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  1. Article ; Online: Microvascular free tissue transfer and cochlear implants: A case series and literature review.

    Lindquist, Nathan R / Vinh, Daniel B / Appelbaum, Eric N / Vrabec, Jeffrey T / Huang, Andrew T

    The Laryngoscope

    2019  Volume 130, Issue 6, Page(s) 1552–1557

    Abstract: Objective: The use of microvascular free tissue transfer (MVFTT) for defects of the scalp and lateral temporal bone in patients with cochlear implants (CI) is uncommon. Herein, we report our experience with the utility, indications, and outcomes for ... ...

    Abstract Objective: The use of microvascular free tissue transfer (MVFTT) for defects of the scalp and lateral temporal bone in patients with cochlear implants (CI) is uncommon. Herein, we report our experience with the utility, indications, and outcomes for MVFTT in patients with cochlear implants.
    Methods: A retrospective review of patients at our institution from September 2016 to December 2017 identified subjects with coexistent cochlear implant and ipsilateral MVFTT of the lateral temporal bone or scalp. Information including demographics, indication for MVFTT, timing of CI and MVFTT, donor site, and previous radiation to the head and neck was collected. To assess the current literature on MVFTT in CI patients, a MEDLINE search was performed using key search terms.
    Results: Two patients with cochlear implants and MVFTT of the ipsilateral temporal bone or scalp were identified. One patient underwent MVFTT for advanced device extrusion with stable audiometric parameters rather than locoregional reconstruction or device explantation. The second patient had primary cochlear implantation at oncologic lateral temporal bone resection (LTBR) and MVFTT for locally advanced squamous cell carcinoma and concurrent profound sensorineural hearing loss (SNHL). A literature review identifies MVFTT as an option for advanced device extrusion, treatment of osteoradionecrosis, and reconstruction after primary oncologic surgery.
    Conclusion: MVFTT is an important reconstructive tool for patients with functional, exposed cochlear implants. Cochlear implantation for severe to profound SNHL should be considered at the time of primary oncologic surgery and MVFTT of the lateral temporal bone or scalp.
    Level of evidence: IV Laryngoscope, 130:1552-1557, 2020.
    MeSH term(s) Aged, 80 and over ; Cochlear Implants ; Female ; Free Tissue Flaps/blood supply ; Humans ; Male ; Microvessels ; Middle Aged ; Reconstructive Surgical Procedures/methods ; Retrospective Studies ; Scalp/surgery
    Language English
    Publishing date 2019-10-25
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.28300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Overview of COVID-19 testing and implications for otolaryngologists.

    Vinh, Daniel B / Zhao, Xiao / Kiong, Kimberley L / Guo, Theresa / Jozaghi, Yelda / Yao, Chris / Kelley, James M / Hanna, Ehab Y

    Head & neck

    2020  Volume 42, Issue 7, Page(s) 1629–1633

    Abstract: Background: Testing for SARS-CoV-2 is important for decision making prior to surgery in otolaryngology. An understanding of current and developing testing methods is important for interpreting test results.: Methods: We performed a literature review ... ...

    Abstract Background: Testing for SARS-CoV-2 is important for decision making prior to surgery in otolaryngology. An understanding of current and developing testing methods is important for interpreting test results.
    Methods: We performed a literature review of current evidence surrounding SARS-CoV-2 diagnostic testing highlighting its utility, limitations, and implications for otolaryngologists.
    Results: The currently accepted RT-PCR test for SARS-CoV-2 has varying sensitivity according to which subsite of the aerodigestive tract is sampled. Nasal swab sensitivities appear to be about 70%. Chest CT imaging for screening purposes is not currently recommended.
    Conclusion: Due to the current sensitivity of RT-PCR based testing for SARS-CoV-2, a negative test cannot rule out COVID-19. Full PPE should be worn during high-risk procedures such as aerosol generating procedures even if testing is negative. Patients who test positive during screening should have their surgeries postponed if possible until asymptomatic and have tested negative for SARS-CoV-2.
    MeSH term(s) Antibodies/blood ; Betacoronavirus/genetics ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Cough/virology ; Diarrhea/virology ; Dyspnea/virology ; Fatigue/virology ; Fever/virology ; Headache/virology ; Hemoptysis/virology ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Lung/diagnostic imaging ; Myalgia/virology ; Nasopharynx/virology ; Otorhinolaryngologic Surgical Procedures ; Pandemics ; Pneumonia, Viral/diagnosis ; Preoperative Care ; Quarantine ; RNA, Viral/isolation & purification ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Sputum/virology ; Tomography, X-Ray Computed
    Chemical Substances Antibodies ; Immunoglobulin G ; Immunoglobulin M ; RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.26213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Overview of COVID-19 testing and implications for otolaryngologists

