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  1. Article: Spontaneous low-protein intake in older CKD patients: one diet may not fit all.

    Vettoretti, Simone / Molinari, Paolo / Armelloni, Silvia / Castellano, Giuseppe / Caldiroli, Lara

    Frontiers in nutrition

    2024  Volume 11, Page(s) 1328939

    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2024.1328939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nutritional Strategies to Prevent Muscle Loss and Sarcopenia in Chronic Kidney Disease: What Do We Currently Know?

    Massini, Giulia / Caldiroli, Lara / Molinari, Paolo / Carminati, Francesca Maria Ida / Castellano, Giuseppe / Vettoretti, Simone

    Nutrients

    2023  Volume 15, Issue 14

    Abstract: Loss of muscle mass is an extremely frequent complication in patients with chronic kidney disease (CKD). The etiology of muscle loss in CKD is multifactorial and may depend on kidney disease itself, dialysis, the typical chronic low-grade inflammation ... ...

    Abstract Loss of muscle mass is an extremely frequent complication in patients with chronic kidney disease (CKD). The etiology of muscle loss in CKD is multifactorial and may depend on kidney disease itself, dialysis, the typical chronic low-grade inflammation present in patients with chronic kidney disease, but also metabolic acidosis, insulin resistance, vitamin D deficiency, hormonal imbalances, amino acid loss during dialysis, and reduced dietary intake. All these conditions together increase protein degradation, decrease protein synthesis, and lead to negative protein balance. Aging further exacerbates sarcopenia in CKD patients. Nutritional therapy, such as protein restriction, aims to manage uremic toxins and slow down the progression of CKD. Low-protein diets (LPDs) and very low-protein diets (VLPDs) supplemented with amino acids or ketoacids are commonly prescribed. Energy intake is crucial, with a higher intake associated with maintaining a neutral or positive nitrogen balance. Adequate nutritional and dietary support are fundamental in preventing nutritional inadequacies and, consequently, muscle wasting, which can occur in CKD patients. This review explores the causes of muscle loss in CKD and how it can be influenced by nutritional strategies aimed at improving muscle mass and muscle strength.
    MeSH term(s) Humans ; Sarcopenia/prevention & control ; Sarcopenia/complications ; Renal Dialysis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Renal Insufficiency, Chronic/metabolism ; Diet, Protein-Restricted ; Amino Acids ; Muscles/metabolism
    Chemical Substances Amino Acids
    Language English
    Publishing date 2023-07-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15143107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Simultaneous removal and replacement of the peritoneal catheter in CAPD patient with refractory peritonitis sustained by P. aeruginosa: A case-report.

    Nardelli, Luca / Scalamogna, Antonio / Moscardino, Sara / Tripodi, Federica / Vettoretti, Simone / Alfieri, Carlo / Castellano, Giuseppe

    The journal of vascular access

    2023  , Page(s) 11297298231178061

    Abstract: Pseudomonas peritonitis is often severe and associated with less than 50% complete cure rate, often requiring catheter removal, and transfer to HD. International guidelines recommend that peritoneal catheter should be removed if peritoneal dialysis (PD) ... ...

    Abstract Pseudomonas peritonitis is often severe and associated with less than 50% complete cure rate, often requiring catheter removal, and transfer to HD. International guidelines recommend that peritoneal catheter should be removed if peritoneal dialysis (PD) effluent does not clear after 5 days of appropriate antibiotic therapy defining the episode as refractory peritonitis. To avoid the shift to hemodialysis (HD), the simultaneous removal and replacement of the peritoneal catheter (SCR) has been employed to treat recurrent peritonitis or tunnel infections associated with peritonitis, obtaining satisfactory outcomes. However, the use of SCR is still controversial in refractory episodes. At present there is growing evidence that refractory peritonitis can be sustained by bacterial adherence along the intraperitoneal portion of the catheter, especially when Pseudomonas species are involved. We describe a case of refractory peritonitis sustained by P. aeruginosa that after a partial response to antibiotics has been successfully treated by SCR.
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2252820-9
    ISSN 1724-6032 ; 1129-7298
    ISSN (online) 1724-6032
    ISSN 1129-7298
    DOI 10.1177/11297298231178061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6414: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Article ; Online: Relationship between number of daily exchanges at CAPD start with clinical outcomes.

