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  1. Article ; Online: Trends in Positive Life Orientation Among 70-Year-Olds: A Comparison of Two Finnish Cohorts Born 20 Years Apart.

    Langén, Ville L / Emidio, Adriana / Vire, Jenni / Viitanen, Matti / Teppo, Konsta

    Clinical gerontologist

    2024  , Page(s) 1–7

    Abstract: Objectives: We assessed if positive life orientation (PLO) has increased among older individuals and explored gender disparities in PLO changes.: Methods: Two cohorts of 70-year-olds from Turku, Finland were included: the 1920 birth cohort (examined ... ...

    Abstract Objectives: We assessed if positive life orientation (PLO) has increased among older individuals and explored gender disparities in PLO changes.
    Methods: Two cohorts of 70-year-olds from Turku, Finland were included: the 1920 birth cohort (examined in 1991;
    Results: The 2011 cohort had a higher mean PLO score than the 1991 cohort (.87 vs. .83,
    Discussion: PLO appears to have increased among older individuals.
    Clinical implications: Recognizing the rising trend of PLO in recent decades may influence the development of societal and healthcare policies to further improve overall well-being among older individuals.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 226146-7
    ISSN 1545-2301 ; 0731-7115
    ISSN (online) 1545-2301
    ISSN 0731-7115
    DOI 10.1080/07317115.2024.2320927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: National treatment guidelines poorly achieved among older subjects with type 2 diabetes - call to action!

    Kummel, Maika / Luther-Tontasse, Emma / Koskenniemi, Jaana / Vahlberg, Tero / Viitanen, Matti / Johansson, Jouni / Korhonen, Päivi / Viikari, Laura / Salminen, Marika

    Primary care diabetes

    2024  Volume 18, Issue 2, Page(s) 126–131

    Abstract: Objective: To assess risk factors and factors associated with nonachievement of the treatment target levels among 75-year-old Finns with type 2 diabetes (T2D).: Design: Cross-sectional study.: Setting: Outpatient.: Subjects: Seventy-five-year- ... ...

    Abstract Objective: To assess risk factors and factors associated with nonachievement of the treatment target levels among 75-year-old Finns with type 2 diabetes (T2D).
    Design: Cross-sectional study.
    Setting: Outpatient.
    Subjects: Seventy-five-year-old participants of the Turku Senior Health Clinic Study (N = 1296) with T2D (n = 247).
    Main outcome measures: Nonachievement of fasting blood glucose (FBG), low-density lipoprotein (LDL-C), and blood pressure (BP) levels set by the national treatment guidelines.
    Results: Nonachievement rates of FBG, BP and LDL-C were 47%, 85%, and 47%, respectively. Non-usage of T2D medication was negatively (adjusted OR 0.38, 95% CI 0.16-0.88) and central obesity positively (1.88, 1.09-3.24) related to nonachievement of FBG target level; alcohol use was positively (3.71, 1.04-13.16) and decreased self-rated health negatively (0.34, 0.12-0.97) related to the nonachievement of BP target level. Nonachievement of LDL-C target level was positively related to poor financial status (3.50, 1.19-10.28) and non-use of lipid-lowering medication (7.70, 4.07-14.56).
    Conclusions: Nonachievement rates of the national treatment goals were high among older T2D patients, and nonachievement was related to use of medication, obesity, alcohol use, poor health, and poor financial status. We emphasize the importance of customized target setting by risk factor levels and active treatment.
    MeSH term(s) Humans ; Aged ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/complications ; Cholesterol, LDL ; Cross-Sectional Studies ; Risk Factors ; Obesity/complications
    Chemical Substances Cholesterol, LDL
    Language English
    Publishing date 2024-02-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2273997-X
    ISSN 1878-0210 ; 1751-9918
    ISSN (online) 1878-0210
    ISSN 1751-9918
    DOI 10.1016/j.pcd.2024.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Long-term effects of stroke

    Viitanen, Matti

    (Umeå University medical dissertations ; N.s., 201)

