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Article ; Online: Cold-induced urticaria in a child with familial Mediterranean fever.

Batu, Ezgi Deniz / Vezir, Emine

The journal of allergy and clinical immunology. In practice

2019 Volume 7, Issue 4, Page(s) 1376

MeSH term(s)	Child ; Familial Mediterranean Fever ; Family ; Humans ; Tertiary Care Centers ; Urticaria
Language	English
Publishing date	2019-04-08
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2019.01.019
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Zs.A 7086: Show issues

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Article ; Online: The frequency of sleep-disordered breathing in preschool children with asthma and its effects on control of asthma.

Capanoglu, Murat / Ginis, Tayfur / Buyuktiryaki, Betul / Guvenir, Hakan / Vezir, Emine / Misirlioglu, Emine Dibek / Toyran, Muge / Ersu, Refika / Kocabas, Can Naci / Civelek, Ersoy

Allergologia et immunopathologia

2024 Volume 52, Issue 1, Page(s) 38–43

Abstract: Conclusion: The frequency and score of SDB were higher in patients with uncontrolled asthma. Frequency and score of SDB were significantly affected by the severity of asthma. SDB must be evaluated in preschool children with uncontrolled asthma.: ... ...

Abstract	Conclusion: The frequency and score of SDB were higher in patients with uncontrolled asthma. Frequency and score of SDB were significantly affected by the severity of asthma. SDB must be evaluated in preschool children with uncontrolled asthma. Conclusion: Sleep-disordered breathing (SDB) is more common in asthmatic patients than in non-asthmatic persons, and SDB affects negatively to control asthma. A limited number of studies are discovered on the effect of SDB in preschool asthmatic children. In this study, we aimed to investigate the prevalence of SDB and its effect on control and severity of asthma in preschool children. A pediatric sleep questionnaire was completed by parents of asthmatic children. Patients who received a score of 0.33 or higher were diagnosed with SDB. Control and severity of asthma was assessed by a pediatric allergy specialist based on the Global Initiative for Asthma (GINA) criteria. The study included 249 patients, with a mean±SD age of 4.37±1.04 (range: 2-5.9) years; 69% were boys; 56.6% children had uncontrolled asthma and 28.7% had SDB. The SDB score was significantly different between controlled and uncontrolled asthma (0.19 vs 0.28; P < 0.001). The frequency of uncontrolled asthma in patients with and without SDB was 74.3% and 49.4%, respectively (P < 0.010). Based on the severity of asthma, the frequency of SDB among patients with mild, moderate, and severe asthma was 23.4%, 35.2%, and 47.4%, respectively (P = 0.010).
MeSH term(s)	Male ; Humans ; Child, Preschool ; Child ; Female ; Asthma/epidemiology ; Hypersensitivity ; Sleep Apnea Syndromes/epidemiology ; Sleep ; Parents
Language	English
Publishing date	2024-01-01
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.15586/aei.v52i1.804
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Zs.A 1165: Show issues

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Article ; Online: Clinical Phenotypes of Severe Cutaneous Drug Hypersensitivity Reactions.

Guvenir, Hakan / Arikoglu, Tugba / Vezir, Emine / Misirlioglu, Emine Dibek

Current pharmaceutical design

2019 Volume 25, Issue 36, Page(s) 3840–3854

Abstract: Drug hypersensitivity reactions are clinically heterogenous ranging from mild to severe. Most drug hypersensitivity reactions are accompanied by cutaneous manifestations. Fever, mucous membrane involvement, large blisters, facial oedema, pustulosis and ... ...

Abstract	Drug hypersensitivity reactions are clinically heterogenous ranging from mild to severe. Most drug hypersensitivity reactions are accompanied by cutaneous manifestations. Fever, mucous membrane involvement, large blisters, facial oedema, pustulosis and visceral involvement are clinical features that lead to suspicion of severe adverse drug reactions. Severe cutaneous adverse drug reactions (SCARs) include Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis. Serum sickness like reactions, drug induced vasculitis and generalized bullous fixed drug eruptions are less severe clinical entities. SCARs are uncommon but associated with significant morbidity and mortality. Physician should be aware of specific red flags and danger signs to immediately identify these reactions. Immediate drug withdrawal is mandatory. Early diagnosis and appropriate treatment significantly affect the prognosis of the disease. The purpose of our review is to discuss clinical phenotypes of severe cutaneous drug hypersensitivity reactions.
MeSH term(s)	Acute Generalized Exanthematous Pustulosis ; Dermatitis, Atopic/classification ; Dermatitis, Atopic/diagnosis ; Drug Hypersensitivity/classification ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity Syndrome ; Humans ; Phenotype ; Skin/physiopathology ; Stevens-Johnson Syndrome
Language	English
Publishing date	2019-11-07
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612825666191107162921
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Zs.A 4714: Show issues

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Article ; Online: Galectin-3: a new biomarker for differentiating periodic fever, adenitis, pharyngitis, aphthous stomatitis (PFAPA) syndrome from familial Mediterranean fever?

