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  1. Article ; Online: The Influence of Heteroresistance on Minimum Inhibitory Concentration, Investigated Using Weak-Acid Stress in Food Spoilage Yeasts.

    Violet, Joseph / Smid, Joost / Pielaat, Annemarie / Sanders, Jan-Willem / Avery, Simon V

    Applied and environmental microbiology

    2023  Volume 89, Issue 6, Page(s) e0012523

    Abstract: Populations of microbial cells may resist environmental stress by maintaining a high population-median resistance ( ... ...

    Abstract Populations of microbial cells may resist environmental stress by maintaining a high population-median resistance (IC
    MeSH term(s) Sorbic Acid ; Food ; Refuse Disposal ; Yeasts ; Microbial Sensitivity Tests ; Zygosaccharomyces/genetics
    Chemical Substances Sorbic Acid (X045WJ989B)
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.00125-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 201: Show issues Location:
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  2. Article ; Online: Cellular Responses and Targets in Food Spoilage Yeasts Exposed to Antifungal Prenylated Isoflavonoids.

    Kalli, Sylvia / Vallieres, Cindy / Violet, Joseph / Sanders, Jan-Willem / Chapman, John / Vincken, Jean-Paul / Avery, Simon V / Araya-Cloutier, Carla

    Microbiology spectrum

    2023  Volume 11, Issue 4, Page(s) e0132723

    Abstract: Prenylated isoflavonoids are phytochemicals with promising antifungal properties. Recently, it was shown that glabridin and wighteone disrupted the plasma membrane (PM) of the food spoilage yeast Zygosaccharomyces parabailii in distinct ways, which led ... ...

    Abstract Prenylated isoflavonoids are phytochemicals with promising antifungal properties. Recently, it was shown that glabridin and wighteone disrupted the plasma membrane (PM) of the food spoilage yeast Zygosaccharomyces parabailii in distinct ways, which led us to investigate further their modes of action (MoA). Transcriptomic profiling with
    MeSH term(s) Saccharomyces cerevisiae/metabolism ; Antifungal Agents/pharmacology ; Antifungal Agents/metabolism ; Food ; Tryptophan/metabolism ; Refuse Disposal ; Yeasts ; Lipids ; Membrane Transport Proteins/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Antifungal Agents ; glabridin (HOC5567T41) ; Tryptophan (8DUH1N11BX) ; Lipids ; Lem3 protein, S cerevisiae ; Membrane Transport Proteins ; Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01327-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Impact on Arabidopsis growth and stress resistance of depleting the Maf1 repressor of RNA polymerase III

    Blayney, Joseph / Geary, James / Chrisp, Ruby / Violet, Joseph / Barratt, Liam / Tavukçu, Laçin / Paine, Katherine / Vaistij, Fabián E. / Graham, Ian A. / Denby, Katherine J. / White, Robert J.

    Gene. 2022 Mar. 20, v. 815

    2022  

    Abstract: Maf1 is a transcription factor that is conserved in sequence and structure between yeasts, animals and plants. Its principal molecular function is also well conserved, being to bind and repress RNA polymerase (pol) III, thereby inhibiting synthesis of ... ...

    Abstract Maf1 is a transcription factor that is conserved in sequence and structure between yeasts, animals and plants. Its principal molecular function is also well conserved, being to bind and repress RNA polymerase (pol) III, thereby inhibiting synthesis of tRNAs and other noncoding RNAs. Restrictions on tRNA production and hence protein synthesis can provide a mechanism to preserve resources under conditions that are suboptimal for growth. Accordingly, Maf1 is found in some organisms to influence growth and/or stress survival. Because of their sessile nature, plants are especially vulnerable to environmental changes and molecular adaptations that enhance growth under benign circumstances can increase sensitivity to external challenges. We tested if Maf1 depletion in the model plant Arabidopsis affects growth, pathogen resistance and tolerance of drought or soil salinity, a common physiological challenge that imposes both osmotic and ionic stress. We find that disruption of the Maf1 gene or RNAi-mediated depletion of its transcript is well-tolerated and confers a modest growth advantage without compromising resistance to common biotic and abiotic challenges.
    Keywords Arabidopsis ; DNA-directed RNA polymerase ; drought ; genes ; pathogens ; protein synthesis ; soil salinity ; stress tolerance ; transcription factors
    Language English
    Dates of publication 2022-0320
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2021.146130
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  4. Article ; Online: Cellular Responses and Targets in Food Spoilage Yeasts Exposed to Antifungal Prenylated Isoflavonoids

    Kalli, Sylvia / Vallieres, Cindy / Violet, Joseph / Sanders, Jan Willem / Chapman, John / Vincken, Jean Paul / Avery, Simon V. / Araya-Cloutier, Carla

    Microbiology Spectrum

    2023  Volume 11, Issue 4

    Abstract: Prenylated isoflavonoids are phytochemicals with promising antifungal properties. Recently, it was shown that glabridin and wighteone disrupted the plasma membrane (PM) of the food spoilage yeast Zygosaccharomyces parabailii in distinct ways, which led ... ...

