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  1. Article: Recent advances in HIV diagnostics: Point-of-care CD4 + T-cell count & viral load assays.

    Balakrishnan, Pachamuthu / Saravanan, Shanmugam / Vignesh, Ramachandran / Shankar, Esaki M

    The Indian journal of medical research

    2024  Volume 158, Issue 5&6, Page(s) 447–450

    MeSH term(s) Humans ; Viral Load ; Point-of-Care Systems ; CD4-Positive T-Lymphocytes ; Lymphocyte Count ; HIV Infections ; CD4 Lymphocyte Count ; RNA, Viral
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2024-01-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.ijmr_1616_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.143: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Could Nutraceutical Approaches Possibly Attenuate the Cytokine Storm in COVID-19 Patients?

    Vignesh, Ramachandran / Velu, Vijayakumar / Sureban, Sripathi M

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 667733

    MeSH term(s) COVID-19 ; Cytokine Release Syndrome ; Dietary Supplements ; Gastrointestinal Microbiome ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-04-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.667733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Updates on Dengue Vaccine and Antiviral: Where Are We Heading?

    Norshidah, Harun / Vignesh, Ramachandran / Lai, Ngit Shin

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 22

    Abstract: Approximately 100-400 million people from more than 100 countries in the tropical and subtropical world are affected by dengue infections. Recent scientific breakthroughs have brought new insights into novel strategies for the production of dengue ... ...

    Abstract Approximately 100-400 million people from more than 100 countries in the tropical and subtropical world are affected by dengue infections. Recent scientific breakthroughs have brought new insights into novel strategies for the production of dengue antivirals and vaccines. The search for specific dengue inhibitors is expanding, and the mechanisms for evaluating the efficacy of novel drugs are currently established, allowing for expedited translation into human trials. Furthermore, in the aftermath of the only FDA-approved vaccine, Dengvaxia, a safer and more effective dengue vaccine candidate is making its way through the clinical trials. Until an effective antiviral therapy and licensed vaccine are available, disease monitoring and vector population control will be the mainstays of dengue prevention. In this article, we highlighted recent advances made in the perspectives of efforts made recently, in dengue vaccine development and dengue antiviral drug.
    MeSH term(s) Antiviral Agents/therapeutic use ; Dengue/prevention & control ; Dengue Vaccines/therapeutic use ; Dengue Virus ; Drug Development ; Humans ; Vaccine Development
    Chemical Substances Antiviral Agents ; Dengue Vaccines
    Language English
    Publishing date 2021-11-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26226768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  4. Article ; Online: Could rapid test reader maximize the benefits to the HIV self-tester?

    Balakrishnan, Pachamuthu / Girija, A S Smiline / Kannan, Iyanar / Vignesh, Ramachandran / Shankar, Esaki M / Sucharitha, Sree T

    Indian journal of medical microbiology

    2022  Volume 43, Page(s) 49–50

    MeSH term(s) Humans ; HIV Infections/diagnosis ; Surveys and Questionnaires
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1038798-5
    ISSN 1998-3646 ; 0255-0857
    ISSN (online) 1998-3646
    ISSN 0255-0857
    DOI 10.1016/j.ijmmb.2022.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2639: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Assessing the potential of NS2B/NS3 protease inhibitors biomarker in curbing dengue virus infections:

    Norshidah, Harun / Leow, Chiuan Herng / Ezleen, Kamarulzaman Ezatul / Wahab, Habibah A / Vignesh, Ramachandran / Rasul, Azhar / Lai, Ngit Shin

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1061937

    Abstract: An increase in the occurrence of viral infectious diseases is a global concern for human health. According to a WHO report, dengue virus (DENV) is one of the most common viral diseases affecting approximately 400 million people annually, with worsening ... ...

