LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 32

Search options

  1. Article ; Online: Atypical presentation of fistula dysfunction due to brachial arterial embolization mimicking stroke.

    Vicente, Rita / Rodriguez, Laura / Vallespín, Joaquim / Rubiella, Carolina / Ibeas, Jose

    The journal of vascular access

    2022  , Page(s) 11297298211067686

    Abstract: Vascular access thrombosis is an important complication with great impact on access patency and, consequently, on a patient's quality of life and survival. We report the case of a 73-year-old woman with chronic kidney disease on hemodialysis with a ... ...

    Abstract Vascular access thrombosis is an important complication with great impact on access patency and, consequently, on a patient's quality of life and survival. We report the case of a 73-year-old woman with chronic kidney disease on hemodialysis with a radiocephalic arteriovenous fistula on the right arm that was brought to the emergency department with decreased strength in her right arm, ipsilateral hypoesthesia and facial hemi-hypoesthesia. The patient was given a brain computed tomographic scan that did not confirm suspicion of stroke. On re-examination, the patient had new-onset pain at arteriovenous fistula level, and her right arm was cold and pale. The nephrology department was called for arteriovenous fistula evaluation. On physical examination, her forearm fistula had a decreased thrill and arm elevation exacerbated its paleness. A bedside ultrasound was performed for arteriovenous fistula assessment. Doppler ultrasound revealed: partial thrombosis at brachial bifurcation, a flow of 80-105 mL/min at brachial artery level and a radial artery with a damped waveform. Anastomosis and draining vein were permeable. In this case, the diagnosis of acute embolic brachial artery occlusion was made by a fast bedside ultrasound evaluation. The patient underwent thromboembolectomy with Fogarty technique, recovering fistula thrill, radial and cubital pulses. Thromboembolism of the fistula feeding artery is a rare cause of vascular access thrombosis and it is rarely mentioned in the literature. In this report, failure to recognize the upper limb ischemia would have led to delayed treatment, potentially resulting in the fistula's complete thrombosis and further limb ischemia. We highlight the importance of a diagnosis method like Doppler ultrasound, which allows for rapid evaluation at the patient's bedside.
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2252820-9
    ISSN 1724-6032 ; 1129-7298
    ISSN (online) 1724-6032
    ISSN 1129-7298
    DOI 10.1177/11297298211067686
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: D313Y variant in two related end-stage renal disease patients - Pathogenic or not yet?

    Vicente, Rita / Santos, Iolanda / Coimbra, Miguel / Santos, Joana / Santos, Ricardo / Amoedo, Manuel / Pires, Carlos

    Nefrologia

    2022  Volume 43, Issue 5, Page(s) 636–639

    Abstract: Fabry disease is a multisystem lysosomal storage disorder caused by mutations in the GLA gene that result in a deficient or absent activity of alpha-galactosidase A. There is a wide spectrum of GLA gene variants, some of which are described as non- ... ...

    Abstract Fabry disease is a multisystem lysosomal storage disorder caused by mutations in the GLA gene that result in a deficient or absent activity of alpha-galactosidase A. There is a wide spectrum of GLA gene variants, some of which are described as non-pathogenic. The clinical importance of the D313Y variant is still under debate, although in recent years it has been considered as a variant of unknown significance or a benign variant. Despite this prevailing notion, there are multiple case reports of patients with D313Y variant that presented signs and symptoms consistent with FD without any other etiological explanation. In this article, we present two family members with an important renal phenotype and other typical manifestations of FD (white matter lesions and left ventricular hypertrophy) that only had the D313Y variant. These cases suggest that this variant of unknown significance may contribute to the development of common features of FD and should not be undervalued.
    MeSH term(s) Humans ; alpha-Galactosidase/genetics ; Fabry Disease/complications ; Fabry Disease/genetics ; Kidney Failure, Chronic/genetics ; Mutation ; Phenotype
    Chemical Substances alpha-Galactosidase (EC 3.2.1.22) ; GLA protein, human (EC 3.2.1.22)
    Language English
    Publishing date 2022-12-12
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2022.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Combined immunodeficiency caused by pathogenic variants in the

    Mongellaz, Cédric / Vicente, Rita / Noroski, Lenora M / Noraz, Nelly / Courgnaud, Valérie / Chinen, Javier / Faria, Emilia / Zimmermann, Valérie S / Taylor, Naomi

    Frontiers in immunology

    2023  Volume 14, Page(s) 1155883

    Abstract: Introduction: ZAP-70, a protein tyrosine kinase recruited to the T cell receptor (TCR), initiates a TCR signaling cascade upon antigen stimulation. Mutations in the : Methods: Genetic analyses were performed on four patients with CD8 lymphopenia and ... ...