    1987  

    Series title Umeå University medical dissertations ; N.s., 201
    Collection
    Keywords Cerebrovascular Disorders ; Prognosis ; Schlaganfall ; Prognose
    Subject Voraussage ; Vorhersage ; Zukunftsvoraussage ; Zukunftsprognose ; Vorausschätzung ; Prädiktion ; Apoplektischer Insult ; Apoplexia cerebri ; Apoplexie ; Gehirnschlag ; Hirnschlag ; Zerebrovaskulärer Insult ; ZVI ; Ischämischer Insult ; Stroke
    Size 114 S. : graph. Darst.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Umeå, Univ., Diss., 1987
    HBZ-ID HT003198800
    ISBN 91-7174-312-X ; 978-91-7174-312-1
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Association of Midlife Inflammatory Markers With Cognitive Performance at 10-Year Follow-up.

    Kipinoinen, Teemu / Toppala, Sini / Rinne, Juha O / Viitanen, Matti H / Jula, Antti M / Ekblad, Laura L

    Neurology

    2022  Volume 99, Issue 20, Page(s) e2294–e2302

    Abstract: Background and objectives: Chronic low-grade inflammation, commonly associated with cardiovascular diseases and risk factors, has been associated inconclusively with cognitive decline and dementia. The aim of our study was to evaluate whether low-grade ... ...

    Abstract Background and objectives: Chronic low-grade inflammation, commonly associated with cardiovascular diseases and risk factors, has been associated inconclusively with cognitive decline and dementia. The aim of our study was to evaluate whether low-grade inflammation, measured in midlife, is associated with a decline in cognitive performance after a 10-year follow-up. We hypothesized that low-grade inflammation, estimated by interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and high-sensitivity CRP (hs-CRP), is a predictor of cognitive decline in the general population.
    Methods: This prospective cohort study is based on a Finnish nationwide, population-based Health 2000 Examination Survey, its supplemental examinations in 2000-2001, and the follow-up Health 2011 Survey. Cognitive performance at baseline and at follow-up was assessed with categorical verbal fluency (VF), word-list learning (WLL), and word-list delayed recall (WLDR). Baseline low-grade inflammation was measured with IL-6, TNF-α, and hs-CRP in 2001. Associations between low-grade inflammation and cognitive performance were analyzed with multivariable linear models adjusted for age, sex, education,
    Results: Nine hundred fifteen participants aged 45-74 years (median age 54 years, 55% women) were included in the analysis. Both higher IL-6 and TNF-α at baseline predicted poorer performance in VF and WLL at 10-year follow-up (VF: IL-6 β: -1.14,
    Discussion: Our results suggest that low-grade inflammation in midlife is an independent risk factor for poorer cognitive performance later in life. Of the studied markers, IL-6 and TNF-α seem to be stronger predictors for cognitive performance and decline than hs-CRP.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; C-Reactive Protein ; Diabetes Mellitus, Type 2 ; Interleukin-6 ; Follow-Up Studies ; Tumor Necrosis Factor-alpha ; Prospective Studies ; Biomarkers ; Cognition ; Inflammation
    Chemical Substances C-Reactive Protein (9007-41-4) ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Biomarkers
    Language English
    Publishing date 2022-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000201116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impaired Early Insulin Response to Glucose Load Predicts Episodic Memory Decline: A 10-Year Population-Based Cohort Follow-Up of 45-74-Year-Old Men and Women.

    Toppala, Sini / Ekblad, Laura L / Viitanen, Matti / Rinne, Juha O / Jula, Antti

    Journal of Alzheimer's disease : JAD

    2022  Volume 92, Issue 1, Page(s) 349–359

    Abstract: Background: Diabetes increases the risk for cognitive decline, but the mechanisms behind this association remain unknown. Impaired early insulin secretion in elderly men and insulin resistance, both of which are pathophysiological features of type 2 ... ...

