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  1. AU="Victor Daka"
  2. AU="Iglesias, C"
  3. AU="Williams, Howard L."
  4. AU=Tilmann Christopher
  5. AU=Stefansson Steingrimur
  6. AU="Schindler, Tobias"
  7. AU="Araújo, Cristina de O"
  8. AU=Goda Jayant S.
  9. AU="Peditto, Piera"
  10. AU="Dünn, Hans-Wilhelm"
  11. AU=Tyznik Aaron J.
  12. AU="Siddiqui, Fasih Sami"
  13. AU="Abt, S."
  14. AU="Sultana, Sufia"
  15. AU="Yuan, Shengwang"
  16. AU="Sedehizadeh, Saam"
  17. AU=Jeon Young-Woo
  18. AU=Narayanan Navaneeth
  19. AU=Beckwith Kyle A.
  20. AU=Anderson Robert H
  21. AU=Trindade P A
  22. AU=Gohil R
  23. AU="Zhengyi, Wu"
  24. AU=Wessels J A M
  25. AU="Porter, Lavinia"
  26. AU=Al-Mayman Sulaiman

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  1. Artikel ; Online: Male partner influence on Women's choices and utilisation of family planning services in Mufulira district, Zambia

    Hildah Nkonde / Bright Mukanga / Victor Daka

    Heliyon, Vol 9, Iss 3, Pp e14405- (2023)

    2023  

    Abstract: Background: Family planning services are essential in reducing maternal deaths as well as improving the reproductive and sexual health of women. Although family planning services are frequently focused on women, men are often the primary decision-makers. ...

    Abstract Background: Family planning services are essential in reducing maternal deaths as well as improving the reproductive and sexual health of women. Although family planning services are frequently focused on women, men are often the primary decision-makers. We conducted a study to explore male partner influence on women's choices and utilisation of family planning services in Mufulira district, Zambia. Methods: A qualitative explorative study design that utilised two focus group discussions (n = 20) and in-depth interviews (n = 30) involving women of reproductive age was conducted. Convenient sampling was employed to select participants. In-depth interviews and focus group discussions were recorded, translated, and transcribed verbatim. Content analysis was utilised through code classification and theme identification. Data were imported into NVivo.×64 for coding and node generation. Findings: The study revealed key themes on male partner influence on contraception use such as fear of infidelity, fear of physical abuse, preference for a large family size , disruption of sexual pleasure, and perceived side effects of contraceptives. These themes highlight the influence of culturally driven gender and power dynamics on male partner attitudes towards contraception. Participants described how their male partners exhibited prenatal attitudes and control over them thereby limiting their decision-making power on contraception use. Undesirable contraception side effects such as reduced vaginal lubrication contributed to sexual pleasure disruption among men. Concerns that women's use of contraception can lead to infidelity also contributed to male partner disapproval of contraception use. Conclusions: Understanding barriers to contraception utilisation presented by male partners is essential in preventing contraception discontinuation and can increase contraception uptake among women. Our findings highlight the influence of culturally driven gender and power dynamics on male partner attitudes towards contraception. ...
    Schlagwörter Male partner ; Contraception ; Family planning ; Zambia ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Exploring the multilevel factors influencing women’s choices and utilisation of family planning services in Mufulira district, Zambia

    Bright Mukanga / Hildah Nkonde / Victor Daka

    Cogent Public Health, Vol 10, Iss

    A socio-ecological perspective

    2023  Band 1

    Abstract: Abstract:Family planning services are useful in helping couples and individuals realize their basic right to decide freely and responsibly if, when, and how many children to have. The study aimed at exploring the multilevel factors influencing women’s ... ...

