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  1. Article ; Online: SARS-CoV-2 Transmission Risk Model in an Urban Area of Mexico, Based on GIS Analysis and Viral Load

    Victor Wagner Barajas-Carrillo / Carlos Eduardo Covantes-Rosales / Mercedes Zambrano-Soria / Lucia Amapola Castillo-Pacheco / Daniel Alberto Girón-Pérez / Ulises Mercado-Salgado / Ansonny Jhovanny Ojeda-Durán / Erica Yolanda Vázquez-Pulido / Manuel Iván Girón-Pérez

    International Journal of Environmental Research and Public Health, Vol 19, Iss 3840, p

    2022  Volume 3840

    Abstract: The COVID-19 pandemic highlighted health systems vulnerabilities, as well as thoughtlessness by governments and society. Due to the nature of this contingency, the use of geographic information systems (GIS) is essential to understand the SARS-CoV-2 ... ...

    Abstract The COVID-19 pandemic highlighted health systems vulnerabilities, as well as thoughtlessness by governments and society. Due to the nature of this contingency, the use of geographic information systems (GIS) is essential to understand the SARS-CoV-2 distribution dynamics within a defined geographic area. This work was performed in Tepic, a medium-sized city in Mexico. The residence of 834 COVID-19 infected individuals was georeferenced and categorized by viral load (Ct). The analysis took place during the maximum contagion of the first four waves of COVID-19 in Mexico, analyzing 158, 254, 143, and 279 cases in each wave respectively. Then heatmaps were built and categorized into five areas ranging from very low to very high risk of contagion, finding that the second wave exhibited a greater number of cases with a high viral load. Additionally, a spatial analysis was performed to measure urban areas with a higher risk of contagion, during this wave this area had 19,203.08 km 2 (36.11% of the city). Therefore, a kernel density spatial model integrated by meaningful variables such as the number of infected subjects, viral load, and place of residence in cities, to establish geographic zones with different degrees of infection risk, could be useful for decision-making in future epidemic events.
    Keywords Mexico ; COVID-19 ; GIS ; heatmap ; risk ; viral load ; Medicine ; R
    Subject code 910
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Organophosphate-Pesticide-Mediated Immune Response Modulation in Invertebrates and Vertebrates

    Karime Guadalupe Bernal-González / Carlos Eduardo Covantes-Rosales / Milton Rafael Camacho-Pérez / Ulises Mercado-Salgado / Victor Wagner Barajas-Carrillo / Daniel Alberto Girón-Pérez / Ashley Carolina Montoya-Hidalgo / Karina Janice Guadalupe Díaz-Resendiz / Rocío Guadalupe Barcelos-García / Gladys Alejandra Toledo-Ibarra / Manuel Iván Girón-Pérez

    International Journal of Molecular Sciences, Vol 24, Iss 5360, p

    2023  Volume 5360

    Abstract: Organophosphate pesticides (OPs) have greatly facilitated food production worldwide, and their use is not limited to agriculture and the control of pests and disease vectors. However, these substances can directly affect the immune response of non-target ...

    Abstract Organophosphate pesticides (OPs) have greatly facilitated food production worldwide, and their use is not limited to agriculture and the control of pests and disease vectors. However, these substances can directly affect the immune response of non-target organisms. In this sense, exposure to OPs can have negative effects on innate and adaptive immunity, promoting deregulation in humoral and cellular processes such as phagocytosis, cytokine expression, antibody production, cell proliferation, and differentiation, which are crucial mechanisms for host defense against external agents. This review focuses on the scientific evidence of exposure to OPs and their toxic effects on the immune system of non-target organisms (invertebrates and vertebrates) from a descriptive perspective of the immuno-toxic mechanisms associated with susceptibility to the development of bacterial, viral, and fungal infectious diseases. During the exhaustive review, we found that there is an important gap in the study of non-target organisms, examples of which are echinoderms and chondrichthyans. It is therefore important to increase the number of studies on other species directly or indirectly affected by Ops, to assess the degree of impact at the individual level and how this affects higher levels, such as populations and ecosystems.
    Keywords organophosphorus pesticides ; diseases ; immune system ; immunotoxicity ; infections ; non-target organisms ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Comparative Analysis of Age, Sex, and Viral Load in Outpatients during the Four Waves of SARS-CoV-2 in A Mexican Medium-Sized City

