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  1. Article: Pulmonary Metastasectomy for Adrenocortical Carcinoma-Not If, but When.

    Carr, Shamus R / Villa Hernandez, Frank / Varghese, Diana Grace / Choo-Wosoba, Hyoyoung / Steinberg, Seth M / Teke, Martha E / Del Rivero, Jaydira / Schrump, David S / Hoang, Chuong D

    Cancers

    2024  Volume 16, Issue 4

    Abstract: Background: Adrenocortical carcinoma (ACC) commonly metastasizes to the lungs, and pulmonary metastasectomy (PM) is utilized due to limited systemic options.: Methods: All ACC patients with initially only lung metastases (LM) from a single ... ...

    Abstract Background: Adrenocortical carcinoma (ACC) commonly metastasizes to the lungs, and pulmonary metastasectomy (PM) is utilized due to limited systemic options.
    Methods: All ACC patients with initially only lung metastases (LM) from a single institution constituted this observational case series. Kaplan-Meier and Cox proportional hazard analyses evaluated the association with potential prognostic factors and outcomes. Overall survival (OS) was calculated from the date of the PM or, in those patients who did not undergo surgery, from the development of LM.
    Results: A total of 75 ACC patients over a 45-year period met the criteria; 52 underwent PM, and 23 did not. The patients undergoing PM had a median OS of 3.1 years (95% CI: 2.4, 4.7 years) with the 5- and 10-year OS being 35.5% and 32.8%, respectively. The total resected LM did not impact the OS nor the DFS. The patients who developed LM after 11 months from the initial ACC resection had an improved OS (4.2 years; 95% CI: 3.2, NR;
    Conclusions: PM appears to have a role in ACC patients. The number of nodules should not be an exclusion factor. Patients developing LM within a year of primary tumor resection may benefit from waiting before further surgeries, which may provide additional insight into who may benefit from PM.
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16040702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Current status of National Institutes of Health funding for thoracic surgeons in the United States: Beacon of hope or candle in the wind?

    Villa Hernandez, Frank / Tolunay, Umay Tuana / Demblowski, Lindsay A / Wang, Haitao / Carr, Shamus R / Hoang, Chuong D / Choo-Wosoba, Hyoyoung / Steinberg, Seth M / Zeiger, Martha A / Schrump, David S

    The Journal of thoracic and cardiovascular surgery

    2022  Volume 167, Issue 1, Page(s) 271–280.e4

    Abstract: Objective: Increasing forces threaten the viability of thoracic surgeon-initiated research, a core component of our academic mission. National Institutes of Health funding is a benchmark of research productivity and innovation. This study examined the ... ...

    Abstract Objective: Increasing forces threaten the viability of thoracic surgeon-initiated research, a core component of our academic mission. National Institutes of Health funding is a benchmark of research productivity and innovation. This study examined the current status of National Institutes of Health funding for thoracic surgeons.
    Methods: Thoracic surgeon principal investigators on National Institutes of Health-funded grants during June 2010, June 2015, and June 2020 were identified using National Institutes of Health iSearchGrants (version 2.4). American Association of Medical Colleges data were used to identify all surgeons in the United States. Types and total costs of National Institutes of Health-funded grants were compared relative to other surgical specialties.
    Results: A total of 61 of 4681 (1.3%), 63 of 4484 (1.4%), and 60 of 4497 (1.3%) thoracic surgeons were principal investigators on 79, 76, and 87 National Institutes of Health-funded grants in 2010, 2015, and 2020, respectively; these rates were higher than those for most other surgical specialties (P ≤ .0001). Total National Institutes of Health costs for Thoracic Surgeon-initiated grants increased 57% from 2010 to 2020, outpacing the 33% increase in total National Institutes of Health budget. Numbers and types of grants varied among cardiovascular, transplant, and oncology subgroups. Although the majority of grants and costs were cardiovascular related, increased National Institutes of Health expenditures primarily were due to funding for transplant and oncology grants. Per-capita costs were highest for transplant-related grants during both years. Percentages of R01-to-total costs were constant at 55%. Rates and levels of funding for female versus male thoracic surgeons were comparable. Awards to 5 surgeons accounted for 33% of National Institutes of Health costs for thoracic surgeon principal investigators in 2020; a similar phenomenon was observed for 2010 and 2015.
    Conclusions: Long-term structural changes must be implemented to more effectively nurture the next generation of thoracic surgeon scientists.
    MeSH term(s) Humans ; Male ; Female ; United States ; Wind ; Biomedical Research ; Surgeons ; National Institutes of Health (U.S.) ; Financing, Organized
    Language English
    Publishing date 2022-10-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2022.10.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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