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  1. Article ; Online: The authors reply.

    Villar, Jesús / González-Martin, Jesús M / Szakmany, Tamas

    Critical care medicine

    2024  Volume 52, Issue 2, Page(s) e106–e107

    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1261: Show issues Location:
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  2. Article ; Online: Redefining ARDS: a paradigm shift.

    Villar, Jesús / Szakmany, Tamas / Grasselli, Giacomo / Camporota, Luigi

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 416

    Abstract: Although the defining elements of "acute respiratory distress syndrome" (ARDS) have been known for over a century, the syndrome was first described in 1967. Since then, despite several revisions of its conceptual definition, it remains a matter of debate ...

    Abstract Although the defining elements of "acute respiratory distress syndrome" (ARDS) have been known for over a century, the syndrome was first described in 1967. Since then, despite several revisions of its conceptual definition, it remains a matter of debate whether ARDS is a discrete nosological entity. After almost 60 years, it is appropriate to examine how critical care has modeled this fascinating syndrome and affected patient's outcome. Given that the diagnostic criteria of ARDS (e.g., increased pulmonary vascular permeability and diffuse alveolar damage) are difficult to ascertain in clinical practice, we believe that a step forward would be to standardize the assessment of pulmonary and extrapulmonary involvement in ARDS to ensure that each patient can receive the most appropriate and effective treatment. The selection of treatments based on arbitrary ranges of PaO
    MeSH term(s) Humans ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/drug therapy ; Lung ; Treatment Outcome ; Critical Care
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04699-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
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  3. Article ; Online: Ten reasons why corticosteroid therapy reduces mortality in severe COVID-19.

    Añón, José M / Villar, Jesús

    Intensive care medicine

    2021  Volume 47, Issue 3, Page(s) 355–356

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; COVID-19 ; Hospital Mortality ; Humans ; SARS-CoV-2
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2021-01-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-020-06330-w
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    Zs.A 1089: Show issues Location:
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  4. Article ; Online: Weaning patients with obesity from ventilatory support.

    Kacmarek, Robert M / Wanderley, Hatus V / Villar, Jesús / Berra, Lorenzo

    Current opinion in critical care

    2022  Volume 27, Issue 3, Page(s) 311–319

    Abstract: Purpose of review: Obesity prevalence is increasing in most countries in the world. In the United States, 42% of the population is obese (body mass index (BMI) > 30) and 9.2% is obese class III (BMI > 40). One of the greatest challenges in critically ... ...

    Abstract Purpose of review: Obesity prevalence is increasing in most countries in the world. In the United States, 42% of the population is obese (body mass index (BMI) > 30) and 9.2% is obese class III (BMI > 40). One of the greatest challenges in critically ill patients with obesity is the optimization of mechanical ventilation. The goal of this review is to describe respiratory physiologic changes in patients with obesity and discuss possible mechanical ventilation strategies to improve respiratory function.
    Recent findings: Individualized mechanical ventilation based on respiratory physiology after a decremental positive end-expiratory pressure (PEEP) trial improves oxygenation and respiratory mechanics. In a recent study, mortality of patients with respiratory failure and obesity was reduced by about 50% when mechanical ventilation was associated with the use of esophageal manometry and electrical impedance tomography (EIT).
    Summary: Obesity greatly alters the respiratory system mechanics causing atelectasis and prolonged duration of mechanical ventilation. At present, novel strategies to ventilate patients with obesity based on individual respiratory physiology showed to be superior to those based on standard universal tables of mechanical ventilation. Esophageal manometry and EIT are essential tools to systematically assess respiratory system mechanics, safely adjust relatively high levels of PEEP, and improve chances for successful weaning.
    MeSH term(s) Electric Impedance ; Humans ; Obesity/complications ; Obesity/therapy ; Positive-Pressure Respiration ; Pulmonary Atelectasis ; Respiration, Artificial/adverse effects
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Predicting Duration of Mechanical Ventilation in Acute Respiratory Distress Syndrome Using Supervised Machine Learning.

    Sayed, Mohammed / Riaño, David / Villar, Jesús

    Journal of clinical medicine

    2021  Volume 10, Issue 17

    Abstract: Background: Acute respiratory distress syndrome (ARDS) is an intense inflammatory process of the lungs. Most ARDS patients require mechanical ventilation (MV). Few studies have investigated the prediction of MV duration over time. We aimed at ... ...

    Abstract Background: Acute respiratory distress syndrome (ARDS) is an intense inflammatory process of the lungs. Most ARDS patients require mechanical ventilation (MV). Few studies have investigated the prediction of MV duration over time. We aimed at characterizing the best early scenario during the first two days in the intensive care unit (ICU) to predict MV duration after ARDS onset using supervised machine learning (ML) approaches.
    Language English
    Publishing date 2021-08-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10173824
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  6. Article ; Online: Novel criteria to classify ARDS severity using a machine learning approach.