    Abstract Abstract:Family planning services are useful in helping couples and individuals realize their basic right to decide freely and responsibly if, when, and how many children to have. The study aimed at exploring the multilevel factors influencing women’s choices and utilisation of family planning services in Mufulira district of Zambia. A qualitative explorative study design that utilised two focus group discussions (n = 20) and in-depth interviews (n = 30) involving women of reproductive age was conducted in Mufulira district, Zambia. Convenient sampling was employed to select participants. In-depth interviews and focus group discussions were recorded, translated, and transcribed verbatim. Content analysis was utilised through code classification and theme identification. Data were imported into NVivo.x64 for coding and node generation. The study revealed overarching themes at the individual level such as distrust of hormonal contraception, misconceptions about the side effects of contraception, perceived side effects of contraceptives, perceived risk of infertility, and lack of adequate information on contraception. At the interpersonal level, themes were mainly centred on male partner influence such as male partner preference for a large family size, fear of partner infidelity, disruption of sexual pleasure, fear of intimate partner violence, and male partner disapproval of contraception use. At the institutional/organisation level, themes such as health providers’ negative attitudes, non-availability of preferred contraception, and lack of guidance and support from health workers were highlighted, and at the community level, we developed themes on the limited autonomy of women in making decisions and social expectations. Women’s choices and utilisation of family planning services are influenced by an interplay of multiple social-level factors. Interventions that address these influencing factors are needed to enhance the uptake of family planning services among women.
    Schlagwörter Male partner ; modern contraception ; contraception side effects ; social-ecological model ; Family planning ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Taylor & Francis Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: COVID-19 positive cases among asymptomatic individuals during the second wave in Ndola, Zambia

    Jonathan Gwasupika / Victor Daka / Justin Chileshe / Moses Mukosha / Steward Mudenda / Bright Mukanga / Ruth L. Mfune / Gershom Chongwe

    African Journal of Laboratory Medicine, Vol 12, Iss 1, Pp e1-e

    2023  Band 5

    Abstract: Background: Coronavirus disease 2019 (COVID-19) is a worldwide public health concern for healthcare workers. About 80% of cases appear to be asymptomatic, and about 3% may experience hospitalisation and later die. Less than 20% of studies have looked at ... ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) is a worldwide public health concern for healthcare workers. About 80% of cases appear to be asymptomatic, and about 3% may experience hospitalisation and later die. Less than 20% of studies have looked at the positivity rate of asymptomatic individuals. Objective: This study investigated the COVID-19 positivity rates among asymptomatic individuals during the second COVID-19 wave at one of Zambia’s largest testing centre. Methods: This was a retrospective cross-sectional study conducted on routine surveillance and laboratory data at the Tropical Diseases Research Centre COVID-19 laboratory in Ndola, Zambia, from 01 December 2020 to 31 March 2021. The study population was made up of persons that had tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection as a requirement for travel. Microsoft Excel was used to come up with an epidemiological curve of daily COVID-19 positive cases; proportions for gender were described using frequencies and percentages. Results: A total of 11 144 asymptomatic individuals tested for SARS-CoV-2 were sampled for the study and 1781 (16.0%) returned positive results. The median age among those tested was 36 years (interquartile range: 29–46). Testing for COVID-19 peaked in the month of January 2021 (37.4%) and declined in March 2021 (21.0%). The epidemiological curve showed a combination of continuous and propagated point-source transmission. Conclusion: The positivity rate of 16.0% among asymptomatic individuals was high and could imply continued community transmission, especially during January 2021 and February 2021. We recommend heightened testing for SARS-CoV-2 among asymptomatic individuals. What this study adds: This study adds critical knowledge to the transmission of COVID-19 among asymptomatic travellers who are usually a key population in driving community infection. This knowledge is critical in instituting evidence-based interventions in the screening and management of travellers, and its control.
    Schlagwörter asymptomatic individuals ; covid-19 disease ; positivity rate ; sars-cov-2 ; zambia ; Public aspects of medicine ; RA1-1270 ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag AOSIS
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Experiences and drivers of verbal abuse among women during labour and delivery in Ndola and Kitwe districts of Zambia

    Bright Mukanga / Herbert Tato Nyirenda / Nancy Choka / David Mulenga / Victor Daka

    Cogent Medicine, Vol 8, Iss

    2021  Band 1

    Abstract: Abstract: Verbal abuse during childbirth constitutes a violation of women’s human rights and indicates poor maternal health care. The aim of the study was to investigate experiences and drivers of verbal abuse among women in Ndola and Kitwe health ... ...

