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Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2 Monoclonal Antibody Combination Therapy in Patients With Coronavirus Disease 2019 and Primary Antibody Deficiency.

Pulvirenti, Federica / Milito, Cinzia / Cinetto, Francesco / Fernandez Salinas, Ane / Terreri, Sara / Piano Mortari, Eva / Auria, Stefania / Soccodato, Valentina / Miriam, Lichtner / Nicastri, Emanuele / Vincenzi, Laura / Carsetti, Rita / D'Offizi, Gianpiero / Quinti, Isabella

The Journal of infectious diseases

2021 Volume 225, Issue 5, Page(s) 820–824

Abstract: Background: Previous reports highlighted the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific monoclonal antibodies (mAbs) against coronavirus disease 2019.: Methods: We conducted a prospective study on the clinical ... ...

Abstract	Background: Previous reports highlighted the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific monoclonal antibodies (mAbs) against coronavirus disease 2019. Methods: We conducted a prospective study on the clinical outcome and antiviral effects of mAbs added to standard of care therapy in SARS-CoV-2-infected patients with primary antibody defects. Results: Median time of SARS-CoV-2 quantitative polymerase chain reaction (qPCR) positivity was shorter in 8 patients treated with mAbs (22 days) than in 10 patients treated with standard of care therapy only (37 days, P=.026). Median time of SARS-CoV-2 qPCR positivity from mAb administration was 10 days. Conclusions: The SARS-CoV-2 mAbs treatment was effective and well tolerated in patients with primary antibody defects.
MeSH term(s)	Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Viral/immunology ; Antibodies, Viral/therapeutic use ; Antineoplastic Agents, Immunological ; COVID-19/drug therapy ; Common Variable Immunodeficiency ; Humans ; Primary Immunodeficiency Diseases/drug therapy ; Prospective Studies ; Real-Time Polymerase Chain Reaction ; SARS-CoV-2/isolation & purification ; Standard of Care
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Viral ; Antineoplastic Agents, Immunological
Language	English
Publishing date	2021-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiab554
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Zs.MO 445: Show issues

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Article: Long-Term Follow-Up of Acute Hepatitis B: New Insights in Its Natural History and Implications for Antiviral Treatment.

Menzo, Stefano / Minosse, Claudia / Vincenti, Donatella / Vincenzi, Laura / Iacomi, Fabio / Zaccaro, Paola / D'Offizi, Gianpiero / Capobianchi, Maria R

Genes

2018 Volume 9, Issue 6

Abstract: Acute hepatitis B infection (AHB) is still a common viral acute hepatitis worldwide. As vaccination, antiviral treatment, and immigration are bound to affect the epidemiological landscape of HBV infections, and some of its aspects need to be investigated: ...

Abstract	Acute hepatitis B infection (AHB) is still a common viral acute hepatitis worldwide. As vaccination, antiviral treatment, and immigration are bound to affect the epidemiological landscape of HBV infections, and some of its aspects need to be investigated: (1) the circulation of vaccine escape mutants and of primary drug resistant strains; (2) the change in HBV genotype prevalence; and (3) the clinical implications of AHB and the probability of chronification. The serological, virological, and clinical parameters of 75 patients, acutely infected by HBV, were gathered for a retrospective study. Long-term follow up, either to complete seroconversion or for up to five years, was possible for 44 patients. Sequence analysis of the reverse transcriptase/HBsAg and precore regions was performed to investigate the molecular epidemiology and pathogenesis of recent infections by HBV. Genotype distribution in AHB in Italian patients was radically different from that of chronic infections, with a dramatic increase of extra-European genotypes (A1, F), suggesting that a proportion of AHBs are currently related to imported strains. None of the documented infections occurred in vaccinated individuals, while HBsAg variants (potentially vaccine escape variants) were rare and less prevalent than in chronic infections. No drug resistant strains were observed. Spontaneous viral clearance occurred in all but three cases. Time to viral clearance was inversely proportional to liver damage, but HBsAg titer on day 28 and, better still, HBsAg decay from day 0 to day 28 after admission, were the best predictors of chronification. They are, thus, potentially useful to guide antiviral treatment to prevent chronic evolution.
Language	English
Publishing date	2018-06-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes9060293
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Article ; Online: The impact of the coronavirus disease 2019 pandemic on a central Italy transplant center.