    Abstract Introduction: ZAP-70, a protein tyrosine kinase recruited to the T cell receptor (TCR), initiates a TCR signaling cascade upon antigen stimulation. Mutations in the
    Methods: Genetic analyses were performed on four patients with CD8 lymphopenia and a high resolution melting screening for
    Results and discussion: Genetic characterization of an infant who presented with pneumocystis pneumonia, mycobacterial infection, and an absence of CD8 T cells revealed a novel homozygous mutation in the C-terminal SH2 domain (SH2-C) of the
    MeSH term(s) Infant ; Humans ; src Homology Domains/genetics ; Primary Immunodeficiency Diseases ; Protein-Tyrosine Kinases ; Arginine ; Lymphopenia/genetics ; ZAP-70 Protein-Tyrosine Kinase/genetics
    Chemical Substances Protein-Tyrosine Kinases (EC 2.7.10.1) ; Arginine (94ZLA3W45F) ; ZAP70 protein, human (EC 2.7.10.2) ; ZAP-70 Protein-Tyrosine Kinase (EC 2.7.10.2)
    Language English
    Publishing date 2023-05-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1155883
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Lupus-like nephritis with positive anti-neutrophil cytoplasmic antibodies and negative antinuclear antibodies.

    Santos, Joana Eugénio / Vicente, Rita / Malvar, Beatriz / Santos, Iolanda / Coimbra, Miguel / Amoedo, Manuel / Pires, Carlos

    Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

    2020  Volume 44, Issue 1, Page(s) 121–125

    Abstract: Antineutrophil cytoplasmic antibodies (ANCAs) are associated with small vessel vasculitis but their prevalence is not rare in other immune diseases. In lupus nephritis (LN), their pathological role and clinical relevance have been the target of ... ...

    Abstract Antineutrophil cytoplasmic antibodies (ANCAs) are associated with small vessel vasculitis but their prevalence is not rare in other immune diseases. In lupus nephritis (LN), their pathological role and clinical relevance have been the target of controversial views. We present a case of acute kidney injury and nephrotic syndrome in a young woman with diffuse global proliferative and membranous nephritis on her kidney biopsy, showing a full-house immunofluorescence pattern, very allusive of class IV + V LN, but lacking associated clinical criteria and laboratory findings to support the diagnosis of systemic lupus erythematosus (SLE). Furthermore, the patient presented with high titers of ANCA, steadily decreasing alongside the renal function and proteinuria improvements, with mycophenolate mofetil (MMF) and steroid treatment. The authors believe this is a case of lupus-like nephritis, in which ANCAs are immunological markers, although they are not directly involved in the pathogenesis.
    MeSH term(s) Antibodies, Antineutrophil Cytoplasmic ; Antibodies, Antinuclear/therapeutic use ; Female ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Nephritis/diagnosis ; Lupus Nephritis/drug therapy ; Mycophenolic Acid/therapeutic use
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Antibodies, Antinuclear ; Mycophenolic Acid (HU9DX48N0T)
    Language Portuguese
    Publishing date 2020-10-26
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 2175-8239
    ISSN (online) 2175-8239
    ISSN 2175-8239
    DOI 10.1590/2175-8239-JBN-2020-0114
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Rituximab use in adult glomerulopathies and its rationale.

    Santos, Joana Eugénio / Fiel, David / Santos, Ricardo / Vicente, Rita / Aguiar, Rute / Santos, Iolanda / Amoedo, Manuel / Pires, Carlos

    Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

    2019  Volume 42, Issue 1, Page(s) 77–93

    Abstract: Glomerulopathies are one of the leading causes of end-stage renal disease. In the last years, clinical research has made significant contributions to the understanding of such conditions. Recently, rituximab (RTX) has appeared as a reasonably safe ... ...

