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  1. Article ; Online: Asymptomatic cerebral cavernous angiomas associated with plasma marker signature.

    Chehuen Bicalho, Vítor / da Fontoura Galvão, Gustavo / Lima Fontes-Dantas, Fabrícia / Paulo da Costa Gonçalves, João / Dutra de Araujo, Amanda / Carolina França, Laise / Emílio Corrêa Leite, Paulo / Campolina Vidal, Diego / Castro Filho, Ricardo / Vieira Alves-Leon, Soniza / Marcondes de Souza, Jorge

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2021  Volume 89, Page(s) 258–263

    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asymptomatic Diseases ; Biomarkers/blood ; Brain Neoplasms/blood ; Brain Neoplasms/diagnostic imaging ; Cohort Studies ; Female ; Follow-Up Studies ; Granulocyte-Macrophage Colony-Stimulating Factor/blood ; Hemangioma, Cavernous, Central Nervous System/blood ; Hemangioma, Cavernous, Central Nervous System/diagnostic imaging ; Humans ; Interleukins/blood ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Young Adult
    Chemical Substances Biomarkers ; Interleukins ; MYDGF protein, human ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
    Language English
    Publishing date 2021-05-14
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2021.04.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3999: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Buffy Coat Transcriptomic Analysis Reveals Alterations in Host Cell Protein Synthesis and Cell Cycle in Severe COVID-19 Patients.

    Cavalcante, Liliane Tavares de Faria / da Fonseca, Guilherme Cordenonsi / Amado Leon, Luciane Almeida / Salvio, Andreza Lemos / Brustolini, Otávio José / Gerber, Alexandra Lehmkuhl / Guimarães, Ana Paula de Campos / Marques, Carla Augusta Barreto / Fernandes, Renan Amphilophio / Ramos Filho, Carlos Henrique Ferreira / Kader, Rafael Lopes / Pimentel Amaro, Marisa / da Costa Gonçalves, João Paulo / Vieira Alves-Leon, Soniza / Vasconcelos, Ana Tereza Ribeiro

    International journal of molecular sciences

    2022  Volume 23, Issue 21

    Abstract: Transcriptome studies have reported the dysregulation of cell cycle-related genes and the global inhibition of host mRNA translation in COVID-19 cases. However, the key genes and cellular mechanisms that are most affected by the severe outcome of this ... ...

    Abstract Transcriptome studies have reported the dysregulation of cell cycle-related genes and the global inhibition of host mRNA translation in COVID-19 cases. However, the key genes and cellular mechanisms that are most affected by the severe outcome of this disease remain unclear. For this work, the RNA-seq approach was used to study the differential expression in buffy coat cells of two groups of people infected with SARS-CoV-2: (a) Mild, with mild symptoms; and (b) SARS (Severe Acute Respiratory Syndrome), who were admitted to the intensive care unit with the severe COVID-19 outcome. Transcriptomic analysis revealed 1009 up-regulated and 501 down-regulated genes in the SARS group, with 10% of both being composed of long non-coding RNA. Ribosome and cell cycle pathways were enriched among down-regulated genes. The most connected proteins among the differentially expressed genes involved transport dysregulation, proteasome degradation, interferon response, cytokinesis failure, and host translation inhibition. Furthermore, interactome analysis showed Fibrillarin to be one of the key genes affected by SARS-CoV-2. This protein interacts directly with the N protein and long non-coding RNAs affecting transcription, translation, and ribosomal processes. This work reveals a group of dysregulated processes, including translation and cell cycle, as key pathways altered in severe COVID-19 outcomes.
    MeSH term(s) Humans ; COVID-19/genetics ; SARS-CoV-2 ; Transcriptome ; Gene Expression Profiling ; RNA, Long Noncoding/genetics ; Cell Cycle/genetics
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2022-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232113588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical Features of COVID-19 on Patients With Neuromyelitis Optica Spectrum Disorders.

