Article: Hemagglutinin activation of pathogenic avian influenza viruses of serotype H7 requires the protease recognition motif R-X-K/R-R
Virology. May 1992. v. 188 (1)
1992
Abstract: The hemagglutinin of influenza virus A/FPV/Rostock/34 (H7) was altered at its multibasic cleavage site by site-directed mutagenesis and assayed for proteolytic activation after expression in CV-1 cells. The results indicated that the cellular protease ... ...
| Abstract | The hemagglutinin of influenza virus A/FPV/Rostock/34 (H7) was altered at its multibasic cleavage site by site-directed mutagenesis and assayed for proteolytic activation after expression in CV-1 cells. The results indicated that the cellular protease responsible for activation recognizes the tetrapeptide motif R-X-K/R-R that must be presented in the correct sequence position. Studies on plaque variants of influenza virus A/fowl/Victoria/75 (H7N7) showed that alteration of the consensus sequence resulted in a loss of pathogenicity for chickens. |
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| Keywords | chickens ; Influenza A virus ; proteinases ; proteolysis ; amino acid sequences ; mutants ; clones ; pathogenicity | |||||
| Language | English | |||||
| Dates of publication | 1992-05 | |||||
| Size | p. 408-413. | |||||
| Document type | Article | |||||
| ZDB-ID | 200425-2 | |||||
| ISSN | 1096-0341 ; 0042-6822 | |||||
| ISSN (online) | 1096-0341 | |||||
| ISSN | 0042-6822 | |||||
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| Database | NAL-Catalogue (AGRICOLA) |
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