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  1. AU="Viecelli, Claudio"
  2. AU=Valls Joan
  3. AU="Yang, Qizhang"
  4. AU=Wilt Timothy J
  5. AU="Dene R. Littler" AU="Dene R. Littler"
  6. AU="Petrenko, Andrei"
  7. AU=Valentino Kristin
  8. AU=Swash M
  9. AU="Adedipe, Ifeoluwa"
  10. AU=Shen Hongcheng
  11. AU="Padhy, Biswajit"
  12. AU="Kruglikov, Alibek"
  13. AU="Tasu, Jean Pierre"
  14. AU="Floate, Kevin D"
  15. AU="Mark Rijpkema"
  16. AU="Gjeloshi, Klodian"
  17. AU="Lucie Beaudoin"

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  1. Artikel ; Online: The non-modifiable factors age, gender, and genetics influence resistance exercise.

    Viecelli, Claudio / Ewald, Collin Y

    Frontiers in aging

    2022  Band 3, Seite(n) 1005848

    Abstract: Muscle mass and force are key for movement, life quality, and health. It is well established that resistance exercise is a potent anabolic stimulus increasing muscle mass and force. The response of a physiological system to resistance exercise is ... ...

    Abstract Muscle mass and force are key for movement, life quality, and health. It is well established that resistance exercise is a potent anabolic stimulus increasing muscle mass and force. The response of a physiological system to resistance exercise is composed of non-modifiable (
    Sprache Englisch
    Erscheinungsdatum 2022-09-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 3076785-4
    ISSN 2673-6217 ; 2673-6217
    ISSN (online) 2673-6217
    ISSN 2673-6217
    DOI 10.3389/fragi.2022.1005848
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: May the Force and Mass Be With You-Evidence-Based Contribution of Mechano-Biological Descriptors of Resistance Exercise.

    Viecelli, Claudio / Aguayo, David

    Frontiers in physiology

    2022  Band 12, Seite(n) 686119

    Abstract: Skeletal muscle is one of the most important tissues of the human body. It comprises up to 40% of the body mass and is crucial to survival. Hence, the maintenance of skeletal muscle mass and strength is pivotal. It is well-established that resistance ... ...

    Abstract Skeletal muscle is one of the most important tissues of the human body. It comprises up to 40% of the body mass and is crucial to survival. Hence, the maintenance of skeletal muscle mass and strength is pivotal. It is well-established that resistance exercise provides a potent anabolic stimulus to increase muscle mass and strength in men and women of all ages. Resistance exercise consists of mechano-biological descriptors, such as load, muscle action, number of repetitions, repetition duration, number of sets, rest interval between sets, frequency, volitional muscular failure, and range of motion, which can be manipulated. Herein, we discuss the evidence-based contribution of these mechano-biological descriptors to muscle mass and strength.
    Sprache Englisch
    Erscheinungsdatum 2022-01-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.686119
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Dissertation / Habilitation ; Online: Using Smartphone Sensors to obtain Mechano-Biological Descriptors of Resistance Exercise

    Viecelli, Claudio / id_orcid:0 000-0002-9093-4864

    2021  

    Schlagwörter info:eu-repo/classification/ddc/570 ; Life sciences
    Sprache Englisch
    Verlag ETH Zurich
    Erscheinungsland ch
    Dokumenttyp Dissertation / Habilitation ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  4. Artikel ; Online: Using smartphone accelerometer data to obtain scientific mechanical-biological descriptors of resistance exercise training.

    Viecelli, Claudio / Graf, David / Aguayo, David / Hafen, Ernst / Füchslin, Rudolf M

    PloS one

    2020  Band 15, Heft 7, Seite(n) e0235156

    Abstract: Background: Single repetition, contraction-phase specific and total time-under-tension (TUT) are crucial mechano-biological descriptors associated with distinct morphological, molecular and metabolic muscular adaptations in response to exercise, ... ...

