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  1. Article ; Online: A redescription of

    Villa, Andrea

    PeerJ

    2023  Volume 11, Page(s) e14717

    Abstract: After its original description, the Middle Miocene ... ...

    Abstract After its original description, the Middle Miocene gekkotan
    MeSH term(s) Animals ; Phylogeny ; Germany ; Europe ; Lizards/anatomy & histology
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.14717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: On skunk rabies and its prevention in North America.

    Velasco-Villa, Andres

    Equine veterinary education

    2024  Volume 35, Issue 11, Page(s) 589–593

    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274488-5
    ISSN 2042-3292 ; 0957-7734
    ISSN (online) 2042-3292
    ISSN 0957-7734
    DOI 10.1111/eve.13843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Three dimensional geophysical modelling: from physics to numerical simulation

    Villa, Andrea

    2010  

    Keywords Mathematics
    Size 1 electronic resource ( p.)
    Publisher Ledizioni - LediPublishing
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020088033
    ISBN 9788895994147 ; 8895994140
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Azathioprine in the Treatment of Severe Pediatric Atopic Dermatitis: Experience in a Referral Hospital in Spain.

    Vicente Villa, A

    Actas dermo-sifiliograficas

    2019  Volume 110, Issue 3, Page(s) 181

    Title translation Azatioprina en el tratamiento de la dermatitis atópica grave en pediatría. Experiencia en un hospital de referencia en España.
    MeSH term(s) Azathioprine/therapeutic use ; Dermatitis, Atopic/drug therapy ; Humans ; Referral and Consultation ; Spain
    Chemical Substances Azathioprine (MRK240IY2L)
    Language Spanish
    Publishing date 2019-01-28
    Document type Letter
    ZDB-ID 2541876-2
    ISSN 2173-5778 ; 2173-5778
    ISSN (online) 2173-5778
    ISSN 2173-5778
    DOI 10.1016/j.ad.2018.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A New Hypothesis Describing the Pathogenesis of Oral Mucosal Injury Associated with the Mammalian Target of Rapamycin (mTOR) Inhibitors.

    Sonis, Stephen T / Villa, Alessandro

    Cancers

    2023  Volume 16, Issue 1

    Abstract: It has been 24 years since rapamycin (sirolimus) was approved to mitigate solid organ transplant rejection and 16 years since mTOR (mammalian/mechanistic target of rapamycin) inhibitors reached patients as a cancer therapy. While the clinical benefits of ...

    Abstract It has been 24 years since rapamycin (sirolimus) was approved to mitigate solid organ transplant rejection and 16 years since mTOR (mammalian/mechanistic target of rapamycin) inhibitors reached patients as a cancer therapy. While the clinical benefits of mTOR inhibitors (mTORi) are robust, so too are their toxicities. Among the most common issues is the development of ulcers of the oral mucosa (mTOR-inhibitor associated stomatitis; mIAS). These lesions are distinct from those of other anti-cancer agents, occur with regularity, and impact patient outcomes. mIAS' pathogenesis has been the subject of speculation, and its similar presentation to recurrent aphthous stomatitis (RAS) has led to the hypothesis that it might serve as a surrogate to better understand RAS. Based on a review of the literature, the current manuscript provides a hypothesis regarding the mechanisms by which mTORis uniquely initiate mucosal injury and an explanation for the observation that steroids (also an immunosuppressive) are effective in its treatment through a non-immunologic mechanism. Unexplained unique features of mIAS are discussed in this review in the context of future investigation.
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16010068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Topical gabapentin solution for the management of burning mouth syndrome: A retrospective study.

    Gramacy, Amanda / Villa, Alessandro

    PloS one

    2023  Volume 18, Issue 12, Page(s) e0295559

    Abstract: Objective: The aim of this retrospective study was to evaluate the effectiveness and safety of topical gabapentin solution (250 mg/mL) for the management of burning mouth syndrome (BMS).: Study design: A retrospective chart review was conducted of ... ...

    Abstract Objective: The aim of this retrospective study was to evaluate the effectiveness and safety of topical gabapentin solution (250 mg/mL) for the management of burning mouth syndrome (BMS).
    Study design: A retrospective chart review was conducted of all patients diagnosed with BMS and managed with gabapentin 250 mg/mL solution (swish and spit) between January 2021 and October 2022. Patient-reported outcomes included changes in burning score ranked on a 10-point numeric rating scale (NRS) and reported adverse drug reactions (ADR). Wilcoxon signed-rank test was used to assess differences in the oral burning score ranked on a NRS (0-10) between the baseline visit and the second visit.
    Results: A total of 19 patients (68.4% females) with BMS were included and evaluated for follow-up at a median of 86 days (range: 29-195). Overall, patients reported a median 2-point burning decrease on a 0-10 NRS between the baseline visit and the second visit (p < 0.01). ADRs were reported by 3 patients (15.8%).
    Conclusion: Although this was a small retrospective study, BMS management with topical gabapentin (250 mg/mL) appears to be effective and well-tolerated. Future randomized prospective studies are needed to verify these preliminary findings.
    MeSH term(s) Female ; Humans ; Male ; Gabapentin/therapeutic use ; Retrospective Studies ; Burning Mouth Syndrome/drug therapy ; Prospective Studies
    Chemical Substances Gabapentin (6CW7F3G59X)
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0295559
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  7. Article ; Online: Pathogenesis of Oral Toxicities Associated with Targeted Therapy and Immunotherapy.

    Villa, Alessandro / Kuten-Shorrer, Michal

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: Targeted therapy and immunotherapy have redefined cancer treatment. While they have enhanced tumor response and improved survival rates in many cancer types, toxicities continue to occur, and these often involve the oral cavity. Broadly reported as " ... ...