    Abstract Prenylated isoflavonoids are phytochemicals with promising antifungal properties. Recently, it was shown that glabridin and wighteone disrupted the plasma membrane (PM) of the food spoilage yeast Zygosaccharomyces parabailii in distinct ways, which led us to investigate further their modes of action (MoA). Transcriptomic profiling with Z. parabailii showed that genes encoding transmembrane ATPase transporters, including Yor1, and genes homologous to the pleiotropic drug resistance (PDR) subfamily in Saccharomyces cerevisiae were upregulated in response to both compounds. Gene functions involved in fatty acid and lipid metabolism, proteostasis, and DNA replication processes were overrepresented among genes upregulated by glabridin and/or wighteone. Chemogenomic analysis using the genome-wide deletant collection for S. cerevisiae further suggested an important role for PM lipids and PM proteins. Deletants of gene functions involved in biosynthesis of very-long-chain fatty acids (constituents of PM sphingolipids) and ergosterol were hypersensitive to both compounds. Using lipid biosynthesis inhibitors, we corroborated roles for sphingolipids and ergosterol in prenylated isoflavonoid action. The PM ABC transporter Yor1 and Lem3-dependent flippases conferred sensitivity and resistance, respectively, to the compounds, suggesting an important role for PM phospholipid asymmetry in their MoAs. Impaired tryptophan availability, likely linked to perturbation of the PM tryptophan permease Tat2, was evident in response to glabridin. Finally, substantial evidence highlighted a role of the endoplasmic reticulum (ER) in cellular responses to wighteone, including gene functions associated with ER membrane stress or with phospholipid biosynthesis, the primary lipid of the ER membrane. IMPORTANCE Preservatives, such as sorbic acid and benzoic acid, inhibit the growth of undesirable yeast and molds in foods. Unfortunately, preservative tolerance and resistance in food spoilage yeast, such as Zygosaccharomyces parabailii, is a ...
    Keywords Saccharomyces cerevisiae ; Zygosaccharomyces parabailii ; antifungal ; chemogenomics ; glabridin ; prenylated isoflavonoids ; transcriptomics ; wighteone
    Subject code 571
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2807133-5
    ISSN 2165-0497
    ISSN 2165-0497
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Evolving challenges and strategies for fungal control in the food supply chain.

    Davies, Catheryn R / Wohlgemuth, Franziska / Young, Taran / Violet, Joseph / Dickinson, Matthew / Sanders, Jan-Willem / Vallieres, Cindy / Avery, Simon V

    Fungal biology reviews

    2021  Volume 36, Page(s) 15–26

    Abstract: Fungi that spoil foods or infect crops can have major socioeconomic impacts, posing threats to food security. The strategies needed to manage these fungi are evolving, given the growing incidence of fungicide resistance, tightening regulations of ... ...

    Abstract Fungi that spoil foods or infect crops can have major socioeconomic impacts, posing threats to food security. The strategies needed to manage these fungi are evolving, given the growing incidence of fungicide resistance, tightening regulations of chemicals use and market trends imposing new food-preservation challenges. For example, alternative methods for crop protection such as RNA-based fungicides, biocontrol, or stimulation of natural plant defences may lessen concerns like environmental toxicity of chemical fungicides. There is renewed focus on natural product preservatives and fungicides, which can bypass regulations for 'clean label' food products. These require investment to find effective, safe activities within complex mixtures such as plant extracts. Alternatively, physical measures may be one key for fungal control, such as polymer materials which passively resist attachment and colonization by fungi. Reducing or replacing traditional chlorine treatments (
    Language English
    Publishing date 2021-02-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 1749-4613
    ISSN 1749-4613
    DOI 10.1016/j.fbr.2021.01.003
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  6. Article: Evolving challenges and strategies for fungal control in the food supply chain

    Davies, Catheryn R / Wohlgemuth, Franziska / Young, Taran / Violet, Joseph / Dickinson, Matthew / Sanders, Jan-Willem / Vallieres, Cindy / Avery, Simon V

    Fungal biology reviews. 2021 June, v. 36

    2021  

    Abstract: Fungi that spoil foods or infect crops can have major socioeconomic impacts, posing threats to food security. The strategies needed to manage these fungi are evolving, given the growing incidence of fungicide resistance, tightening regulations of ... ...