    Abstract Glomerulopathies are one of the leading causes of end-stage renal disease. In the last years, clinical research has made significant contributions to the understanding of such conditions. Recently, rituximab (RTX) has appeared as a reasonably safe treatment. The Kidney Disease: Improving Global Outcomes guidelines (KDIGO) recommended RTX only as initial treatment in antineutrophil cytoplasm antibody associated vasculitis (AAV) and in non-responders patients with lupus nephritis (LN), but these guidelines have not been updated since 2012. Nowadays, RTX seems to be at least as effective as other immunosuppressive regimens in idiopathic membranous nephropathy (IMN). In minimal-change disease, (MCD) this drug might allow a long-lasting remission period in steroid-dependent or frequently relapsing patients. Preliminary results support the use of RTX in patients with pure membranous LN and immunoglobulin-mediated membranoproliferative glomerulonephritis (MPGN), but not in patients with class III/IV LN or complement-mediated MPGN. No conclusion can be drawn in idiopathic focal segmental glomerulosclerosis (FSGS) and anti-glomerular basement membrane antibody glomerulonephritis (anti-GBM GN) because studies are small, heterogeneous, and scarce. Lastly, immunosuppression including RTX is not particularly useful in IgA nephropathy. This review presents the general background, outcomes, and safety for RTX treatment in different glomerulopathies. In this regard, we describe randomized controlled trials (RCTs) performed in adults, whenever possible. A literature search was performed using clinicaltrials.gov and PubMed.
    MeSH term(s) Adult ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Glomerulonephritis/drug therapy ; Humans ; Immunosuppressive Agents/adverse effects ; Nephrosis, Lipoid/drug therapy ; Randomized Controlled Trials as Topic ; Rituximab/adverse effects ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2019-12-20
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 0101-2800
    ISSN (online) 2175-8239
    ISSN 0101-2800
    DOI 10.1590/2175-8239-jbn-2018-0254
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis.

    Mausset-Bonnefont, Anne-Laure / Cren, Maïlys / Vicente, Rita / Quentin, Julie / Jorgensen, Christian / Apparailly, Florence / Louis-Plence, Pascale

    Arthritis research & therapy

    2019  Volume 21, Issue 1, Page(s) 264

    Abstract: Background: In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has been detected. In this study, we ...

    Abstract Background: In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has been detected. In this study, we extensively quantified sensory and motor deficits in CIA mice during natural disease progression and therapeutic treatment. Then, we used these data to build a scale to predict functional deficits on the basis of the classical clinical score.
    Methods: Using the CIA mouse model, we longitudinally screened multiple approaches to assess locomotion (open field test, Catwalk™), sensitivity (Von Frey, Hargreaves, static weight-bearing tests), and inflammation (skin temperature), and identified the most accurate tests to correlate sensory and motor deficits with disease severity, measured by clinical score. We then used these tests to characterize functional deficits in control (naïve and mice injected with complete Freund's adjuvant) and CIA mice, either untreated or treated with methotrexate to prevent functional deficits. By mathematical approaches, we finally investigated the relationship between functional deficits and clinical score.
    Results: We found that the functional disability scores obtained with the open field, Catwalk™, Hargreaves, and skin temperature tests significantly correlated with the clinical score in CIA mice, either untreated or treated with methotrexate. Mathematical correlation showed that motor deficits, robustly characterized by two different tests, were twice more responsive than thermal sensitivity deficits.
    Conclusion: We propose the arthritis sensory and motor (ArthriSM) scale as a new theranostic tool to predict motor and sensory deficit based on the clinical score, in the experimental mouse model of CIA. This ArthriSM scale may facilitate the transfer of knowledge between preclinical and clinical studies.
    MeSH term(s) Animals ; Antirheumatic Agents/pharmacology ; Arthritis, Experimental/complications ; Arthritis, Rheumatoid/complications ; Inflammation/etiology ; Locomotion/physiology ; Male ; Methotrexate/pharmacology ; Mice ; Pain/etiology ; Skin Temperature
    Chemical Substances Antirheumatic Agents ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2019-12-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/s13075-019-2047-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Deregulation and therapeutic potential of microRNAs in arthritic diseases.

    Vicente, Rita / Noël, Danièle / Pers, Yves-Marie / Apparailly, Florence / Jorgensen, Christian

    Nature reviews. Rheumatology

    2016  Volume 12, Issue 4, Page(s) 211–220

    Abstract: Epigenetic abnormalities are part of the pathogenetic alterations involved in the development of rheumatic disorders. In this context, the main musculoskeletal cell lineages, which are generated from the pool of mesenchymal stromal cells (MSCs), and the ... ...

    Abstract Epigenetic abnormalities are part of the pathogenetic alterations involved in the development of rheumatic disorders. In this context, the main musculoskeletal cell lineages, which are generated from the pool of mesenchymal stromal cells (MSCs), and the immune cells that participate in rheumatic diseases are deregulated. In this Review, we focus on microRNA (miRNA)-mediated regulatory pathways that control cell proliferation, drive the production of proinflammatory mediators and modulate bone remodelling. The main studies that identify miRNAs as regulators of immune cell fate, MSC differentiation and immunomodulatory properties - parameters that are altered in rheumatoid arthritis (RA) and osteoarthritis (OA) - are also discussed, with emphasis on the importance of miRNAs in the regulation of cellular machinery, extracellular matrix remodelling and cytokine release. A deeper understanding of the involvement of miRNAs in rheumatic diseases is needed before these regulatory pathways can be explored as therapeutic approaches for patients with RA or OA.
    MeSH term(s) Arthritis, Rheumatoid/immunology ; Cell Differentiation/physiology ; Humans ; Immune Tolerance/physiology ; Mesenchymal Stromal Cells/physiology ; MicroRNAs/physiology ; MicroRNAs/therapeutic use ; Myeloid Cells/physiology ; Osteoarthritis/immunology ; Tissue Engineering/methods
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/nrrheum.2015.162
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Cellular senescence impact on immune cell fate and function.