    Nardelli, Luca / Scalamogna, Antonio / Cicero, Elisa / Tripodi, Federica / Vettoretti, Simone / Alfieri, Carlo / Castellano, Giuseppe

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

    2023  Volume 44, Issue 2, Page(s) 98–108

    Abstract: Background: Peritoneal dialysis (PD) continues to be demanding for patients affected by kidney failure. In kidney failure patients with residual kidney function, the employment of incremental PD, a less onerous dialytic prescription, could translate ... ...

    Abstract Background: Peritoneal dialysis (PD) continues to be demanding for patients affected by kidney failure. In kidney failure patients with residual kidney function, the employment of incremental PD, a less onerous dialytic prescription, could translate into a decrease burden on both health systems and patients.
    Methods: Between 1st January 2009 and 31st December 2021, 182 patients who started continuous ambulatory peritoneal dialysis (CAPD) at our institution were included in the study. The CAPD population was divided into three groups according to the initial number of daily CAPD exchanges prescribed: one or two (50 patients, CAPD-1/2 group), three (97 patients, CAPD-3 group) and four (35 patients, CAPD-4 group), respectively.
    Results: Multivariate analysis showed a difference in term of peritonitis free survival in CAPD-1/2 in comparison to CAPD-3 (hazard ratio (HR): 2.20,
    Conclusions: One- or two-exchange CAPD start was associated with a lower risk of peritonitis in comparison to three- or four-exchange start. Furthermore, an initial PD prescription with less than three exchanges may be associated with an advantage in term of hospitalisation rate and patient survival.
    MeSH term(s) Humans ; Peritoneal Dialysis, Continuous Ambulatory ; Peritoneal Dialysis ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/therapy ; Renal Dialysis ; Peritonitis/etiology ; Renal Insufficiency
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645010-6
    ISSN 1718-4304 ; 0896-8608
    ISSN (online) 1718-4304
    ISSN 0896-8608
    DOI 10.1177/08968608231209849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1936: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease

    Dozio, Elena / Caldiroli, Lara / Molinari, Paolo / Castellano, Giuseppe / Delfrate, Nicholas Walter / Romanelli, Massimiliano Marco Corsi / Vettoretti, Simone

    Antioxidants. 2023 Feb. 26, v. 12, no. 3

    2023  

    Abstract: Advanced glycation end products (AGEs) are aging products. In chronic kidney disease (CKD), AGEs accumulate due to the increased production, reduced excretion, and the imbalance between oxidant/antioxidant capacities. CKD is therefore a model of aging. ... ...

    Abstract Advanced glycation end products (AGEs) are aging products. In chronic kidney disease (CKD), AGEs accumulate due to the increased production, reduced excretion, and the imbalance between oxidant/antioxidant capacities. CKD is therefore a model of aging. The aim of this review is to summarize the present knowledge of AGEs in CKD onset and progression, also focusing on CKD-related disorders (cardiovascular diseases, sarcopenia, and nutritional imbalance) and CKD mortality. The role of AGEs as etiopathogenetic molecules, as well as potential markers of disease progression and/or therapeutic targets, will be discussed.
    Keywords antioxidants ; disease progression ; excretion ; kidney diseases ; models ; mortality ; oxidants ; prognosis ; sarcopenia ; therapeutics
    Language English
    Dates of publication 2023-0226
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12030584
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Can Mediterranean Diet Have a Positive Impact on Kidney Health? A Pending Answer to a Long-Time Question.