    Carlos Eduardo Covantes-Rosales / Victor Wagner Barajas-Carrillo / Daniel Alberto Girón-Pérez / Gladys Alejandra Toledo-Ibarra / Karina Janice Guadalupe Díaz-Reséndiz / Migdalia Sarahy Navidad-Murrieta / Guadalupe Herminia Ventura-Ramón / Mirtha Elena Pulido-Muñoz / Ulises Mercado-Salgado / Ansonny Jhovanny Ojeda-Durán / Aimée Argüero-Fonseca / Manuel Iván Girón-Pérez

    International Journal of Environmental Research and Public Health, Vol 19, Iss 5719, p

    2022  Volume 5719

    Abstract: Governments have implemented measures to minimize SARS-CoV-2 spread. However, these measures were relaxed, and the appearance of new variants has prompted periods of high contagion known as waves. In Mexico, four waves distributed between July and August ...

    Abstract Governments have implemented measures to minimize SARS-CoV-2 spread. However, these measures were relaxed, and the appearance of new variants has prompted periods of high contagion known as waves. In Mexico, four waves distributed between July and August 2020, January and February 2021, August and September 2021, and January and February 2022 have appeared. Current health policies discourage mass sampling, preferring to focus on the corrective treatment of severe cases. Outpatients are only advised to undergo brief voluntary confinement and symptomatic treatment, with no follow-up. Therefore, the present study aimed to analyze sex, age, and viral load in outpatients during the four waves in a medium-sized city in Mexico. For each wave, the date of peak contagion was identified, and data were collected within ±15 days. In this regard, data from 916 patients (434 men and 482 women) were analyzed. The age range of positive patients (37–45 years) presented a higher frequency during the first and third waves, while 28–36 years was the most frequent age range during the second and fourth waves, while the viral load values were significantly higher, for both sexes, during the fourth wave. Obtained data of COVID-19 prevalence in population segments can be used for decision-making in the design of effective public health policies.
    Keywords SARS-CoV-2 ; viral load ; age groups ; sex ; qRT-PCR ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: In Vitro and In Silico Screening of 2,4,5-Trisubstituted Imidazole Derivatives as Potential Xanthine Oxidase and Acetylcholinesterase Inhibitors, Antioxidant, and Antiproliferative Agents

    Eduardo Noriega-Iribe / Laura Díaz-Rubio / Arturo Estolano-Cobián / Victor Wagner Barajas-Carrillo / José M. Padrón / Ricardo Salazar-Aranda / Raúl Díaz-Molina / Victor García-González / Rocio Alejandra Chávez-Santoscoy / Daniel Chávez / Iván Córdova-Guerrero

    Applied Sciences, Vol 10, Iss 2889, p

    2020  Volume 2889

    Abstract: The employment of privileged scaffolds in medicinal chemistry supplies scientists with a solid start in the search for new and improved therapeutic molecules. One of these scaffolds is the imidazole ring, from which several derivatives have shown a wide ... ...

    Abstract The employment of privileged scaffolds in medicinal chemistry supplies scientists with a solid start in the search for new and improved therapeutic molecules. One of these scaffolds is the imidazole ring, from which several derivatives have shown a wide array of biological activities. A series of 2,4,5-triphenyl imidazole derivatives were synthesized, characterized, and evaluated in vitro as antioxidant molecules using 1,1-diphenyl-2-picrylhydrazyl (DPPH . ) and 2-2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS .+ ) assays, acetylcholinesterase (AChE) and xanthine oxidase (XO) inhibitors as well as antiproliferative agents. Additional in silico studies such as docking and determination of their absorption, distribution, metabolism, and excretion (ADME) properties were calculated. Compounds 3 and 10 were the most active antioxidants in both the DPPH and ABTS assays (EC 50 of 0.141 and 0.174 mg/mL, and 0.168 and 0.162 mg/mL, respectively). In the enzymatic inhibition, compound 1 showed the best activity, inhibiting 25.8% of AChE at a concentration of 150 μg/mL, and compound 3 was the most active XO inhibitor with an IC 50 of 85.8 μg/mL. Overall, against the six different evaluated cancerous cell lines, molecules 2 , 10 , and 11 were the most antiproliferative compounds. In silico predictions through docking point out 11 , and ADME analysis to 11 and 12 , as good candidates for being lead compounds for further derivations.
    Keywords imidazole ; antiproliferative ; antioxidant activities ; docking ; DPPH ; ABTS ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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