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  1. Article ; Online: Detecting Tweets Containing Cannabidiol-Related COVID-19 Misinformation Using Transformer Language Models and Warning Letters From Food and Drug Administration: Content Analysis and Identification.

    Turner, Jason / Kantardzic, Mehmed / Vickers-Smith, Rachel / Brown, Andrew G

    JMIR infodemiology

    2023  Volume 3, Page(s) e38390

    Abstract: Background: COVID-19 has introduced yet another opportunity to web-based sellers of loosely regulated substances, such as cannabidiol (CBD), to promote sales under false pretenses of curing the disease. Therefore, it has become necessary to innovate ... ...

    Abstract Background: COVID-19 has introduced yet another opportunity to web-based sellers of loosely regulated substances, such as cannabidiol (CBD), to promote sales under false pretenses of curing the disease. Therefore, it has become necessary to innovate ways to identify such instances of misinformation.
    Objective: We sought to identify COVID-19 misinformation as it relates to the sales or promotion of CBD and used transformer-based language models to identify tweets semantically similar to quotes taken from known instances of misinformation. In this case, the known misinformation was the publicly available Warning Letters from Food and Drug Administration (FDA).
    Methods: We collected tweets using CBD- and COVID-19-related terms. Using a previously trained model, we extracted the tweets indicating commercialization and sales of CBD and annotated those containing COVID-19 misinformation according to the FDA definitions. We encoded the collection of tweets and misinformation quotes into sentence vectors and then calculated the cosine similarity between each quote and each tweet. This allowed us to establish a threshold to identify tweets that were making false claims regarding CBD and COVID-19 while minimizing the instances of false positives.
    Results: We demonstrated that by using quotes taken from Warning Letters issued by FDA to perpetrators of similar misinformation, we can identify semantically similar tweets that also contain misinformation. This was accomplished by identifying a cosine distance threshold between the sentence vectors of the Warning Letters and tweets.
    Conclusions: This research shows that commercial CBD or COVID-19 misinformation can potentially be identified and curbed using transformer-based language models and known prior instances of misinformation. Our approach functions without the need for labeled data, potentially reducing the time at which misinformation can be identified. Our approach shows promise in that it is easily adapted to identify other forms of misinformation related to loosely regulated substances.
    Language English
    Publishing date 2023-01-23
    Publishing country Canada
    Document type Journal Article
    ISSN 2564-1891
    ISSN (online) 2564-1891
    DOI 10.2196/38390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Perceptions of community risk assessment and challenges to implementation.

    Clark, Paul R / Lewis, Corey / Comeau, Ed / Vickers-Smith, Rachel

    Burns : journal of the International Society for Burn Injuries

    2023  Volume 49, Issue 8, Page(s) 1866–1878

    Abstract: Quick, easy access to data-driven community risk assessment principles and to related community risk reduction activities can encourage fire departments to learn about, conduct, and complete district risk reduction practices. With the ultimate goal of ... ...

    Abstract Quick, easy access to data-driven community risk assessment principles and to related community risk reduction activities can encourage fire departments to learn about, conduct, and complete district risk reduction practices. With the ultimate goal of creating web-based community risk assessment and community risk reduction resources, we first evaluated fire department needs. Over an eight-month period, a quantitative online survey was administered to officers from 45 unique fire departments in 44 Kentucky counties, with follow-up qualitative telephone interviews administered to 11 fire officials. Mixed-methods, sequential analysis of the data clarified the "what," "who," and "how" of risk analysis/reduction activities, noted what specific reduction activities departments used to prepare for and mitigate risk, and named specific facilitators and barriers to risk assessment and reduction. Respondents described data use for community risk assessment and for planning community risk reduction activities; how a lack of time, personnel, and funding impacts community risk assessment and community risk reduction activities; and how to involve both firefighters and the community in the process. Innovative solutions such as a website containing resources on how to assess community risk information along with resources such as community risk assessment/ reduction education, program planning, and tools, can assist departments to use community risk assessment data in the development of community risk reduction activities.
    MeSH term(s) Humans ; Burns ; Kentucky ; Surveys and Questionnaires ; Program Development ; Risk Assessment
    Language English
    Publishing date 2023-06-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 197308-3
    ISSN 1879-1409 ; 0305-4179
    ISSN (online) 1879-1409
    ISSN 0305-4179
    DOI 10.1016/j.burns.2023.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploring the nexus of binge eating disorder (BED), New Psychoactive Substances (NPS), and misuse of pharmaceuticals: charting a path forward.

