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  1. Article: Aspergillus fumigatus

    James, Matthew R / Aufiero, Mariano A / Vesely, Elisa M / Dhingra, Sourabh / Liu, Ko-Wei / Hohl, Tobias M / Cramer, Robert A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Invasive pulmonary aspergillosis (IPA) is a life-threatening infection caused by species in the ubiquitous fungal genus : Importance: Aspergillus ... ...

    Abstract Invasive pulmonary aspergillosis (IPA) is a life-threatening infection caused by species in the ubiquitous fungal genus
    Importance: Aspergillus fumigatus
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.07.544103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aspergillus fumigatus

    James, Matthew R / Aufiero, Mariano A / Vesely, Elisa M / Dhingra, Sourabh / Liu, Ko-Wei / Hohl, Tobias M / Cramer, Robert A

    mSphere

    2023  Volume 8, Issue 6, Page(s) e0030523

    Abstract: Importance: Aspergillus ... ...

    Abstract Importance: Aspergillus fumigatus
    MeSH term(s) Animals ; Humans ; Aspergillus fumigatus/metabolism ; Cytochromes c/metabolism ; Spores, Fungal ; Sterilizing Immunity ; Virulence ; Invasive Pulmonary Aspergillosis/microbiology ; Invasive Pulmonary Aspergillosis/pathology ; Mammals
    Chemical Substances Cytochromes c (9007-43-6)
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00305-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The cystic fibrosis treatment Trikafta affects the growth, viability, and cell wall of

    Jones, Jane T / Morelli, Kaesi A / Vesely, Elisa M / Puerner, Charles T S / Pavuluri, Chetan K / Ross, Brandon S / van Rhijn, Norman / Bromley, Michael J / Cramer, Robert A

    mBio

    2023  Volume 14, Issue 5, Page(s) e0151623

    Abstract: Importance: PwCF commonly test positive for pathogenic fungi, and more than 90% of the cystic fibrosis patient population is approved for the modulator treatment, Trikafta. Therefore, it is critical to understand how fungal communities, ... ...

    Abstract Importance: PwCF commonly test positive for pathogenic fungi, and more than 90% of the cystic fibrosis patient population is approved for the modulator treatment, Trikafta. Therefore, it is critical to understand how fungal communities, specifically
    MeSH term(s) Humans ; Aspergillus fumigatus ; Cystic Fibrosis/microbiology ; Mycoses ; Cell Wall ; Biofilms
    Chemical Substances elexacaftor, ivacaftor, tezacaftor drug combination
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.01516-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: N

    Vesely, Elisa M / Williams, Robert B / Konopka, James B / Lorenz, Michael C

    mSphere

    2017  Volume 2, Issue 5

    Abstract: Phagocytosis by innate immune cells is one of the most effective barriers against the multiplication and dissemination of microbes within the mammalian host. ...

    Abstract Phagocytosis by innate immune cells is one of the most effective barriers against the multiplication and dissemination of microbes within the mammalian host.
    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5042
    ISSN 2379-5042
    DOI 10.1128/mSphere.00357-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An Alanine Aminotransferase Is Required for Biofilm-Specific Resistance of Aspergillus fumigatus to Echinocandin Treatment.

    Kerkaert, Joshua D / Le Mauff, François / Wucher, Benjamin R / Beattie, Sarah R / Vesely, Elisa M / Sheppard, Donald C / Nadell, Carey D / Cramer, Robert A

    mBio

    2022  Volume 13, Issue 2, Page(s) e0293321

    Abstract: Alanine metabolism has been suggested as an adaptation strategy to oxygen limitation in organisms ranging from plants to mammals. Within the pulmonary infection microenvironment, Aspergillus fumigatus forms biofilms with steep oxygen gradients defined by ...

