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Article ; Online: Safety and performance of a hybrid closed-loop insulin delivery system with carbohydrate suggestion in adults with type 1 diabetes prone to hypoglycemia.

Mesa, Alex / Beneyto, Aleix / Martín-SanJosé, Juan-Fernando / Viaplana, Judith / Bondia, Jorge / Vehí, Josep / Conget, Ignacio / Giménez, Marga

Diabetes research and clinical practice

2023 Volume 205, Page(s) 110956

Abstract: Aims: To evaluate the safety and performance of a hybrid closed-loop (HCL) system with automatic carbohydrate suggestion in adults with type 1 diabetes (T1D) prone to hypoglycemia.: Methods: A 32-hour in-hospital pilot study, including a night period, ...

Abstract	Aims: To evaluate the safety and performance of a hybrid closed-loop (HCL) system with automatic carbohydrate suggestion in adults with type 1 diabetes (T1D) prone to hypoglycemia. Methods: A 32-hour in-hospital pilot study, including a night period, 4 meals and 2 vigorous unannounced 45-minute aerobic sessions, was conducted in 11 adults with T1D prone to hypoglycemia. The primary outcome was the percentage of time in range 70-180 mg/dL (TIR). Main secondary outcomes were time below range < 70 mg/dL (TBR < 70) and < 54 (TBR < 54). Data are presented as median (10th-90th percentile ranges). Results: The participants, 6 (54.5%) men, were 24 (22-48) years old, and had 22 (9-32) years of T1D duration. All of them regularly used an insulin pump and a continuous glucose monitoring system. The median TIR was 78.7% (75.6-91.2): 92.7% (68.2-100.0) during exercise and recovery period, 79.3% (34.9-100.0) during postprandial period, and 95.4% (66.4-100.0) during overnight period. The TBR < 70 and TBR < 54 were 0.0% (0.0-6.6) and 0.0% (0.0-1.2), respectively. A total of 4 (3-9) 15-g carbohydrate suggestions were administered per person. No severe acute complications occurred during the study. Conclusions: The HCL system with automatic carbohydrate suggestion performed well and was safe in this population during challenging conditions in a hospital setting.
MeSH term(s)	Male ; Adult ; Humans ; Young Adult ; Middle Aged ; Female ; Insulin/adverse effects ; Diabetes Mellitus, Type 1/drug therapy ; Blood Glucose ; Hypoglycemic Agents/adverse effects ; Blood Glucose Self-Monitoring ; Pilot Projects ; Treatment Outcome ; Insulin Infusion Systems ; Hypoglycemia/epidemiology ; Insulin, Regular, Human/therapeutic use
Chemical Substances	Insulin ; Blood Glucose ; Hypoglycemic Agents ; Insulin, Regular, Human
Language	English
Publishing date	2023-10-14
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2023.110956
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Article ; Online: Positive Effects of a Mediterranean Diet Supplemented with Almonds on Female Adipose Tissue Biology in Severe Obesity.

Osorio-Conles, Óscar / Olbeyra, Romina / Moizé, Violeta / Ibarzabal, Ainitze / Giró, Oriol / Viaplana, Judith / Jiménez, Amanda / Vidal, Josep / de Hollanda, Ana

Nutrients

2022 Volume 14, Issue 13

Abstract: It has been suggested that weight-loss-independent Mediterranean diet benefits on cardiometabolic health and diabetes prevention may be mediated, at least in part, through the modulation of white adipose tissue (WAT) biology. This study aimed to evaluate ...