    Abstract An increase in the occurrence of viral infectious diseases is a global concern for human health. According to a WHO report, dengue virus (DENV) is one of the most common viral diseases affecting approximately 400 million people annually, with worsening symptoms in nearly 1% of cases. Both academic and industrial researchers have conducted numerous studies on viral epidemiology, virus structure and function, source and route of infection, treatment targets, vaccines, and drugs. The development of CYD-TDV or Dengvaxia
    MeSH term(s) Humans ; Protease Inhibitors/pharmacology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Biomarkers ; Molecular Targeted Therapy ; Dengue/drug therapy
    Chemical Substances Protease Inhibitors ; Antiviral Agents ; Biomarkers
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1061937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome-An Extempore Game of Misfiring with Defense Arsenals.

    Vignesh, Ramachandran / Balakrishnan, Pachamuthu / Tan, Hong Yien / Yong, Yean Kong / Velu, Vijayakumar / Larsson, Marie / Shankar, Esaki M

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: The lethal combination involving TB and HIV, known as "syndemic" diseases, synergistically act upon one another to magnify the disease burden. Individuals on anti-retroviral therapy (ART) are at risk of developing TB-associated immune reconstitution ... ...

    Abstract The lethal combination involving TB and HIV, known as "syndemic" diseases, synergistically act upon one another to magnify the disease burden. Individuals on anti-retroviral therapy (ART) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS). The underlying inflammatory complication includes the rapid restoration of immune responses following ART, eventually leading to exaggerated inflammatory responses to MTB antigens. TB-IRIS continues to be a cause of morbidity and mortality among HIV/TB coinfected patients initiating ART, and although a significant quantum of knowledge has been acquired on the pathogenesis of IRIS, the underlying pathomechanisms and identification of a sensitive and specific diagnostic marker still remain a grey area of investigation. Here, we reviewed the latest research developments into IRIS immunopathogenesis, and outlined the modalities to prevent and manage strategies for better clinical and diagnostic outcomes for IRIS.
    Language English
    Publishing date 2023-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12020210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Impact of COVID-19 Vaccination on Pregnant Women.

    Chaubey, Ishaan / Vijay, Harini / Govindaraj, Sakthivel / Babu, Hemalatha / Cheedarla, Narayanaiah / Shankar, Esaki M / Vignesh, Ramachandran / Velu, Vijayakumar

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: In light of the COVID-19 pandemic, researchers across the world hastened to develop vaccines that would aid in bolstering herd immunity. Utilizing mRNA coding and viral vector technology, the currently approved vaccines were required to undergo extensive ...

    Abstract In light of the COVID-19 pandemic, researchers across the world hastened to develop vaccines that would aid in bolstering herd immunity. Utilizing mRNA coding and viral vector technology, the currently approved vaccines were required to undergo extensive testing to confirm their safety for mass usage in the general population. However, clinical trials failed to test the safety and efficacy of the COVID-19 vaccines in groups with weakened immune systems, especially pregnant women. Lack of information on the effects of vaccinations in pregnancy and the safety of fetuses are among the topmost reasons preventing pregnant women from receiving immunization. Thus, the lack of data examining the effects of COVID-19 vaccinations on pregnant women must be addressed. This review focused on the safety and efficacy of the approved COVID-19 vaccinations in pregnancy and their impact on both maternal and fetal immune responses. For that, we took the approach of combined systematic review/meta-analysis and compiled the available data from the original literature from PubMed, Web of Science, EMBASE and Medline databases. All articles analyzed presented no adverse effects of vaccination in pregnancy, with varying conclusions on the degree of effectiveness. The majority of the findings described robust immune responses in vaccinated pregnant women, successful transplacental antibody transfer, and implications for neonatal immunity. Hence, findings from the cumulative data available can be helpful in achieving COVID-19 herd immunization, including pregnant women.
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12030431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Implementation of HIV Self-Testing in Resource-Limited Settings Where the HIV Disease Burden is High.

    Balakrishnan, Pachamuthu / Smiline Girija, A S / Shanmugam, Saravanan / Kannan, Iyanar / Vignesh, Ramachandran / Shankar, Esaki M / Sucharitha, Sree T

    International journal of public health

    2023  Volume 68, Page(s) 1605790

    Abstract: In resource-limited settings, there is growing evidence that HIV testing is lacking among high-risk key populations such as men having sex with men, injection drug users, and transgenders largely due to stigma, discrimination, and lack of confidentiality. ...