Montalbano, Marzia / Levi Sandri, Giovanni Battista / Visco Comandini, Ubaldo / Lionetti, Raffaella / Vincenzi, Laura / Berardi, Giammauro / Guglielmo, Nicola / Pellicelli, Adriano / Ettorre, Giuseppe Maria / D'Offizi, Gianpiero

Medicine

2020 Volume 99, Issue 41, Page(s) e22174

Abstract: Coronavirus disease 2019 (COVID-19) is challenging health care systems worldwide, raising the question of reducing the transplant program due to the shortage of intensive care unit beds and to the risk of infection in donors and recipients.We report the ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is challenging health care systems worldwide, raising the question of reducing the transplant program due to the shortage of intensive care unit beds and to the risk of infection in donors and recipients.We report the positive experience of a single Transplant Center in Rome, part of the National Institute for Infectious Diseases Lazzaro Spallanzani, one of the major national centers involved in the COVID-19 emergency.
MeSH term(s)	COVID-19 ; Coronavirus Infections ; Hospitals/statistics & numerical data ; Humans ; Italy ; Liver Transplantation/statistics & numerical data ; Pandemics ; Pneumonia, Viral
Keywords	covid19
Language	English
Publishing date	2020-10-08
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000022174
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Article: Acute rifampicin-associated interstitial tubulopathy in a patient with pulmonary tuberculosis: a case report.

Rosati, Silvia / Cherubini, Chiara / Iacomi, Fabio / Giannakakis, Konstantinos / Vincenzi, Laura / Ippolito, Giuseppe / Palmieri, Fabrizio

Journal of medical case reports

2013 Volume 7, Page(s) 106

Abstract: Introduction: Rifampicin is one of the most effective antibiotics for treating tuberculosis, but it has been associated with adverse reactions, such as nephrotoxicity, sometimes resulting in acute renal failure with oligoanuria, and hepatotoxicity. ... ...

Abstract	Introduction: Rifampicin is one of the most effective antibiotics for treating tuberculosis, but it has been associated with adverse reactions, such as nephrotoxicity, sometimes resulting in acute renal failure with oligoanuria, and hepatotoxicity. Although deterioration of renal function, determined by acute tubulointerstitial nephritis and/or acute tubular necrosis, typically appears in patients receiving intermittent rifampicin therapy, some authors have also reported cases occurring during continuous rifampicin therapy. Case presentation: We describe the case of acute renal failure with polyuria occurring in a previously healthy 50-year-old Caucasian man undergoing continuous therapy with rifampicin for culture-confirmed pulmonary tuberculosis. The patient was admitted to the L. Spallanzani National Institute for Infectious Diseases, Rome, Italy, with a 1-month history of coughing, fever and weight loss. After 6 weeks of standard antituberculous treatment, progressive deterioration of his renal function was observed: creatinine levels rose from 38.9μmol/L to 318.2μmol/L and urine volume also progressively increased to reach a state of true polyuria (8 to 10L of urine per day). He was diagnosed with suspected acute rifampicin-induced renal failure. A renal biopsy showed focal segmental glomerulosclerosis associated with acute tubulointerstitial nephritis. Rifampicin was discontinued with excellent results: after 15 days his renal function began to improve and his serum creatinine values returned to normal. Conclusion: A high index of suspicion for rifampicin-associated acute renal failure should be maintained in patients with pulmonary tuberculosis who develop progressive deterioration of renal function during treatment with rifampicin. Early diagnosis and discontinuation of rifampicin are of fundamental importance for recovering renal function.
Language	English
Publishing date	2013-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947
ISSN	1752-1947
DOI	10.1186/1752-1947-7-106
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Article: The impact of the coronavirus disease 2019 pandemic on a central Italy transplant center

Medicine (Baltimore)

Abstract	Coronavirus disease 2019 (COVID-19) is challenging health care systems worldwide, raising the question of reducing the transplant program due to the shortage of intensive care unit beds and to the risk of infection in donors and recipients.We report the positive experience of a single Transplant Center in Rome, part of the National Institute for Infectious Diseases Lazzaro Spallanzani, one of the major national centers involved in the COVID-19 emergency.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #841113
Database	COVID19

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Article ; Online: Acute hepatitis associated with clopidogrel: a case report and review of the literature.

Pisapia, Raffaella / Abdeddaim, Amina / Mariano, Andrea / Rianda, Alessia / Vincenzi, Laura / Taibi, Chiara / Baiocchini, Andrea / Del Nonno, Franca / DʼOffizi, Gianpiero

American journal of therapeutics

2015 Volume 22, Issue 1, Page(s) e8–e13

Abstract: Drug-induced hepatotoxicity is a common cause of acute hepatitis, and the recognition of the responsible drug may be difficult. We describe a case of clopidogrel-related acute hepatitis. The diagnosis is strongly suggested by an accurate medical history ... ...