    Abstract Background: Diabetes increases the risk for cognitive decline, but the mechanisms behind this association remain unknown. Impaired early insulin secretion in elderly men and insulin resistance, both of which are pathophysiological features of type 2 diabetes, have previously been linked to Alzheimer's disease.
    Objective: To examine if the early insulin response to oral glucose load predicts cognitive performance after 10 years in men and women aged 45-74 years.
    Methods: This study was based on a subpopulation of the Health 2000 Survey, a Finnish nationwide, population-based health examination study, and its follow-up, the Health 2011 Study. In total, 961 45-74-year-old individuals (mean age at baseline 55.6 years, 55.8% women) were examined. An oral glucose tolerance test was performed in 2001-2002, and early insulin response was defined as the ratio of the 30-min increment in insulin concentration to that of glucose concentration. Cognitive function was evaluated at baseline and follow-up with categorical verbal fluency, word-list learning, and word-list delayed recall. Statistical analyses were performed using multivariable linear models adjusted for age, sex, education, APOE&z.epsi;4 genotype, vascular risk factors including diabetes, and depressive symptoms.
    Results: A lower early insulin response to glucose load predicted lower performance (β: 0.21, p = 0.03) and greater decline (β: 0.19, p = 0.03) in the word-list delayed recall test. Baseline early insulin response did not predict verbal fluency or word-list learning (all p-values≥0.13).
    Conclusion: Our results suggest that decreased early insulin secretion predicts episodic memory decline in middle-aged to elderly men and women.
    MeSH term(s) Aged ; Male ; Humans ; Female ; Middle Aged ; Insulin ; Diabetes Mellitus, Type 2 ; Follow-Up Studies ; Glucose ; Memory, Episodic
    Chemical Substances Insulin ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-03-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-220894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Senior Health Clinic for 75-year-old home-dwelling Finns - study design, clinic protocol and non-response analysis.

    Salminen, Marika / Stenholm, Sari / Koskenniemi, Jaana / Korhonen, Päivi / Pitkänen, Tiina / Viikari, Paula / Wuorela, Maarit / Viitanen, Matti / Viikari, Laura

    BMC health services research

    2023  Volume 23, Issue 1, Page(s) 210

    Abstract: Background: In the Finnish policy on older people preventive activities, which maintain functional capacity and independent living, are emphasized. The Turku Senior Health Clinic, aimed at maintaining independent coping of all home-dwelling 75-year-old ... ...

    Abstract Background: In the Finnish policy on older people preventive activities, which maintain functional capacity and independent living, are emphasized. The Turku Senior Health Clinic, aimed at maintaining independent coping of all home-dwelling 75-year-old citizens in the city of Turku, was founded in the beginning of 2020. The aim of this paper is to describe design and protocol of the Turku Senior Health Clinic Study (TSHeC) and provide results of the non-response analysis.
    Methods: The non-response analysis used data from 1296 participants (71% of those eligible) and 164 non-participants of the study. Sociodemographic, health status, psychosocial and physical functional ability indicators were included in the analysis. Participants and non-participants were also compared in respect to their neighborhood socioeconomic disadvantage. Differences between participants and non-participants were tested using the Chi squared or Fisher´s exact test for categorical variables and t-test for continuous variable.
    Results: The proportions of women (43% vs. 61%) and of those with only satisfying, poor or very poor self-rated financial status (38% vs. 49%) were significantly lower in non-participants than in participants. Comparison of the non-participants and participants in respect to their neighborhood socioeconomic disadvantage showed no differences. The prevalence of hypertension (66% vs. 54%), chronic lung disease (20% vs. 11%), and kidney failure (6% vs. 3%) were higher among non-participants compared to participants. Feelings of loneliness were less frequent among non-participants (14%) compared to participants (32%). The proportions of those using assistive mobility devices (18% vs. 8%) as well as those having previous falls (12% vs. 5%) were higher in non-participants than in participants.
    Conclusions: The participation rate of TSHeC was high. No neighborhood differences in participation were found. Health status and physical functioning of non-participants seemed to be slightly worse than those of the participants, and more women than men participated. These differences may weaken the generalizability of the findings of the study. The differences have to be taken into account when recommendation for the content and implementation of preventive nurse-managed health clinic in primary health care in Finland is going to be given.
    Trial registration: ClinicalTrials.gov Identifier: NCT05634239; registration date; 1st of December 2022. Retrospectively registered.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Finland/epidemiology ; Research Design ; Activities of Daily Living ; Adaptation, Psychological ; Ambulatory Care Facilities
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-023-09199-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Midlife insulin resistance, APOE genotype, and change in late-life brain beta-amyloid accumulation - A 5-year follow-up [

    Pietilä, Elina / Snellman, Anniina / Tuisku, Jouni / Helin, Semi / Viitanen, Matti / Jula, Antti / Rinne, Juha O / Ekblad, Laura L

    Neurobiology of disease

    2023  Volume 190, Page(s) 106385

    Abstract: We studied if midlife insulin resistance (IR) and APOE genotype would predict brain beta-amyloid (Aβ) accumulation and Aβ change in late-life in 5-year follow-up [ ...

