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Article ; Online: Discovering Composite Lifestyle Biomarkers With Artificial Intelligence From Clinical Studies to Enable Smart eHealth and Digital Therapeutic Services

Sofoklis Kyriazakos / Aristodemos Pnevmatikakis / Alfredo Cesario / Konstantina Kostopoulou / Luca Boldrini / Vincenzo Valentini / Giovanni Scambia

Frontiers in Digital Health, Vol

2021 Volume 3

Abstract: Discovery of biomarkers is a continuous activity of the research community in the clinical domain that recently shifted its focus toward digital, non-traditional biomarkers that often use physiological, psychological, social, and environmental data to ... ...

Abstract	Discovery of biomarkers is a continuous activity of the research community in the clinical domain that recently shifted its focus toward digital, non-traditional biomarkers that often use physiological, psychological, social, and environmental data to derive an intermediate biomarker. Such biomarkers, by triggering smart services, can be used in a clinical trial framework and eHealth or digital therapeutic services. In this work, we discuss the APACHE trial for determining the quality of life (QoL) of cervical cancer patients and demonstrate how we are discovering a biomarker for this therapeutic area that predicts significant QoL variations. To this extent, we present how real-world data can unfold a big potential for detecting the cervical cancer QoL biomarker and how it can be used for novel treatments. The presented methodology, derived in APACHE, is introduced by Healthentia eClinical solution, and it is beginning to be used in several clinical studies.
Keywords	digital biomarkers ; machine learning ; ai clinical trials ; Healthentia ; real world data ; e-clinical platform ; Medicine ; R ; Public aspects of medicine ; RA1-1270 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	310
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: FORECAST – A cloud-based personalized intelligent virtual coaching platform for the well-being of cancer patients

Sofoklis Kyriazakos / Vincenzo Valentini / Alfredo Cesario / Robert Zachariae

Clinical and Translational Radiation Oncology, Vol 8, Iss C, Pp 50-

2018 Volume 59

Abstract: Well-being of cancer patients and survivors is a challenge worldwide, considering the often chronic nature of the disease. Today, a large number of initiatives, products and services are available that aim to provide strategies to face the challenge of ... ...

Abstract	Well-being of cancer patients and survivors is a challenge worldwide, considering the often chronic nature of the disease. Today, a large number of initiatives, products and services are available that aim to provide strategies to face the challenge of well-being in cancer patients; nevertheless the proposed solutions are often non-sustainable, costly, unavailable to those in need, and less well-received by patients. These challenges were considered in designing FORECAST, a cloud-based personalized intelligent virtual coaching platform for improving the well-being of cancer patients. Personalized coaching for cancer patients focuses on physical, mental, and emotional concerns, which FORECAST is able to identify. Cancer patients can benefit from coaching that addresses their emotional problems, helps them focus on their goals, and supports them in coping with their disease-related stressors. Personalized coaching in FORECAST offers support, encouragement, motivation, confidence, and hope and is a valuable tool for the wellbeing of a patient.
Keywords	Cancer coaching ; Personalized medicine ; Cloud eHealth platforms ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction

Stanislao Rizzo / Alfonso Savastano / Jacopo Lenkowicz / Maria Cristina Savastano / Luca Boldrini / Daniela Bacherini / Benedetto Falsini / Vincenzo Valentini

Diagnostics, Vol 12, Iss 1593, p

Rizzo et al. Artificial Intelligence and OCT Angiography in Full Thickness Macular Hole. New Developments for Personalized Medicine. Diagnostics 2021, 11 , 2319

2022 Volume 1593

Abstract: In the original publication [.] ...

Abstract	In the original publication [.]
Keywords	n/a ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ablative Radiotherapy (ART) for Locally Advanced Pancreatic Cancer (LAPC)

Nicola Simoni / Gabriella Rossi / Francesco Cellini / Viviana Vitolo / Ester Orlandi / Vincenzo Valentini / Renzo Mazzarotto / Nicola Sverzellati / Nunziata D’Abbiero

Life, Vol 12, Iss 465, p

Toward a New Paradigm?

2022 Volume 465

Abstract: Locally advanced pancreatic cancer (LAPC) represents a major urgency in oncology. Due to the massive involvement of the peripancreatic vessels, a curative-intent surgery is generally precluded. Historically, LAPC has been an indication for palliative ... ...

Abstract	Locally advanced pancreatic cancer (LAPC) represents a major urgency in oncology. Due to the massive involvement of the peripancreatic vessels, a curative-intent surgery is generally precluded. Historically, LAPC has been an indication for palliative systemic therapy. In recent years, with the introduction of intensive multi-agent chemotherapy regimens and aggressive surgical approaches, the survival of LAPC patients has significantly improved. In this complex and rapidly evolving scenario, the role of radiotherapy is still debated. The use of standard-dose conventional fractionated radiotherapy in LAPC has led to unsatisfactory oncological outcomes. However, technological advances in radiation therapy over recent years have definitively changed this paradigm. The use of ablative doses of radiotherapy, in association with image-guidance, respiratory organ-motion management, and adaptive protocols, has led to unprecedented results in terms of local control and survival. In this overview, principles, clinical applications, and current pitfalls of ablative radiotherapy (ART) as an emerging treatment option for LAPC are discussed.
Keywords	locally advanced ; pancreatic cancer ; ablative radiotherapy ; intensive chemotherapy ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prioritization on palliative radiotherapy during the COVID-19 pandemic (and beyond).