    Abstract Background: Single repetition, contraction-phase specific and total time-under-tension (TUT) are crucial mechano-biological descriptors associated with distinct morphological, molecular and metabolic muscular adaptations in response to exercise, rehabilitation and/or fighting sarcopenia. However, to date, no simple, reliable and valid method has been developed to measure these descriptors.
    Objective: In this study we aimed to test whether accelerometer data obtained from a standard smartphone placed on the weight stack can be used to extract single repetition, contraction-phase specific and total TUT.
    Methods: Twenty-two participants performed two sets of ten repetitions of their 60% one repetition maximum with a self-paced velocity on nine commonly used resistance exercise machines. Two identical smartphones were attached on the resistance exercise weight stacks and recorded all user-exerted accelerations. An algorithm extracted the number of repetitions, single repetition, contraction-phase specific and total TUT. All exercises were video-recorded. The TUT determined from the algorithmically-derived mechano-biological descriptors was compared with the video recordings that served as the gold standard. The agreement between the methods was examined using Limits of Agreement (LoA). The association was calculated using the Pearson correlation coefficients and interrater reliability was determined using the intraclass correlation coefficient (ICC 2.1).
    Results: The error rate of the algorithmic detection of single repetitions derived from two smartphones accelerometers was 0.16%. Comparing algorithmically-derived, contraction-phase specific TUT against video, showed a high degree of correlation (r>0.93) for all exercise machines. Agreement between the two methods was high on all exercise machines as follows: LoA ranged from -0.3 to 0.3 seconds for single repetition TUT (0.1% of mean TUT), from -0.6 to 0.3 seconds for concentric contraction TUT (7.1% of mean TUT), from -0.3 to 0.5 seconds for eccentric contraction TUT (4.1% of mean TUT) and from -1.9 to 1.1 seconds for total TUT (0.5% of mean TUT). Interrater reliability for single repetition, contraction-phase specific TUT was high (ICC > 0.99).
    Conclusion: Data from smartphone accelerometer derived resistance exercise can be used to validly and reliably extract crucial mechano-biological descriptors. Moreover, the presented multi-analytical algorithmic approach enables researchers and clinicians to reliably and validly report missing mechano-biological descriptors.
    Mesh-Begriff(e) Accelerometry/instrumentation ; Adult ; Aged ; Female ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Muscle Contraction/physiology ; Muscle, Skeletal/physiology ; Reproducibility of Results ; Resistance Training ; Smartphone ; Weight Lifting/physiology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-07-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0235156
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Algorithmic extraction of smartphone accelerometer-derived mechano-biological descriptors of resistance exercise is robust to changes in intensity and velocity.

    Viecelli, Claudio / Aguayo, David / Dällenbach, Samuel / Graf, David / Achermann, Basil / Hafen, Ernst / Füchslin, Rudolf M

    PloS one

    2021  Band 16, Heft 7, Seite(n) e0254164

    Abstract: Background: It was shown that single repetition, contraction-phase specific and total time-under-tension (TUT) can be extracted reliably and validly from smartphone accelerometer-derived data of resistance exercise machines using user-determined ... ...

    Abstract Background: It was shown that single repetition, contraction-phase specific and total time-under-tension (TUT) can be extracted reliably and validly from smartphone accelerometer-derived data of resistance exercise machines using user-determined resistance exercise velocities at 60% one repetition maximum (1-RM). However, it remained unclear how robust the extraction of these mechano-biological descriptors is over a wide range of movement velocities (slow- versus fast-movement velocity) and intensities (30% 1-RM versus 80% 1-RM) that reflect the interindividual variability during resistance exercise.
    Objective: In this work, we examined whether the manipulation of velocity or intensity would disrupt an algorithmic extraction of single repetitions, contraction-phase specific and total TUT.
    Methods: Twenty-seven participants performed four sets of three repetitions of their 30% and 80% 1-RM with velocities of 1 s, 2 s, 6 s and 8 s per repetition, respectively. An algorithm extracted the number of repetitions, single repetition, contraction-phase specific and total TUT. All exercises were video-recorded. The video recordings served as the gold standard to which algorithmically-derived TUT was compared. The agreement between the methods was examined using Limits of Agreement (LoA). The Pearson correlation coefficients were used to calculate the association, and the intraclass correlation coefficient (ICC 2.1) examined the interrater reliability.
    Results: The calculated error rate for the algorithmic detection of the number of single repetitions derived from two smartphones accelerometers was 1.9%. The comparison between algorithmically-derived, contraction-phase specific TUT against video, revealed a high degree of correlation (r > 0.94) for both exercise machines. The agreement between the two methods was high on both exercise machines, intensities and velocities and was as follows: LoA ranged from -0.21 to 0.22 seconds for single repetition TUT (2.57% of mean TUT), from -0.24 to 0.22 seconds for concentric contraction TUT (6.25% of mean TUT), from -0.22 to 0.24 seconds for eccentric contraction TUT (5.52% of mean TUT) and from -1.97 to 1.00 seconds for total TUT (5.13% of mean TUT). Interrater reliability for single repetition, contraction-phase specific TUT was high (ICC > 0.99).
    Conclusion: Neither intensity nor velocity disrupts the proposed algorithmic data extraction approach. Therefore, smartphone accelerometers can be used to extract scientific mechano-biological descriptors of dynamic resistance exercise with intensities ranging from 30% to 80% of the 1-RM with velocities ranging from 1 s to 8 s per repetition, respectively, thus making this simple method a reliable tool for resistance exercise mechano-biological descriptors extraction.
    Mesh-Begriff(e) Accelerometry/methods ; Adult ; Aged ; Algorithms ; Biochemical Phenomena/physiology ; Exercise/physiology ; Exercise Therapy/standards ; Female ; Humans ; Male ; Middle Aged ; Muscle, Skeletal/physiology ; Resistance Training/standards ; Smartphone
    Sprache Englisch
    Erscheinungsdatum 2021-07-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0254164
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Knee extensor and flexor strength before and after anterior cruciate ligament reconstruction in a large sample of patients: influence of graft type.

