A

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 7, Page(s) e2205486

    Abstract: Major depressive disorder (MDD) is associated with structural and functional brain abnormalities. MDD as well as brain anatomy and function are influenced by genetic factors, but the role of gene expression remains unclear. Here, this work investigates ... ...

    Abstract Major depressive disorder (MDD) is associated with structural and functional brain abnormalities. MDD as well as brain anatomy and function are influenced by genetic factors, but the role of gene expression remains unclear. Here, this work investigates how cortical gene expression contributes to structural and functional brain abnormalities in MDD. This work compares the gray matter volume and resting-state functional measures in a Chinese sample of 848 MDD patients and 749 healthy controls, and these case-control differences are then associated with cortical variation of gene expression. While whole gene expression is positively associated with structural abnormalities, it is negatively associated with functional abnormalities. This work observes the relationships of expression levels with brain abnormalities for individual genes, and found that transcriptional correlates of brain structure and function show opposite relations with gene dysregulation in postmortem cortical tissue from MDD patients. This work further identifies genes that are positively or negatively related to structural abnormalities as well as functional abnormalities. The MDD-related genes are enriched for brain tissue, cortical cells, and biological pathways. These findings suggest that distinct genetic mechanisms underlie structural and functional brain abnormalities in MDD, and highlight the importance of cortical gene expression for the development of cortical abnormalities.
    MeSH term(s) Humans ; Depressive Disorder, Major/genetics ; Magnetic Resonance Imaging ; Brain ; Gray Matter ; Brain Diseases ; Gene Expression/genetics
    Language English
    Publishing date 2023-01-13
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202205486
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