Abstract	It has been suggested that weight-loss-independent Mediterranean diet benefits on cardiometabolic health and diabetes prevention may be mediated, at least in part, through the modulation of white adipose tissue (WAT) biology. This study aimed to evaluate the short-term effects of a dietary intervention based on the Mediterranean diet supplemented with almonds (MDSA) on the main features of obesity-associated WAT dysfunction. A total of 38 women with obesity were randomly assigned to a 3-month intervention with MDSA versus continuation of their usual dietary pattern. Subcutaneous (SAT) and visceral adipose tissue (VAT) biopsies were obtained before and after the dietary intervention, and at the end of the study period, respectively. MDSA favored the abundance of small adipocytes in WAT. In SAT, the expression of angiogenesis genes increased after MDSA intervention. In VAT, the expression of genes implicated in adipogenesis, angiogenesis, autophagy and fatty acid usage was upregulated. In addition, a higher immunofluorescence staining for PPARG, CD31+ cells and M2-like macrophages and increased ADRB1 and UCP2 protein contents were found compared to controls. Changes in WAT correlated with a significant reduction in circulating inflammatory markers and LDL-cholesterol levels. These results support a protective effect of a Mediterranean diet supplemented with almonds on obesity-related WAT dysfunction.
MeSH term(s)	Adipose Tissue/metabolism ; Adipose Tissue, White/metabolism ; Biology ; Diet, Mediterranean ; Female ; Humans ; Obesity/metabolism ; Obesity, Morbid/metabolism ; Prunus dulcis
Language	English
Publishing date	2022-06-24
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14132617
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Article: Positive Effects of a Mediterranean Diet Supplemented with Almonds on Female Adipose Tissue Biology in Severe Obesity

Osorio-Conles, Óscar / Olbeyra, Romina / Moizé, Violeta / Ibarzabal, Ainitze / Giró, Oriol / Viaplana, Judith / Jiménez, Amanda / Vidal, Josep / de Hollanda, Ana

Nutrients. 2022 June 24, v. 14, no. 13

2022

Abstract	It has been suggested that weight-loss-independent Mediterranean diet benefits on cardiometabolic health and diabetes prevention may be mediated, at least in part, through the modulation of white adipose tissue (WAT) biology. This study aimed to evaluate the short-term effects of a dietary intervention based on the Mediterranean diet supplemented with almonds (MDSA) on the main features of obesity-associated WAT dysfunction. A total of 38 women with obesity were randomly assigned to a 3-month intervention with MDSA versus continuation of their usual dietary pattern. Subcutaneous (SAT) and visceral adipose tissue (VAT) biopsies were obtained before and after the dietary intervention, and at the end of the study period, respectively. MDSA favored the abundance of small adipocytes in WAT. In SAT, the expression of angiogenesis genes increased after MDSA intervention. In VAT, the expression of genes implicated in adipogenesis, angiogenesis, autophagy and fatty acid usage was upregulated. In addition, a higher immunofluorescence staining for PPARG, CD31+ cells and M2-like macrophages and increased ADRB1 and UCP2 protein contents were found compared to controls. Changes in WAT correlated with a significant reduction in circulating inflammatory markers and LDL-cholesterol levels. These results support a protective effect of a Mediterranean diet supplemented with almonds on obesity-related WAT dysfunction.
Keywords	Mediterranean diet ; adipocytes ; adipogenesis ; angiogenesis ; autophagy ; diabetes ; eating habits ; fatty acids ; females ; fluorescent antibody technique ; low density lipoprotein cholesterol ; macrophages ; nutritional intervention ; obesity ; peroxisome proliferator-activated receptor gamma ; protective effect ; white adipose tissue
Language	English
Dates of publication	2022-0624
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14132617
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Article ; Online: Effects of Bariatric Surgery on Blood and Vascular Large Extracellular Vesicles According to Type 2 Diabetes Status.

Pané, Adriana / Viaplana, Judith / Giró, Oriol / Llopis, Jaume / Ibarzabal, Ainitze / de Hollanda, Ana / Vidal, Josep / Ortega, Emilio / Jiménez, Amanda / Chiva-Blanch, Gemma

The Journal of clinical endocrinology and metabolism

2023 Volume 109, Issue 1, Page(s) e107–e118

Abstract: Context: Large extracellular vesicles (lEVs) enriched for endothelial and blood cell markers are increased in metabolic conditions such as obesity or type 2 diabetes (T2D), actively contribute to the atherosclerotic process, and have been identified as ... ...