    Huber, Raphael / Viecelli, Claudio / Bizzini, Mario / Friesenbichler, Bernd / Dohm-Acker, Markus / Rosenheck, Thomas / Harder, Laurent / Maffiuletti, Nicola A

    The Physician and sportsmedicine

    2018  Band 47, Heft 1, Seite(n) 85–90

    Abstract: Objective: Hamstring and patellar tendon autografts are the most frequently-used graft types for anterior cruciate ligament (ACL) reconstruction, with no consensus on their respective effects on thigh muscle strength. The objective of this study was to ... ...

    Abstract Objective: Hamstring and patellar tendon autografts are the most frequently-used graft types for anterior cruciate ligament (ACL) reconstruction, with no consensus on their respective effects on thigh muscle strength. The objective of this study was to re-examine isokinetic knee extensor and flexor strength before and after ACL reconstruction with patellar and hamstring tendon grafts using a single-center and a relatively large database, where surgical, rehabilitation and testing procedures were strictly standardized for all patients.
    Methods: A total of 464 patients with a unilateral ACL rupture underwent arthroscopic ACL reconstruction with either patellar or hamstring tendon grafts. Isokinetic concentric strength was evaluated prior to surgery and at 5- and 9-month postoperative follow-ups in different patient subgroups (n = 140, 464 and 215, respectively).
    Results: Knee extensor strength was lower in patients operated with the patellar tendon graft at the 5-month (p < 0.05) but not at the 9-month follow-up. Knee flexor strength was lower in patients operated with the hamstring tendon graft at both postoperative time points (p < 0.05). The prevalence of quadriceps weakness was high (66-91%) in both patient groups at both follow-ups.
    Conclusion: Overall, postoperative recovery of thigh muscle function seems to be better with the patellar than with the hamstring tendon graft due to the fact that both, knee extensor and flexor strength, were more impaired after ACL reconstruction with the hamstring tendon autograft.
    Mesh-Begriff(e) Adult ; Anterior Cruciate Ligament Injuries/physiopathology ; Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Reconstruction/methods ; Arthroscopy ; Female ; Follow-Up Studies ; Hamstring Tendons/transplantation ; Humans ; Knee/physiology ; Knee/surgery ; Male ; Muscle Strength/physiology ; Muscle Weakness/physiopathology ; Patellar Ligament/transplantation ; Quadriceps Muscle/physiology ; Quadriceps Muscle/physiopathology ; Thigh ; Transplantation, Autologous ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2018-09-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 753046-8
    ISSN 2326-3660 ; 0091-3847
    ISSN (online) 2326-3660
    ISSN 0091-3847
    DOI 10.1080/00913847.2018.1526627
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    Zs.B 1926: Hefte anzeigen Standort:
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  7. Artikel: Knee Extensors Muscle Plasticity Over a 5-Years Rehabilitation Process After Open Knee Surgery.