    Chiappini, Stefania / Papanti Pelletier, G Duccio / Vickers-Smith, Rachel / Corkery, John M / Guirguis, Amira / Martinotti, Giovanni / Schifano, Fabrizio

    Expert opinion on pharmacotherapy

    2024  Volume 24, Issue 18, Page(s) 1915–1918

    MeSH term(s) Humans ; Binge-Eating Disorder/drug therapy ; Obesity ; Central Nervous System Agents ; Pharmaceutical Preparations
    Chemical Substances Central Nervous System Agents ; Pharmaceutical Preparations
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Editorial
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2023.2271389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Infodemiological Examination of Personal and Commercial Tweets About Cannabidiol: Term and Sentiment Analysis.

    Turner, Jason / Kantardzic, Mehmed / Vickers-Smith, Rachel

    Journal of medical Internet research

    2021  Volume 23, Issue 12, Page(s) e27307

    Abstract: Background: In the absence of official clinical trial information, data from social networks can be used by public health and medical researchers to assess public claims about loosely regulated substances such as cannabidiol (CBD). For example, this can ...

    Abstract Background: In the absence of official clinical trial information, data from social networks can be used by public health and medical researchers to assess public claims about loosely regulated substances such as cannabidiol (CBD). For example, this can be achieved by comparing the medical conditions targeted by those selling CBD against the medical conditions patients commonly treat with CBD.
    Objective: The objective of this study was to provide a framework for public health and medical researchers to use for identifying and analyzing the consumption and marketing of unregulated substances. Specifically, we examined CBD, which is a substance that is often presented to the public as medication despite complete evidence of efficacy and safety.
    Methods: We collected 567,850 tweets by searching Twitter with the Tweepy Python package using the terms "CBD" and "cannabidiol." We trained two binary text classifiers to create two corpora of 167,755 personal use and 143,322 commercial/sales tweets. Using medical, standard, and slang dictionaries, we identified and compared the most frequently occurring medical conditions, symptoms, side effects, body parts, and other substances referenced in both corpora. In addition, to assess popular claims about the efficacy of CBD as a medical treatment circulating on Twitter, we performed sentiment analysis via the VADER (Valence Aware Dictionary for Sentiment Reasoning) model on the personal CBD tweets.
    Results: We found references to medically relevant terms that were unique to either personal or commercial CBD tweet classes, as well as medically relevant terms that were common to both classes. When we calculated the average sentiment scores for both personal and commercial CBD tweets referencing at least one of 17 medical conditions/symptoms terms, an overall positive sentiment was observed in both personal and commercial CBD tweets. We observed instances of negative sentiment conveyed in personal CBD tweets referencing autism, whereas CBD was also marketed multiple times as a treatment for autism within commercial tweets.
    Conclusions: Our proposed framework provides a tool for public health and medical researchers to analyze the consumption and marketing of unregulated substances on social networks. Our analysis showed that most users of CBD are satisfied with it in regard to the condition that it is being advertised for, with the exception of autism.
    MeSH term(s) Attitude ; Cannabidiol ; Humans ; Public Health ; Sentiment Analysis ; Social Media
    Chemical Substances Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2021-12-20
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2028830-X
    ISSN 1438-8871 ; 1439-4456
    ISSN (online) 1438-8871
    ISSN 1439-4456
    DOI 10.2196/27307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Changes in transmucosal buprenorphine utilization for opioid use disorder treatment during the COVID‐19 pandemic in Kentucky

    Lei, Feitong / Lofwall, Michelle R. / Freeman, Patricia R. / Slade, Emily / Vickers‐Smith, Rachel / Slavova, Svetla

    The Journal of Rural Health. 2023 Jan., v. 39, no. 1 p.186-196

    2023  

    Abstract: PURPOSE: With surging opioid‐involved overdoses, maintaining access to opioid use disorder (OUD) treatment is critical during the COVID‐19 pandemic. We examined changes in transmucosal buprenorphine prescribing for OUD treatment in Kentucky after the ... ...