Abstract	Drug-induced hepatotoxicity is a common cause of acute hepatitis, and the recognition of the responsible drug may be difficult. We describe a case of clopidogrel-related acute hepatitis. The diagnosis is strongly suggested by an accurate medical history and liver biopsy. Reports about cases of hepatotoxicity due to clopidogrel are increasing in the last few years, after the increased use of this drug. In conclusion, we believe that physicians should carefully consider the risk of drug-induced hepatic injury when clopidogrel is prescribed.
MeSH term(s)	Acute Disease ; Biopsy ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Female ; Humans ; Middle Aged ; Platelet Aggregation Inhibitors/adverse effects ; Ticlopidine/adverse effects ; Ticlopidine/analogs & derivatives
Chemical Substances	Platelet Aggregation Inhibitors ; clopidogrel (A74586SNO7) ; Ticlopidine (OM90ZUW7M1)
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1280786-2
ISSN	1536-3686 ; 1075-2765
ISSN (online)	1536-3686
ISSN	1075-2765
DOI	10.1097/MJT.0b013e318293b0d6
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Zs.A 4351: Show issues

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Article: Endocarditis and meningitis associated to nape piercing in a young female: a case report.

Mariano, Andrea / Pisapia, Raffaella / Abdeddaim, Amina / Taibi, Chiara / Rianda, Alessia / Vincenzi, Laura / D'Offizi, Gianpiero

Le infezioni in medicina

2015 Volume 23, Issue 3, Page(s) 275–279

Abstract: Body piercing is a social phenomenon on the rise especially among young people. This procedure may be complicated by serious bacterial and viral infections. We report a case of Staphylococcus aureus infective endocarditis and meningitis arising from the ... ...

Abstract	Body piercing is a social phenomenon on the rise especially among young people. This procedure may be complicated by serious bacterial and viral infections. We report a case of Staphylococcus aureus infective endocarditis and meningitis arising from the site of a nape piercing, after its removal. A 21-year-old Italian female was admitted to hospital with neurological impairment and sepsis. A diagnosis of endocarditis associated with meningitis by S. aureus, complicated by septic emboli in the brain, retina, skin and kidney, was formulated on the basis of modified Duke's criteria. The likely port-of-entry was the site of a nape piercing, removed two months before. In view of the widespread practice of body piercing, provision of correct and timely information concerning the associated serious risks is now imperative. Such information should emphasise the option for antibiotic prophylaxis, and the importance of careful local hygiene, even after piercing removal.
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/complications ; Bacteremia/diagnosis ; Bacteremia/microbiology ; Body Piercing/adverse effects ; Drug Therapy, Combination ; Endocarditis, Bacterial/diagnostic imaging ; Endocarditis, Bacterial/microbiology ; Female ; Gentamicins/therapeutic use ; Humans ; Meningitis, Bacterial/diagnosis ; Meningitis, Bacterial/microbiology ; Oxacillin/therapeutic use ; Risk Factors ; Staphylococcal Infections/complications ; Staphylococcal Infections/diagnosis ; Staphylococcus aureus/isolation & purification ; Time Factors ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Gentamicins ; Oxacillin (UH95VD7V76)
Language	English
Publishing date	2015-09-22
Publishing country	Italy
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041081-5
ISSN	1124-9390
ISSN	1124-9390
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Zs.A 5576: Show issues

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Article ; Online: Varicella zoster virus infection presenting as isolated diplopia: a case report.

Pisapia, Raffaella / Rianda, Alessia / Mariano, Andrea / Testa, Angela / Galgani, Simonetta / Vincenzi, Laura / Abdeddaim, Amina / Oliva, Alessandra / Narciso, Pasquale

BMC infectious diseases

2013 Volume 13, Page(s) 138

Abstract: Background: Involvement of trochlear nerve during Varicella Zoster Virus (VZV) Infection has been rarely described, and always in association with skin rash.: Case presentation: We describe the case of a patient with VZV infection presenting as ... ...

Abstract	Background: Involvement of trochlear nerve during Varicella Zoster Virus (VZV) Infection has been rarely described, and always in association with skin rash. Case presentation: We describe the case of a patient with VZV infection presenting as isolated diplopia due to fourth cranial nerve palsy. The diagnosis has been obtained through the application of a standardized molecular diagnostic panel, and diplopia resolved after specific antiviral and corticosteroid therapy. Conclusion: This case evidences that clinicians should be aware of atypical VZV infection, even in the absence of the typical skin rash.
MeSH term(s)	Adult ; Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Diagnosis, Differential ; Diplopia/diagnosis ; Herpes Zoster/diagnosis ; Herpes Zoster/drug therapy ; Herpesvirus 3, Human/genetics ; Herpesvirus 3, Human/isolation & purification ; Humans ; Male ; Molecular Diagnostic Techniques ; Trochlear Nerve Diseases/diagnosis
Chemical Substances	Anti-Inflammatory Agents ; Antiviral Agents
Language	English
Publishing date	2013-03-15
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/1471-2334-13-138
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Article: Endocarditi infettive. Protocollo per la diagnosi e la terapia.