    Vinh, Daniel B / Zhao, Xiao / Kiong, Kimberley L / Guo, Theresa / Jozaghi, Yelda / Yao, Chris / Kelley, James M / Hanna, Ehab Y

    Head Neck

    Abstract: BACKGROUND: Testing for SARS-CoV-2 is important for decision making prior to surgery in otolaryngology. An understanding of current and developing testing methods is important for interpreting test results. METHODS: We performed a literature review of ... ...

    Abstract BACKGROUND: Testing for SARS-CoV-2 is important for decision making prior to surgery in otolaryngology. An understanding of current and developing testing methods is important for interpreting test results. METHODS: We performed a literature review of current evidence surrounding SARS-CoV-2 diagnostic testing highlighting its utility, limitations, and implications for otolaryngologists. RESULTS: The currently accepted RT-PCR test for SARS-CoV-2 has varying sensitivity according to which subsite of the aerodigestive tract is sampled. Nasal swab sensitivities appear to be about 70%. Chest CT imaging for screening purposes is not currently recommended. CONCLUSION: Due to the current sensitivity of RT-PCR based testing for SARS-CoV-2, a negative test cannot rule out COVID-19. Full PPE should be worn during high-risk procedures such as aerosol generating procedures even if testing is negative. Patients who test positive during screening should have their surgeries postponed if possible until asymptomatic and have tested negative for SARS-CoV-2.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #133574
    Database COVID19

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  4. Article ; Online: Overview of COVID ‐19 testing and implications for otolaryngologists

    Vinh, Daniel B. / Zhao, Xiao / Kiong, Kimberley L. / Guo, Theresa / Jozaghi, Yelda / Yao, Chris / Kelley, James M. / Hanna, Ehab Y.

    Head & Neck

    2020  Volume 42, Issue 7, Page(s) 1629–1633

    Keywords Otorhinolaryngology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ISSN 1043-3074
    DOI 10.1002/hed.26213
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Oncologic Safety of Close Margins in Patients With Low- to Intermediate-Grade Major Salivary Gland Carcinoma.

    Sajisevi, Mirabelle / Nguyen, Kenny / Callas, Peter / Holcomb, Andrew J / Vural, Emre / Davis, Kyle P / Thomas, Carissa M / Plonowska-Hirschfeld, Karolina A / Stein, John S / Eskander, Antoine / Kakarala, Kiran / Enepekides, Danny J / Hier, Michael P / Ryan, William R / Asarkar, Ameya A / Aulet, Ricardo / Bell, Rebecca K / Blasco, Michael A / Bowmaster, Vanessa B /
    Burruss, Clayton P / Chung, Jeffson / Chan, Kimberly / Chang, Brent A / Coffey, Charles S / Cognetti, David M / Cooper, Dylan J / Cordero, Joehassin / Donovan, John / Du, Yue Jennifer / Dundar, Yusuf / Dedivitis, Rogerio A / Edwards, Heather A / Erovic, Boban M / Feinberg, Philip A / Garvey, Emily A / Goldstein, David P / Goodman, Joseph F / Goulart, Rafael N / Goyal, Neerav / Grasl, Stefan / Giurintano, Jonathan P / Gupta, Nikita / Habib, Andy M / Hackman, Trevor G / Hara, Jared H / Henson, Christina / Hinni, Michael L / Hua, Nadia / Johnson-Obaseki, Stephanie / Juloori, Aditya / Kalman, Noah S / Kejner, Alexandra E / Khaja, Sobia F / Ku, Jamie A / Lambert, Arnaud / Luu, Bao K / Magliocca, Kelly R / Dos Santos, Luiz R Medina / Michael, Cara / Miles, Brett A / de Melo, Giulianno Molina / Moore, Michael G / Morand, Gregoire B / Moura, Kauê / Mukdad, Laith / Noroozi, Hesameddin / Patel, Rusha / Paydarfar, Joseph A / Sadeghi, Nader / Savaria, Fabrice N / Schmitt, Nicole C / Shapiro, Justin / Shaver, Timothy B / Stoeckli, Sandro J / St John, Maie / Stokes, William Alvo / Sulibhavi, Anita / Tasoulas, Jason / Vendra, Varun / Vinh, Daniel B / Virgen, Celina G / Wooten, Christian / Woody, Neil M / Young, Geoffrey D