    Abstract PURPOSE: With surging opioid‐involved overdoses, maintaining access to opioid use disorder (OUD) treatment is critical during the COVID‐19 pandemic. We examined changes in transmucosal buprenorphine prescribing for OUD treatment in Kentucky after the national COVID‐19 emergency declaration, with a focus on rural‐urban differences. METHODS: Using 2019‐2020 prescription monitoring data, we performed segmented regression analysis for an interrupted time series design to evaluate changes in weekly rates (per 100,000 residents) of dispensed prescriptions, unique individuals with dispensed prescriptions, and average days’ supply for dispensed prescriptions of transmucosal buprenorphine. FINDINGS: The weekly rates of dispensed prescriptions and unique individuals with dispensed prescriptions were higher for rural residents than urban residents. After the national COVID‐19 emergency declaration, rural and urban residents experienced similar immediate drops in the rate of dispensed prescriptions (rural –33.4; urban –24.3) and unique patients with dispensed prescriptions (rural –25.0; urban –17.1), followed by similar sustained increases. Both measures surpassed the prepandemic levels in mid‐June 2020. Patients residing in urban areas received averagely longer prescriptions at baseline (urban: 11.0 days; rural: 10.5 days). The average weekly days’ supply increased in the week after the national emergency declaration, but the estimated increase was higher (P = .004) for urban (0.8 days) versus rural (0.5 days) residents. CONCLUSIONS: Transmucosal buprenorphine utilization increased during the COVID‐19 pandemic after experiencing interruption during the initial weeks of the pandemic. Future studies should evaluate the contribution of the relaxed telemedicine buprenorphine prescribing regulations during the COVID‐19 national emergency on initiation and maintenance of buprenorphine treatment.
    Keywords COVID-19 infection ; buprenorphine ; pandemic ; regression analysis ; rural health ; telemedicine ; time series analysis ; Kentucky
    Language English
    Dates of publication 2023-01
    Size p. 186-196.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 639160-6
    ISSN 0890-765X
    ISSN 0890-765X
    DOI 10.1111/jrh.12669
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: COVID-19 and Opioid Use in Appalachian Kentucky: Challenges and Silver Linings.

    Vickers-Smith, Rachel / Cooper, Hannah L F / Young, April M

    Journal of Appalachian health

    2021  Volume 2, Issue 4, Page(s) 11–16

    Abstract: Appalachian Kentucky is currently fighting two public health emergencies-COVID-19 and the opioid epidemic-leaving the area strapped for resources to care for these ongoing crises. During this time, people who use opioids (PWUO) have increased ... ...

    Abstract Appalachian Kentucky is currently fighting two public health emergencies-COVID-19 and the opioid epidemic-leaving the area strapped for resources to care for these ongoing crises. During this time, people who use opioids (PWUO) have increased vulnerability to fatal overdoses and drug-related harms (e.g., HIV). Disruption of already limited services posed by COVID-19 could have an especially detrimental impact on the health of PWUO. Though the COVID-19 pandemic is jeopardizing hard-won progress in fighting the opioid epidemic, innovations in state policy and service delivery brought about by the pandemic may improve the health of PWUO long-term if they are retained.
    Language English
    Publishing date 2021-07-02
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7804
    ISSN (online) 2641-7804
    DOI 10.13023/jah.0204.03
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A Focus on Abuse/Misuse and Withdrawal Issues with Selective Serotonin Reuptake Inhibitors (SSRIs): Analysis of Both the European EMA and the US FAERS Pharmacovigilance Databases.