    Abstract We studied if midlife insulin resistance (IR) and APOE genotype would predict brain beta-amyloid (Aβ) accumulation and Aβ change in late-life in 5-year follow-up [
    MeSH term(s) Humans ; Aged ; Middle Aged ; Follow-Up Studies ; Insulin Resistance/genetics ; Amyloid beta-Peptides/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Genotype ; Apolipoproteins E/genetics ; Positron-Emission Tomography/methods ; Alzheimer Disease ; Aniline Compounds
    Chemical Substances Amyloid beta-Peptides ; Apolipoproteins E ; Aniline Compounds
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2023.106385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Re-examination of successful agers with lower biological than chronological age still after a 20-year follow-up period.

    Viljanen, Anna / Salminen, Marika / Irjala, Kerttu / Korhonen, Päivi / Vahlberg, Tero / Viitanen, Matti / Löppönen, Minna / Viikari, Laura

    BMC geriatrics

    2023  Volume 23, Issue 1, Page(s) 128

    Abstract: Background: Successful ageing is the term often used for depicting exceptional ageing but a uniform definition is lacking. The aim was to re-examine and describe the successful agers living at home at the age of 84 years or over after a 20-year follow- ... ...

    Abstract Background: Successful ageing is the term often used for depicting exceptional ageing but a uniform definition is lacking. The aim was to re-examine and describe the successful agers living at home at the age of 84 years or over after a 20-year follow-up. The purpose was also to identify possible factors leading to their successful ageing.
    Methods: Successful ageing was defined as the ability to live at home without daily care. Data on the participants' functional ability, objective health, self-rated health and satisfaction with life were gathered at baseline and after a 20-year follow-up period. A measurement of personal biological age (PBA) was established and the difference between the PBA and the chronological age (CA) was counted.
    Results: The participants' mean age was 87.6 years (Standard deviation 2.5, range 84-96). All analyzed variables depicted poorer physical ability and subjective health at re-examination than at baseline. Still, 99% of the participants were at least moderately satisfied with their lives. The PBA at baseline was 6.5 years younger than CA, and at re-examination, the difference was even more pronounced at 10.5 years.
    Discussion: Even though the participants were chronologically older, had poorer physical ability and subjective health, they were still satisfied with their lives indicating possible psychological resilience. The difference between the PBA and CA was greater at re-examination than at baseline indicating that they were also biologically successful agers.
    Conclusions: Successful agers were satisfied with life despite hardships and had a lower biological than chronological age. Further research is needed to evaluate causality.
    MeSH term(s) Humans ; Aged, 80 and over ; Follow-Up Studies ; Activities of Daily Living ; Aging ; Diagnostic Self Evaluation ; Physical Examination
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-023-03844-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: New reference limits for cardiac troponin T and N-terminal b-type natriuretic propeptide in elders.

    Heikkilä, Elisa / Katajamäki, Taina / Salminen, Marika / Irjala, Kerttu / Viljanen, Anna / Koivula, Marja-Kaisa / Pulkki, Kari / Isoaho, Raimo / Kivelä, Sirkka-Liisa / Viitanen, Matti / Löppönen, Minna / Vahlberg, Tero / Viikari, Laura

    Clinica chimica acta; international journal of clinical chemistry

    2024  Volume 556, Page(s) 117844

    Abstract: Background and aims: Our aim was to define reference limits for cardiac troponin T (cTnT) and N-terminal pro B-type natriuretic peptide (proBNP) that would better reflect their concentrations in older people. In addition, the incidence of acute ... ...

