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  1. Article: Nucleic Acid Quadruplexes and Metallo-Drugs.

    Vilar, Ramon

    Metal ions in life sciences

    2018  Volume 18

    Abstract: Guanine-rich sequences of DNA can readily fold into tetra-stranded helical assemblies known as G-quadruplexes (G4s). It has been proposed that these structures play important biological roles in transcription, translation, replication, and telomere ... ...

    Abstract Guanine-rich sequences of DNA can readily fold into tetra-stranded helical assemblies known as G-quadruplexes (G4s). It has been proposed that these structures play important biological roles in transcription, translation, replication, and telomere maintenance. Therefore, over the past 20 years they have been investigated as potential drug targets for small molecules including metal complexes. This chapter provides an overview of the different classes of metal complexes as G4-binders and discusses the application of these species as optical probes for G-quadruplexes as well as metallo-drugs.
    MeSH term(s) Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Binding Sites ; Coordination Complexes ; DNA, Neoplasm/chemistry ; DNA, Neoplasm/genetics ; DNA, Neoplasm/metabolism ; Drug Design ; G-Quadruplexes ; Gene Expression Regulation, Neoplastic ; Humans ; Models, Molecular ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Organometallic Compounds/chemistry ; Organometallic Compounds/metabolism ; Organometallic Compounds/pharmacology ; RNA, Neoplasm/chemistry ; RNA, Neoplasm/genetics ; RNA, Neoplasm/metabolism ; Structure-Activity Relationship ; Telomere/chemistry ; Telomere/genetics ; Telomere/metabolism
    Chemical Substances Antineoplastic Agents ; Coordination Complexes ; DNA, Neoplasm ; Organometallic Compounds ; RNA, Neoplasm
    Language English
    Publishing date 2018--05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1559-0836
    ISSN 1559-0836
    DOI 10.1515/9783110470734-018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Quantum cyclic redundancy check codes

    Vilar, Ricard / Ball, Simeon

    2023  

    Abstract: We extend the idea of classical cyclic redundancy check codes to quantum cyclic redundancy check codes. This allows us to construct codes quantum stabiliser codes which can correct burst errors where the burst length attains the quantum Reiger bound. We ... ...

    Abstract We extend the idea of classical cyclic redundancy check codes to quantum cyclic redundancy check codes. This allows us to construct codes quantum stabiliser codes which can correct burst errors where the burst length attains the quantum Reiger bound. We then consider a certain family of quantum cyclic redundancy check codes for which we present a fast linear time decoding algorithm.
    Keywords Quantum Physics ; Computer Science - Information Theory ; 94b20 ; 94b35 ; 94b15
    Publishing date 2023-05-24
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Editorial overview: Bioinorganic chemistry.

    Casini, Angela / Vilar, Ramon

    Current opinion in chemical biology

    2021  Volume 61, Page(s) A4–A5

    MeSH term(s) Chemistry, Bioinorganic ; Metals/chemistry ; Polymers/chemistry
    Chemical Substances Metals ; Polymers
    Language English
    Publishing date 2021-08-30
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1439176-4
    ISSN 1879-0402 ; 1367-5931
    ISSN (online) 1879-0402
    ISSN 1367-5931
    DOI 10.1016/j.cbpa.2021.04.007
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  4. Article ; Online: Radiolabelling Pt-based quadruplex DNA binders via click chemistry.

    Lo, Rainbow / Majid, Aatikah / Fruhwirth, Gilbert O / Vilar, Ramon

    Bioorganic & medicinal chemistry

    2022  Volume 76, Page(s) 117097

    Abstract: Guanine-rich sequences of DNA and RNA can fold into intramolecular tetra-helical assemblies known as G-quadruplexes (G4). Their formation in vivo has been associated to a range of biological functions and therefore they have been identified as potential ... ...

    Abstract Guanine-rich sequences of DNA and RNA can fold into intramolecular tetra-helical assemblies known as G-quadruplexes (G4). Their formation in vivo has been associated to a range of biological functions and therefore they have been identified as potential drug targets. Consequently, a broad range of small molecules have been developed to target G4s. Amongst those are metal complexes with Schiff base ligands. Herein, we report the functionalisation of one of these well-established G4 DNA binders (based on a square planar platinum(II)-salphen complex) with two different radiolabelled complexes. An
    MeSH term(s) Animals ; Mice ; G-Quadruplexes ; Click Chemistry ; DNA
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-11-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2022.117097
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  5. Article ; Online: Metal complexes as optical probes for DNA sensing and imaging.