Boumis, Evangelo / Alba, Lucia / Cicalini, Stefania / De Marco, Michele / Festa, Anna / Macrì, Giulia / Vincenzi, Laura / Petrosillo, Nicola

Recenti progressi in medicina

2004 Volume 95, Issue 12, Page(s) 591–603

Abstract: After careful review of evidence-based literature, clinical and laboratory criteria for diagnosis of bacterial and fungal endocarditis are examined. The choice criteria for therapy of bacterial endocarditis, both empiric and directed against a specific ... ...

Title translation	Infective endocarditis. Guidelines for diagnosis and treatment.
Abstract	After careful review of evidence-based literature, clinical and laboratory criteria for diagnosis of bacterial and fungal endocarditis are examined. The choice criteria for therapy of bacterial endocarditis, both empiric and directed against a specific pathogen, are reviewed, on the basis of the clinical and epidemiological context (prosthetic or native valve, left or right heart, drug addiction). Different treatment options are proposed, based on results of antibiotic resistance testing. Indications and contraindications for a parenteral home treatment and those for surgical treatment are examined, also according to the results of ultrasonography.
MeSH term(s)	Administration, Oral ; Ambulatory Care ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Cardiac Surgical Procedures/standards ; Contraindications ; Diagnosis, Differential ; Drug Administration Schedule ; Drug Resistance, Bacterial ; Echocardiography ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/microbiology ; Endocarditis, Bacterial/surgery ; Endocarditis, Bacterial/therapy ; Evidence-Based Medicine ; Heart Valve Prosthesis/microbiology ; Home Infusion Therapy/standards ; Humans ; Infusions, Intravenous
Chemical Substances	Anti-Bacterial Agents
Language	Italian
Publishing date	2004-12
Publishing country	Italy
Document type	Guideline ; Journal Article ; Practice Guideline ; Review
ZDB-ID	138266-4
ISSN	0034-1193
ISSN	0034-1193
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Zs.B 193: Show issues

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Article: NK cell activity controls human herpesvirus 8 latent infection and is restored upon highly active antiretroviral therapy in AIDS patients with regressing Kaposi's sarcoma.

Sirianni, Maria Caterina / Vincenzi, Laura / Topino, Simone / Giovannetti, Antonello / Mazzetta, Francesca / Libi, Fabio / Scaramuzzi, Donato / Andreoni, Massimo / Pinter, Elena / Baccarini, Sara / Rezza, Giovanni / Monini, Paolo / Ensoli, Barbara

European journal of immunology

2002 Volume 32, Issue 10, Page(s) 2711–2720

Abstract: Kaposi's sarcoma (KS) develops upon reactivation of human herpesvirus 8 (HHV8) infection and virus dissemination to blood and tissue cells, including endothelial and KS spindle cells where the virus is mostly present in a latent form. However, this may ... ...

Abstract	Kaposi's sarcoma (KS) develops upon reactivation of human herpesvirus 8 (HHV8) infection and virus dissemination to blood and tissue cells, including endothelial and KS spindle cells where the virus is mostly present in a latent form. However, this may likely require the presence of compromised host immune responses and/or the evasion of infected cells from the host immune response. In this regard, mechanisms of evasion of productively infected cells from both CTL and NK cell responses, and resistance of latently infected cells from specific CTL, have already been shown. Here we show that cells which are latently infected by HHV8 are indeed efficiently lysed by NK cells from individuals with a normal immune response. Notably, NK cell-mediated immunity was found to be significantly reduced in AIDS patients with progressing KS as compared to both HIV-negative patients with indolent classic KS or normal blood donors. However, it was restored after treatment with the highly active antiretroviral therapy (HAART) in AIDS-KS patients, that showed regression and clearance of HHV8 from PBMC. By contrast, AIDS-KS patients with a more aggressive disease and no clinical response had persistent HHV8 viremia associated with reduced NK cell cytotoxicity. These results suggest a key role for NK cells in the control of HHV8 latent infection, KS development, and in disease remission upon HAART.
MeSH term(s)	Acquired Immunodeficiency Syndrome/drug therapy ; Acquired Immunodeficiency Syndrome/immunology ; Acquired Immunodeficiency Syndrome/virology ; Antibodies, Viral/blood ; Antiretroviral Therapy, Highly Active ; Cytotoxicity, Immunologic ; DNA, Viral/blood ; Herpesvirus 8, Human/immunology ; Herpesvirus 8, Human/isolation & purification ; Humans ; Killer Cells, Natural/immunology ; Sarcoma, Kaposi/immunology ; Sarcoma, Kaposi/virology
Chemical Substances	Antibodies, Viral ; DNA, Viral
Language	English
Publishing date	2002-10
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/1521-4141(2002010)32:10<2711::AID-IMMU2711>3.0.CO;2-3
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