    Abstract Fungi that spoil foods or infect crops can have major socioeconomic impacts, posing threats to food security. The strategies needed to manage these fungi are evolving, given the growing incidence of fungicide resistance, tightening regulations of chemicals use and market trends imposing new food-preservation challenges. For example, alternative methods for crop protection such as RNA-based fungicides, biocontrol, or stimulation of natural plant defences may lessen concerns like environmental toxicity of chemical fungicides. There is renewed focus on natural product preservatives and fungicides, which can bypass regulations for ‘clean label’ food products. These require investment to find effective, safe activities within complex mixtures such as plant extracts. Alternatively, physical measures may be one key for fungal control, such as polymer materials which passively resist attachment and colonization by fungi. Reducing or replacing traditional chlorine treatments (e.g. of post-harvest produce) is desirable to limit formation of disinfection by-products. In addition, the current growth in lower sugar food products can alter metabolic routing of carbon utilization in spoilage yeasts, with implications for efficacy of food preservatives acting via metabolism. The use of preservative or fungicide combinations, while involving more than one chemical, can reduce total chemicals usage where these act synergistically. Such approaches might also help target different subpopulations within heteroresistant fungal populations. These approaches are discussed in the context of current challenges for food preservation, focussing on pre-harvest fungal control, fresh produce and stored food preservation. Several strategies show growing potential for mitigating or reversing the risks posed by fungi in the food supply chain.
    Keywords biological control ; carbon ; chlorine ; disinfection ; ecotoxicology ; food preservation ; food security ; food supply chain ; fresh produce ; fungi ; fungicide resistance ; fungicides ; markets ; metabolism ; mycology ; plant protection ; polymers ; spoilage ; sugars
    Language English
    Dates of publication 2021-06
    Size p. 15-26.
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ISSN 1749-4613
    DOI 10.1016/j.fbr.2021.01.003
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Impact on Arabidopsis growth and stress resistance of depleting the Maf1 repressor of RNA polymerase III.

    Blayney, Joseph / Geary, James / Chrisp, Ruby / Violet, Joseph / Barratt, Liam / Tavukçu, Laçin / Paine, Katherine / Vaistij, Fabián E / Graham, Ian A / Denby, Katherine J / White, Robert J

    Gene

    2022  Volume 815, Page(s) 146130

    Abstract: Maf1 is a transcription factor that is conserved in sequence and structure between yeasts, animals and plants. Its principal molecular function is also well conserved, being to bind and repress RNA polymerase (pol) III, thereby inhibiting synthesis of ... ...

    Abstract Maf1 is a transcription factor that is conserved in sequence and structure between yeasts, animals and plants. Its principal molecular function is also well conserved, being to bind and repress RNA polymerase (pol) III, thereby inhibiting synthesis of tRNAs and other noncoding RNAs. Restrictions on tRNA production and hence protein synthesis can provide a mechanism to preserve resources under conditions that are suboptimal for growth. Accordingly, Maf1 is found in some organisms to influence growth and/or stress survival. Because of their sessile nature, plants are especially vulnerable to environmental changes and molecular adaptations that enhance growth under benign circumstances can increase sensitivity to external challenges. We tested if Maf1 depletion in the model plant Arabidopsis affects growth, pathogen resistance and tolerance of drought or soil salinity, a common physiological challenge that imposes both osmotic and ionic stress. We find that disruption of the Maf1 gene or RNAi-mediated depletion of its transcript is well-tolerated and confers a modest growth advantage without compromising resistance to common biotic and abiotic challenges.
    MeSH term(s) Arabidopsis/growth & development ; Arabidopsis/physiology ; Arabidopsis Proteins/genetics ; Botrytis/pathogenicity ; Gene Expression Regulation, Plant ; MADS Domain Proteins/genetics ; Mutation ; Plant Diseases/genetics ; Plant Diseases/microbiology ; Plant Leaves/genetics ; Plant Leaves/growth & development ; Plants, Genetically Modified ; RNA Interference ; RNA Polymerase III/genetics ; RNA Polymerase III/metabolism ; RNA, Transfer/genetics ; Salinity ; Soil/chemistry ; Stress, Physiological/genetics
    Chemical Substances Arabidopsis Proteins ; FLM protein, Arabidopsis ; MADS Domain Proteins ; Soil ; RNA, Transfer (9014-25-9) ; RNA Polymerase III (EC 2.7.7.6)
    Language English
    Publishing date 2022-01-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2021.146130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1357: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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