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  1. Article: Optimizing management of patients with pancreatic exocrine insufficiency.

    Arvanitakis, Marianna / Hadefi, Alia / Viesca, Michael Fernandez Y

    Hepatobiliary surgery and nutrition

    2023  Volume 12, Issue 1, Page(s) 128–130

    Language English
    Publishing date 2023-01-09
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-22-635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intravenous Hemin, a potential heme oxygenase-1 activator, does not protect from post-ERCP acute pancreatitis in humans: Results of a randomized multicentric multinational placebo-controlled trial.

    Yared, Rawad A / Chen, Chieh-Chang / Vandorpe, Astrid / Arvanitakis, Marianna / Delhaye, Myriam / Viesca, Michael Fernandez Y / Huberty, Vincent / Blero, Daniel / Toussaint, Emmanuel / Hittelet, Axel / Verset, Didier / Margos, Walter / Le Moine, Olivier / Njimi, Hassane / Liao, Wei-Chih / Devière, Jacques / Lemmers, Arnaud

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2024  Volume 24, Issue 3, Page(s) 363–369

    Abstract: Objective: Hemin, a heme oxygenase 1 activator has shown efficacy in the prevention and treatment of acute pancreatitis in mouse models. We conducted a randomized controlled trial (RCT) to assess the protective effect of Hemin administration to prevent ... ...

    Abstract Objective: Hemin, a heme oxygenase 1 activator has shown efficacy in the prevention and treatment of acute pancreatitis in mouse models. We conducted a randomized controlled trial (RCT) to assess the protective effect of Hemin administration to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in patients at risk.
    Methods: In this multicenter, multinational, placebo-controlled, double-blind RCT, we assigned patients at risk for PEP to receive a single intravenous dose of Hemin (4 mg/kg) or placebo immediately after ERCP. Patients were considered to be at risk on the basis of validated patient- and/or procedure-related risk factors. Neither rectal NSAIDs nor pancreatic stent insertion were allowed in randomized patients. The primary outcome was the incidence of PEP. Secondary outcomes included lipase elevation, mortality, safety, and length of stay.
    Results: A total of 282 of the 294 randomized patients had complete follow-up. Groups were similar in terms of clinical, laboratory, and technical risk factors for PEP. PEP occurred in 16 of 142 patients (11.3%) in the Hemin group and in 20 of 140 patients (14.3%) in the placebo group (p = 0.48). Incidence of severe PEP reached 0.7% and 4.3% in the Hemin and placebo groups, respectively (p = 0.07). Significant lipase elevation after ERCP did not differ between groups. Length of hospital stay, mortality and severe adverse events rates were similar between groups.
    Conclusion: We failed to detect large improvements in PEP rate among participants at risk for PEP who received IV hemin immediately after the procedure compared to placebo.
    Trial registration number: ClinicalTrials.gov number, NCT01855841).
    MeSH term(s) Animals ; Humans ; Mice ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Heme Oxygenase-1 ; Hemin/therapeutic use ; Lipase ; Pancreatitis/etiology ; Pancreatitis/prevention & control ; Administration, Intravenous
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Heme Oxygenase-1 (EC 1.14.14.18) ; Hemin (743LRP9S7N) ; Lipase (EC 3.1.1.3)
    Language English
    Publishing date 2024-02-15
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2024.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5553: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Performance and safety of motorized spiral enteroscopy: a systematic review and meta-analysis.

    Papaefthymiou, Apostolis / Ramai, Daryl / Maida, Marcello / Tziatzios, Georgios / Viesca, Michael Fernandez Y / Papanikolaou, Ioannis / Paraskeva, Konstantina / Triantafyllou, Konstantinos / Repici, Alessandro / Hassan, Cesare / Binda, Cecilia / Beyna, Torsten / Facciorusso, Antonio / Arvanitakis, Marianna / Gkolfakis, Paraskevas

    Gastrointestinal endoscopy

    2023  Volume 97, Issue 5, Page(s) 849–858.e5

    Abstract: Background and aims: The introduction of motorized spiral enteroscopy (mSE) into clinical practice holds diagnostic and therapeutic potential for small-bowel investigations. This systematic review and meta-analysis aims to evaluate the performance of ... ...