    Vicente, Rita / Mausset-Bonnefont, Anne-Laure / Jorgensen, Christian / Louis-Plence, Pascale / Brondello, Jean-Marc

    Aging cell

    2016  Volume 15, Issue 3, Page(s) 400–406

    Abstract: Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent findings on the role of cellular senescence in immune cell fate ...

    Abstract Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent findings on the role of cellular senescence in immune cell fate decisions in macrophage polarization, natural killer cell phenotype, and following T-lymphocyte activation. We also introduce the involvement of the onset of cellular senescence in some immune responses including T-helper lymphocyte-dependent tissue homeostatic functions and T-regulatory cell-dependent suppressive mechanisms. Altogether, these data propose that cellular senescence plays a wide-reaching role as a homeostatic orchestrator.
    MeSH term(s) Cell Lineage ; Cellular Senescence ; Homeostasis/immunology ; Humans ; Immunity ; Lymphocytes/cytology
    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.12455
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Deregulation and therapeutic potential of microRNAs in arthritic diseases.

    Vicente, Rita / Noël, Danièle / Pers, Yves-Marie / Apparailly, Florence / Jorgensen, Christian

    Nature reviews. Rheumatology

    2016  Volume 12, Issue 8, Page(s) 496

    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/nrrheum.2016.119
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Cecum perforation associated with a calcium polystyrene sulfonate bezoar - a rare entity.

    Fiel, David Carvalho / Santos, Iolanda / Santos, Joana Eugénio / Vicente, Rita / Ribeiro, Susana / Silva, Artur / Malvar, Beatriz / Pires, Carlos

    Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

    2018  Volume 41, Issue 3, Page(s) 440–444

    Abstract: Hyperkalemia is one of the most common electrolyte disorders, responsible for a high number of adverse outcomes, including life-threatening arrhythmias. Potassium binders are largely prescribed drugs used for hyperkalemia treatment but unfortunately, ... ...

    Abstract Hyperkalemia is one of the most common electrolyte disorders, responsible for a high number of adverse outcomes, including life-threatening arrhythmias. Potassium binders are largely prescribed drugs used for hyperkalemia treatment but unfortunately, there are many adverse events associated with its use, mostly gastrointestinal. Identification of patients at highest risk for the serious complications associated with the current potassium binders, such as colon necrosis and perforation, could prevent fatal outcomes. The authors present a case of a 56-year-old man with secondary diabetes and chronic renal disease that was treated for hyperkalemia with Calcium Polystyrene Sulfonate (CPS). He later presented with acute abdomen due to cecum perforation and underwent ileocecal resection but ultimately died from septic shock a week later. During surgery, a solid white mass was isolated in the lumen of the colon. The mass was identified as a CPS bezoar, a rare drug-mass formed in the gastrointestinal tract that contributed to the perforation. A previous history of partial gastrectomy and vagothomy was identified as a probable risk factor for the CPS bezoar development. Hopefully, the two new potassium binders patiromer and (ZS-9) Sodium Zirconium Cyclosilicate will help treat such high-risk patients, in the near future.
    MeSH term(s) Bezoars/complications ; Cecum/pathology ; Diabetes Mellitus/etiology ; Fatal Outcome ; Humans ; Hyperkalemia/drug therapy ; Hyperkalemia/etiology ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery ; Male ; Middle Aged ; Polymers/therapeutic use ; Polystyrenes/adverse effects ; Polystyrenes/therapeutic use ; Renal Insufficiency, Chronic/complications ; Shock, Septic/mortality ; Silicates/therapeutic use
    Chemical Substances Polymers ; Polystyrenes ; Silicates ; patiromer (1FQ2RY5YHH) ; polystyrene sulfonic acid (70KO0R01RY) ; sodium zirconium cyclosilicate (D652ZWF066)
    Language Portuguese
    Publishing date 2018-12-06
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 0101-2800
    ISSN (online) 2175-8239
    ISSN 0101-2800
    DOI 10.1590/2175-8239-JBN-2018-0158
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top