Batu, Ezgi D / Vezir, Emine / Öğüş, Elmas / Özbaş Demirel, Özlem / Akpınar, Gizem / Demir, Selcan / Özen, Seza

Rheumatology international

2021 Volume 42, Issue 1, Page(s) 71–80

Abstract: Differentiating PFAPA (periodic fever, aphthosis, pharyngitis, and adenitis) syndrome from familial Mediterranean fever (FMF) could be challenging in some cases. Galectin-3 is a lectin with regulatory functions in apoptosis and inflammation. We aimed to ... ...

Abstract	Differentiating PFAPA (periodic fever, aphthosis, pharyngitis, and adenitis) syndrome from familial Mediterranean fever (FMF) could be challenging in some cases. Galectin-3 is a lectin with regulatory functions in apoptosis and inflammation. We aimed to test whether galectin-3 could be a biomarker for differentiating PFAPA syndrome from FMF. Patients with PFAPA syndrome, FMF, cryopyrin-associated periodic syndrome (CAPS), and streptococcal pharyngitis, and healthy controls were included in this study. Serum galectin-3 levels were measured using enzyme-linked immunosorbent assay. Eighty-seven patients (36 with PFAPA, 39 with FMF, 8 with CAPS, 4 with streptococcal pharyngitis), and 17 healthy controls were included. Blood samples were drawn during attacks from 20 PFAPA and 7 FMF patients and attack-free periods from 22 PFAPA, 35 FMF, and 8 CAPS patients. The median serum galectin-3 level in the PFAPA-attack group (1.025 ng/ml) was significantly lower than the levels in healthy control (2.367 ng/ml), streptococcal pharyngitis (3.021 ng/ml), FMF attack (2.402 ng/ml), and FMF-attack-free groups (2.797 ng/ml) (p = 0.006, 0.03, 0.01, and < 0.001, respectively). PFAPA-attack-free group had lower galectin-3 levels than the FMF-attack-free group (1.794 vs. 2.797 ng/ml, respectively; p = 0.01). Galectin-3 levels did not differ significantly between CAPS and attack-free PFAPA patients (1.439 ng/ml vs. 1.794 ng/ml, respectively; p = 0.63). In our study, for the first time, we defined galectin-3 as a promising biomarker that differs between PFAPA and FMF patients during both disease flares and attack-free periods. Further studies with high number of patients could validate its role as a biomarker.
MeSH term(s)	Adolescent ; Biomarkers/blood ; Case-Control Studies ; Child ; Child, Preschool ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Familial Mediterranean Fever/blood ; Familial Mediterranean Fever/diagnosis ; Familial Mediterranean Fever/genetics ; Female ; Galectin 3/blood ; Humans ; Infant ; Infant, Newborn ; Lymphadenitis/blood ; Lymphadenitis/diagnosis ; Male ; Pharyngitis/blood ; Pharyngitis/diagnosis ; Stomatitis, Aphthous/blood ; Stomatitis, Aphthous/diagnosis ; Syndrome
Chemical Substances	Biomarkers ; Galectin 3
Language	English
Publishing date	2021-03-11
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-021-04827-1
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Zs.A 1639: Show issues

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Article ; Online: Does aeroallergen sensitivity and allergic rhinitis in children cause milder COVID-19 infection?

Vezir, Emine / Hizal, Mina / Cura Yayla, Burcu / Aykac, Kubra / Yilmaz, Arzu / Kaya, Gamze / Oygar, Pembe Derin / Ozsurekci, Yasemin / Ceyhan, Mehmet

Allergy and asthma proceedings

2021 Volume 42, Issue 6, Page(s) 522–529

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adolescent ; Allergens/adverse effects ; Asthma/diagnosis ; Asthma/epidemiology ; Asthma/immunology ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Child ; Child, Preschool ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/immunology ; Female ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/epidemiology ; Hypersensitivity/immunology ; Immunoglobulin E/blood ; Male ; Respiratory Function Tests ; Rhinitis, Allergic/diagnosis ; Rhinitis, Allergic/epidemiology ; Rhinitis, Allergic/immunology ; SARS-CoV-2 ; Severity of Illness Index ; Skin Tests/statistics & numerical data ; Turkey/epidemiology
Chemical Substances	Allergens ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2021-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1312445-6
ISSN	1539-6304 ; 1088-5412
ISSN (online)	1539-6304
ISSN	1088-5412
DOI	10.2500/aap.2021.42.210087
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Zs.A 1804: Show issues

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Article ; Online: Hemophagocytic Lymphohistiocytosis Associated With Hemolytic Uremic Syndrome in a Child: A Case Report and Systematic Literature Review.

