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  1. Article: Prevalence of osteoporosis and vertebral fractures in postmenopausal women with type 2 diabetes mellitus and their relationship with duration of the disease and chronic complications

    Viégas, Maíra / Costa, Christiane / Lopes, Arthur / Griz, Luiz / Medeiro, Maria Antonieta / Bandeira, Francisco

    Journal of diabetes and its complications. 2011 , v. 25, no. 4

    2011  

    Abstract: Controversial data suggest that patients with type 2 diabetes mellitus have an increased risk of fractures despite having, in some studies, higher bone mineral density. METHODS: The aim of this study was to determine the prevalence of osteoporosis and ... ...

    Abstract Controversial data suggest that patients with type 2 diabetes mellitus have an increased risk of fractures despite having, in some studies, higher bone mineral density. METHODS: The aim of this study was to determine the prevalence of osteoporosis and morphometric vertebral fractures in 148 postmenopausal diabetic women, aged 61.87±7.85 years, and their relationship with clinical and metabolic factors and chronic complications of the disease. RESULTS: The prevalence of osteoporosis was 30.4% at lumbar spine (LS) and 9.5% at femoral neck (FN). The prevalence of vertebral fractures was 23%, mostly mild and located at the thoracic spine. Patients with fractures were older (P<.001), had been in the menopause for a long period (P=.005), had lower creatinine clearance (P=.026) had and lower bone mineral density at LS (P=.01) and FN (P=.042). The frequency of fractures increased with age (P<.001), with the duration of the disease (P=.037) and with the presence of retinopathy (P=.030). In patients with fractures, the prevalence of osteoporosis increased to 40% at LS (P=.004) and to 35.7% at FN (P=.049). After logistic regression adjustment, it was observed that the likelihood of presenting vertebral fractures was significantly increased at the age of 60 years or older (P<.001) and with the presence of osteoporosis at LS (P=.006), irrespective of blood glucose control. CONCLUSION: We found a high prevalence of osteoporosis and vertebral fractures in postmenopausal women with type 2 diabetes mellitus, irrespective of blood glucose control, and these conditions were more frequent in long-standing disease and in patients with retinopathy and impaired renal function.
    Keywords blood glucose ; bone density ; chronic diseases ; complications (disease) ; creatinine ; femur ; glycemic control ; lumbar spine ; morphometry ; noninsulin-dependent diabetes mellitus ; osteoporosis ; patients ; postmenopause ; regression analysis ; renal function ; retinal diseases ; risk ; thoracic spine ; women
    Language English
    Dates of publication 2011-07
    Size p. 216-221.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1105840-7
    ISSN 1056-8727
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2011.02.004
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2225: Show issues Location:
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  2. Article ; Online: Prevalence of osteoporosis and vertebral fractures in postmenopausal women with type 2 diabetes mellitus and their relationship with duration of the disease and chronic complications.

    Viégas, Maíra / Costa, Christiane / Lopes, Arthur / Griz, Luiz / Medeiro, Maria Antonieta / Bandeira, Francisco

    Journal of diabetes and its complications

    2011  Volume 25, Issue 4, Page(s) 216–221

    Abstract: Unlabelled: Controversial data suggest that patients with type 2 diabetes mellitus have an increased risk of fractures despite having, in some studies, higher bone mineral density.: Methods: The aim of this study was to determine the prevalence of ... ...

