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  1. Article ; Online: 20 years of research into the aetiology of molar-incisor hypomineralization.

    Vieira, A R

    European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

    2023  Volume 24, Issue 2, Page(s) 273–274

    MeSH term(s) Humans ; Molar Hypomineralization ; Dental Enamel Hypoplasia/etiology ; Molar ; Prevalence
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2472851-2
    ISSN 1996-9805 ; 1818-6300
    ISSN (online) 1996-9805
    ISSN 1818-6300
    DOI 10.1007/s40368-022-00774-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6730: Show issues Location:
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  2. Article ; Online: The Challenges of the Present Rooted in the Past.

    Vieira, A R

    Journal of dental research

    2023  Volume 102, Issue 7, Page(s) 707–708

    Abstract: The speech of the AADOCR President-Elect Alexandre R. Vieira given at the opening ceremony of the 52nd Annual Meeting and Exhibition in Portland, March 15, 2023. ...

    Abstract The speech of the AADOCR President-Elect Alexandre R. Vieira given at the opening ceremony of the 52nd Annual Meeting and Exhibition in Portland, March 15, 2023.
    MeSH term(s) Health Physics ; Awards and Prizes ; Societies, Scientific
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345231175470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.75: Show issues Location:
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    Zs.MO 262: Show issues

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  3. Article ; Online: Prevalence of molar incisor hypomineralisation has a North-South gradient between Europe and North Africa.

    Vieira, A R

    European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

    2019  Volume 20, Issue 5, Page(s) 501–502

    MeSH term(s) Africa, Northern ; Dental Enamel Hypoplasia ; Europe ; Humans ; Molar ; Prevalence
    Language English
    Publishing date 2019-02-06
    Publishing country England
    Document type Letter
    ZDB-ID 2472851-2
    ISSN 1996-9805 ; 1818-6300
    ISSN (online) 1996-9805
    ISSN 1818-6300
    DOI 10.1007/s40368-019-00417-9
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    Zs.A 6730: Show issues Location:
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  4. Article ; Online: Dental Anomalies and Genetic Polymorphisms as Predictors of Maxillofacial Growth in Individuals Born with Cleft Lip and Palate.

    Lacerda, R H W / Vieira, A R

    Journal of dental research

    2023  Volume 102, Issue 9, Page(s) 979–987

    Abstract: Cleft lip and palate have a complex inheritance, and 90% of its variation in the population is due to genetic contributors. The impact of surgical procedures on maxillofacial growth is well known, but the interference of intrinsic factors in these growth ...

    Abstract Cleft lip and palate have a complex inheritance, and 90% of its variation in the population is due to genetic contributors. The impact of surgical procedures on maxillofacial growth is well known, but the interference of intrinsic factors in these growth outcomes is not elucidated. The present study aimed to analyze genetic polymorphisms and frequency of dental anomalies as predictors of maxillofacial growth in patients born with cleft lip with or without cleft palate. From a cohort of 537 individuals, operated on by the same surgeon, 121 were analyzed 2 times, to define changes in maxillary growth prognosis by occlusal scores in a minimum 4-y follow-up. In a second step, a subset of 360 individuals had maxillofacial growth outcomes evaluated using Wits, nasion perpendicular to point A, and occlusal scores. The markers
    MeSH term(s) Humans ; Cleft Lip/genetics ; Cleft Lip/surgery ; Cleft Palate/genetics ; Cleft Palate/surgery ; Matrix Metalloproteinase 2 ; Retrospective Studies ; Polymorphism, Genetic
    Chemical Substances Matrix Metalloproteinase 2 (EC 3.4.24.24)
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345231169915
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    Zs.MO 262: Show issues

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  5. Article ; Online: Risk of orofacial clefts in relation to maternal body mass index, diabetes and hypertension.

    Da Silva, A M / De Lavôr, J R / Freitas, V S / Vieira, A R

    Journal of neonatal-perinatal medicine

    2024  Volume 17, Issue 1, Page(s) 41–48

    Abstract: Background: To investigate if maternal body mass index, diabetes and hypertension are associated with orofacial clefts.: Methods: Case-control study. Information from 53,188 live births with and without orofacial cleft registered at USA Vital ... ...