Tas, Nesrin / Gokceoglu, Arife U / Yayla, Burcu C C / Ozcan, Ayşegul / Sac, Rukiye U / Vezir, Emine / Alioglu, Bulent

Journal of pediatric hematology/oncology

2021 Volume 44, Issue 5, Page(s) e905–e910

Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder resulting from excessive activation and nonmalignant proliferation of T-lymphocytes and macrophages. Hemolytic uremic syndrome (HUS) is a disease characterized by microangiopathic ... ...

Abstract	Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder resulting from excessive activation and nonmalignant proliferation of T-lymphocytes and macrophages. Hemolytic uremic syndrome (HUS) is a disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Reports pertaining to the association between HLH and HUS are rarely published; however, we report on a 4-year-old boy who was diagnosed with both conditions and treated successfully with high-dose steroid and intravenous immunoglobulin. Differentiating HUS from HLH can be challenging because of their clinical similarities. Therefore, prompt diagnosis and immunosuppressive treatment are essential and life-saving to these patients.
MeSH term(s)	Acute Kidney Injury/complications ; Anemia, Hemolytic ; Child ; Child, Preschool ; Hemolytic-Uremic Syndrome/diagnosis ; Humans ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Lymphohistiocytosis, Hemophagocytic/drug therapy ; Male ; Thrombocytopenia/complications
Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Case Reports ; Journal Article ; Systematic Review
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002265
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Zs.A 1537: Show issues

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Article ; Online: Evaluation of intestinal parasites in patients with chronic spontaneous urticaria in a territory hospital in Turkey.

Vezir, Sedat / Kaya, Filiz / Vezir, Emine / Karaosmanoğlu, Nermin / Adiloğlu, Ali Kudret

Journal of infection in developing countries

2019 Volume 13, Issue 10, Page(s) 927–932

Abstract: Introduction: Chronic spontaneous urticaria (CSU) which develops without a known stimulation is defined as the occurrence of spontaneous wheals, angioedema or both for longer than six weeks. Infections, autoimmunity, food intolerance and internal ... ...

Abstract	Introduction: Chronic spontaneous urticaria (CSU) which develops without a known stimulation is defined as the occurrence of spontaneous wheals, angioedema or both for longer than six weeks. Infections, autoimmunity, food intolerance and internal parasitic infections are supposed to be underlying causes of CSU. The aim of this study was to evaluate the intestinal parasites in children and adult patients diagnosed as CSU, to determine the frequency of parasites in chronic urticaria, and to compare these patients with healthy demographic control groups. Methodology: Seventy six children and 38 adult patients with CSU were examined in terms of parasitic infections. The patients whom parasites were detected received anti-parasitic therapy and the improvements in CSU symptoms were evaluated. Stool samples were examined with direct microscopic examination (native-lugol), stool concentration and trichrome staining methods. Results: In pediatric patient group, 18.4% (n = 14) of the stool samples were positive for Blastocystis sp., 2.6% (n = 2), Dientamoeba fragilis and 1.3% (n = 1), Giardia duodenalis. In adult patient group, Blastocystis sp. was detected in 18.4% (n = 7) of the stool samples. Anti-parasitic therapy yielded substantial improvement in urticaria symptoms in 57.1% of pediatric and 60.0% of adult patients. Conclusions: Blastocystis sp. and D. fragilis may play a role in chronic urticaria which seriously disrupts the patient's quality of life. Parasitic infections should not be neglected in patients with cutaneous manifestations.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antiparasitic Agents/therapeutic use ; Blastocystis/isolation & purification ; Child ; Child, Preschool ; Chronic Urticaria/parasitology ; Dientamoeba/isolation & purification ; Eosinophils ; Female ; Giardia lamblia/isolation & purification ; Humans ; Immunoglobulin E/blood ; Infant ; Intestinal Diseases, Parasitic/complications ; Intestinal Diseases, Parasitic/drug therapy ; Intestinal Diseases, Parasitic/parasitology ; Male ; Metronidazole/therapeutic use ; Middle Aged ; Turkey ; Young Adult
Chemical Substances	Antiparasitic Agents ; Metronidazole (140QMO216E) ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2019-10-31
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.11552
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Article ; Online: Cold-induced urticaria in children: A multicenter, retrospective cohort study.