    Berrones Reyes, Jessica / Kuimova, Marina K / Vilar, Ramon

    Current opinion in chemical biology

    2021  Volume 61, Page(s) 179–190

    Abstract: Transition and lanthanide metal complexes have rich photophysical properties that can be used for cellular imaging, biosensing and phototherapy. One of the applications of such luminescent compounds is the detection and visualisation of nucleic acids. In ...

    Abstract Transition and lanthanide metal complexes have rich photophysical properties that can be used for cellular imaging, biosensing and phototherapy. One of the applications of such luminescent compounds is the detection and visualisation of nucleic acids. In this brief review, we survey the recent literature on the use of luminescent metal complexes (including Re
    MeSH term(s) Coordination Complexes/chemistry ; DNA/chemistry ; Metals/chemistry
    Chemical Substances Coordination Complexes ; Metals ; DNA (9007-49-2)
    Language English
    Publishing date 2021-03-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1439176-4
    ISSN 1879-0402 ; 1367-5931
    ISSN (online) 1879-0402
    ISSN 1367-5931
    DOI 10.1016/j.cbpa.2021.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Semi-Automated, High-Throughput Approach for the Synthesis and Identification of Highly Photo-Cytotoxic Iridium Complexes.

    Kench, Timothy / Rahardjo, Arielle / Terrones, Gianmarco G / Bellamkonda, Adinarayana / Maher, Thomas E / Storch, Marko / Kulik, Heather J / Vilar, Ramon

    Angewandte Chemie (International ed. in English)

    2024  Volume 63, Issue 18, Page(s) e202401808

    Abstract: The discovery of new compounds with pharmacological properties is usually a lengthy, laborious and expensive process. Thus, there is increasing interest in developing workflows that allow for the rapid synthesis and evaluation of libraries of compounds ... ...

    Abstract The discovery of new compounds with pharmacological properties is usually a lengthy, laborious and expensive process. Thus, there is increasing interest in developing workflows that allow for the rapid synthesis and evaluation of libraries of compounds with the aim of identifying leads for further drug development. Herein, we apply combinatorial synthesis to build a library of 90 iridium(III) complexes (81 of which are new) over two synthesise-and-test cycles, with the aim of identifying potential agents for photodynamic therapy. We demonstrate the power of this approach by identifying highly active complexes that are well-tolerated in the dark but display very low nM phototoxicity against cancer cells. To build a detailed structure-activity relationship for this class of compounds we have used density functional theory (DFT) calculations to determine some key electronic parameters and study correlations with the experimental data. Finally, we present an optimised semi-automated synthesise-and-test protocol to obtain multiplex data within 72 hours.
    MeSH term(s) Iridium/pharmacology ; Antineoplastic Agents/pharmacology ; Photochemotherapy/methods ; Structure-Activity Relationship ; Coordination Complexes/pharmacology
    Chemical Substances Iridium (44448S9773) ; Antineoplastic Agents ; Coordination Complexes
    Language English
    Publishing date 2024-03-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202401808
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  7. Article: Do left-wingers discriminate? A cross-country study on the links between political orientation, values, moral foundations, and the Covid-19 passport.

    Coelho, Gabriel Lins de Holanda / Wolf, Lukas J / Vilar, Roosevelt / Monteiro, Renan Pereira / Hanel, Paul H P

    Current psychology (New Brunswick, N.J.)

    2023  , Page(s) 1–12

    Abstract: To increase Covid-19 vaccine uptake and protect vulnerable people, many countries have introduced a Covid-19 passport in 2021, allowing vaccinated individuals to access indoor facilities more freely and travel to foreign countries. However, the passport ... ...