    Sayed, Mohammed / Riaño, David / Villar, Jesús

    Critical care (London, England)

    2021  Volume 25, Issue 1, Page(s) 150

    Abstract: Background: Usually, arterial oxygenation in patients with the acute respiratory distress syndrome (ARDS) improves substantially by increasing the level of positive end-expiratory pressure (PEEP). Herein, we are proposing a novel variable [PaO: ... ...

    Abstract Background: Usually, arterial oxygenation in patients with the acute respiratory distress syndrome (ARDS) improves substantially by increasing the level of positive end-expiratory pressure (PEEP). Herein, we are proposing a novel variable [PaO
    Methods: We examined P/FP
    Results: P/FP
    Conclusions: The novel P/FP
    MeSH term(s) Humans ; Machine Learning/standards ; Machine Learning/trends ; Respiratory Distress Syndrome/classification ; Severity of Illness Index
    Language English
    Publishing date 2021-04-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-021-03566-w
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  7. Article ; Online: Early Paralytic Agents for ARDS? Yes, No, and Sometimes.

    Slutsky, Arthur S / Villar, Jesús

    The New England journal of medicine

    2019  Volume 380, Issue 21, Page(s) 2061–2063

    MeSH term(s) Dyspnea ; Humans ; Neuromuscular Blockade ; Respiration, Artificial ; Respiratory Distress Syndrome, Adult
    Language English
    Publishing date 2019-05-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1905627
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  8. Article ; Online: Brugada Phenocopy Induced by a Lethal Methanol Intoxication

    Monterrubio-Villar Jesús / Llinares-Moya David

    European Journal of Case Reports in Internal Medicine (2020)

    2020  

    Abstract: Brugada phenocopies (BrP) are clinical entities that present with an ECG pattern identical to either the type 1 or type 2 Brugada pattern without true congenital Brugada syndrome. This ECG pattern is associated with an identifiable condition and ... ...

    Abstract Brugada phenocopies (BrP) are clinical entities that present with an ECG pattern identical to either the type 1 or type 2 Brugada pattern without true congenital Brugada syndrome. This ECG pattern is associated with an identifiable condition and normalizes upon resolution or treatment of the underlying cause. We present a case of a 54-year-old man with extreme metabolic acidosis, hyperkalaemia and a Brugada type 1 ECG pattern in the setting of a suicidal methanol (MeOH) poisoning. Upon correction of these metabolic derangements with bicarbonate infusions and continuous veno-venous haemodiafiltration (CVVH), the Brugada type 1 ECG pattern normalized. Unfortunately, the patient developed signs of cerebral herniation followed by brain death and died on the first day of ICU admission.
    Keywords immunocompetent ; lymphoma ; central nervous system ; zoster virus ; Medicine ; R
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Lung-protective Ventilation in the Operating Room: Individualized Positive End-expiratory Pressure Is Needed!

    Kacmarek, Robert M / Villar, Jesús

    Anesthesiology

    2018  Volume 129, Issue 6, Page(s) 1057–1059

    MeSH term(s) Humans ; Operating Rooms ; Positive-Pressure Respiration ; Pulmonary Atelectasis ; Respiration, Artificial ; Tidal Volume
    Language English
    Publishing date 2018-10-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000002476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 199: Show issues

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  10. Article ; Online: Brugada Phenocopy Induced by a Lethal Methanol Intoxication.

    Monterrubio-Villar, Jesús / Llinares-Moya, David

    European journal of case reports in internal medicine

    2020  Volume 7, Issue 2, Page(s) 1374

    Abstract: Brugada phenocopies (BrP) are clinical entities that present with an ECG pattern identical to either the type 1 or type 2 Brugada pattern without true congenital Brugada syndrome. This ECG pattern is associated with an identifiable condition and ... ...

    Abstract Brugada phenocopies (BrP) are clinical entities that present with an ECG pattern identical to either the type 1 or type 2 Brugada pattern without true congenital Brugada syndrome. This ECG pattern is associated with an identifiable condition and normalizes upon resolution or treatment of the underlying cause. We present a case of a 54-year-old man with extreme metabolic acidosis, hyperkalaemia and a Brugada type 1 ECG pattern in the setting of a suicidal methanol (MeOH) poisoning. Upon correction of these metabolic derangements with bicarbonate infusions and continuous veno-venous haemodiafiltration (CVVH), the Brugada type 1 ECG pattern normalized. Unfortunately, the patient developed signs of cerebral herniation followed by brain death and died on the first day of ICU admission.
    Learning points: Brugada-like ECG patterns are described in several metabolic conditions such as extreme hyperglycaemia, glucose/insulin challenge, isolated hyperkalaemia or in association with hyponatraemia and acidosis.Until now, there have been no published case reports of BrP in association with methanol intoxication.Correction of hyperkalaemia and acidosis and specific therapy for methanol intoxication leads to a complete resolution of a Brugada type 1 ECG pattern.
    Language English
    Publishing date 2020-01-01
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2020_001374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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