    Caldiroli, Lara / Molinari, Paolo / Abinti, Matteo / Rusconi, Chiara / Castellano, Giuseppe / Vettoretti, Simone

    Nutrients

    2022  Volume 14, Issue 20

    Abstract: Dietary studies conducted in chronic kidney disease (CKD) patients were focused on the quantities of single nutrients, however it is possible that the excessive attention put on the restriction of proteins, sodium, potassium and phosphorus may compromise ...

    Abstract Dietary studies conducted in chronic kidney disease (CKD) patients were focused on the quantities of single nutrients, however it is possible that the excessive attention put on the restriction of proteins, sodium, potassium and phosphorus may compromise the overall quality of the diet in terms of micronutrients and palatability. Instead, concentrating on the nutritional quality healthy dietary patterns, may provide a better approach to improve nutritional prescriptions in CKD patients. All these dietary regimens share common features as reduced content of red meat, salt and saturated fatty acids, and higher fiber content, but may differ in terms of single nutrients consumption. In particular, Mediterranean Diet (Med Diet) has been associated with reduced incidence of diabetes, cardiovascular diseases and obesity, all conditions that are also strictly related to CKD. Given its low content of animal proteins and high contents of fiber it is possible that Med Diet may exert also positive effects on CKD as well as on its metabolic complications. In this review we summarize the role of Med Diet in primary prevention of CKD and on its progression.
    MeSH term(s) Humans ; Diet, Mediterranean ; Renal Insufficiency, Chronic/prevention & control ; Renal Insufficiency, Chronic/complications ; Diet ; Micronutrients ; Dietary Fiber ; Kidney ; Sodium ; Potassium ; Phosphorus ; Fatty Acids
    Chemical Substances Micronutrients ; Dietary Fiber ; Sodium (9NEZ333N27) ; Potassium (RWP5GA015D) ; Phosphorus (27YLU75U4W) ; Fatty Acids
    Language English
    Publishing date 2022-10-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14204366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Frailty index and adverse outcomes in older patients in haemodialysis.

    Soldati, Anna / Poggi, Marta Maria / Azzolino, Domenico / Vettoretti, Simone / Cesari, Matteo

    Archives of gerontology and geriatrics

    2022  Volume 101, Page(s) 104673

    Abstract: Background: In older people, the prevalence frailty is inversely proportional to renal function, therefore it is supposed to be the highest in haemodialysis patients. However, frailty and its association with adverse outcomes have been scarcely ... ...

    Abstract Background: In older people, the prevalence frailty is inversely proportional to renal function, therefore it is supposed to be the highest in haemodialysis patients. However, frailty and its association with adverse outcomes have been scarcely investigated in this population. The aim of the present study was to characterize the frailty status and explore its association with hospitalization and mortality in a cohort of older patients undergoing chronic haemodialysis.
    Materials and methods: This is a retrospective longitudinal study based on data from 105 older patients undergoing haemodialysis for at least 3 months. We computed a 24-item frailty index (FI) based on sociodemographic, clinical and biological data collected at baseline. During the follow-up, death and hospitalizations events were recorded. Unadjusted and adjusted Cox proportional hazard models were performed to test the association of frailty with hospitalization and death.
    Results: Mean age of the patients was 79.1 (SD 7.6) years, and their mean FI was 0.23 (SD 0.10). About 55% of patients were classified as frail (i.e., FI≥ 0.25). Patients were observed for 21 (interquartile range [IQR] 8-32) months. Overall, during the follow-up, 75% of patients required hospitalization and 28% died. Frail subjects where at higher risk of hospitalization (HR 1.60, 95% CI 1.00-2.57, p = 0.05) and of all-cause mortality (HR 2.52, 95% CI 1.10-5.80, p = 0.03) CONCLUSIONS: : Frailty is highly prevalent among older people undergoing haemodialysis. Frail individuals present a higher risk of hospitalizations and mortality. The FI is a reliable tool to study vulnerability in this population.
    MeSH term(s) Aged ; Frail Elderly ; Frailty/epidemiology ; Frailty/etiology ; Geriatric Assessment ; Hospitalization ; Humans ; Longitudinal Studies ; Renal Dialysis/adverse effects ; Retrospective Studies
    Language English
    Publishing date 2022-03-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2022.104673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1729: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease.

