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  1. Book ; Online ; E-Book: Rapid-eye-movement sleep behavior disorder

    Schenck, Carlos H. / Högl, Birgit / Videnovic, Aleksandar

    2019  

    Title variant Rapid eye movement sleep behavior disorder
    Author's details Carlos H. Schenck, Birgit Högl, Aleksandar Videnovic, editors
    Keywords Sleep Wake Disorders / physiopathology ; Sleep, REM / physology ; Neurology ; Psychiatry ; Psychology, clinical ; Neurosciences
    Subject code 616.8
    Language English
    Size 1 Online-Ressource (XX, 678 Seiten), Illustrationen
    Publisher Springer International Publishing
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019851312
    ISBN 978-3-319-90152-7 ; 9783319901510 ; 3-319-90152-4 ; 3319901516
    DOI 10.1007/978-3-319-90152-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Disorders of sleep and wake in Parkinson's Disease

    Videnovic, Aleksandar / Högl, Birgit

    2015  

    Keywords Circadian ; PD ; Parkinson's Disease ; REM Behavior Disorders ; Sleep ; Somnolence
    Language English
    Size XII, 229 S., 235 mm x 155 mm
    Publisher Springer
    Publishing place Wien : u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018653971
    ISBN 978-3-7091-1630-2 ; 9783709116319 ; 3-7091-1630-9 ; 3709116317
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 1870 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Sleep Disorders and Circadian Disruption in Huntington's Disease.

    Saade-Lemus, Sandra / Videnovic, Aleksandar

    Journal of Huntington's disease

    2023  Volume 12, Issue 2, Page(s) 121–131

    Abstract: Sleep and circadian alterations are common in patients with Huntington's disease (HD). Understanding the pathophysiology of these alterations and their association with disease progression and morbidity can guide HD management. We provide a narrative ... ...

    Abstract Sleep and circadian alterations are common in patients with Huntington's disease (HD). Understanding the pathophysiology of these alterations and their association with disease progression and morbidity can guide HD management. We provide a narrative review of the clinical and basic-science studies centered on sleep and circadian function on HD. Sleep/wake disturbances among HD patients share many similarities with other neurodegenerative diseases. Overall, HD patients and animal models of the disease present with sleep changes early in the clinical course of the disease, including difficulties with sleep initiation and maintenance leading to decreased sleep efficiency, and progressive deterioration of normal sleep architecture. Despite this, sleep alterations remain frequently under-reported by patients and under-recognized by health professionals. The degree of sleep and circadian alterations has not consistently shown to be CAG dose-dependent. Evidence based treatment recommendations are insufficient due to lack of well-designed intervention trials. Approaches aimed at improving circadian entrainment, such as including light therapy, and time-restricted feeding have demonstrated a potential to delay symptom progression in some basic HD investigations. Larger study cohorts, comprehensive assessment of sleep and circadian function, and reproducibility of findings are needed in future in order to better understand sleep and circadian function in HD and to develop effective treatments.
    MeSH term(s) Animals ; Huntington Disease ; Circadian Rhythm/physiology ; Reproducibility of Results ; Sleep/physiology ; Sleep Wake Disorders/complications ; Disease Models, Animal
    Language English
    Publishing date 2023-06-26
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2673033-9
    ISSN 1879-6400 ; 1879-6397
    ISSN (online) 1879-6400
    ISSN 1879-6397
    DOI 10.3233/JHD-230576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Disturbances of Sleep and Alertness in Parkinson's Disease.

    Videnovic, Aleksandar

    Current neurology and neuroscience reports

    2018  Volume 18, Issue 6, Page(s) 29

    Abstract: Purpose of review: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Sleep dysfunction is one of the most common non-motor manifestations of PD that has gained significant interest over the past two decades due to its impact ...

    Abstract Purpose of review: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Sleep dysfunction is one of the most common non-motor manifestations of PD that has gained significant interest over the past two decades due to its impact on the daily lives of PD patients, poorly understood mechanisms, and limited treatment options. In this review, we discuss the most common sleep disorders in PD and present recent investigations that have broadened our understanding of the epidemiology, clinical manifestations, diagnosis, and treatment of disturbed sleep and alertness in PD.
    Resent findings: The etiology of impaired sleep-wake cycles in PD is multifactorial. Sleep dysfunction in PD encompasses insomnia, REM sleep behavior disorder, sleep-disordered breathing, restless legs syndrome, and circadian dysregulation. Despite the high prevalence of sleep dysfunction in PD, evidence supporting the efficacy of treatment strategies is limited. We are at the opportune time to advance our understanding of sleep dysfunction in PD, which will hopefully lead to mechanisms-driven interventions for better sleep and allow us to approach sleep as a modifiable therapeutic target for other non-motor and motor manifestations in PD.
    MeSH term(s) Humans ; Parkinson Disease/complications ; Parkinson Disease/epidemiology ; Parkinson Disease/physiopathology ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/therapy
    Language English
    Publishing date 2018-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-018-0838-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5549: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Sodium oxybate-a new horizon for symptomatic treatment of RBD?