Abstract	Context: Large extracellular vesicles (lEVs) enriched for endothelial and blood cell markers are increased in metabolic conditions such as obesity or type 2 diabetes (T2D), actively contribute to the atherosclerotic process, and have been identified as diagnostic and prognostic biomarkers for cardiovascular disease (CVD). Although bariatric surgery (BS) in individuals with obesity is related to decreased cardiovascular (CV) risk and increased life expectancy, after BS these subjects are still at higher CV risk than the general population. Objective: We aimed to compare the lEV profiles between individuals with obesity, with or without T2D, before and 1 year after BS, and normal-weight controls. Methods: Prospective longitudinal study with individuals eligible for BS, with or without T2D (T2D and OB groups, respectively) and healthy controls (HC group) matched by age and sex. The concentration and phenotype of lEVs were assessed by flow cytometry. Results: The study cohort included 108 individuals (age 48.0 ± 10.5 years; 84.3% females). Before BS, the OB group presented higher concentrations of lEV enriched for endothelial and blood cell biomarkers than the HC group, but lower concentrations than those observed in the T2D group (P < .05). BS resulted in a significant reduction in most of the lEVs enriched for cell-specific markers in both subgroups. lEV differences between OB and T2D groups were no longer observed after BS (P > .05). However, compared with HC group, OB and T2D groups still showed increased concentrations of lEVs enriched for platelet and endothelial cell markers (P < .05). Conclusion: At 1 year after BS, lEV concentrations remain above the physiological range. These abnormalities might contribute to explaining the increased CV risk after BS and underscore the importance of long-term CV risk factor control in post-BS individuals.
MeSH term(s)	Female ; Humans ; Adult ; Middle Aged ; Male ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/surgery ; Prospective Studies ; Longitudinal Studies ; Obesity/surgery ; Bariatric Surgery/methods ; Biomarkers ; Obesity, Morbid/surgery
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgad473
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Article: Bariatric Surgery Outcomes in Patients with Chronic Kidney Disease.

Pané, Adriana / Claro, Maria / Molina-Andujar, Alicia / Olbeyra, Romina / Romano-Andrioni, Bárbara / Boswell, Laura / Montagud-Marrahi, Enrique / Jiménez, Amanda / Ibarzabal, Ainitze / Viaplana, Judith / Ventura-Aguiar, Pedro / Amor, Antonio J / Vidal, Josep / Flores, Lilliam / de Hollanda, Ana

Journal of clinical medicine

2023 Volume 12, Issue 18

Abstract: Obesity increases the risk of developing chronic kidney disease (CKD), which has a major negative impact on global health. Bariatric surgery (BS) has demonstrated a substantial improvement of obesity-related comorbidities and thus, it has emerged as a ... ...

Abstract	Obesity increases the risk of developing chronic kidney disease (CKD), which has a major negative impact on global health. Bariatric surgery (BS) has demonstrated a substantial improvement of obesity-related comorbidities and thus, it has emerged as a potential therapeutic tool in order to prevent end-stage renal disease. A limited number of publications to date have examined the beneficial effects and risks of BS in patients with non-advanced stages of CKD. We aimed to investigate the safety of BS in patients with CKD stages 3-4 (directly related or not to obesity) and both the metabolic/renal outcomes post-BS. A total of 57 individuals were included (n = 19 for CKD-group; n = 38 for patients with obesity, but normal eGFR [control-group]). Weight loss and obesity comorbidities resolution after BS were similar in both groups. Renal function (eGFR [CKD-EPI]) improved significantly at the 1-year follow-up: Δ10.2 (5.2-14.9) (
Language	English
Publishing date	2023-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12186095
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Article: Bariatric Surgery Outcomes in Patients with Kidney Transplantation.

Pané, Adriana / Molina-Andujar, Alicia / Olbeyra, Romina / Romano-Andrioni, Bárbara / Boswell, Laura / Montagud-Marrahi, Enrique / Jiménez, Amanda / Ibarzabal, Ainitze / Viaplana, Judith / Ventura-Aguiar, Pedro / Amor, Antonio J / Vidal, Josep / Flores, Lilliam / de Hollanda, Ana

Journal of clinical medicine

2022 Volume 11, Issue 20

Abstract: Obesity and kidney transplantation (KTx) are closely related. Obesity increases the risk of chronic kidney disease and can be a relative contraindication for KTx. Besides, KTx recipients are predisposed to obesity and its comorbidities. Consequently, ... ...