    Abstract Abstract: Verbal abuse during childbirth constitutes a violation of women’s human rights and indicates poor maternal health care. The aim of the study was to investigate experiences and drivers of verbal abuse among women in Ndola and Kitwe health facilities. The study adopted a cross-sectional survey. Qualitative and quantitative data using questionnaires and focus group interviews were employed. The study was done in the Ndola and Kitwe districts of Zambia. The target population were women attending postnatal services who had a live birth within 28 days of delivery. Twenty clinics were randomly selected and a total of 306 women were recruited using convenient sampling. Eleven percent of the study population experienced verbal abuse during intrapartum care. A 1-year increase in age reduced the odds of experiencing verbal abuse (Adjusted Odds Ratio [AOR] 0.89, 95% CI: 0.80–0.99). Women who consumed alcohol more frequently experienced verbal abuse than women who never consumed alcohol (adjusted odds ratio [AOR] 5.91, 99% CI 2.12–16.51), and women with bleached skin color more often experienced verbal abuse than women with natural skin tone (AOR = 3.95, 95% CI 1.13–13.83). Further, women with a medium skin tone were less likely (AOR = 0.17, 95% CI = 0.03–0.84) to experience verbal abuse. Other key drivers of verbal abuse include language barriers, laziness, vomiting, lack of seriousness, crying, lack of cooperation, and moving around during labour. We conclude that women experience various forms of verbal abuse. Therefore, there is a need to implement interventions that tackle the multiplicity of factors that drive verbal abuse at the individual, structural, and policy level. Further, there is a need to enhance training in respectful maternity care among service providers.
    Schlagwörter verbal ; abuse ; maternal ; labour ; delivery ; health care ; health ; Medicine ; R
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Taylor & Francis Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: High ELF4 expression in human cancers is associated with worse disease outcomes and increased resistance to anticancer drugs.

    Doris Kafita / Victor Daka / Panji Nkhoma / Mildred Zulu / Ephraim Zulu / Rabecca Tembo / Zifa Ngwira / Florence Mwaba / Musalula Sinkala / Sody Munsaka

    PLoS ONE, Vol 16, Iss 4, p e

    2021  Band 0248984

    Abstract: The malignant phenotype of tumour cells is fuelled by changes in the expression of various transcription factors, including some of the well-studied proteins such as p53 and Myc. Despite significant progress made, little is known about several other ... ...

    Abstract The malignant phenotype of tumour cells is fuelled by changes in the expression of various transcription factors, including some of the well-studied proteins such as p53 and Myc. Despite significant progress made, little is known about several other transcription factors, including ELF4, and how they help shape the oncogenic processes in cancer cells. To this end, we performed a bioinformatics analysis to facilitate a detailed understanding of how the expression variations of ELF4 in human cancers are related to disease outcomes and the cancer cell drug responses. Here, using ELF4 mRNA expression data of 9,350 samples from the Cancer Genome Atlas pan-cancer project, we identify two groups of patient's tumours: those that expressed high ELF4 transcripts and those that expressed low ELF4 transcripts across 32 different human cancers. We uncover that patients segregated into these two groups are associated with different clinical outcomes. Further, we find that tumours that express high ELF4 mRNA levels tend to be of a higher-grade, afflict a significantly older patient population and have a significantly higher mutation burden. By analysing dose-response profiles to 397 anti-cancer drugs of 612 well-characterised human cancer cell lines, we discover that cell lines that expressed high ELF4 mRNA transcript are significantly less responsive to 129 anti-cancer drugs, and only significantly more response to three drugs: dasatinib, WH-4-023, and Ponatinib, all of which remarkably target the proto-oncogene tyrosine-protein kinase SRC and tyrosine-protein kinase ABL1. Collectively our analyses have shown that, across the 32 different human cancers, the patients afflicted with tumours that overexpress ELF4 tended to have a more aggressive disease that is also is more likely more refractory to most anti-cancer drugs, a finding upon which we could devise novel categorisation of patient tumours, treatment, and prognostic strategies.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Epidemiological Trends of Malaria in Five Years and under Children of Nsanje District in Malawi, 2015–2019

    Theodore Gondwe / Yongi Yang / Simeon Yosefe / Maisa Kasanga / Griffin Mulula / Mphatso Prince Luwemba / Annie Jere / Victor Daka / Tobela Mudenda

    International Journal of Environmental Research and Public Health, Vol 18, Iss 12784, p

    2021  Band 12784

    Abstract: Background: Malaria continues to be a major public health problem in Malawi and the greatest load of mortality and morbidity occurs in children five years and under. However, there is no information yet regarding trends and predictions of malaria ... ...