    Abstract Background and aims: The introduction of motorized spiral enteroscopy (mSE) into clinical practice holds diagnostic and therapeutic potential for small-bowel investigations. This systematic review and meta-analysis aims to evaluate the performance of this modality in diagnosing and treating small-bowel lesions.
    Methods: A systematic search of MEDLINE, Cochrane, and ClinicalTrials.gov databases were performed through September 2022. The primary outcome was diagnostic success, defined as the identification of a lesion relative to the indication. Secondary outcomes were successful therapeutic manipulation, total enteroscopy rate (examination from the duodenojejunal flexion to the cecum), technical success (passage from the ligament of Treitz or ileocecal valve for anterograde and retrograde approach, respectively), and adverse event rates. We performed meta-analyses using a random-effects model, and the results are reported as percentages with 95% confidence intervals (CIs).
    Results: From 2016 to 2022, 9 studies (959 patients; 42% women; mean age >45 years; 474 patients [49.4%] investigated for mid-GI bleeding/anemia) were considered eligible and included in analysis. The diagnostic success rate of mSE was 78% (95% CI, 72-84; I
    Conclusions: mSE provides high rates of diagnostic and therapeutic success with a low prevalence of severe adverse events.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Intestine, Small/pathology ; Endoscopy, Gastrointestinal
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2023.01.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 283: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 519: Show issues

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  4. Article: The impact of a multidisciplinary team approach on the management of focal pancreatic lesions: a single tertiary center experience.

    Francisse, Sophie / Gkolfakis, Paraskevas / Viesca, Michael Fernandez Y / Mans, Laura / Demols, Anne / Pezzullo, Martina / Loi, Patricia / Navez, Julie / Closset, Jean / Bali, Maria Antonietta / Wettere, Morgane Van / D'Haene, Nicki / Demetter, Pieter / Verset, Laurine / Bouchart, Christelle / Lemmers, Arnaud / Deviere, Jacques / Delhaye, Myriam / Laethem, Jean-Luc Van /
    Arvanitakis, Marianna

    Annals of gastroenterology

    2023  Volume 36, Issue 5, Page(s) 580–587

    Abstract: Background: Multidisciplinary team (MDT) meetings aim to optimize patient management. We evaluated the impact of MDT discussions on the management and diagnosis of focal pancreatic lesions in a single tertiary center.: Methods: All patients with an ... ...

    Abstract Background: Multidisciplinary team (MDT) meetings aim to optimize patient management. We evaluated the impact of MDT discussions on the management and diagnosis of focal pancreatic lesions in a single tertiary center.
    Methods: All patients with an initial diagnosis of solid or cystic pancreatic lesion discussed in our institution's MDT meeting on pancreatic diseases between January 1, 2020, and December 31, 2021, were included. The impact of MDT discussion on patient management, defined as a modification of the initially proposed therapeutic plan after MDT discussion, as well as the criteria leading to this modification, were the primary outcomes. Impact on diagnosis was the secondary outcome.
    Results: A total of 522 patients were included. Of these, 185 (35.4%) and 337 (64.6%) had an initial diagnosis of cystic or solid lesion, respectively. The most common referral query was regarding the management plan (349/522; 66.9%). Endoscopy was the procedure most often proposed before MDT discussion (109/522; 20.9%). Overall, the MDT discussion led to modification of the management plan in 377/522 patients (72.2%), with a statistically significant difference between cystic and solid lesions (63.2% vs. 77.2%; P<0.001). Management modifications were mainly driven by revision of cross-sectional radiological images. MDT discussion led to modification of the diagnosis in 92/522 patients (17.6%), with a significant difference regarding cystic lesions (35.7% vs. 7.7%; P<0.001).
    Conclusion: MDT discussion impacts the management of patients with cystic and solid pancreatic lesions, leading to a modification of the initially proposed management in two-thirds of them, mainly through revision of cross-sectional imaging.
    Language English
    Publishing date 2023-07-25
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2032850-3
    ISSN 1108-7471
    ISSN 1108-7471
    DOI 10.20524/aog.2023.0827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2455: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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