    Abstract Alanine metabolism has been suggested as an adaptation strategy to oxygen limitation in organisms ranging from plants to mammals. Within the pulmonary infection microenvironment, Aspergillus fumigatus forms biofilms with steep oxygen gradients defined by regions of oxygen limitation. An alanine aminotransferase, AlaA, was observed to function in alanine catabolism and is required for several aspects of A. fumigatus biofilm physiology. Loss of
    MeSH term(s) Alanine/metabolism ; Alanine/pharmacology ; Alanine/therapeutic use ; Alanine Transaminase/metabolism ; Alanine Transaminase/pharmacology ; Animals ; Antifungal Agents/metabolism ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Aspergillus fumigatus ; Biofilms ; Disease Models, Animal ; Echinocandins/metabolism ; Echinocandins/pharmacology ; Echinocandins/therapeutic use ; Invasive Pulmonary Aspergillosis ; Mammals ; Mice ; Oxygen/metabolism
    Chemical Substances Antifungal Agents ; Echinocandins ; Alanine Transaminase (EC 2.6.1.2) ; Alanine (OF5P57N2ZX) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02933-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Postinfluenza Environment Reduces Aspergillus fumigatus Conidium Clearance and Facilitates Invasive Aspergillosis

    Liu, Ko-Wei / Grau, Madeleine S / Jones, Jane T / Wang, Xi / Vesely, Elisa M / James, Matthew R / Gutierrez-Perez, Cecilia / Cramer, Robert A / Obar, Joshua J

    mBio

    2022  Volume 13, Issue 6, Page(s) e0285422

    Abstract: Aspergillus fumigatus is a human fungal pathogen that is most often avirulent in immunecompetent individuals because the innate immune system is efficient at eliminating fungal conidia. However, recent clinical observations have shown that severe ... ...

    Abstract Aspergillus fumigatus is a human fungal pathogen that is most often avirulent in immunecompetent individuals because the innate immune system is efficient at eliminating fungal conidia. However, recent clinical observations have shown that severe influenza A virus (IAV) infection can lead to secondary A. fumigatus infections with high mortality. Little is currently known about how IAV infection alters the innate antifungal immune response. Here, we established a murine model of IAV-induced A. fumigatus (IAV-
    MeSH term(s) Humans ; Animals ; Mice ; Aspergillus fumigatus ; Spores, Fungal ; Superinfection ; Influenza A Virus, H1N1 Subtype ; Zymosan ; Aspergillosis/microbiology ; Aspergillus
    Chemical Substances Zymosan (9010-72-4)
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02854-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Expression of proteolipid protein gene in spinal cord stem cells and early oligodendrocyte progenitor cells is dispensable for normal cell migration and myelination.

    Harlow, Danielle E / Saul, Katherine E / Culp, Cecilia M / Vesely, Elisa M / Macklin, Wendy B

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2014  Volume 34, Issue 4, Page(s) 1333–1343

    Abstract: Plp1 gene expression occurs very early in development, well before the onset of myelination, creating a conundrum with regard to the function of myelin proteolipid protein (PLP), one of the major proteins in compact myelin. Using PLP-EGFP mice to ... ...

    Abstract Plp1 gene expression occurs very early in development, well before the onset of myelination, creating a conundrum with regard to the function of myelin proteolipid protein (PLP), one of the major proteins in compact myelin. Using PLP-EGFP mice to investigate Plp1 promoter activity, we found that, at very early time points, PLP-EGFP was expressed in Sox2+ undifferentiated precursors in the spinal cord ventricular zone (VZ), as well as in the progenitors of both neuronal and glial lineages. As development progressed, most PLP-EGFP-expressing cells gave rise to oligodendrocyte progenitor cells (OPCs). The expression of PLP-EGFP in the spinal cord was quite dynamic during development. PLP-EGFP was highly expressed as cells delaminated from the VZ. Expression was downregulated as cells moved laterally through the cord, and then robustly upregulated as OPCs differentiated into mature myelinating oligodendrocytes. The presence of PLP-EGFP expression in OPCs raises the question of its role in this migratory population. We crossed PLP-EGFP reporter mice into a Plp1-null background to investigate the role of PLP in early OPC development. In the absence of PLP, normal numbers of OPCs were generated and their distribution throughout the spinal cord was unaffected. However, the orientation and length of OPC processes during migration was abnormal in Plp1-null mice, suggesting that PLP plays a role either in the structural integrity of OPC processes or in their response to extracellular cues that orient process outgrowth.
    MeSH term(s) Animals ; Blotting, Western ; Cell Count ; Cell Differentiation/physiology ; Cell Movement/physiology ; Immunohistochemistry ; In Situ Hybridization ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Microscopy, Confocal ; Myelin Proteolipid Protein/metabolism ; Myelin Sheath/metabolism ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Neurogenesis/physiology ; Oligodendroglia/cytology ; Oligodendroglia/metabolism ; Spinal Cord/cytology ; Spinal Cord/metabolism ; Stem Cells/cytology ; Stem Cells/metabolism
    Chemical Substances Myelin Proteolipid Protein ; Plp1 protein, mouse
    Language English
    Publishing date 2014-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.2477-13.2014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Robust Extracellular pH Modulation by Candida albicans during Growth in Carboxylic Acids.