Karabag Citlak, Hilal / Azkur, Dilek / Kavas Yildiz, Yuksel / Demirel, Ali Can / Kot, Hakan / Vezir, Emine / Kilic, Mehmet / Usta Guc, Belgin / Kilic, Mehtap / Yakici, Nalan / Kocabas, Can Naci / Dibek Misirlioglu, Emine / Civelek, Ersoy / Orhan, Fazil

Allergy and asthma proceedings

2023 Volume 44, Issue 6, Page(s) e36–e43

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Male ; Female ; Child ; Humans ; Child, Preschool ; Adolescent ; Retrospective Studies ; Ice ; Urticaria/diagnosis ; Urticaria/epidemiology ; Urticaria/etiology ; Chronic Urticaria ; Immunoglobulin E
Chemical Substances	Ice ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	1312445-6
ISSN	1539-6304 ; 1088-5412
ISSN (online)	1539-6304
ISSN	1088-5412
DOI	10.2500/aap.2023.44.230050
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Article: Hyperimmunoglobulin D Syndrome Presenting with Volvulus Due to Abdominal Fibro-Inflammatory Bands.

Aslan, Muzaffer Kaan / Cesur, Özkan / Özcan, Ayşegül / Avcı, Nihal / Goncu, Sultan / Ünsal Saç, Rukiye / Sandal, Semih / Cura Yayla, Burcu Ceylan / Vezir, Emine / Tasar, Medine Aysin / Sağ, Erdal

Turkish archives of pediatrics

2022 Volume 58, Issue 1, Page(s) 109–111

Language	English
Publishing date	2022-09-22
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-6256
ISSN	2757-6256
DOI	10.5152/TurkArchPediatr.2022.22125
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Article ; Online: Evaluation of the Clinical Characteristics of Patients with Food Protein-Induced Enterocolitis Syndrome: A Multicenter Study.

Metbulut, Azize Pınar / Özen, Selime / Kendirci, Nergiz / Usta Güç, Belgin / Güvenir, Hakan / Vezir, Emine / Bahçeci, Semiha / Can, Demet / Kılıç, Mehtap / Çapanoğlu, Murat / Kılıç, Mehmet / Karaatmaca, Betül / Kocabaş, Can Naci / Dibek Mısırlıoğlu, Emine / Orhan, Fazıl

International archives of allergy and immunology

2022 Volume 183, Issue 8, Page(s) 805–813

Abstract: Introduction: Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE, cell-mediated food allergy disorder. We aimed to report the demographic characteristics, clinical features, and management of pediatric patients with FPIES.: Methods!# ...

Abstract	Introduction: Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE, cell-mediated food allergy disorder. We aimed to report the demographic characteristics, clinical features, and management of pediatric patients with FPIES. Methods: This retrospective study included all children diagnosed with FPIES at the pediatric allergy departments of the participating twelve study centers from January 2015 to November 2020. Results: A total of 73 patients (39 males, 53.4%) with a male/female ratio of 1.1 were included in the study. The median (interquartile ranges) age at symptom onset was 6 months (0.5-168, 4-9.5). The most frequent offending foods were cow's milk, egg's yolk, fish, and egg's white, identified in 38.4% (n = 28), 32.9% (n = 24), 21.9% (n = 16) and 20.5% (n = 15) of the patients, respectively. The total number of reported FPIES episodes was 290 (3.9 episodes per child). Oral food challenge (OFC) was performed in 54.8% (n = 40) of the patients, and tolerance was detected in 17 OFCs (42.5%) at a median age of 15 months (range 8-132 months). Conclusion: FPIES is a non-IgE-mediated food hypersensitivity that commonly affects infants and is often misdiagnosed. The pathophysiology of the disease remains unclear and the low awareness of FPIES among physicians and parents highlights the need for more education.
MeSH term(s)	Allergens ; Animals ; Cattle ; Dietary Proteins/adverse effects ; Enterocolitis/diagnosis ; Enterocolitis/epidemiology ; Enterocolitis/etiology ; Female ; Food Hypersensitivity/diagnosis ; Food Hypersensitivity/epidemiology ; Humans ; Immune Tolerance ; Male ; Retrospective Studies
Chemical Substances	Allergens ; Dietary Proteins
Language	English
Publishing date	2022-06-03
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000522496
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