    Chiappini, Stefania / Vickers-Smith, Rachel / Guirguis, Amira / Corkery, John Martin / Martinotti, Giovanni / Schifano, Fabrizio

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 5

    Abstract: Despite increasing reports, antidepressant (AD) misuse and dependence remain underestimated issues, possibly due to limited epidemiological and pharmacovigilance evidence. Thus, here we aimed to determine available pharmacovigilance misuse/abuse/ ... ...

    Abstract Despite increasing reports, antidepressant (AD) misuse and dependence remain underestimated issues, possibly due to limited epidemiological and pharmacovigilance evidence. Thus, here we aimed to determine available pharmacovigilance misuse/abuse/dependence/withdrawal signals relating to the Selective Serotonin Reuptake Inhibitors (SSRI) citalopram, escitalopram, paroxetine, fluoxetine, and sertraline. Both EudraVigilance (EV) and Food and Drug Administration-FDA Adverse Events Reporting System (FAERS) datasets were analysed to identify AD misuse/abuse/dependence/withdrawal issues. A descriptive analysis was performed; moreover, pharmacovigilance measures, including the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the information component (IC), and the empirical Bayesian geometric mean (EBGM) were calculated. Both datasets showed increasing trends of yearly reporting and similar signals regarding abuse and dependence. From the EV, a total of 5335 individual ADR reports were analysed, of which 30% corresponded to paroxetine (
    Language English
    Publishing date 2022-05-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15050565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Changes in transmucosal buprenorphine utilization for opioid use disorder treatment during the COVID-19 pandemic in Kentucky.

    Lei, Feitong / Lofwall, Michelle R / Freeman, Patricia R / Slade, Emily / Vickers-Smith, Rachel / Slavova, Svetla

    The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association

    2022  Volume 39, Issue 1, Page(s) 186–196

    Abstract: Purpose: With surging opioid-involved overdoses, maintaining access to opioid use disorder (OUD) treatment is critical during the COVID-19 pandemic. We examined changes in transmucosal buprenorphine prescribing for OUD treatment in Kentucky after the ... ...

    Abstract Purpose: With surging opioid-involved overdoses, maintaining access to opioid use disorder (OUD) treatment is critical during the COVID-19 pandemic. We examined changes in transmucosal buprenorphine prescribing for OUD treatment in Kentucky after the national COVID-19 emergency declaration, with a focus on rural-urban differences.
    Methods: Using 2019-2020 prescription monitoring data, we performed segmented regression analysis for an interrupted time series design to evaluate changes in weekly rates (per 100,000 residents) of dispensed prescriptions, unique individuals with dispensed prescriptions, and average days' supply for dispensed prescriptions of transmucosal buprenorphine.
    Findings: The weekly rates of dispensed prescriptions and unique individuals with dispensed prescriptions were higher for rural residents than urban residents. After the national COVID-19 emergency declaration, rural and urban residents experienced similar immediate drops in the rate of dispensed prescriptions (rural -33.4; urban -24.3) and unique patients with dispensed prescriptions (rural -25.0; urban -17.1), followed by similar sustained increases. Both measures surpassed the prepandemic levels in mid-June 2020. Patients residing in urban areas received averagely longer prescriptions at baseline (urban: 11.0 days; rural: 10.5 days). The average weekly days' supply increased in the week after the national emergency declaration, but the estimated increase was higher (P = .004) for urban (0.8 days) versus rural (0.5 days) residents.
    Conclusions: Transmucosal buprenorphine utilization increased during the COVID-19 pandemic after experiencing interruption during the initial weeks of the pandemic. Future studies should evaluate the contribution of the relaxed telemedicine buprenorphine prescribing regulations during the COVID-19 national emergency on initiation and maintenance of buprenorphine treatment.
    MeSH term(s) Humans ; Buprenorphine/therapeutic use ; Analgesics, Opioid/therapeutic use ; Kentucky/epidemiology ; Pandemics ; COVID-19/epidemiology ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/epidemiology
    Chemical Substances Buprenorphine (40D3SCR4GZ) ; Analgesics, Opioid
    Language English
    Publishing date 2022-05-24
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 639160-6
    ISSN 1748-0361 ; 0890-765X
    ISSN (online) 1748-0361
    ISSN 0890-765X
    DOI 10.1111/jrh.12669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cannabinoid Poisoning-Related Emergency Department Visits and Inpatient Hospitalizations in Kentucky, 2017 to 2019.