    Stefani, Ambra / Högl, Birgit / Videnovic, Aleksandar

    Sleep

    2023  Volume 46, Issue 8

    MeSH term(s) Humans ; Sodium Oxybate/therapeutic use ; Narcolepsy ; REM Sleep Behavior Disorder ; Sleep
    Chemical Substances Sodium Oxybate (7G33012534)
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsad150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1475: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Management of sleep disorders in Parkinson's disease and multiple system atrophy.

    Videnovic, Aleksandar

    Movement disorders : official journal of the Movement Disorder Society

    2017  Volume 32, Issue 5, Page(s) 659–668

    Abstract: Parkinson's disease (PD) and multiple system atrophy (MSA) are disorders associated with α synuclein-related neurodegeneration. Nonmotor symptoms are common hallmarks of these disorders, and disturbances of the sleep-wake cycle are among the most common ... ...

    Abstract Parkinson's disease (PD) and multiple system atrophy (MSA) are disorders associated with α synuclein-related neurodegeneration. Nonmotor symptoms are common hallmarks of these disorders, and disturbances of the sleep-wake cycle are among the most common nonmotor symptoms. It is only recently that sleep disturbances have received the attention of the medical and research community. Significant progress has been made in understanding the pathophysiology of sleep and wake disruption in alphasynucleinopathies during the past few decades. Despite these advancements, treatment options are limited and frequently associated with problematic side effects. Further studies that center on the development of novel treatment approaches are very much needed. In this article, the author discusses the current state of the management of disturbed sleep and alertness in PD and MSA. © 2017 International Parkinson and Movement Disorder Society.
    MeSH term(s) Chronobiology Disorders/complications ; Chronobiology Disorders/physiopathology ; Chronobiology Disorders/therapy ; Disease Management ; Disorders of Excessive Somnolence/complications ; Disorders of Excessive Somnolence/physiopathology ; Disorders of Excessive Somnolence/therapy ; Humans ; Multiple System Atrophy/complications ; Multiple System Atrophy/therapy ; Parkinson Disease/complications ; Parkinson Disease/therapy ; REM Sleep Behavior Disorder/complications ; REM Sleep Behavior Disorder/physiopathology ; REM Sleep Behavior Disorder/therapy ; Restless Legs Syndrome/complications ; Restless Legs Syndrome/physiopathology ; Restless Legs Syndrome/therapy ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/physiopathology ; Sleep Apnea Syndromes/therapy ; Sleep Initiation and Maintenance Disorders/complications ; Sleep Initiation and Maintenance Disorders/physiopathology ; Sleep Initiation and Maintenance Disorders/therapy ; Sleep Wake Disorders/complications ; Sleep Wake Disorders/physiopathology ; Sleep Wake Disorders/therapy
    Language English
    Publishing date 2017-01-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.26918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2555: Show issues Location:
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    Zs.MO 238: Show issues

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  7. Article ; Online: Circadian rhythms in neurodegenerative disorders.

    Nassan, Malik / Videnovic, Aleksandar

    Nature reviews. Neurology

    2021  Volume 18, Issue 1, Page(s) 7–24

    Abstract: Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the circadian rhythms that synchronize physiological and behavioural functions in humans. The circadian system influences most physiological processes, including sleep, ... ...

    Abstract Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the circadian rhythms that synchronize physiological and behavioural functions in humans. The circadian system influences most physiological processes, including sleep, alertness and cognitive performance. Disruption of circadian homeostasis has deleterious effects on human health. Neurodegenerative disorders involve a wide range of symptoms, many of which exhibit diurnal variations in frequency and intensity. These disorders also disrupt circadian homeostasis, which in turn has negative effects on symptoms and quality of life. Emerging evidence points to a bidirectional relationship between circadian homeostasis and neurodegeneration, suggesting that circadian function might have an important role in the progression of neurodegenerative disorders. Therefore, the circadian system has become an attractive target for research and clinical care innovations. Studying circadian disruption in neurodegenerative disorders could expand our understanding of the pathophysiology of neurodegeneration and facilitate the development of novel, circadian-based interventions for these disabling disorders. In this Review, we discuss the alterations to the circadian system that occur in movement (Parkinson disease and Huntington disease) and cognitive (Alzheimer disease and frontotemporal dementia) neurodegenerative disorders and provide directions for future investigations in this field.
    MeSH term(s) Animals ; Circadian Clocks ; Circadian Rhythm ; Humans ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/physiopathology
    Language English
    Publishing date 2021-11-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-021-00577-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6257: Show issues Location:
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    Zs.MG 88: Show issues

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  8. Article: Circadian and Sleep Dysfunctions in Neurodegenerative Disorders-An Update.