    Abstract Unlabelled: Controversial data suggest that patients with type 2 diabetes mellitus have an increased risk of fractures despite having, in some studies, higher bone mineral density.
    Methods: The aim of this study was to determine the prevalence of osteoporosis and morphometric vertebral fractures in 148 postmenopausal diabetic women, aged 61.87±7.85 years, and their relationship with clinical and metabolic factors and chronic complications of the disease.
    Results: The prevalence of osteoporosis was 30.4% at lumbar spine (LS) and 9.5% at femoral neck (FN). The prevalence of vertebral fractures was 23%, mostly mild and located at the thoracic spine. Patients with fractures were older (P<.001), had been in the menopause for a long period (P=.005), had lower creatinine clearance (P=.026) had and lower bone mineral density at LS (P=.01) and FN (P=.042). The frequency of fractures increased with age (P<.001), with the duration of the disease (P=.037) and with the presence of retinopathy (P=.030). In patients with fractures, the prevalence of osteoporosis increased to 40% at LS (P=.004) and to 35.7% at FN (P=.049). After logistic regression adjustment, it was observed that the likelihood of presenting vertebral fractures was significantly increased at the age of 60 years or older (P<.001) and with the presence of osteoporosis at LS (P=.006), irrespective of blood glucose control.
    Conclusion: We found a high prevalence of osteoporosis and vertebral fractures in postmenopausal women with type 2 diabetes mellitus, irrespective of blood glucose control, and these conditions were more frequent in long-standing disease and in patients with retinopathy and impaired renal function.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Blood Glucose/analysis ; Bone Density ; Bone Diseases, Metabolic/complications ; Bone Diseases, Metabolic/epidemiology ; Brazil/epidemiology ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/therapy ; Diabetic Nephropathies/complications ; Diabetic Retinopathy/complications ; Female ; Femoral Neck Fractures/epidemiology ; Femur Neck/chemistry ; Femur Neck/injuries ; Humans ; Lumbar Vertebrae/chemistry ; Lumbar Vertebrae/injuries ; Middle Aged ; Osteoporosis, Postmenopausal/complications ; Osteoporosis, Postmenopausal/epidemiology ; Postmenopause ; Prevalence ; Severity of Illness Index ; Spinal Fractures/complications ; Spinal Fractures/epidemiology ; Thoracic Vertebrae/chemistry ; Thoracic Vertebrae/injuries
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2011-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1105840-7
    ISSN 1873-460X ; 1056-8727
    ISSN (online) 1873-460X
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2011.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevalence of central obesity in a large sample of adolescents from public schools in Recife, Brazil.

    Griz, Luiz H M / Viégas, Maíra / Barros, Mauro / Griz, Adriana L / Freese, Eduardo / Bandeira, Francisco

    Arquivos brasileiros de endocrinologia e metabologia

    2010  Volume 54, Issue 7, Page(s) 607–611

    Abstract: Objective: To determine the prevalence and association of central obesity (CO) and hypertension and its associations with alcohol intake, smoking and physical activity in adolescents.: Subjects and methods: Cross sectional study in 1,824 students ... ...

    Abstract Objective: To determine the prevalence and association of central obesity (CO) and hypertension and its associations with alcohol intake, smoking and physical activity in adolescents.
    Subjects and methods: Cross sectional study in 1,824 students from 29 public schools in Recife.
    Results: 89.6% were normal weight, 6.7% overweight and 3.7% obese; 77.2% were normotensive, 5.9% prehypertensive and 16.9% hypertensive; CO was 10.2% when the 90th percentile was used as cutoff and 25.2% when the 75th percentile was used. There was a higher likelihood of central obesity among students aged 18 to 20 years, smoking and alcohol intake. The probability of hypertension increases if the subject is male, has a waist circumference (WC) ≥ 90, WC ≥ 75 and does not practice physical activity.
    Conclusions: A high prevalence of CO and hypertension was found in adolescents. CO was more frequent in students aged 18 to 20 years, smokers and with alcohol intake and hypertension was associated with male, CO and no physical activity.
    MeSH term(s) Adolescent ; Alcohol Drinking/epidemiology ; Brazil/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Hypertension/epidemiology ; Logistic Models ; Male ; Motor Activity ; Obesity, Abdominal/epidemiology ; Obesity, Abdominal/etiology ; Prevalence ; Public Sector ; Risk Factors ; Schools ; Smoking/epidemiology ; Waist Circumference ; Young Adult
    Language English
    Publishing date 2010-08-01
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/s0004-27302010000700004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bariatric surgery and bone metabolism: a systematic review.

