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  1. Article ; Online: Drosophila

    Rambur, Amandine / Vialat, Marine / Beaudoin, Claude / Lours-Calet, Corinne / Lobaccaro, Jean-Marc / Baron, Silvère / Morel, Laurent / de Joussineau, Cyrille

    Cells

    2021  Volume 10, Issue 9

    Abstract: Prostate cancer is the most common cancer in aging men. Despite recent progress, there are still few effective treatments to cure its aggressive and metastatic stages. A better understanding of the molecular mechanisms driving disease initiation and ... ...

    Abstract Prostate cancer is the most common cancer in aging men. Despite recent progress, there are still few effective treatments to cure its aggressive and metastatic stages. A better understanding of the molecular mechanisms driving disease initiation and progression appears essential to support the development of more efficient therapies and improve patient care. To do so, multiple research models, such as cell culture and mouse models, have been developed over the years and have improved our comprehension of the biology of the disease. Recently, a new model has been added with the use of the
    MeSH term(s) Animals ; Disease Models, Animal ; Drosophila/physiology ; Genitalia, Male/pathology ; Humans ; Male ; Prostatic Neoplasms/pathology
    Language English
    Publishing date 2021-09-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10092387
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  2. Article ; Online: Searching for Hidden Neutrons with a Reactor Neutrino Experiment: Constraints from the STEREO Experiment.

    Almazán, H / Bernard, L / Blanchet, A / Bonhomme, A / Buck, C / Del Amo Sanchez, P / El Atmani, I / Labit, L / Lamblin, J / Letourneau, A / Lhuillier, D / Licciardi, M / Lindner, M / Materna, T / Méplan, O / Pessard, H / Pignol, G / Réal, J-S / Ricol, J-S /
    Roca, C / Rogly, R / Salagnac, T / Sarrazin, M / Savu, V / Schoppmann, S / Soldner, T / Stutz, A / Vialat, M

    Physical review letters

    2022  Volume 128, Issue 6, Page(s) 61801

    Abstract: Different extensions of the standard model of particle physics, such as braneworld or mirror matter models, predict the existence of a neutron sterile state, possibly as a dark matter candidate. This Letter reports a new experimental constraint on the ... ...

    Abstract Different extensions of the standard model of particle physics, such as braneworld or mirror matter models, predict the existence of a neutron sterile state, possibly as a dark matter candidate. This Letter reports a new experimental constraint on the probability p for neutron conversion into a hidden neutron, set by the STEREO experiment at the high flux reactor of the Institut Laue-Langevin. The limit is p<3.1×10^{-11} at 95% C.L. improving the previous limit by a factor of 13. This result demonstrates that short-baseline neutrino experiments can be used as competitive passing-through-walls neutron experiments to search for hidden neutrons.
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.128.061801
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  3. Article ; Online: Persistent organic pollutants promote aggressiveness in prostate cancer.

    Buñay, Julio / Kossai, Myriam / Damon-Soubeyrant, Christelle / De Haze, Angélique / Saru, Jean-Paul / Trousson, Amalia / de Joussineau, Cyrille / Bouchareb, Erwan / Kocer, Ayhan / Vialat, Marine / Dallel, Sarah / Degoul, Françoise / Bost, Frédéric / Clavel, Stephan / Penault-Llorca, Frédérique / Valli, Marie-Pierre / Guy, Laurent / Matthews, Jason / Renaud, Yoan /
    Ittmann, Michael / Jones, Jeffrey / Morel, Laurent / Lobaccaro, Jean-Marc / Baron, Silvère

    Oncogene

    2023  Volume 42, Issue 38, Page(s) 2854–2867

    Abstract: Increasing evidence points towards a causal link between exposure to persistent organic pollutants (POPs) with increased incidence and aggressivity of various cancers. Among these POPs, dioxin and PCB-153 are widely found in our environment and represent ...

    Abstract Increasing evidence points towards a causal link between exposure to persistent organic pollutants (POPs) with increased incidence and aggressivity of various cancers. Among these POPs, dioxin and PCB-153 are widely found in our environment and represent a significant source of contamination. Dioxin exposure has already been linked to cancer such as non-Hodgkin's lymphoma, but remains to be more extensively investigated in other cancers. Potential implications of dioxin and PCB-153 in prostate cancer progression spurred us to challenge both ex vivo and in vivo models with low doses of these POPs. We found that dioxin or PCB-153 exposure increased hallmarks of growth and metastasis of prostate cancer cells ex vivo and in grafted NOD-SCID mice. Exposure induced histopathological carcinoma-like patterns in the Pten
    MeSH term(s) Male ; Humans ; Animals ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Persistent Organic Pollutants ; Dioxins/toxicity ; Prostatic Neoplasms/chemically induced ; Prostatic Neoplasms/genetics ; Polychlorinated Dibenzodioxins ; Acetyltransferases
    Chemical Substances 2,4,5,2',4',5'-hexachlorobiphenyl (ZRU0C9E32O) ; Persistent Organic Pollutants ; Dioxins ; Polychlorinated Dibenzodioxins ; Acetyltransferases (EC 2.3.1.-)
    Language English
    Publishing date 2023-08-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-023-02788-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2218: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila.