    Fifel, Karim / Videnovic, Aleksandar

    Frontiers in neuroscience

    2021  Volume 14, Page(s) 627330

    Abstract: Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian ... ...

    Abstract Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian disturbances may influence the neurodegenerative processes as well as be their consequence. In this perspective, we provide an update of the current understanding of sleep and circadian dysregulation in Alzheimer's, Parkinson's, and Huntington's diseases.
    Language English
    Publishing date 2021-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2020.627330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Chronotype, sleep, and sleepiness in Parkinson's disease.

    Murphy, Samantha / Chibnik, Lori B / Videnovic, Aleksandar

    Parkinsonism & related disorders

    2022  Volume 106, Page(s) 105189

    Abstract: We aimed to determine the distribution of chronotypes in a cohort of PD patients and to evaluate the relationships between chronotype and PD characteristics, and self-reported metrics of sleep and sleepiness. Chronotype was characterized using the Horne- ... ...

    Abstract We aimed to determine the distribution of chronotypes in a cohort of PD patients and to evaluate the relationships between chronotype and PD characteristics, and self-reported metrics of sleep and sleepiness. Chronotype was characterized using the Horne-Ostberg Morningness-Eveningness Questionnaire (MEQ). PD participants were categorized as Evening Types (ET), Neither Types (NT), or Morning Types (MT). Sleepiness was assessed by the Epworth Sleepiness Scale. Sleep metrics included self-reported sleep times and latency. 186 participants with PD, age 65.5 ± 9.8 yrs, disease duration 6.17 ± 6.7 yrs completed the MEQ. Most participants were classified as MT (63.4%). Participants in the ET group were younger than those in the NT and MT groups (57.6 ± 6.3 vs 67.3 ± 10.2 vs 64.9 ± 9.5). The mean disease duration was not different among chronotypes. No significant relationship between chronotype and sleepiness was found. MT participants woke up and went to bed significantly earlier than NT participants. There was no significant difference between chronotypes and PD medications. Further studies should examine if PD severity and progression affect the chronotype, and whether certain chronotype differentially affects the quality of life, symptom control, and medication effectiveness in the PD population.
    MeSH term(s) Humans ; Middle Aged ; Aged ; Circadian Rhythm ; Chronotype ; Sleepiness ; Parkinson Disease/complications ; Quality of Life ; Sleep ; Surveys and Questionnaires
    Language English
    Publishing date 2022-10-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2022.10.011
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    Zs.A 4553: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 420: Show issues

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  10. Article ; Online: Circadian alterations in patients with neurodegenerative diseases: Neuropathological basis of underlying network mechanisms.

    Fifel, Karim / Videnovic, Aleksandar

    Neurobiology of disease

    2020  Volume 144, Page(s) 105029

    Abstract: Circadian organization of physiology and behavior is an important biological process that allows organisms to anticipate and prepare for daily changes and demands. Disruptions in this system precipitates a wide range of health issues. In patients with ... ...

    Abstract Circadian organization of physiology and behavior is an important biological process that allows organisms to anticipate and prepare for daily changes and demands. Disruptions in this system precipitates a wide range of health issues. In patients with neurodegenerative diseases, alterations of circadian rhythms are among the most common and debilitating symptoms. Although a growing awareness of these symptoms has occurred during the last decade, their underlying neuropathophysiological circuitry remains poorly understood and consequently no effective therapeutic strategies are available to alleviate these health issues. Recent studies have examined the neuropathological status of the different neural components of the circuitry governing the generation of circadian rhythms in neurodegenerative diseases. In this review, we will dissect the potential contribution of dysfunctions in the different nodes of this circuitry to circadian alterations in patients with neurodegenerative diseases. A deeper understanding of these mechanisms will provide not only a better understanding of disease neuro-pathophysiology, but also hold the promise for developing effective and mechanisms-based therapies.
    MeSH term(s) Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Brain/pathology ; Brain/physiopathology ; Chronobiology Disorders/pathology ; Chronobiology Disorders/physiopathology ; Circadian Rhythm/physiology ; Humans ; Huntington Disease/pathology ; Huntington Disease/physiopathology ; Neural Pathways/pathology ; Neural Pathways/physiopathology ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/physiopathology ; Parkinson Disease/pathology ; Parkinson Disease/physiopathology
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2020.105029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4444: Show issues Location:
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