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  1. Article ; Online: Letter in Response to: Near-Peer Teaching in Conjunction with Flipped Classroom to Teach First-Year Medical Students Basic Surgical Skills.

    George, Nicole / Vineall, Owen

    Medical science educator

    2022  Volume 32, Issue 5, Page(s) 1233

    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article
    ISSN 2156-8650
    ISSN (online) 2156-8650
    DOI 10.1007/s40670-022-01622-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Kisspeptin-neuron control of LH pulsatility and ovulation.

    Stevenson, Harvey / Bartram, Samuel / Charalambides, Mikaela Maria / Murthy, Sruthi / Petitt, Theo / Pradeep, Anjali / Vineall, Owen / Abaraonye, Ikenna / Lancaster, Amelia / Koysombat, Kanyada / Patel, Bijal / Abbara, Ali

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 951938

    Abstract: Feedback from oestradiol (E2) plays a critical role in the regulation of major events in the physiological menstrual cycle including the release of gonadotrophins to stimulate follicular growth, and the mid-cycle luteinising hormone (LH) surge that leads ...

    Abstract Feedback from oestradiol (E2) plays a critical role in the regulation of major events in the physiological menstrual cycle including the release of gonadotrophins to stimulate follicular growth, and the mid-cycle luteinising hormone (LH) surge that leads to ovulation. E2 predominantly exerts its action
    MeSH term(s) Kisspeptins ; Neurokinin B ; Dynorphins ; Luteinizing Hormone ; Gonadotropin-Releasing Hormone ; Neurons
    Chemical Substances Kisspeptins ; Neurokinin B (86933-75-7) ; Dynorphins (74913-18-1) ; Luteinizing Hormone (9002-67-9) ; Gonadotropin-Releasing Hormone (33515-09-2)
    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.951938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A longitudinal comparison of spike and nucleocapsid SARS-CoV-2 antibody responses in a tertiary hospitals laboratory workers with validation of DBS specimen analysis.

    Murrell, Isa / Forde, Donall / Tyson, Linda / Chichester, Lisa / Garratt, Anna / Vineall, Owen / Palmer, Nicki / Jones, Rachel / Moore, Catherine

    medRxiv

    Keywords covid19
    Language English
    Publishing date 2020-11-03
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.10.29.20219931
    Database COVID19

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  4. Article ; Online: A longitudinal comparison of spike and nucleocapsid SARS-CoV-2 antibody responses in a tertiary hospitals laboratory workers with validation of DBS specimen analysis

    Murrell, Isa / Forde, Donall / Tyson, Linda / Chichester, Lisa / Garratt, Anna / Vineall, Owen / Palmer, Nicki / Jones, Rachel / Moore, Catherine

    Abstract: There is a requirement for easily accessible, high throughput serological testing as part of the SARS-CoV-2 pandemic response. Whilst of limited diagnostic use in an acute individual setting, its use on a population level is key to informing a coherent ... ...

    Abstract There is a requirement for easily accessible, high throughput serological testing as part of the SARS-CoV-2 pandemic response. Whilst of limited diagnostic use in an acute individual setting, its use on a population level is key to informing a coherent public health response. As experience of commercial assays increases, so too does knowledge of their precision and limitations. Here we present our experience of these systems thus far. We perform a spot sero-prevalence study amongst staff in a tertiary hospitals clinical microbiology laboratory, before undertaking validation of DBS serological testing as an alternate specimen for analysis. Finally, we characterise the spike and nucleocapsid antibody response over 160 days post a positive PCR test in nine non-hospitalised staff members. Amongst a cohort of 195 staff, 17 tested positive for SARS-CoV-2 antibodies (8.7%). Self-reporting of SARS-CoV2 infection (P=<0.0001) and testing of a household contact (P = 0.027) were significant variables amongst the positive and negative sub-groups. Testing of 28 matched serum and DBS samples demonstrated 96% accuracy between the sample types. A differential rate of decline of SARS-CoV-2 antibodies against nucleocapsid or spike protein was observed. At 4 months post a positive PCR test 7/9 (78%) individuals had detectable antibodies against spike protein, but only 2/9 (22%) had detectable antibodies against nucleocapsid protein. This study reveals a broad agreement amongst commercial platforms tested and suggests the use of DBS as an alternate specimen option to enable widespread population testing for SARS-CoV-2 antibodies. These results suggest potential limitations of these platforms in estimating historical infection. By setting this temporal point of reference for this cohort of non-patient facing laboratory staff, future exposure risks and mitigation strategies can be evaluated more fully.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #20219931
    DOI 10.1101/2020.10.29.20219931
    Database COVID19

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