Cellini, Francesco / Manfrida, Stefania / Gambacorta, Maria Antonietta / Vincenzo, Valentini

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2020 Volume 150, Page(s) 181–182

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Neoplasms/radiotherapy ; Palliative Care ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Time-to-Treatment ; Triage
Keywords	covid19
Language	English
Publishing date	2020-07-01
Publishing country	Ireland
Document type	Letter
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2020.06.033
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Article ; Online: Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions

Roberto Iezzi / Alessandro Posa / Cosimo Tommaso Caputo / Davide De Leoni / Fabio Sbaraglia / Marco Rossi / Giampaolo Tortora / Luca Tagliaferri / Vincenzo Valentini / Cesare Colosimo

Life, Vol 13, Iss 631, p

2023 Volume 631

Abstract: Interventional Oncology treatments grant low-risk mini-invasive alternatives to surgery for cancer patients. Percutaneous ablative therapies represent a cornerstone for treatment of liver cancer patients. Among these, a newly emerging one is represented ... ...

Abstract	Interventional Oncology treatments grant low-risk mini-invasive alternatives to surgery for cancer patients. Percutaneous ablative therapies represent a cornerstone for treatment of liver cancer patients. Among these, a newly emerging one is represented by electrochemotherapy. Improvements in analgesia and sedation can nowadays offer optimal support for ablative procedures, serving as a valid alternative to general anesthesia. The intention of this retrospective monocentric study is to report our preliminary experience on feasibility and safety of electrochemotherapy for treatment of complex liver tumors unfit for thermal ablation, using analgosedation instead of general anesthesia. Five patients were enrolled in the study, undergoing electrochemotherapy under analgosedation. Mean procedural time and hospitalization time were recorded. Immediate post-procedural cone-beam CT showed complete coverage of the lesion without complications. One-month CT examination showed an overall response rate of 100% (four complete responses, one partial response). Electrochemotherapy under analgosedation seems to be a safe, feasible, and effective option for liver cancer patients not amenable to other ablative techniques.
Keywords	electrochemotherapy ; interventional oncology ; ablation ; liver cancer ; sedation ; analgesia ; Science ; Q
Subject code	616
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Is an Interventional Oncology Center an advantage in the service of cancer patients or in the education? The Gemelli Hospital and INTERACTS experience

György Kovács / Luca Tagliaferri / Vincenzo Valentini

Journal of Contemporary Brachytherapy, Vol 9, Iss 6, Pp 497-

2017 Volume 498

Keywords	Medicine ; R
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Artificial Intelligence and OCT Angiography in Full Thickness Macular Hole. New Developments for Personalized Medicine

Stanislao Rizzo / Alfonso Savastano / Jacopo Lenkowicz / Maria Cristina Savastano / Luca Boldrini / Daniela Bacherini / Benedetto Falsini / Vincenzo Valentini

Diagnostics, Vol 11, Iss 2319, p

2021 Volume 2319

Abstract: Purpose: To evaluate the 1-year visual acuity predictive performance of an artificial intelligence (AI) based model applied to optical coherence tomography angiography (OCT-A) vascular layers scans from eyes with a full-thickness macular hole (FTMH). ... ...

Abstract	Purpose: To evaluate the 1-year visual acuity predictive performance of an artificial intelligence (AI) based model applied to optical coherence tomography angiography (OCT-A) vascular layers scans from eyes with a full-thickness macular hole (FTMH). Methods: In this observational cross-sectional, single-center study, 35 eyes of 35 patients with FTMH were analyzed by OCT-A before and 1-year after surgery. Superficial vascular plexus (SVP) and deep vascular plexus (DVP) images were collected for the analysis. AI approach based on convolutional neural networks (CNN) was used to generate a continuous predictive variable based on both SVP and DPV. Different pre-trained CNN networks were used for feature extraction and compared for predictive accuracy. Results: Among the different tested models, the inception V3 network, applied on the combination of deep and superficial OCT-A images, showed the most significant differences between the two obtained image clusters defined in C1 and C2 (best-corrected visual acuity [BCVA] C1 = 49.10 [±18.60 SD] and BCVA C2 = 66.67 [±16.00 SD, p = 0.005]). Conclusions: The AI-based analysis of preoperative OCT-A images of eyes affected by FTMH may be a useful support system in setting up visual acuity recovery prediction. The combination of preoperative SVP and DVP images showed a significant morphological predictive performance for visual acuity recovery.
Keywords	artificial intelligence ; deep learning ; full thickness macular hole ; innovative biotechnologies ; optical coherence tomography angiography ; personalized medicine ; Medicine (General) ; R5-920
Subject code	006
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Online adaptive magnetic resonance guided radiotherapy for pancreatic cancer

Luca Boldrini / Davide Cusumano / Francesco Cellini / Luigi Azario / Gian Carlo Mattiucci / Vincenzo Valentini

Radiation Oncology, Vol 14, Iss 1, Pp 1-

state of the art, pearls and pitfalls

2019 Volume 6

Abstract: Abstract Background Different studies have proved in recent years that hypofractionated radiotherapy (RT) improves overall survival of patients affected by locally advanced, unresectable, pancreatic cancer. The clinical management of these patients ... ...