    Rambur, Amandine / Lours-Calet, Corinne / Beaudoin, Claude / Buñay, Julio / Vialat, Marine / Mirouse, Vincent / Trousson, Amalia / Renaud, Yoan / Lobaccaro, Jean-Marc A / Baron, Silvère / Morel, Laurent / de Joussineau, Cyrille

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 2300

    Abstract: One of the most important but less understood step of epithelial tumourigenesis occurs when cells acquire the ability to leave their epithelial compartment. This phenomenon, described as basal epithelial cell extrusion (basal extrusion), represents the ... ...

    Abstract One of the most important but less understood step of epithelial tumourigenesis occurs when cells acquire the ability to leave their epithelial compartment. This phenomenon, described as basal epithelial cell extrusion (basal extrusion), represents the first step of tumour invasion. However, due to lack of adequate in vivo model, implication of emblematic signalling pathways such as Ras/Mitogen-Activated Protein Kinase (MAPK) and phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathways, is scarcely described in this phenomenon. We have developed a unique model of basal extrusion in the Drosophila accessory gland. There, we demonstrate that both Ras/MAPK and PI3K/AKT/mTOR pathways are necessary for basal extrusion. Furthermore, as in prostate cancer, we show that these pathways are co-activated. This occurs through set up of Epidermal Growth Factor Receptor (EGFR) and Insulin Receptor (InR) dependent autocrine loops, a phenomenon that, considering human data, could be relevant for prostate cancer.
    MeSH term(s) Animals ; Drosophila ; Drosophila Proteins/metabolism ; Exocrine Glands/metabolism ; Male ; Mitogen-Activated Protein Kinases/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Prostatic Neoplasms/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/physiology ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances Drosophila Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2020-05-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-16123-w
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  5. Article ; Online: Accurate Measurement of the Electron Antineutrino Yield of ^{235}U Fissions from the STEREO Experiment with 119 Days of Reactor-On Data.

    Almazán, H / Bernard, L / Blanchet, A / Bonhomme, A / Buck, C / Sanchez, P Del Amo / Atmani, I El / Haser, J / Labit, L / Lamblin, J / Letourneau, A / Lhuillier, D / Licciardi, M / Lindner, M / Materna, T / Minotti, A / Onillon, A / Pessard, H / Réal, J-S /
    Roca, C / Rogly, R / Salagnac, T / Savu, V / Schoppmann, S / Sergeyeva, V / Soldner, T / Stutz, A / Vialat, M

    Physical review letters

    2020  Volume 125, Issue 20, Page(s) 201801

    Abstract: We report a measurement of the antineutrino rate from the fission of ^{235}U with the STEREO detector using 119 days of reactor turned on. In our analysis, we perform several detailed corrections and achieve the most precise single measurement at ... ...

    Abstract We report a measurement of the antineutrino rate from the fission of ^{235}U with the STEREO detector using 119 days of reactor turned on. In our analysis, we perform several detailed corrections and achieve the most precise single measurement at reactors with highly enriched ^{235}U fuel. We measure an IBD cross section per fission of σ_{f}=(6.34±0.06[stat]±0.15[sys]±0.15[model])×10^{-43}  cm^{2}/fission and observe a rate deficit of (5.2±0.8[stat]±2.3[sys]±2.3[model])% compared to the model, consistent with the deficit of the world average. Testing ^{235}U as the sole source of the deficit, we find a tension between the results of lowly and highly enriched ^{235}U fuel of 2.1 standard deviations.
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.125.201801
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    In stock of ZB MED Bonn / Germany

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  6. Article ; Online: Joint Measurement of the ^{235}U Antineutrino Spectrum by PROSPECT and STEREO.