    Viégas, Maíra / Vasconcelos, Renata Simões de / Neves, Ana Paula / Diniz, Erik Trovão / Bandeira, Francisco

    Arquivos brasileiros de endocrinologia e metabologia

    2010  Volume 54, Issue 2, Page(s) 158–163

    Abstract: Few studies have demonstrated the risk of metabolic bone disease and a reduction in bone mineral density (BMD) after bariatric surgery. A systematic review was conducted of case-control and cohort studies with the aim of evaluating the relationship ... ...

    Abstract Few studies have demonstrated the risk of metabolic bone disease and a reduction in bone mineral density (BMD) after bariatric surgery. A systematic review was conducted of case-control and cohort studies with the aim of evaluating the relationship between bariatric surgery and bone metabolism. The search was undertaken in MedLine, covering the period from January 1997 to August 2009, using the keywords: "bariatric surgery" AND "osteoporosis", "fracture", "bone diseases", "metabolic". Six studies were included, comprising four cohort and two case-control studies. Three studies evaluated bone metabolism and BMD, and the other evaluated bone metabolism only. Based on this review, bariatric surgery is associated with alterations in bone metabolism, loss of bone mass and an increased risk of fracture. However, the maximum evaluation period covered by these studies was two years after surgery, hence the need to undertake further studies of longer duration in order to achieve a more thorough understanding of this association.
    MeSH term(s) Bariatric Surgery/adverse effects ; Bone Diseases, Metabolic/etiology ; Bone Resorption/etiology ; Bone and Bones/metabolism ; Case-Control Studies ; Cohort Studies ; Fractures, Bone/etiology ; Humans ; Obesity/complications ; Obesity/surgery
    Language English
    Publishing date 2010-05-19
    Publishing country Brazil
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/s0004-27302010000200011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Factors associated with secondary hyperparathyroidism in premenopausal women undergoing Roux-en-Y gastric bypass for the treatment of obesity.

    Vasconcelos, Renata Simões de / Viégas, Maíra / Marques, Thyciara Fontenele / Diniz, Erik Trovão / Lucena, Cynthia Salgado / Câmara Neto, José Bezerra / Bandeira, Francisco

    Arquivos brasileiros de endocrinologia e metabologia

    2010  Volume 54, Issue 2, Page(s) 233–238

    Abstract: Objective: To evaluate bone metabolism, bone density (BMD) and vertebral fractures in morbidly obese individuals.: Subjects and methods: Case series of 29 premenopausal obese patients, 15 of whom had been submitted to bariatric surgery. Serum calcium, ...

    Abstract Objective: To evaluate bone metabolism, bone density (BMD) and vertebral fractures in morbidly obese individuals.
    Subjects and methods: Case series of 29 premenopausal obese patients, 15 of whom had been submitted to bariatric surgery. Serum calcium, albumin, PTH and 25-hydroxy vitamin D (25OHD) were measured as well as bone densitometry of the lumbar spine and proximal femur, and lateral spine x-rays.
    Results: High parathyroid hormone (PTH) levels were recorded in 46.6% of the surgical patients and in 21.4% of the non-surgical patients (p = 0.245); 26.7% of the former and 28.6% of the latter revealed levels 25OHD < 30 ng/mL (p = 1.000). Calcium intake was higher in the surgical group (p = 0.004) along with lower serum calcium concentrations (p = 0.019). There were no significant differences in bone mineral density (BMD) or in the prevalence of vertebral fractures between groups.
    Conclusion: In premenopausal women undergoing Roux-en-Y gastric bypass there is important intestinal calcium mal absorption which seems to be the main factor causing secondary hyperparathyroidism.
    MeSH term(s) Adolescent ; Adult ; Biomarkers/blood ; Bone Density/physiology ; Bone Diseases, Metabolic/etiology ; Bone Remodeling/physiology ; Bone and Bones/metabolism ; Calcium/blood ; Calcium, Dietary/administration & dosage ; Female ; Gastric Bypass ; Humans ; Hyperparathyroidism, Secondary/etiology ; Obesity/surgery ; Parathyroid Hormone/blood ; Premenopause/blood ; Spinal Fractures ; Young Adult
    Chemical Substances Biomarkers ; Calcium, Dietary ; Parathyroid Hormone ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2010-05-19
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/s0004-27302010000200021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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