    Flück, Martin / Viecelli, Claudio / Bapst, Andreas M / Kasper, Stephanie / Valdivieso, Paola / Franchi, Martino V / Ruoss, Severin / Lüthi, Jean-Marc / Bühler, Martin / Claassen, Helgard / Hoppeler, Hans / Gerber, Christian

    Frontiers in physiology

    2018  Band 9, Seite(n) 1343

    Abstract: We investigated molecular and cellular parameters which set metabolic and mechanical functioning of knee extensor muscles in the operated and contralateral control leg of 9 patients with a chronically insufficient anterior cruciate ligament (ACL; 26.6 ± ... ...

    Abstract We investigated molecular and cellular parameters which set metabolic and mechanical functioning of knee extensor muscles in the operated and contralateral control leg of 9 patients with a chronically insufficient anterior cruciate ligament (ACL; 26.6 ± 8.3 years, 8 males, 1 female) after open reconstructive surgery (week 0), after ambulant physiotherapy under cast immobilization (week 9), succeeding rehabilitation training (up to week 26), and subsequent voluntary physical activity (week 260). Clinical indices of knee function in the operated leg were improved at 52 weeks and remained at a comparable level at week 260. CSA of the quadriceps (-18%), MCSA of muscle fibers (-24%), and capillary-to-fiber ratio (-24%) in
    Sprache Englisch
    Erscheinungsdatum 2018-09-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2018.01343
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  8. Artikel ; Online: Hepatocyte Transfection in Small Pigs After Weaning by Hydrodynamic Intraportal Injection of Naked DNA/Minicircle Vectors.

    Stoller, Fabienne / Schlegel, Andrea / Viecelli, Hiu Man / Rüfenacht, Véronique / Cesarovic, Nikola / Viecelli, Claudio / Deplazes, Sereina / Bettschart, Regula / Hurter, Karin / Schmierer, Philipp / Sidler, Xaver / Kron, Philipp / Dutkowski, Philipp / Graf, Rolf / Thöny, Beat / Häberle, Johannes

    Human gene therapy methods

    2015  Band 26, Heft 5, Seite(n) 181–192

    Abstract: Liver is an attractive organ for gene delivery in order to correct various genetic (metabolic) diseases. Hydrodynamic vein injection of naked DNA/minicircles devoid of viral or plasmid backbones was demonstrated in, for example, murine phenylketonuria to ...

    Abstract Liver is an attractive organ for gene delivery in order to correct various genetic (metabolic) diseases. Hydrodynamic vein injection of naked DNA/minicircles devoid of viral or plasmid backbones was demonstrated in, for example, murine phenylketonuria to allow sustained therapeutic transduction of hepatocytes. Here we show successful hepatocyte transfusion in domestic small pigs immediately after weaning upon portal vein catheterization and hydrodynamic injection of naked DNA/minicircle vectors expressing the luciferase gene from the CMV or a liver-specific promoter. First, we established a surgical method allowing hydrodynamic portal vein pressurization up to 120 mmHg and infusion of naked DNA in pigs (n = 5) with long-term survival. No acute adverse effects such as changes in liver transaminases or signs of liver cell damage were observed. We then showed efficiency of stable hepatocyte transfection at 10 and 28 days in single experiments (n = 7) where we found that up to 60% of samples (45/75) were polymerase chain reaction (PCR)-positive for minicircle-DNA. Of these samples, 13% of the positive specimen (6/45) showed low but stable luciferase expression when driven by a liver-specific promoter, as well as appropriate copy numbers per diploid genome. In conclusion, we accomplished a safe procedure for stable transfection of liver cells upon hydrodynamic gene delivery using minicircle vectors in small pigs as a prerequisite to potentially treat infants with genetic liver diseases.
    Mesh-Begriff(e) Animals ; Catheterization ; DNA/administration & dosage ; Genetic Vectors/administration & dosage ; Hydrodynamics ; Liver Diseases/genetics ; Liver Diseases/therapy ; Metabolic Diseases/genetics ; Metabolic Diseases/therapy ; Portal Vein/metabolism ; Swine ; Transgenes
    Chemische Substanzen DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2015-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2654800-8
    ISSN 1946-6544 ; 1946-6536
    ISSN (online) 1946-6544
    ISSN 1946-6536
    DOI 10.1089/hgtb.2014.140
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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