    Abstract In resource-limited settings, there is growing evidence that HIV testing is lacking among high-risk key populations such as men having sex with men, injection drug users, and transgenders largely due to stigma, discrimination, and lack of confidentiality. Findings from recent studies among high-risk key populations and the general population from various regions including resource-limited settings support the need for wider accessibility of HIV self-testing (HIV-ST) to reach those who may not otherwise have access to testing. Therefore, HIV-ST has untapped potential as a strategy to improve access to HIV testing and to increase testing frequency among key high-risk populations and their partners. Though HIV-ST has emerged as a safe, acceptable, and effective way to reach people, there are several roadblocks to implementing the HIV-ST policy, and fast-track policy implementation needs to be necessitated with newer or modified strategic plans.
    MeSH term(s) Male ; Humans ; HIV ; Homosexuality, Male ; Self-Testing ; Resource-Limited Settings ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Testing
    Language English
    Publishing date 2023-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2274130-6
    ISSN 1661-8564 ; 1661-8556
    ISSN (online) 1661-8564
    ISSN 1661-8556
    DOI 10.3389/ijph.2023.1605790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Thalidomide as a Potential HIV Latency Reversal Agent: Is It the Right Time to Forget the Ancestral Sins?

    Vignesh, Ramachandran / Shankar, Esaki M

    EBioMedicine

    2017  Volume 24, Page(s) 20–21

    MeSH term(s) CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/virology ; HIV Infections/immunology ; HIV Infections/metabolism ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/physiology ; Humans ; Immunomodulation/drug effects ; Immunosuppressive Agents/pharmacology ; Thalidomide/pharmacology ; Virus Activation/drug effects ; Virus Activation/immunology ; Virus Latency/drug effects ; Virus Latency/immunology
    Chemical Substances Immunosuppressive Agents ; Thalidomide (4Z8R6ORS6L)
    Language English
    Publishing date 2017-08-30
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2017.08.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7090: Show issues Location:
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  10. Article ; Online: Occult hepatitis B virus infection and current perspectives on global WHO 2030 eradication.

    Saravanan, Shanmugam / Shankar, Esaki M / Vignesh, Ramachandran / Ganesh, Pitchaipillai Sankar / Sankar, Sathish / Velu, Vijayakumar / Smith, Davey M / Balakrishnan, Pachamuthu / Viswanathan, Dhivya / Govindasamy, Rajakumar / Venkateswaran, Arcot R

    Journal of viral hepatitis

    2024  

    Abstract: The current World Health Organization (WHO) Hepatitis Elimination Strategy suffers from lack of a target for diagnosing or expunging occult HBV infection. A sizable segment of the global population has an undetected HBV infection, particularly the high- ... ...

    Abstract The current World Health Organization (WHO) Hepatitis Elimination Strategy suffers from lack of a target for diagnosing or expunging occult HBV infection. A sizable segment of the global population has an undetected HBV infection, particularly the high-risk populations and those residing in countries like India with intermediate endemicity. There is growing proof that people with hidden HBV infection can infect others, and that these infections are linked to serious chronic hepatic complications, especially hepatocellular carcinoma. Given the current diagnostic infrastructure in low-resource settings, the WHO 2030 objective of obliterating hepatitis B appears to be undeniably challenging to accomplish. Given the molecular basis of occult HBV infection strongly linked to intrahepatic persistence, patients may inexplicably harbour HBV genomes for a prolonged duration without displaying any pronounced clinical or biochemical signs of liver disease, and present histological signs of moderate degree necro-inflammation, diffuse fibrosis, and hence the international strategy to eradicate viral hepatitis warrants inclusion of occult HBV infection.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1212497-7
    ISSN 1365-2893 ; 1352-0504
    ISSN (online) 1365-2893
    ISSN 1352-0504
    DOI 10.1111/jvh.13928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4119: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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