Abstract	Abstract Background Different studies have proved in recent years that hypofractionated radiotherapy (RT) improves overall survival of patients affected by locally advanced, unresectable, pancreatic cancer. The clinical management of these patients generally leads to poor results and is considered very challenging, due to different factors, heavily influencing treatment delivery and its outcomes. Firstly, the dose prescribed to the target is limited by the toxicity that the highly radio-sensitive organs at risk (OARs) surrounding the disease can develop. Treatment delivery is also complicated by the significant inter-fractional and intra-fractional variability of therapy volumes, mainly related to the presence of hollow organs and to the breathing cycle. Main body of the abstract The recent introduction of magnetic resonance guided radiotherapy (MRgRT) systems leads to the opportunity to control most of the aforementioned sources of uncertainty influencing RT treatment workflow in pancreatic cancer. MRgRT offers the possibility to accurately identify radiotherapy volumes, thanks to the high soft-tissue contrast provided by the Magnetic Resonance imaging (MRI), and to monitor the tumour and OARs positions during the treatment fraction using a high-temporal cine MRI. However, the main advantage offered by the MRgRT is the possibility to online adapt the RT treatment plan, changing the dose distribution while the patient is still on couch and successfully addressing most of the sources of variability. Short conclusion Aim of this study is to present and discuss the state of the art, the main pitfalls and the innovative opportunities offered by online adaptive MRgRT in pancreatic cancer treatment.
Keywords	Online adaptive radiotherapy ; MR-guided radiotherapy ; Pancreatic cancer ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	610
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Predictive and prognostic value of inflammatory markers in locally advanced rectal cancer (PILLAR) – A multicentric analysis by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Study Group

Giuditta Chiloiro / Angela Romano / Silvia Mariani / Gabriella Macchia / Diana Giannarelli / Luciana Caravatta / Pierfrancesco Franco / Luca Boldrini / Alessandra Arcelli / Almalina Bacigalupo / Liliana Belgioia / Antonella Fontana / Elisa Meldolesi / Giampaolo Montesi / Rita Marina Niespolo / Elisa Palazzari / Cristina Piva / Vincenzo Valentini / Maria Antonietta Gambacorta

Clinical and Translational Radiation Oncology, Vol 39, Iss , Pp 100579- (2023)

2023

Abstract: Background: Patients (pts) affected with locally advanced rectal cancer (LARC) may respond differently to neoadjuvant chemoradiotherapy (nCRT). The identification of reliable biomarkers able to predict oncological outcomes could help in the development ... ...

Abstract	Background: Patients (pts) affected with locally advanced rectal cancer (LARC) may respond differently to neoadjuvant chemoradiotherapy (nCRT). The identification of reliable biomarkers able to predict oncological outcomes could help in the development of risk-adapted treatment strategies. It has been suggested that inflammation parameters may have a role in predicting tumor response to nCRT and survival outcomes and in rectal cancer, but no definitive conclusion can be drawn at present. The aim of the current study is to evaluate the role of baseline inflammatory markers as prognostic and predictive factors in a large multicentric Italian cohort of LARC pts. Methods: Patients diagnosed with LARC from January 2002 to December 2019 in 9 Italian centers were retrospectively collected. Patients underwent long-course RT with chemotherapy based on fluoropyrimidine ± oxaliplatin followed by surgery. Inflammatory markers were retrieved based on a pre-treatment blood sample including HEI (hemo-eosinophils inflammation index), SII (systemic index of inflammation), NLR (neutrophil-to-lymphocyte ratio), PLR (platelet-to-lymphocyte ratio) and MLR (monocyte-to-lymphocyte ratio). Outcomes of interest were pathological complete response (pCR), disease-free survival (DFS), and overall survival (OS). Results: 808 pts were analyzed. pCR rate was 22 %, 5yOS and 5yDFS were 84.0% and 63.1% respectively. Multivariate analysis identified that a NLR cut-off value >1.2 and SII cut-off value >500 could predict pCR (p = 0.05 and 0.009 respectively). In addition to age, extramesorectal nodes and RT dose, MLR >0.18 (p = 0.03) and HEI = 3 (p = 0.05) were independent prognostic factors for DFS. Finally, age, RT dose, MLR with a cut-off >0.35 (p = 0.028) and HEI = 3 (p = 0.045) were independent predictors of OS. Conclusions: Higher values of baseline composite inflammatory markers can serve as predictors of lower pCR rates and worse survival outcomes in LARC patients undergoing nCRT. More reliable data from prospective studies ...
Keywords	Rectal cancer ; Neoadjuvant radiotherapy ; Inflammatory markers ; Prognostic factors ; Predictive factors ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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