    Apostolos-Pereira, Samira Luisa / Campos Ferreira, Lis / Boaventura, Mateus / de Carvalho Sousa, Nise Alessandra / Joca Martins, Gabriela / d'Almeida, José Arthur / Pitombeira, Milena / Silvestre Mendes, Lucas / Fukuda, Thiago / Souza Cabeça, Hideraldo Luíz / Chaves Rocha, Luciano / Santos de Oliveira, Bianca / Vieira Stella, Carla Renata / Lobato de Oliveira, Enedina Maria / de Souza Amorim, Leizian / Ferrari de Castro, Andréa / Pereira Gomes Neto, Antonio / Diogo Silva, Guilherme / Bueno, Lucas /
    de Morais Machado, Maria / Castello Dias-Carneiro, Rafael / Maciel Dias, Ronaldo / Porto Moreira, Alvaro / Piccolo, Ana / Kuntz Grzesiuk, Anderson / Muniz, Andre / Diniz Disserol, Caio / Ferreira Vasconcelos, Claudia / Kaimen-Maciel, Damacio / Sisterolli Diniz, Denise / Comini-Frota, Elizabeth / Coronetti Rocha, Fernando / Cruz Dos Santos, Gutemberg Augusto / Dadalti Fragoso, Yara / Sciascia do Olival, Guilherme / Ruocco, Heloisa Helena / Siqueira, Heloise Helena / Sato, Henry Koity / Figueiredo, José Alexandre / Cortoni Calia, Leandro / Teixeira Dourado, Mario Emilio / Scolari, Letícia / Ribeiro Soares Neto, Herval / Melges, Luiz / Magno Gonçalves, Marcus Vinicius / Vellutini Pimentel, Maria Lucia / de Castro Ribeiro, Marlise / Gurrola Arambula, Omar / Diniz da Gama, Paulo / Leite Menon, Renata / Barbosa Thomaz, Rodrigo / de Rizo Morales, Rogério / Sobreira, Silvana / Machado, Suzana Nunes / Gonsalves Jubé Ribeiro, Taysa / Coelho Santa Rita Pereira, Valéria / Maia Costa, Vanessa / da Nóbrega Junior, Adaucto Wanderley / Vieira Alves-Leon, Soniza / Mamprim de Morais Perin, Marilia / Donadi, Eduardo / Adoni, Tarso / Gomes, Sidney / Brito Ferreira, Maria / Callegaro, Dagoberto / Mendes, Maria Fernanda / Brum, Doralina / von Glehn, Felipe

    Neurology(R) neuroimmunology & neuroinflammation

    2021  Volume 8, Issue 6

    Abstract: Background and objectives: To describe the clinical features and disease outcomes of coronavirus disease 2019 (COVID-19) in patients with neuromyelitis optica spectrum disorder (NMOSD).: Methods: The Neuroimmunology Brazilian Study Group has set up ... ...

    Abstract Background and objectives: To describe the clinical features and disease outcomes of coronavirus disease 2019 (COVID-19) in patients with neuromyelitis optica spectrum disorder (NMOSD).
    Methods: The Neuroimmunology Brazilian Study Group has set up the report of severe acute respiratory syndrome (SARS-CoV2) cases in patients with NMOSD (pwNMOSD) using a designed web-based case report form. All neuroimmunology outpatient centers and individual neurologists were invited to register their patients across the country. Data collected between March 19 and July 25, 2020, were uploaded at the REDONE.br platform. Inclusion criteria were as follows: (1) NMOSD diagnosis according to the 2015 International Panel Criteria and (2) confirmed SARS-CoV2 infection (reverse transcription-polymerase chain reaction or serology) or clinical suspicion of COVID-19, diagnosed according to Center for Disease Control / Council of State and Territorial Epidemiologists (CDC/CSTE) case definition. Demographic and NMOSD-related clinical data, comorbidities, disease-modifying therapy (DMT), COVID-19 clinical features, and severity were described.
    Results: Among the 2,061 pwNMOSD followed up by Brazilian neurologists involved on the registry of COVID-19 in pwNMOSD at the REDONE.br platform, 34 patients (29 women) aged 37 years (range 8-77), with disease onset at 31 years (range 4-69) and disease duration of 6 years (range 0.2-20.5), developed COVID-19 (18 confirmed and 16 probable cases). Most patients exhibited mild disease, being treated at home (77%); 4 patients required admission at intensive care units (severe cases); and 1 patient died. Five of 34 (15%) presented neurologic manifestations (relapse or pseudoexacerbation) during or after SARS-CoV2 infection.
    Discussion: Most NMOSD patients with COVID-19 presented mild disease forms. However, pwNMOSD had much higher odds of hospitalization and intensive care unit admission comparing with the general Brazilian population. The frequency of death was not clearly different. NMOSD disability, DMT type, and comorbidities were not associated with COVID-19 outcome. SARS-CoV2 infection was demonstrated as a risk factor for NMOSD relapses. Collaborative studies using shared NMOSD data are needed to suitably define factors related to COVID-19 severity and neurologic manifestations.
    MeSH term(s) Adolescent ; Adult ; Aged ; Brazil/epidemiology ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19/therapy ; Child ; Disease Progression ; Female ; Hospitalization/statistics & numerical data ; Humans ; Immunosuppressive Agents/therapeutic use ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Neuromyelitis Optica/drug therapy ; Neuromyelitis Optica/epidemiology ; Neuromyelitis Optica/physiopathology ; Recurrence ; SARS-CoV-2 ; Severity of Illness Index ; Young Adult
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2767740-0
    ISSN 2332-7812 ; 2332-7812
    ISSN (online) 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000001060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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