    JAMA otolaryngology-- head & neck surgery

    2023  Volume 150, Issue 2, Page(s) 107–116

    Abstract: Importance: Postoperative radiation therapy for close surgical margins in low- to intermediate-grade salivary carcinomas lacks multi-institutional supportive evidence.: Objective: To evaluate the oncologic outcomes for low- and intermediate-grade ... ...

    Abstract Importance: Postoperative radiation therapy for close surgical margins in low- to intermediate-grade salivary carcinomas lacks multi-institutional supportive evidence.
    Objective: To evaluate the oncologic outcomes for low- and intermediate-grade salivary carcinomas with close and positive margins.
    Design, setting, and participants: The American Head and Neck Society Salivary Gland Section conducted a retrospective cohort study from 2010 to 2019 at 41 centers. Margins were classified as R0 (negative), R1 (microscopically positive), or R2 (macroscopically positive). R0 margins were subclassified into clear (>1 mm) or close (≤1 mm). Data analysis was performed from June to October 2023.
    Main outcomes and measures: Main outcomes were risk factors for local recurrence.
    Results: A total of 865 patients (median [IQR] age at surgery, 56 [43-66] years; 553 female individuals [64%] and 312 male individuals [36%]) were included. Of these, 801 (93%) had parotid carcinoma and 64 (7%) had submandibular gland carcinoma, and 748 (86%) had low-grade tumors and 117 (14%) had intermediate-grade tumors, with the following surgical margins: R0 in 673 (78%), R1 in 168 (19%), and R2 in 24 (3%). Close margins were found in 395 of 499 patients with R0 margins (79%), for whom margin distances were measured. A total of 305 patients (35%) underwent postoperative radiation therapy. Of all 865 patients, 35 (4%) had local recurrence with a median (IQR) follow-up of 35.3 (13.9-59.1) months. In patients with close margins as the sole risk factor for recurrence, the local recurrence rates were similar between those who underwent postoperative radiation therapy (0 of 46) or observation (4 of 165 [2%]). Patients with clear margins (n = 104) had no recurrences. The local recurrence rate in patients with R1 or R2 margins was better in those irradiated (2 of 128 [2%]) compared to observed (13 of 64 [20%]) (hazard ratio [HR], 0.05; 95% CI, 0.01-0.24). Multivariable analysis for local recurrence found the following independent factors: age at diagnosis (HR for a 10-year increase in age, 1.33; 95% CI, 1.06-1.67), R1 vs R0 (HR, 5.21; 95% CI, 2.58-10.54), lymphovascular invasion (HR, 4.47; 95% CI, 1.43-13.99), and postoperative radiation therapy (HR, 0.10; 95% CI, 0.04-0.29). The 3-year local recurrence-free survivals for the study population were 96% vs 97% in the close margin group.
    Conclusions and relevance: In this cohort study of patients with low- and intermediate-grade major salivary gland carcinoma, postoperative radiation therapy for positive margins was associated with decreased risk of local recurrence. In isolation from other risk factors for local recurrence, select patients with close surgical margins (≤1 mm) may safely be considered for observation.
    MeSH term(s) Humans ; Male ; Female ; Infant ; Adult ; Middle Aged ; Aged ; Retrospective Studies ; Cohort Studies ; Margins of Excision ; Carcinoma/surgery ; Salivary Gland Neoplasms/radiotherapy ; Salivary Gland Neoplasms/surgery ; Salivary Gland Neoplasms/pathology
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2023.3952
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    Ul II Zs.87: Show issues Location:
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