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  1. Article ; Online: Reply: Navigating the Role of Ticagrelor in Elective Complex PCI: Time to Rule Out or Reassess?

    Lattuca, Benoit / Silvain, Johanne / Vicaut, Eric / Montalescot, Gilles

    JACC. Cardiovascular interventions

    2024  Volume 17, Issue 8, Page(s) 1070

    MeSH term(s) Humans ; Ticagrelor/therapeutic use ; Ticagrelor/adverse effects ; Percutaneous Coronary Intervention/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Aggregation Inhibitors/adverse effects ; Treatment Outcome ; Clinical Decision-Making ; Risk Factors ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Purinergic P2Y Receptor Antagonists/adverse effects ; Risk Assessment ; Patient Selection ; Coronary Artery Disease/therapy ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/mortality ; Hemorrhage/chemically induced
    Chemical Substances Ticagrelor (GLH0314RVC) ; Platelet Aggregation Inhibitors ; Purinergic P2Y Receptor Antagonists
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Letter
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2024.03.018
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    Zs.A 6669: Show issues Location:
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  2. Article ; Online: Reply.

    Senet, Patricia / Vicaut, Eric

    Arthritis & rheumatology (Hoboken, N.J.)

    2022  Volume 75, Issue 3, Page(s) 486–487

    Language English
    Publishing date 2022-12-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42377
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    Zs.A 24: Show issues Location:
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  3. Article ; Online: Association Between Early Patient Characteristics and IgE-Mediated Allergy in the Perioperative Setting.

    Dewachter, Pascale / Mouton-Faivre, Claudie / Dimby, Solohaja Faniaha / Vicaut, Eric / Beloucif, Sadek

    The journal of allergy and clinical immunology. In practice

    2024  

    Abstract: Background: Early recognition of perioperative anaphylaxis, a life-threatening, usually IgE-mediated, immediate hypersensitivity, is essential, but bedside diagnosis is not always straightforward because clinical presentation may vary.: Objectives: ... ...

    Abstract Background: Early recognition of perioperative anaphylaxis, a life-threatening, usually IgE-mediated, immediate hypersensitivity, is essential, but bedside diagnosis is not always straightforward because clinical presentation may vary.
    Objectives: To describe early characteristics of perioperative immediate hypersensitivity, with special attention to cutaneous phenotypes, and identify risk factors for IgE-mediated allergy.
    Methods: We retrospectively analyzed data from adults with suspected perioperative immediate hypersensitivity who were investigated in two academic medical centers. Multivariable logistic regression was conducted to evaluate associations among patient, clinical, and paraclinical characteristics and IgE-mediated allergy.
    Results: Of 145 enrolled patients, 99 (68.3%) and 46 (31.7%) were respectively categorized in the IgE-mediated allergy and non-allergy groups. Cutaneous vasoconstriction phenotype (pallor, piloerection, thelerethism, and sweating with or without cyanosis) occurring within minutes (or even 1 minute) of drug exposure was strongly associated with IgE-mediated allergy (adjusted odds ratio [aOR] = 28.02; 95% CI, 4.41-305.18). IgE-mediated allergy was always life-threatening in this setting. Other early factors associated with allergy were low end-tidal carbon dioxide 25 mm Hg or less (aOR = 5.45; 95% CI, 2.39-26.45), low mean arterial pressure 60 mm Hg or less (aOR = 3.82; 95% CI, 1.28-17.31), and early cutaneous vasodilation (erythema, urticaria, and/or angioedema) (aOR = 2.78; 95% CI, 0.73-20.54). Late cutaneous vasodilation after restoration of hemodynamics corroborated the diagnosis of allergy (aOR = 23.67; 95% CI, 4.94-205.09). The best-fit model including three readily available variables (cutaneous phenotype involving the three modalities [reference lack of cutaneous signs], low mean arterial pressure, and low end-tidal carbon dioxide) had an area under the curve of 0.91.
    Conclusions: Cutaneous vasoconstriction phenotype is associated with the strongest risk of life-threatening allergy and thus may be regarded as pathognomonic of perioperative IgE-mediated anaphylaxis.
    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2024.02.009
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  4. Article ; Online: Basket, Umbrella, and Platform Trials: The Potential for Master Protocol -Based Trials in Inflammatory Bowel Disease.

    Honap, Sailish / Sands, Bruce E / Jairath, Vipul / Danese, Silvio / Vicaut, Eric / Peyrin-Biroulet, Laurent

    Gastroenterology

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.04.020
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  5. Article ; Online: Control of mean arterial pressure using a closed-loop system for norepinephrine infusion in severe brain injury patients: the COMAT randomized controlled trial.