Abstract	Obesity and kidney transplantation (KTx) are closely related. Obesity increases the risk of chronic kidney disease and can be a relative contraindication for KTx. Besides, KTx recipients are predisposed to obesity and its comorbidities. Consequently, bariatric surgery (BS) emerges as a powerful therapeutic tool either before or after KTx. Since evidence regarding the best approach is still scarce, we aimed to describe renal and metabolic outcomes in a single centre with more than 15-year experience in both surgeries. Methods: A retrospective study including patients who had received a KTx either before or after BS. Usual metabolic and renal outcomes, but also new variables (as renal graft dysfunction) were collected for a minimum follow-up of 1-year post-BS. Results: A total of 11 patients were included: Conclusions: BS in patients with KTx appears to be safe and effective attending to metabolic and renal outcomes. These results seem irrespective of the time course, except for weight regain, which appears to be a common pattern in the BS-post-KTx group.
Language	English
Publishing date	2022-10-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11206030
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Article ; Online: Blood glucose monitoring during aerobic and anaerobic physical exercise using a new artificial pancreas system.

Quirós, Carmen / Bertachi, Arthur / Giménez, Marga / Biagi, Lyvia / Viaplana, Judith / Viñals, Clara / Vehí, Josep / Conget, Ignacio / Bondia, Jorge

Endocrinologia, diabetes y nutricion

2018 Volume 65, Issue 6, Page(s) 342–347

Abstract: Aim: To assess an artificial pancreas system during aerobic (AeE) and anaerobic exercise (AnE).: Methods: A pilot clinical trial on five subjects with type 1 diabetes (4 males) aged 37±10.9 years, diabetes diagnosed 21.2±12.2 years before, insulin ... ...

Title translation	Control de la glucemia durante el ejercicio físico aeróbico y anaeróbico mediante un nuevo sistema de páncreas artificial.
Abstract	Aim: To assess an artificial pancreas system during aerobic (AeE) and anaerobic exercise (AnE). Methods: A pilot clinical trial on five subjects with type 1 diabetes (4 males) aged 37±10.9 years, diabetes diagnosed 21.2±12.2 years before, insulin pump users, and with a mean HbA Results: The mean glucose level was 124.0±25.1mg/dL in the AeE studies and 152.1±34.1mg/dL in the AnE studies. Percent times in the different glucose ranges of 70-180, >180 and <70mg/dL were 89.8±18.6% and 75.9±27.6%; 7.7±18.4% and 23.2±28.0%; and 2.5±6.3% and 1.0±3.6% during the AeE and AnE sessions, respectively. Only six rescues with carbohydrates (15g) were required during the studies (4 in AeE and 2 in AnE). Total insulin dose during the five hours of the study was 3.1±1.0IU in the AeE studies and 3.5±1.3IU in the AnE studies. Conclusions: Blood glucose response to AeE and AnE exercise is different. The evaluated artificial pancreas system appeared to achieve effective and safe blood glucose control during exercise and up to four hours later. However, new control strategies that minimize patient intervention should be designed.
MeSH term(s)	Adult ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring ; Diabetes Mellitus, Type 1/blood ; Exercise ; Female ; Humans ; Male ; Pancreas, Artificial
Chemical Substances	Blood Glucose
Language	Spanish
Publishing date	2018-02-23
Publishing country	Spain
Document type	Clinical Trial ; Journal Article
ISSN	2530-0180
ISSN (online)	2530-0180
DOI	10.1016/j.endinu.2017.12.012
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Article ; Online: Longitudinal changes of blood pressure after weight loss: factors involved.

Flores, Lilliam / Vidal, Josep / Núñez, Isabel / Rueda, Sergio / Viaplana, Judith / Esmatjes, Enric

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

2015 Volume 11, Issue 1, Page(s) 215–221

Abstract: Background: The combination of obesity and hypertension (HT) places patients at a higher risk for adverse cardiovascular outcomes and raises the need to establish the pathogenic mechanisms of this relationship. The aim of this study was to assess the ... ...