    Britch, Stevie C / Walsh, Sharon L / Vickers-Smith, Rachel / Babalonis, Shanna / Slavova, Svetla

    Substance use & misuse

    2022  Volume 58, Issue 1, Page(s) 66–76

    Abstract: Background and ... ...

    Abstract Background and objectives
    MeSH term(s) Male ; United States ; Humans ; Adolescent ; Young Adult ; Adult ; Cannabinoids/adverse effects ; Kentucky/epidemiology ; Inpatients ; Cannabis/adverse effects ; Hallucinogens ; Hospitalization ; Emergency Service, Hospital
    Chemical Substances Cannabinoids ; Hallucinogens
    Language English
    Publishing date 2022-12-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1310358-1
    ISSN 1532-2491 ; 1082-6084
    ISSN (online) 1532-2491
    ISSN 1082-6084
    DOI 10.1080/10826084.2022.2148478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Higher First 30-Day Dose of Buprenorphine for Opioid Use Disorder Treatment Is Associated With Decreased Mortality.

    Lei, Feitong / Lofwall, Michelle R / McAninch, Jana / Adatorwovor, Reuben / Slade, Emily / Freeman, Patricia R / Moga, Daniela C / Dasgupta, Nabarun / Walsh, Sharon L / Vickers-Smith, Rachel / Slavova, Svetla

    Journal of addiction medicine

    2024  

    Abstract: Objective: Buprenorphine is a medication for opioid use disorder that reduces mortality. This study aims to investigate the less well-understood relationship between the dose in the early stages of treatment and the subsequent risk of death.: Methods!# ...

    Abstract Objective: Buprenorphine is a medication for opioid use disorder that reduces mortality. This study aims to investigate the less well-understood relationship between the dose in the early stages of treatment and the subsequent risk of death.
    Methods: We used Kentucky prescription monitoring data to identify adult Kentucky residents initiating transmucosal buprenorphine medication for opioid use disorder (January 2017 to November 2019). Average daily buprenorphine dose for days covered in the first 30 days of treatment was categorized as ≤8 mg, >8 to ≤16 mg, and >16 mg. Patients were followed for 365 days after the first 30 days of buprenorphine treatment. Endpoints were opioid-involved overdose death and death from other causes. Causes and dates of death were obtained using Kentucky death certificate records. Associations were evaluated using multivariable Fine and Gray models adjusting for patient baseline characteristics.
    Results: In the cohort of 49,857 patients, there were 227 opioid-involved overdose deaths and 459 deaths from other causes. Compared with ≤8 mg, the adjusted subdistribution hazard ratio (aSHR) of opioid-involved overdose death decreased by 55% (aSHR, 0.45; 95% confidence interval [CI], 0.34-0.60) and 64% (aSHR, 0.36; 95% CI, 0.25-0.52) for patients receiving doses of >8 to ≤16 mg and >16 mg, respectively. The incidence of death from other causes was lower in patients receiving >8 to ≤16 mg (aSHR, 0.78; 95% CI, 0.62-0.98) and >16 mg (aSHR, 0.62; 95% CI, 0.47-0.80) versus ≤8 mg dose.
    Conclusions: Higher first 30-day buprenorphine doses were associated with reduced opioid-involved overdose death and death from other causes, supporting benefit of higher dosing in reducing mortality.
    Language English
    Publishing date 2024-04-10
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1935-3227
    ISSN (online) 1935-3227
    DOI 10.1097/ADM.0000000000001300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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