Artikel ; Online: Prophylactic intravenous tranexamic acid and thromboembolism in non-cardiac surgery: a systematic review, meta-analysis and trial sequential analysis.
2023 Band 78, Heft 9, Seite(n) 1153–1161
Abstract: Tranexamic acid is an antifibrinolytic drug that is widely used during surgery, but there are concerns about its thromboembolic effects. We aimed to investigate the effect of prophylactic intravenous tranexamic acid on thromboembolic outcomes in patients ...
| Abstract | Tranexamic acid is an antifibrinolytic drug that is widely used during surgery, but there are concerns about its thromboembolic effects. We aimed to investigate the effect of prophylactic intravenous tranexamic acid on thromboembolic outcomes in patients undergoing non-cardiac surgery. The MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials were searched. Randomised controlled trials comparing intravenous tranexamic acid with placebo or no treatment in patients undergoing non-cardiac surgery were included. The primary outcome was a composite of peri-operative cardiovascular thromboembolic events, defined as any deep vein thrombosis, pulmonary embolism, myocardial ischaemia/infarction or cerebral ischaemia/infarction. A total of 191 randomised controlled trials (40,621 patients) were included in the review. The primary outcome occurred in 4.5% of patients receiving intravenous tranexamic acid compared with 4.9% of patients in the control group. Our analysis showed that there was no difference between groups for composite cardiovascular thromboembolic events (risk ratio 1.02, 95%CI 0.94-1.11, p = 0.65, I |
|||||
|---|---|---|---|---|---|---|
| Mesh-Begriff(e) | Humans ; Tranexamic Acid/adverse effects ; Antifibrinolytic Agents/adverse effects ; Thromboembolism/prevention & control ; Blood Transfusion ; Myocardial Infarction ; Blood Loss, Surgical/prevention & control | |||||
| Chemische Substanzen | Tranexamic Acid (6T84R30KC1) ; Antifibrinolytic Agents | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2023-06-14 | |||||
| Erscheinungsland | England | |||||
| Dokumenttyp | Systematic Review ; Meta-Analysis ; Journal Article ; Review | |||||
| ZDB-ID | 80033-8 | |||||
| ISSN | 1365-2044 ; 0003-2409 | |||||
| ISSN (online) | 1365-2044 | |||||
| ISSN | 0003-2409 | |||||
| DOI | 10.1111/anae.16058 | |||||
| Signatur |
|
|||||
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
| Zs.A 388: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.