    Dozio, Elena / Caldiroli, Lara / Molinari, Paolo / Castellano, Giuseppe / Delfrate, Nicholas Walter / Romanelli, Massimiliano Marco Corsi / Vettoretti, Simone

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Advanced glycation end products (AGEs) are aging products. In chronic kidney disease (CKD), AGEs accumulate due to the increased production, reduced excretion, and the imbalance between oxidant/antioxidant capacities. CKD is therefore a model of aging. ... ...

    Abstract Advanced glycation end products (AGEs) are aging products. In chronic kidney disease (CKD), AGEs accumulate due to the increased production, reduced excretion, and the imbalance between oxidant/antioxidant capacities. CKD is therefore a model of aging. The aim of this review is to summarize the present knowledge of AGEs in CKD onset and progression, also focusing on CKD-related disorders (cardiovascular diseases, sarcopenia, and nutritional imbalance) and CKD mortality. The role of AGEs as etiopathogenetic molecules, as well as potential markers of disease progression and/or therapeutic targets, will be discussed.
    Language English
    Publishing date 2023-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12030584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Vitamin D and Calcium Supplementation and Urolithiasis: A Controversial and Multifaceted Relationship.

    Messa, Piergiorgio / Castellano, Giuseppe / Vettoretti, Simone / Alfieri, Carlo Maria / Giannese, Domenico / Panichi, Vincenzo / Cupisti, Adamasco

    Nutrients

    2023  Volume 15, Issue 7

    Abstract: Patients with urolithiasis, and particularly those with hypercalciuria, frequently have a marked reduction of bone mineral content up to the levels of osteoporosis, with a significant increase in bone fracture risk. For these reasons, the indication to ... ...

    Abstract Patients with urolithiasis, and particularly those with hypercalciuria, frequently have a marked reduction of bone mineral content up to the levels of osteoporosis, with a significant increase in bone fracture risk. For these reasons, the indication to prescribe vitamin D and/or calcium supplementations is very frequent in such patients. On the other hand, both calcium supplementation, and even more vitamin D therapy, can worsen the risk of developing urolithiasis by increasing calcium, phosphate, and oxalate urinary excretion. Despite the clinical and practical relevance of this issue, the evidence on this topic is scarce and contradictory. Therefore, some concerns exist about how and whether to prescribe such supplements to a patient with a history of kidney stones. In this narrative review, we resume some pivotal pathophysiological concepts strictly related to the dealt topic, and we draw some considerations and personal opinions on the pros and cons of such prescriptions. Finally, we share with the reader our pragmatic algorithm for handling the urolithiasis risk in patients who have strong indications to be prescribed vitamin D and calcium supplementations.
    MeSH term(s) Humans ; Vitamin D/therapeutic use ; Calcium/urine ; Vitamins ; Urolithiasis/etiology ; Urolithiasis/prevention & control ; Dietary Supplements/adverse effects ; Kidney Calculi/prevention & control ; Kidney Calculi/chemically induced
    Chemical Substances Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP) ; Vitamins
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15071724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Corrigendum: Impact of hyperparathyroidism and its different subtypes on long term graft outcome: a single Transplant Center cohort study.

    Molinari, Paolo / Regalia, Anna / Leoni, Alessandro / Campise, Mariarosaria / Cresseri, Donata / Cicero, Elisa / Vettoretti, Simone / Nardelli, Luca / Brigati, Emilietta / Favi, Evaldo / Messa, Piergiorgio / Castellano, Giuseppe / Alfieri, Carlo M

    Frontiers in medicine

    2024  Volume 11, Page(s) 1362741

    Abstract: This corrects the article DOI: 10.3389/fmed.2023.1221086.]. ...

    Abstract [This corrects the article DOI: 10.3389/fmed.2023.1221086.].
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1362741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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