    Abstract Background: To investigate if maternal body mass index, diabetes and hypertension are associated with orofacial clefts.
    Methods: Case-control study. Information from 53,188 live births with and without orofacial cleft registered at USA Vital Statistics Natality Birth Data between 2017 and 2021. Case group consisted of all affected live births diagnosed with orofacial clefts (13,297 cases). Comparison group consisted of 39,891 live births without clefts or any other congenital malformation. Information about orofacial cleft cases were compared with the comparison group. The unadjusted and adjusted Odds Ratios were estimated to evaluate the strength of association between mother's pre-pregnancy body mass index, maternal diabetes and hypertension and orofacial cleft occurrence, assuming a p value < 0.05 and 95% confidence intervals (95% C.I.) for statistically significant differences.
    Results: Mother's pre-pregnancy body mass index, maternal diabetes and maternal hypertension are conditions associated with an increased risk of orofacial cleft development in the child (OR = 1.08, p = 0.004, 95% C.I. = 1.024-1.149; OR = 1.32, 95%, p = 0.000, 95% C.I. = 1.202-1.444; and OR = 1.35, p = 0.000, 95% C.I. = 1.239-1.484; respectively). Maternal ethnicity, sex of infant, and cigarette smoking pregnancy remained as covariates after adjustments in all logistic regression models.
    Conclusion: Due to the increased prevalence of obesity, diabetes, and hypertension, and also to their association with congenital malformations, such as clefts, it is recommended that mothers planning to become pregnant to follow healthy habits, maintain healthy weight, and be screened for possible diabetes or hypertension prior to conception and early in pregnancy.
    MeSH term(s) Female ; Pregnancy ; Child ; Humans ; Cleft Lip/epidemiology ; Cleft Palate/epidemiology ; Cleft Palate/complications ; Case-Control Studies ; Body Mass Index ; Risk Factors ; Diabetes, Gestational/epidemiology ; Hypertension/epidemiology ; Hypertension/complications
    Language English
    Publishing date 2024-01-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2435387-5
    ISSN 1878-4429 ; 1934-5798
    ISSN (online) 1878-4429
    ISSN 1934-5798
    DOI 10.3233/NPM-230118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Three Decades of Molecular Studies of Multifactorial Cleft Lip and Palate.

    Vieira, A R

    JDR clinical and translational research

    2016  Volume 2, Issue 1, Page(s) 93–94

    Language English
    Publishing date 2016-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2842304-5
    ISSN 2380-0852 ; 2380-0844
    ISSN (online) 2380-0852
    ISSN 2380-0844
    DOI 10.1177/2380084416673618
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    Zs.A 7111: Show issues Location:
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  7. Article ; Online: From Caries Progression and Restoration Failures to Periapical Lesions in the Era of Precision.

    Leonardi, D P / Vieira, A R

    JDR clinical and translational research

    2019  Volume 5, Issue 1, Page(s) 10–12

    Abstract: Knowledge transfer statement: Dental research can be thought of as a continuum of clinical observations that are dissected in the laboratory with answers that can be brought back to the clinic to change patient management. We believe this is the case ... ...

    Abstract Knowledge transfer statement: Dental research can be thought of as a continuum of clinical observations that are dissected in the laboratory with answers that can be brought back to the clinic to change patient management. We believe this is the case for the use of adhesive systems and outcomes of dental treatment. Clinical observations related to negative outcomes have been tested in the laboratory and solutions have been proposed, with more precise implementation of these solutions possible when genomic approaches are added. Here we elaborate on this process based on the observations that lead to an attempt to inactivate metalloproteinase activity by dentin crosslinking.
    MeSH term(s) Dental Caries ; Dentin ; Humans
    Language English
    Publishing date 2019-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2842304-5
    ISSN 2380-0852 ; 2380-0844
    ISSN (online) 2380-0852
    ISSN 2380-0844
    DOI 10.1177/2380084419846436
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  8. Article ; Online: Outbreak of anthrax in livestock with human occupational exposures - Minnesota, 2023.

    Schenk, Kelly Elizabeth / Cornille, K / Cater, J / Vieira, A R / Holzbauer, S / Bye, M / Scheftel, J

    Journal of agromedicine

    2024  , Page(s) 1–4

    Abstract: In July 2023, the Minnesota Department of Health (MDH) was notified of possible occupational exposures to anthrax during an outbreak in animals. In consultation with the Centers for Disease Control and Prevention, MDH epidemiologists created a ... ...