    Danhof, Heather A / Vylkova, Slavena / Vesely, Elisa M / Ford, Amy E / Gonzalez-Garay, Manuel / Lorenz, Michael C

    mBio

    2016  Volume 7, Issue 6

    Abstract: The opportunistic fungal pathogen Candida albicans thrives within diverse niches in the mammalian host. Among the adaptations that underlie this fitness is an ability to utilize a wide array of nutrients, especially sources of carbon that are disfavored ... ...

    Abstract The opportunistic fungal pathogen Candida albicans thrives within diverse niches in the mammalian host. Among the adaptations that underlie this fitness is an ability to utilize a wide array of nutrients, especially sources of carbon that are disfavored by many other fungi; this contributes to its ability to survive interactions with the phagocytes that serve as key barriers against disseminated infections. We have reported that C. albicans generates ammonia as a byproduct of amino acid catabolism to neutralize the acidic phagolysosome and promote hyphal morphogenesis in a manner dependent on the Stp2 transcription factor. Here, we report that this species rapidly neutralizes acidic environments when utilizing carboxylic acids like pyruvate, α-ketoglutarate (αKG), or lactate as the primary carbon source. Unlike in cells growing in amino acid-rich medium, this does not result in ammonia release, does not induce hyphal differentiation, and is genetically distinct. While transcript profiling revealed significant similarities in gene expression in cells grown on either carboxylic or amino acids, genetic screens for mutants that fail to neutralize αKG medium identified a nonoverlapping set of genes, including CWT1, encoding a transcription factor responsive to cell wall and nitrosative stresses. Strains lacking CWT1 exhibit retarded αKG-mediated neutralization in vitro, exist in a more acidic phagolysosome, and are more susceptible to macrophage killing, while double cwt1Δ stp2Δ mutants are more impaired than either single mutant. Together, our observations indicate that C. albicans has evolved multiple ways to modulate the pH of host-relevant environments to promote its fitness as a pathogen.
    Importance: The fungal pathogen Candida albicans is a ubiquitous and usually benign constituent of the human microbial ecosystem. In individuals with weakened immune systems, this organism can cause potentially life-threatening infections and is one of the most common causes of hospital-acquired infections. Understanding the interactions between C. albicans and immune phagocytic cells, such as macrophages and neutrophils, will define the mechanisms of pathogenesis in this species. One such adaptation is an ability to make use of nonstandard nutrients that we predict are plentiful in certain niches within the host, including within these phagocytic cells. We show here that the metabolism of certain organic acids enables C. albicans to neutralize acidic environments, such as those within macrophages. This phenomenon is distinct in several significant ways from previous reports of similar processes, indicating that C. albicans has evolved multiple mechanisms to combat the harmful acidity of phagocytic cells.
    MeSH term(s) Amino Acids/metabolism ; Amino Acids/pharmacology ; Ammonia/metabolism ; Animals ; Candida albicans/drug effects ; Candida albicans/genetics ; Candida albicans/growth & development ; Candida albicans/metabolism ; Carboxylic Acids/metabolism ; Carboxylic Acids/pharmacology ; Gene Expression Profiling ; Host-Pathogen Interactions ; Humans ; Hydrogen-Ion Concentration ; Ketoglutaric Acids/metabolism ; Lactic Acid/metabolism ; Macrophages/metabolism ; Macrophages/microbiology ; Mice ; Mutation ; Phagosomes/chemistry ; Pyruvic Acid/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Amino Acids ; Carboxylic Acids ; Ketoglutaric Acids ; Transcription Factors ; Lactic Acid (33X04XA5AT) ; Ammonia (7664-41-7) ; Pyruvic Acid (8558G7RUTR)
    Language English
    Publishing date 2016-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.01646-16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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