    Almazán, H / Andriamirado, M / Balantekin, A B / Band, H R / Bass, C D / Bergeron, D E / Bernard, L / Blanchet, A / Bonhomme, A / Bowden, N S / Bryan, C D / Buck, C / Classen, T / Conant, A J / Deichert, G / Del Amo Sanchez, P / Delgado, A / Diwan, M V / Dolinski, M J /
    El Atmani, I / Erickson, A / Foust, B T / Gaison, J K / Galindo-Uribarri, A / Gilbert, C E / Hans, S / Hansell, A B / Heeger, K M / Heffron, B / Jaffe, D E / Jayakumar, S / Ji, X / Jones, D C / Koblanski, J / Kyzylova, O / Labit, L / Lamblin, J / Lane, C E / Langford, T J / LaRosa, J / Letourneau, A / Lhuillier, D / Licciardi, M / Lindner, M / Littlejohn, B R / Lu, X / Maricic, J / Materna, T / Mendenhall, M P / Meyer, A M / Milincic, R / Mueller, P E / Mumm, H P / Napolitano, J / Neilson, R / Nikkel, J A / Nour, S / Palomino, J L / Pessard, H / Pushin, D A / Qian, X / Réal, J-S / Ricol, J-S / Roca, C / Rogly, R / Rosero, R / Salagnac, T / Savu, V / Schoppmann, S / Searles, M / Sergeyeva, V / Soldner, T / Stutz, A / Surukuchi, P T / Tyra, M A / Varner, R L / Venegas-Vargas, D / Vialat, M / Weatherly, P B / White, C / Wilhelmi, J / Woolverton, A / Yeh, M / Zhang, C / Zhang, X

    Physical review letters

    2022  Volume 128, Issue 8, Page(s) 81802

    Abstract: The PROSPECT and STEREO collaborations present a combined measurement of the pure ^{235}U antineutrino spectrum, without site specific corrections or detector-dependent effects. The spectral measurements of the two highest precision experiments at ... ...

    Abstract The PROSPECT and STEREO collaborations present a combined measurement of the pure ^{235}U antineutrino spectrum, without site specific corrections or detector-dependent effects. The spectral measurements of the two highest precision experiments at research reactors are found to be compatible with χ^{2}/ndf=24.1/21, allowing a joint unfolding of the prompt energy measurements into antineutrino energy. This ν[over ¯]_{e} energy spectrum is provided to the community, and an excess of events relative to the Huber model is found in the 5-6 MeV region. When a Gaussian bump is fitted to the excess, the data-model χ^{2} value is improved, corresponding to a 2.4σ significance.
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.128.081802
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  7. Book ; Online: Improved Sterile Neutrino Constraints from the STEREO Experiment with 179 Days of Reactor-On Data

    STEREO Collaboration / Almazán, H. / Bernard, L. / Blanchet, A. / Bonhomme, A. / Buck, C. / Sanchez, P. del Amo / Atmani, I. El / Haser, J. / Kandzia, F. / Kox, S. / Labit, L. / Lamblin, J. / Letourneau, A. / Lhuillier, D. / Licciardi, M. / Lindner, M. / Materna, T. / Minotti, A. /
    Pessard, H. / Réal, J. -S. / Roca, C. / Rogly, R. / Salagnac, T. / Savu, V. / Schoppmann, S. / Sergeyeva, V. / Soldner, T. / Stutz, A. / Vialat, M.

    2019  

    Abstract: The STEREO experiment is a very short baseline reactor antineutrino experiment. It is designed to test the hypothesis of light sterile neutrinos being the cause of a deficit of the observed antineutrino interaction rate at short baselines with respect to ...

    Abstract The STEREO experiment is a very short baseline reactor antineutrino experiment. It is designed to test the hypothesis of light sterile neutrinos being the cause of a deficit of the observed antineutrino interaction rate at short baselines with respect to the predicted rate, known as the reactor antineutrino anomaly. The STEREO experiment measures the antineutrino energy spectrum in six identical detector cells covering baselines between 9 and 11 m from the compact core of the ILL research reactor. In this article, results from 179 days of reactor turned on and 235 days of reactor turned off are reported at a high degree of detail. The current results include improvements in the modelling of detector optical properties and the gamma-cascade after neutron captures by gadolinium, the treatment of backgrounds, and the statistical method of the oscillation analysis. Using a direct comparison between antineutrino spectra of all cells, largely independent of any flux prediction, we find the data compatible with the null oscillation hypothesis. The best-fit point of the reactor antineutrino anomaly is rejected at more than 99.9% C.L.

    Comment: 31 pages, 35 figures, for supplemental data see http://doi.org/10.17182/hepdata.92323
    Keywords High Energy Physics - Experiment ; Physics - Instrumentation and Detectors
    Subject code 660
    Publishing date 2019-12-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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