    Abstract In July 2023, the Minnesota Department of Health (MDH) was notified of possible occupational exposures to anthrax during an outbreak in animals. In consultation with the Centers for Disease Control and Prevention, MDH epidemiologists created a questionnaire that assessed exposure risks and helped determine individual illness monitoring and antibiotic post-exposure prophylaxis needs. This investigation and the resources developed for it could be useful in future scenarios where there are occupational exposures to naturally occurring anthrax.
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1289325-0
    ISSN 1545-0813 ; 1059-924X
    ISSN (online) 1545-0813
    ISSN 1059-924X
    DOI 10.1080/1059924X.2024.2306835
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    Z 6210: Show issues

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  9. Article ; Online: Molar-incisor hypomineralisation: an updated view for aetiology 20 years later.

    Bussaneli, D G / Vieira, A R / Santos-Pinto, L / Restrepo, M

    European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

    2021  Volume 23, Issue 1, Page(s) 193–198

    Abstract: Background: The term Molar-Incisor Hypomineralisation (MIH) was introduced in 2001 by Weerheijm, Jälevik and Alaluusua, and describes a defect of systemic origin that affects one to four first permanent molars, often associated with permanent incisors. ... ...

    Abstract Background: The term Molar-Incisor Hypomineralisation (MIH) was introduced in 2001 by Weerheijm, Jälevik and Alaluusua, and describes a defect of systemic origin that affects one to four first permanent molars, often associated with permanent incisors. In the past 20 years, this definition dictated the work regarding MIH prevalence, associated risk factors, association with dental caries, impact on quality of life, and therapeutic options.
    Purpose: In this report, we offer an updated and comprehensive view of MIH centred on the patient and the tooth.
    Conclusion: MIH today is globally recognized as a potential public health problem and it is not a defect of purely systemic origin but rather a condition with complex aetiology that in some instances may be the result of gene-environmental interactions.
    MeSH term(s) Dental Caries/complications ; Dental Caries/etiology ; Dental Enamel Hypoplasia/epidemiology ; Dental Enamel Hypoplasia/etiology ; Humans ; Incisor ; Molar ; Prevalence ; Quality of Life
    Language English
    Publishing date 2021-08-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2472851-2
    ISSN 1996-9805 ; 1818-6300
    ISSN (online) 1996-9805
    ISSN 1818-6300
    DOI 10.1007/s40368-021-00659-6
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  10. Article: Genome-wide association study identifies novel risk loci for apical periodontitis.

    Petty, L E / Silva, R / de Souza, L Chaves / Vieira, A R / Shaw, D M / Below, J E / Letra, Ariadne

    Research square

    2023  

    Abstract: Apical periodontitis (AP) is a common consequence of root canal infection leading to periapical bone resorption. Microbial and host genetic factors, and their interactions, have been shown to play a role in AP development and progression. Variations in a ...

    Abstract Apical periodontitis (AP) is a common consequence of root canal infection leading to periapical bone resorption. Microbial and host genetic factors, and their interactions, have been shown to play a role in AP development and progression. Variations in a few genes have been reported in association with AP, however, the lack of genome-wide studies has hindered progress in understanding the mechanisms involved in AP. Here, we report the first genome-wide association study of AP in a well-characterized population. Male and female adults (n=932) presenting with deep caries with AP (cases) or without AP (controls) were included. Genotyping was performed using the Illumina Expanded Multi-Ethnic Genotyping Array. Single-variant association testing was performed adjusting for sex and five principal components. Subphenotype association testing, analyses of genetically regulated gene expression, polygenic risk score and phenome-wide association (PheWAS) analyses were also performed. Eight loci reached near-genome-wide significant association with AP (p < 5 x 10-6); gene-focused analyses replicated three previously reported associations (p < 8.9 x 10-5). Sex-specific and subphenotype analyses revealed additional significant associations with variants genome-wide. Functionally oriented gene-based analyses revealed eight genes significantly associated with AP (p < 5 x 10-5), and PheWAS analysis revealed 33 phecodes associated with AP risk score (p < 3.08 x 10-5). This study identified novel genes/loci contributing to AP and revealed specific contributions to AP risk in males and females. Importantly, we identified additional systemic conditions significantly associated with AP risk. Our findings provide strong evidence for host-mediated effects on AP susceptibility.
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2515434/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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