    Abstract Background and aims: Our aim was to define reference limits for cardiac troponin T (cTnT) and N-terminal pro B-type natriuretic peptide (proBNP) that would better reflect their concentrations in older people. In addition, the incidence of acute myocardial infarctions (AMIs) was studied using these reference limits in an older population with and without previous heart diseases.
    Materials and methods: A population-based study with a ten-year follow-up. The reference population was formed by 763 individuals aged over 64 years, with no diagnoses of heart or kidney diseases.
    Results: There was a significant increase in cTnT and proBNP concentrations with age. The 99 % reference limits for cTnT were 25 ng/L, 28 ng/l, 38 ng/l, and 71 ng/l for men in five-year-intervals starting from 64 to 69 years to 80 years and older, and 18 ng/L, 22 ng/l, 26 ng/l, and 52 ng/L for women, respectively. The 97.5 % reference limits for proBNP were 272 ng/L, 287 ng/l, 373 ng/l and 686 ng/L for men, and 341 ng/L, 377 ng/l, 471 ng/l, and 794 ng/L for women, respectively. Elevated proBNP was statistically significantly associated with future AMIs in subjects with and without a previous heart disease.
    Conclusions: Age-specific reference limits for cTnT and proBNP are needed to better evaluate cardiac symptoms.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Troponin T ; Biomarkers ; Myocardial Infarction/diagnosis ; Heart ; Heart Diseases ; Peptide Fragments ; Natriuretic Peptide, Brain
    Chemical Substances Troponin T ; Biomarkers ; Peptide Fragments ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2024-02-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2024.117844
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  10. Article: Combining diagnostic memory clinic with rehabilitation follow-up after hip fracture.

    Jaatinen, Roope / Luukkaala, Tiina / Viitanen, Matti / Nuotio, Maria S

    European geriatric medicine

    2020  Volume 11, Issue 4, Page(s) 603–611

    Abstract: Purpose: Cognitive impairment and dementia are common in older hip fracture patients. We describe new diagnoses of cognitive disorders (NDCDs) and associated factors in a two-year post-hip fracture follow-up including the use of the diagnostic ... ...

    Abstract Purpose: Cognitive impairment and dementia are common in older hip fracture patients. We describe new diagnoses of cognitive disorders (NDCDs) and associated factors in a two-year post-hip fracture follow-up including the use of the diagnostic facilities of a memory clinic.
    Methods: Data were collected on admission and at outpatient assessment 4-6 months post-hip fracture. Diagnoses of cognitive disorders followed the evidence-based Finnish national care guideline including internationally accepted criteria. NDCDs up to 2 years post-hip fracture were extracted manually from the patient files. Logistic regression models were computed to examine the associations between the pre-fracture factors and the domains of the outpatient geriatric assessment and NDCDs.
    Results: Of the 1165 hip fracture patients aged ≥ 65 years, 831 had no previous diagnosis of cognitive disorder. Of these, NDCD was documented in 23.3%. Alzheimer's disease (AD) with or without vascular cognitive impairment (VCI) was the most common diagnosis. Cognitive disorder was usually at a moderate stage. Age, higher ASA score and poor nutritional status on admission were associated with new cognitive disorders. At the outpatient follow-up, poorer activities of daily living and mobility disability were associated with NDCD. Patients with a NDCD were more likely to suffer greater mobility impairment, poorer nutritional status and to have more supported living arrangements at follow-up than in the pre-fracture situation.
    Conclusion: NDCDs are common after hip fracture and associated with impaired rehabilitation outcomes and poor nutritional status. A post-hip fracture assessment co-organized in the form of a memory clinic seems to be feasible to detect previously undiagnosed cognitive disorders. Earlier diagnosis of cognitive disorders is warranted.
    MeSH term(s) Activities of Daily Living ; Aged ; Follow-Up Studies ; Geriatric Assessment ; Hip Fractures/complications ; Humans ; Malnutrition
    Language English
    Publishing date 2020-05-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2556794-9
    ISSN 1878-7657 ; 1878-7649
    ISSN (online) 1878-7657
    ISSN 1878-7649
    DOI 10.1007/s41999-020-00334-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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