Abstract	Background: The combination of obesity and hypertension (HT) places patients at a higher risk for adverse cardiovascular outcomes and raises the need to establish the pathogenic mechanisms of this relationship. The aim of this study was to assess the effects of important weight loss on longitudinal changes in blood pressure (BP) and investigate the pathogenic factors associated with these changes. Methods: We performed a prospective, open-label study including 37 obese hypertensive patients (28 females, mean age 52±8 yr) undergoing BS. Before BS, and at 4 and 12 months postoperatively, the body mass index (BMI), 24-h ambulatory BP, renin-angiotensin-aldosterone system (RAAS: plasma rennin activity, aldosterone, angiotensin II, and angiotensin converting enzyme), sympathetic nervous system (SNS: metanephrines, normetanephrines, and norepinephrine) components, leptin, insulin, and abdominal fat were measured. Results: Before BS, HT-duration was 6±6 years, the BMI 45±5 kg/m2 and excess weight (EBW) was 53±12 kg. At 12 months, the excess BMI loss was 14 kg/m2 and the EBW loss was 70 %; HT remission was observed in 70%; 24-h (systolic 19±13/diastolic 7±9 mm Hg), day and night BP levels and aldosterone, norepinephrine, leptin, insulin, subcutaneous and visceral abdominal fat (VAT) significantly decreased (P<.05). Mixed models for repeated measures revealed that HT-duration, baseline BP, BMI, and VAT area were the main variables associated with longitudinal changes in BP. Conclusion: These results demonstrate that the hypotensive response after weight loss in severely hypertensive obese patients is mainly regulated by HT-duration, baseline BP, BMI and VAT area, independently of suppression of hyperinsulinemia or changes in RAAS and SNS components.
MeSH term(s)	Abdominal Fat ; Aldosterone/blood ; Bariatric Surgery ; Body Mass Index ; Female ; Humans ; Hypertension/complications ; Hypertension/therapy ; Insulin/blood ; Leptin/blood ; Longitudinal Studies ; Male ; Middle Aged ; Norepinephrine ; Obesity/complications ; Obesity/surgery ; Prospective Studies ; Remission Induction ; Weight Loss
Chemical Substances	Insulin ; Leptin ; Aldosterone (4964P6T9RB) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2274243-8
ISSN	1878-7533 ; 1550-7289
ISSN (online)	1878-7533
ISSN	1550-7289
DOI	10.1016/j.soard.2014.04.028
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Zs.A 6572: Show issues

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Article ; Online: Gastrointestinal Hormones and Weight Loss Maintenance Following Roux-en-Y Gastric Bypass.

de Hollanda, Ana / Casals, Gregori / Delgado, Salvadora / Jiménez, Amanda / Viaplana, Judith / Lacy, Antonio M / Vidal, Josep

The Journal of clinical endocrinology and metabolism

2015 Volume 100, Issue 12, Page(s) 4677–4684

Abstract: Context: Factors underlying variable weight loss (WL) after Roux-en-Y gastric bypass (RYGB) are poorly understood.: Objective: Our objective was to gain insight on the role of gastrointestinal hormones on poor WL maintenance (P-WLM) following RYGB.!## ...