    Joosten, Alexandre / Rinehart, Joseph / Cannesson, Maxime / Coeckelenbergh, Sean / Pochard, Jonas / Vicaut, Eric / Duranteau, Jacques

    Journal of clinical monitoring and computing

    2024  Volume 38, Issue 1, Page(s) 25–30

    Abstract: Brain injury patients require precise blood pressure (BP) management to maintain cerebral perfusion pressure (CPP) and avoid intracranial hypertension. Nurses have many tasks and norepinephrine titration has been shown to be suboptimal. This can lead to ... ...

    Abstract Brain injury patients require precise blood pressure (BP) management to maintain cerebral perfusion pressure (CPP) and avoid intracranial hypertension. Nurses have many tasks and norepinephrine titration has been shown to be suboptimal. This can lead to limited BP control in patients that are in critical need of cerebral perfusion optimization. We have designed a closed-loop vasopressor (CLV) system capable of maintaining mean arterial pressure (MAP) in a narrow range and we aimed to assess its performance when treating severe brain injury patients. Within the first 48 h of intensive care unit (ICU) admission, 18 patients with a severe brain injury underwent either CLV or manual norepinephrine titration. In both groups, the objective was to maintain MAP in target (within ± 5 mmHg of a predefined target MAP) to achieve optimal CPP. Fluid administration was standardized in the two groups. The primary objective was the percentage of time patients were in target. Secondary outcomes included time spent over and under target. Over the four-hour study period, the mean percentage of time with MAP in target was greater in the CLV group than in the control group (95.8 ± 2.2% vs. 42.5 ± 27.0%, p < 0.001). Severe undershooting, defined as MAP < 10 mmHg of target value was lower in the CLV group (0.2 ± 0.3% vs. 7.4 ± 14.2%, p < 0.001) as was severe overshooting defined as MAP > 10 mmHg of target (0.0 ± 0.0% vs. 22.0 ± 29.0%, p < 0.001). The CLV system can maintain MAP in target better than nurses caring for severe brain injury patients.
    MeSH term(s) Humans ; Norepinephrine ; Arterial Pressure ; Vasoconstrictor Agents/therapeutic use ; Brain Injuries/drug therapy ; Intensive Care Units ; Intracranial Pressure
    Chemical Substances Norepinephrine (X4W3ENH1CV) ; Vasoconstrictor Agents
    Language English
    Publishing date 2024-02-04
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-023-01119-w
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    Zs.A 2054: Show issues Location:
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  6. Article ; Online: Evaluation of a new point-of-care diagnostic test measuring inflammation in emergency settings.

    Charansonney, Olivier L / Al-Dandachi, Ghanima / Plaisance, Patrick / Vicaut, Eric

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 19551

    Abstract: Erythrocyte aggregation kinetics is accelerated in diseases with a strong inflammation component. This study aimed to evaluate whether, in an emergency setting, a new point-of-care test measuring erythrocyte aggregation kinetics (EAK) can identify ... ...

    Abstract Erythrocyte aggregation kinetics is accelerated in diseases with a strong inflammation component. This study aimed to evaluate whether, in an emergency setting, a new point-of-care test measuring erythrocyte aggregation kinetics (EAK) can identify patients with underlying inflammation. Patients visiting an emergency department and needing a blood exam were successively included. EAK was measured at the point-of-care in 20 s directly on the blood samples collected in regular tubes without any manipulation. The primary measure was EAK's half-life during the first 5 s (EAK5s). Each patient's inflammation status was assessed blind to the EAK test results. Receiver Operating Characteristic (ROC) curves for inflammation status were built. 268 patients had their EAK5s measured, and a clear inflammation status was determined for 214 patients (65 had inflammation). Mean EAK5s were 2.18 s and 1.75 s for no inflammation and inflammation groups respectively (p < 0.001). EAK5s appears to be a better inflammation marker than C-Reactive protein (CRP), with an area under the ROC curve of 0.845 compared to 0.806 for CRP (p < 0.0001). The Youden threshold for prediction of inflammation was 1.86 s with 84.6% (78.5-89.9%) specificity and 70.8% (60-81.5%) sensitivity. Point-of-care EAK is an easily measured, immediately available marker of inflammation with a better predictive power than CRP's.
    MeSH term(s) Humans ; Sensitivity and Specificity ; Predictive Value of Tests ; Inflammation/diagnosis ; C-Reactive Protein/analysis ; ROC Curve ; Point-of-Care Testing ; Biomarkers
    Chemical Substances C-Reactive Protein (9007-41-4) ; Biomarkers
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-46347-x
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  7. Article ; Online: Description and validation of a new, simple, easy-to handle, point-of-care technique for measuring erythrocyte aggregation kinetics.