    Abstract To increase Covid-19 vaccine uptake and protect vulnerable people, many countries have introduced a Covid-19 passport in 2021, allowing vaccinated individuals to access indoor facilities more freely and travel to foreign countries. However, the passport has had unintended consequences as it discriminates against those who do not want to get vaccinated for medical, religious, or political reasons, or those who do not have access to vaccines. The present study (
    Supplementary information: The online version contains supplementary material available at 10.1007/s12144-023-04554-9.
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2021598-8
    ISSN 1936-4733 ; 1046-1310
    ISSN (online) 1936-4733
    ISSN 1046-1310
    DOI 10.1007/s12144-023-04554-9
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  8. Article ; Online: Platinum(II)-Based Optical Probes for Imaging Quadruplex DNA Structures via Phosphorescence Lifetime Imaging Microscopy.

    Berrones Reyes, Jessica / Sherin, Peter S / Sarkar, Amrita / Kuimova, Marina K / Vilar, Ramon

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 42, Page(s) e202310402

    Abstract: G-quadruplex DNA is a non-canonical structure that forms in guanine-rich regions of the genome. There is increasing evidence showing that G-quadruplexes have important biological functions, and therefore molecular tools to visualise these structures are ... ...

    Abstract G-quadruplex DNA is a non-canonical structure that forms in guanine-rich regions of the genome. There is increasing evidence showing that G-quadruplexes have important biological functions, and therefore molecular tools to visualise these structures are important. Herein we report on a series of new cyclometallated platinum(II) complexes which, upon binding to G-quadruplex DNA, display an increase in their phosphorescence, acting as switch-on probes. More importantly, upon binding to G-quadruplexes they display a selective and distinct lengthening of their emission lifetime. We show that this effect can be used to selectively visualise these structures in cells using Phosphorescence Lifetime Imaging Microscopy (PLIM).
    MeSH term(s) Platinum/chemistry ; G-Quadruplexes ; Microscopy ; DNA/chemistry
    Chemical Substances Platinum (49DFR088MY) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-09-08
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202310402
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  9. Article: Platinum(II)-Based Optical Probes for Imaging Quadruplex DNA Structures via Phosphorescence Lifetime Imaging Microscopy.

    Berrones Reyes, Jessica / Sherin, Peter S / Sarkar, Amrita / Kuimova, Marina K / Vilar, Ramon

    Angewandte Chemie (Weinheim an der Bergstrasse, Germany)

    2023  Volume 135, Issue 42, Page(s) e202310402

    Abstract: G-quadruplex DNA is a non-canonical structure that forms in guanine-rich regions of the genome. There is increasing evidence showing that G-quadruplexes have important biological functions, and therefore molecular tools to visualise these structures are ... ...

    Abstract G-quadruplex DNA is a non-canonical structure that forms in guanine-rich regions of the genome. There is increasing evidence showing that G-quadruplexes have important biological functions, and therefore molecular tools to visualise these structures are important. Herein we report on a series of new cyclometallated platinum(II) complexes which, upon binding to G-quadruplex DNA, display an increase in their phosphorescence, acting as switch-on probes. More importantly, upon binding to G-quadruplexes they display a selective and distinct lengthening of their emission lifetime. We show that this effect can be used to selectively visualise these structures in cells using Phosphorescence Lifetime Imaging Microscopy (PLIM).
    Language English
    Publishing date 2023-09-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 506609-8
    ISSN 1521-3757 ; 0044-8249 ; 0932-2140
    ISSN (online) 1521-3757
    ISSN 0044-8249 ; 0932-2140
    DOI 10.1002/ange.202310402
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    Ui VI 2770: Show issues Location:
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  10. Article ; Online: Síndrome de Andersen-Tawil con fenotipo sexo-específico: utilidad del test de ejercicio largo.

    Parra, S / Leal, D / Vilar, R / Mateo, M / Melero, J

    Neurologia (Barcelona, Spain)

    2019  Volume 35, Issue 9, Page(s) 675–676

    Title translation Andersen-Tawil syndrome with sex-specific phenotype: Usefulness of the long exercise test.
    MeSH term(s) Andersen Syndrome/diagnosis ; Exercise Test ; Female ; Humans ; Male ; Phenotype ; Potassium Channels, Inwardly Rectifying/genetics
    Chemical Substances Potassium Channels, Inwardly Rectifying
    Language Spanish
    Publishing date 2019-12-30
    Publishing country Spain
    Document type Letter
    ZDB-ID 2654369-2
    ISSN 2173-5808 ; 2173-5808
    ISSN (online) 2173-5808
    ISSN 2173-5808
    DOI 10.1016/j.nrl.2019.09.005
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