Abstract	Context: Factors underlying variable weight loss (WL) after Roux-en-Y gastric bypass (RYGB) are poorly understood. Objective: Our objective was to gain insight on the role of gastrointestinal hormones on poor WL maintenance (P-WLM) following RYGB. Design and patients: First, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and ghrelin responses to a standardized mixed liquid meal (SMLM) were compared between subjects with good WL (G-WL, n = 32) or P-WLM (n = 22). Second, we evaluated food intake (FI) following blockade of gut hormonal secretion in G-WL (n = 23) or P-WLM (n = 19) subjects. Finally, the impact of dietary-induced WL on the hormonal response in subjects with P-WLM (n = 14) was assessed. Setting: This study was undertaken in a tertiary hospital. Main outcome measures: In studies 1 and 3, the outcomes measures were the areas under the curve of gut hormones following a SMLM; in study 2, FI following subcutaneous injection of saline or octreotide were evaluated. Results: P-WLM associated a blunted GLP-1 (P = .044) and PYY (P = .001) responses and lesser suppression of ghrelin (P = .032) following the SMLM challenge. On saline day, FI in the G-WL (393 ± 143 kcal) group was less than in the P-WLM (519 ± 143 Kcal; P = .014) group. Octreotide injection resulted in enlarged FI in both groups (G-WL: 579 ± 248 kcal, P = .014; P-WLM: 798 ± 284 Kcal, P = .036), but the difference in FI between groups remained (P < .001). In subjects with P-WLM, dietary-induced WL resulted in larger ghrelin suppression (P = .046), but no change in the GLP-1 or PYY responses. Conclusion: Our data show gastrointestinal hormones play a role in the control of FI following RYGB, but do not support that changes in GLP-1, PYY, or ghrelin play a major role as determinants of P-WLM after this type of surgery.
MeSH term(s)	Adult ; Case-Control Studies ; Cohort Studies ; Diet ; Diet, Reducing ; Eating ; Female ; Gastric Bypass ; Gastrointestinal Hormones/blood ; Ghrelin/blood ; Glucagon-Like Peptide 1/blood ; Humans ; Male ; Middle Aged ; Obesity, Morbid/diet therapy ; Obesity, Morbid/metabolism ; Obesity, Morbid/surgery ; Octreotide/pharmacology ; Peptide YY/blood ; Treatment Outcome ; Weight Loss
Chemical Substances	Gastrointestinal Hormones ; Ghrelin ; Peptide YY (106388-42-5) ; Glucagon-Like Peptide 1 (89750-14-1) ; Octreotide (RWM8CCW8GP)
Language	English
Publishing date	2015-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jc.2015-3065
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Article ; Online: Long-term effects of sleeve gastrectomy and Roux-en-Y gastric bypass surgery on type 2 diabetes mellitus in morbidly obese subjects.

Jiménez, Amanda / Casamitjana, Roser / Flores, Lílliam / Viaplana, Judith / Corcelles, Ricard / Lacy, Antonio / Vidal, Josep

Annals of surgery

2012 Volume 256, Issue 6, Page(s) 1023–1029

Abstract: Objective: To identify the rates and the predictors of long-term remission and the recurrence of type 2 diabetes mellitus (T2DM) after Roux-en-Y gastric bypass (RYGBP) or sleeve gastrectomy (SG).: Background: The durability of the improvement of T2DM ...

Abstract	Objective: To identify the rates and the predictors of long-term remission and the recurrence of type 2 diabetes mellitus (T2DM) after Roux-en-Y gastric bypass (RYGBP) or sleeve gastrectomy (SG). Background: The durability of the improvement of T2DM after bariatric surgery is not well characterized. Methods: One hundred fifty-three subjects with T2DM (RYGBP: n = 98; SG: n = 55) were evaluated for remission and recurrence of the disease throughout 35.4 ± 13.5 months' follow-up. The type of surgery, demographic, anthropometric, and biochemical parameters were ascertained as predictors of T2DM outcomes. Glucagon-like peptide 1 (GLP-1) responses after a standard mixed liquid meal were compared between patients presenting with T2DM remission after RYGBP or SG. Results: 75.2% of subjects presented with remission of T2DM lasting at least 12 months. However, in 12.1% of subjects, T2DM recurred. Regression analysis showed a longer duration of T2DM (P = 0.006), a higher presurgical glycated hemoglobin level (P = 0.019), insulin treatment at baseline (P = 0.001), and a lower excess weight loss at last follow-up visit (P < 0.001) as independent predictors for the lack of T2DM remission. Insulin use before surgery (P = 0.005), an older age (P = 0.05), and weight regain after remission (P = 0.021) predicted recurrence of the disease. Long-term remission of T2DM after SG or RYGBP was associated with a comparably enlarged GLP-1 response to a standard mixed liquid meal challenge. Conclusions: Roux-en-Y gastric bypass and SG are associated with comparable remission rates of T2DM. However, insufficient weight loss or weight regain in those with a more advanced disease may hamper the benefits of these surgical techniques on T2DM.
MeSH term(s)	Diabetes Complications/surgery ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/surgery ; Female ; Gastrectomy/methods ; Gastric Bypass ; Humans ; Male ; Middle Aged ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Prospective Studies ; Remission Induction
Language	English
Publishing date	2012-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0b013e318262ee6b
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