    Charansonney, Olivier L / Morel, Pascal / Dufaux, Jacques / Vicaut, Eric

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 14798

    Abstract: Erythrocyte aggregation (EA) is a physiological process by which erythrocytes reversibly stick together within the blood vessels. EA plays a major role in blood viscosity in vivo, thereby impacting blood flow to organs. EA is no doubt greatly important ... ...

    Abstract Erythrocyte aggregation (EA) is a physiological process by which erythrocytes reversibly stick together within the blood vessels. EA plays a major role in blood viscosity in vivo, thereby impacting blood flow to organs. EA is no doubt greatly important in both physiological and pathophysiological conditions, but the studies its importance calls for are complicated by the lack of a reliable and easy way to measure it. We have developed a new point-of-care technique which can very specifically measure EA initial kinetics (EAK) in 20 s directly on blood samples routinely collected in tubes commonly used in clinical settings. We present the results of the validation studies of this EAK test: A mono-exponential curve explains 99% of EAK variance. EAK is normally distributed in healthy individuals, with an interindividual 15% coefficient of variation and is stable for least one hour after blood collection. Intraindividual coefficient of variation is 2.6%. EA can now be easily measured in any clinical setting.
    MeSH term(s) Blood Viscosity ; Erythrocyte Aggregation ; Erythrocytes ; Humans ; Kinetics ; Point-of-Care Systems
    Language English
    Publishing date 2022-08-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-18410-6
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  8. Article ; Online: Positive Impact of a New Compressive Garment in Patients with Genital Lymphedema: OLYMPY Study.

    Mestre, Sandrine / Vignes, Stéphane / Malloizel-Delaunay, Julie / Abba, Sarah / Villet, Stéphanie / Picolet, Astrid / Vicaut, Eric / Quéré, Isabelle

    Lymphatic research and biology

    2024  Volume 22, Issue 2, Page(s) 138–146

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Humans ; Quality of Life ; Prospective Studies ; Lymphedema ; Clothing ; Genitalia
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2147953-7
    ISSN 1557-8585 ; 1539-6851
    ISSN (online) 1557-8585
    ISSN 1539-6851
    DOI 10.1089/lrb.2023.0055
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    Zs.A 5921: Show issues Location:
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  9. Article ; Online: Reduced Acute Diabetes Events After FreeStyle Libre System Initiation in People 65 Years or Older with Type 2 Diabetes on Intensive Insulin Therapy in France.

    Guerci, Bruno / Levrat-Guillen, Fleur / Vicaut, Eric / De Pouvourville, Gérard / Detournay, Bruno / Emery, Corinne / Riveline, Jean-Pierre

    Diabetes technology & therapeutics

    2023  Volume 25, Issue 6, Page(s) 384–394

    Abstract: Background and Aims: ...

    Abstract Background and Aims:
    MeSH term(s) Adult ; Humans ; Aged ; Diabetes Mellitus, Type 2/drug therapy ; Insulin ; Hypoglycemic Agents ; Retrospective Studies ; Blood Glucose ; Hypoglycemia/chemically induced ; Hypoglycemia/epidemiology ; Hypoglycemia/prevention & control ; Insulin, Regular, Human ; Diabetic Ketoacidosis/chemically induced ; France/epidemiology
    Chemical Substances Insulin ; Hypoglycemic Agents ; Blood Glucose ; Insulin, Regular, Human
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1452816-2
    ISSN 1557-8593 ; 1520-9156
    ISSN (online) 1557-8593
    ISSN 1520-9156
    DOI 10.1089/dia.2023.0034
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    Zs.A 5269: Show issues Location:
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  10. Article ; Online: Low anterior resection syndrome after rectal resection management: multicentre randomized clinical trial of transanal irrigation with a dedicated device (cone catheter) versus conservative bowel management.

    Meurette, Guillaume / Faucheron, Jean-Luc / Cotte, Eddy / Denost, Quentin / Portier, Guillaume / Loriau, Jerôme / Hansen, Andreas Wolff / Vicaut, Eric / Lakkis, Zaher

    The British journal of surgery

    2023  Volume 110, Issue 9, Page(s) 1092–1095

    MeSH term(s) Humans ; Low Anterior Resection Syndrome ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Rectal Neoplasms/surgery ; Rectum/surgery ; Catheters
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad078
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