    Abstract Background: Malaria continues to be a major public health problem in Malawi and the greatest load of mortality and morbidity occurs in children five years and under. However, there is no information yet regarding trends and predictions of malaria incidence in children five years and under at district hospital level, particularly at Nsanje district hospital. Aim: Therefore, this study aimed at investigating the trends of malaria morbidity and mortality in order to design appropriate interventions on the best approach to contain the disease in the near future. Methodology: Trend analysis of malaria morbidity and mortality together with time series analysis using the SARIMA (Seasonal Autoregressive Integrated Moving Average) model was used to predict malaria incidence in Nsanje district. Results: The SARIMA model used malaria cases from 2015 to 2019 and created the best model to forecast the malaria cases in Nsanje from 2020 to 2022. An SARIMA (0, 1, 2) (0,1,1) 12 was suitable for forecasting the incidence of malaria for Nsanje. Conclusion: The mortality and morbidity trend showed that malaria cases were growing at a fluctuating rate at Nsanje district hospital. The relative errors between the actual values and predicted values indicated that the predicted values matched the actual values well. Therefore, the model proved that it was adequate to forecast monthly malaria cases and it had a good fit, hence, was appropriate for this study
    Schlagwörter malaria incidence ; time series ; SARIMA ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: A cross-sectional study of the factors associated with male circumcision status among college youth in Ndola, Zambia, 2016

    Ernest Kateule / Ramya Kumar / David Mwakazanga / Modest Mulenga / Victor Daka / Gershom Chongwe

    Southern African Journal of HIV Medicine, Vol 20, Iss 1, Pp e1-e

    2019  Band 7

    Abstract: Background: New cases of HIV are increasing among young adults in Zambia; yet voluntary medical male circumcision (VMMC) coverage as an HIV prevention measure remains low. Despite having the highest HIV burden in the province, Ndola district had a VMMC ... ...

    Abstract Background: New cases of HIV are increasing among young adults in Zambia; yet voluntary medical male circumcision (VMMC) coverage as an HIV prevention measure remains low. Despite having the highest HIV burden in the province, Ndola district had a VMMC coverage of 23% in 2015 compared to the national target of 80% among high-risk groups. Objectives: To determine predictive factors associated with circumcision status among male students in Ndola district. Methods: We conducted a cross-sectional study in May 2016 among students aged 18–35 years enrolled in five conveniently sampled colleges. We administered a structured questionnaire to assess the knowledge, attitudes and perceptions about VMMC. We used multivariable logistic regression to determine factors associated with male circumcision (MC) status. Results: Of 136 students interviewed, 63% were circumcised, and of those, 96% were medically circumcised. Half of all students were aged 21–24 years. Those who perceived the circumcision procedure to be ‘safe’ (adjusted odds ratio [aOR] = 5.13; 95% CI: 2.09–14.82), and knew that it reduced female to male HIV transmission risk (aOR = 3.65; 95% CI: 3.12–11.67), were more likely to be circumcised. The perception that MC promotes ‘promiscuous behaviour’ (aOR = 0.20; 95% CI: 0.07–0.61), and that sexual sensitivity is the ‘same’ regardless of circumcision status, were associated with not being circumcised (aOR = 0.13; 95% CI: 0.02–0.80). Conclusion: Students had adequate knowledge about the safety of medical circumcision, and the subsequent risk reduction of HIV infection. Interventions aimed at addressing negative sexual perceptions about circumcision may increase VMMC coverage among college students.
    Schlagwörter College students ; Ethnicity ; HIV ; Voluntary medical male circumcision ; Ndola ; Zambia ; Public aspects of medicine ; RA1-1270 ; Infectious and parasitic diseases ; RC109-216
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag AOSIS
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: COVID-19 vaccine uptake and associated factors among adolescents and youths