    Abstract Targeted therapy and immunotherapy have redefined cancer treatment. While they have enhanced tumor response and improved survival rates in many cancer types, toxicities continue to occur, and these often involve the oral cavity. Broadly reported as "mucositis" or "stomatitis," oral toxicities induced by targeted therapies differ clinically and mechanistically from those associated with conventional chemotherapy. Manifesting primarily as mucosal lesions, salivary gland hypofunction, or orofacial neuropathies, these oral toxicities may nonetheless lead to significant morbidity and impact patients' quality of life, thereby compromising clinical outcomes. We conclude that familiarity with the spectrum of associated toxicities and understanding of their pathogenesis represent important areas of clinical research and may lead to better characterization, prevention, and management of these adverse events.
    MeSH term(s) Humans ; Quality of Life ; Neoplasms/drug therapy ; Neoplasms/complications ; Gastrointestinal Diseases/etiology ; Stomatitis/etiology ; Immunotherapy/adverse effects ; Antineoplastic Agents/adverse effects
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-05-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24098188
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  8. Article ; Online: Radiotherapy-induced severe oral mucositis: pharmacotherapies in recent and current clinical trials.

    Villa, Alessandro / Sonis, Stephen T

    Expert opinion on investigational drugs

    2023  Volume 32, Issue 4, Page(s) 301–310

    Abstract: Introduction: Oral mucositis (OM) is among the most common, damaging side effects of head and neck radiation therapy and may interfere with patients' ability to comply with optimal treatment.: Areas covered: The increasing unmet clinical need, recent ...

    Abstract Introduction: Oral mucositis (OM) is among the most common, damaging side effects of head and neck radiation therapy and may interfere with patients' ability to comply with optimal treatment.
    Areas covered: The increasing unmet clinical need, recent clinical trial successes, and the commercial potential have catalyzed interest in the development of effective intervention for OM. A range of small molecules are under development - some still in the preclinical stage, but others close to NDA submission. This review will focus on those drugs which have recently been assessed in a clinical trial and those which are still under clinical study as a prevention or treatment for radiation-associated OM.
    Expert opinion: In response to the unmet clinical need, both the biotechnology and pharmacological industries have been actively pursuing an agent to prevent/treat radiation-associated OM. This effort has been catalyzed by the identification of multiple drug targets which contribute to OM's pathogenesis. The lessons learned from the many trials which have previously stumbled have led to standardization of clinical trial design, endpoint efficacy definitions, rater assessment, and data interpretation over the past decade. Consequently, results of recently completed clinical trials provide optimism that effective treatment options should be available in the not-too-distant future.
    MeSH term(s) Humans ; Stomatitis/drug therapy ; Stomatitis/etiology ; Radiation Injuries/drug therapy ; Radiation Injuries/etiology ; Head and Neck Neoplasms
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2023.2193324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3739: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Occupational allergic contact dermatitis caused by tripropylene glycol diacrylate in a professional casino dealer.

    Denis, Simon / Villa, Antoine / Lehucher-Michel, Marie-Pascale

    Contact dermatitis

    2024  

    Language English
    Publishing date 2024-04-27
    Publishing country England
    Document type Case Reports
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/cod.14565
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1116: Show issues Location:
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  10. Article ; Online: Update on Oral and Oropharyngeal Cancers: A guide for oral health care providers.

    Johnson, Lisa Bennett / Reznik, Alex Samuel / Villa, Alessandro

    Journal of dental hygiene : JDH

    2024  Volume 98, Issue 2, Page(s) 39–46

    Abstract: Oral squamous cell carcinomas (OSCC) signs and symptoms may be first identified by dental hygienists during routine extra and intra-oral examinations. A comprehensive extra-oral and intra-oral examination during regular dental hygiene assessment is ... ...

    Abstract Oral squamous cell carcinomas (OSCC) signs and symptoms may be first identified by dental hygienists during routine extra and intra-oral examinations. A comprehensive extra-oral and intra-oral examination during regular dental hygiene assessment is paramount to identifying oral potentially malignant disorders (OPMD) and cancerous lesions for timely referral and treatment. Integrating a systematic list of questions during the medical and dental assessment along with careful visual and tactile examinations is critical to identifying OPMDs and cancerous lesions. Understanding the relationship between oropharyngeal squamous cell carcinomas (OPSCC) and Human Papilloma Virus (HPV) and how vaccination can prevent HPV-related OPSCC is critical to providing evidence-based recommendations and care. The purpose of this report is to provide an update on current epidemiological trends of OSCC and OPSCC rates in the United States (US) and provide the latest evidence on what dental hygienists must know to improve health outcomes and mitigate the consequences of undiagnosed cancer. This report considers enduring challenges with the annual rise in OPSCC rates and the public health burden of HPV-related cancers in the US. Emphasis on regular, quality continuing education about OSCC and OPSCC is emphasized along with recommendations for evidence-based training.
    MeSH term(s) Humans ; Oropharyngeal Neoplasms/virology ; Oropharyngeal Neoplasms/diagnosis ; Oropharyngeal Neoplasms/prevention & control ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/prevention & control ; Mouth Neoplasms/virology ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/prevention & control ; United States/epidemiology ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/virology ; Carcinoma, Squamous Cell/prevention & control ; Carcinoma, Squamous Cell/epidemiology ; Dental Hygienists/education
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035719-1
    ISSN 1553-0205 ; 1043-254X
    ISSN (online) 1553-0205
    ISSN 1043-254X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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