    Steward Mudenda / Johanna C. Meyer / Joseph O. Fadare / Olayinka O. Ogunleye / Zikria Saleem / Scott K. Matafwali / Victor Daka / Billy Chabalenge / Jacob Chama / Moses Mukosha / Phumzile Skosana / Bwalya A. Witika / Aubrey C. Kalungia / Audrey Hamachila / Webrod Mufwambi / Brian Godman

    PLOS Global Public Health, Vol 3, Iss

    Findings and implications for future vaccination programmes

    2023  Band 9

    Schlagwörter Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Knowledge and practices toward COVID-19 among healthcare students

    Steward Mudenda / Nelly Ngalande / Moses Mukosha / Christabel Nang'andu Hikaambo / Victor Daka / Scott Kaba Matafwali / Michelo Banda / Ruth Lindizyani Mfune / Godfrey Mayoka / Bwalya Angel Witika

    Frontiers in Public Health, Vol

    A cross-sectional study at the University of Zambia

    2022  Band 10

    Abstract: BackgroundThe COVID-19 pandemic led to the disruption of physical classes for university students globally, as large gatherings fuelled the transmission of the virus. In the efforts to mitigate its transmission and return to normality, prevention ... ...

    Abstract BackgroundThe COVID-19 pandemic led to the disruption of physical classes for university students globally, as large gatherings fuelled the transmission of the virus. In the efforts to mitigate its transmission and return to normality, prevention measures, including vaccination, have been encouraged. Therefore, it is critical to understand the knowledge and practices of students regarding COVID-19. This study assessed the knowledge and practices toward COVID-19 among healthcare students at the University of Zambia.Materials and methodsThis questionnaire-based cross-sectional study was carried out from August 2021 to October 2021 among 478 healthcare students (pharmacy, physiotherapy, nursing, biomedical, medicine, and radiography). We used a previously validated questionnaire to measure knowledge and practice. The predictors of knowledge and practices were assessed using logistic regression with robust estimation of standard errors. Statistical analysis was conducted using Stata/BE version 17.0.ResultsOf the 478 respondents, 243 (50.8%) were females. A larger proportion, 175 (36.6%) were in Pharmacy training, and 156 (32.6%) were in their fifth year of study. The overall mean knowledge score of the participants was 87.9 (SD = 16.1), being higher at 89.6 (SD = 14.3) among medical students and the lowest at 86.7 (SD = 17.1) among Pharmacy students, although this was statistically non-significant (p = 0.488). The overall mean practice score was 60.0 (SD = 24.7), being significantly higher at 63.5 (23.4) among nursing, physiotherapy and environmental students compared to other students (p = 0.048). In multivariable analysis, the participant training program was non-significantly associated with knowledge and practice toward COVID-19. However, increased age (AOR = 1.09, 95% CI: 1.01–1.117) and residing in urban areas (AOR = 1.79, 95% CI: 1.07–3.01) than in rural areas were associated with higher odds of good practice toward COVID-19.ConclusionThe healthcare students generally showed good knowledge levels and poor ...
    Schlagwörter COVID-19 ; healthcare students ; knowledge ; practices ; Zambia ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 690 ; 420
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Increased number of brought-in-dead cases with COVID-19

    Misheck Chileshe / David Mulenga / Ruth Lindizyani Mfune / Tato Herbert Nyirenda / James Mwanza / Bright Mukanga / Steward Mudenda / Victor Daka

    The Pan African Medical Journal, Vol 37, Iss

    is it due to poor health-seeking behaviour among the Zambian population?

    2020  Band 136

    Abstract: The novel Coronavirus Disease-2019 which was first reported on 31st December, 2019 in Wuhan city, China has resulted in over 889, 256 deaths and over 27 million infections worldwide. In Zambia there have been a total of 295 deaths among which there were ... ...

    Abstract The novel Coronavirus Disease-2019 which was first reported on 31st December, 2019 in Wuhan city, China has resulted in over 889, 256 deaths and over 27 million infections worldwide. In Zambia there have been a total of 295 deaths among which there were 214 brought-in-dead (BID). This high number of BIDs raises critical questions about the health seeking behaviour among the Zambian population. There is need to investigate drivers of community deaths. Here we postulate possible causes and suggest possible mitigation measures.
    Schlagwörter coronavirus disease 2019 ; brought-in-dead ; zambia ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag The Pan African Medical Journal
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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