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  1. Article: Editorial: Gut permeability-related endotoxemia and cardiovascular disease: A new clinical challenge.

    Violi, Francesco / Nocella, Cristina

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1118625

    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1118625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial commentary: Nox2: A new challenge for antiplatelet treatment?

    Violi, Francesco

    Trends in cardiovascular medicine

    2018  Volume 28, Issue 7, Page(s) 435–436

    MeSH term(s) Humans ; NADPH Oxidase 2 ; Oxidative Stress ; Platelet Activation ; Thrombosis
    Chemical Substances NADPH Oxidase 2 (EC 1.6.3.-)
    Language English
    Publishing date 2018-03-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2018.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Metabolic Endotoxemia and Arterial Stiffness in Diabetes.

    Loffredo, Lorenzo / Violi, Francesco

    Circulation research

    2022  Volume 131, Issue 6, Page(s) 555–557

    MeSH term(s) Blood Pressure ; Diabetes Mellitus ; Endotoxemia ; Humans ; Hypertension ; Vascular Stiffness
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.122.321702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Endotoxemia and Platelets: 2 Players of Intrahepatic Microthrombosis in NAFLD.

    Violi, Francesco / Pastori, Daniele / Pignatelli, Pasquale / Cammisotto, Vittoria

    JACC. Basic to translational science

    2023  Volume 9, Issue 3, Page(s) 404–413

    Abstract: Gut dysbiosis-related intestinal barrier dysfunction with increased translocation of bacterial products such as lipopolysaccharide (LPS) into systemic circulation is emerging as pathogenic factor of nonalcoholic fatty liver disease (NAFLD). Experimental ... ...

    Abstract Gut dysbiosis-related intestinal barrier dysfunction with increased translocation of bacterial products such as lipopolysaccharide (LPS) into systemic circulation is emerging as pathogenic factor of nonalcoholic fatty liver disease (NAFLD). Experimental and clinical studies suggested a potential role of LPS as a trigger eliciting in situ liver inflammation upon interaction with its receptor toll-like receptor 4. Also, LPS has been reported to prime platelets to respond to the common agonists indicating that it behaves as a prothrombotic molecule. Of note, recent studies suggested platelet-related intrahepatic thrombosis triggered by LPS as a mechanism implicated in the process of liver inflammation. This review describes: 1) the impact of gut barrier dysfunction and endotoxemia in the process of NAFLD; 2) the relationship between endotoxemia and platelet activation in NAFLD; 3) clinical evidence for the use of antiplatelet drugs in NAFLD/nonalcoholic steatohepatitis patients; and 4) the potential therapeutic approach to modulate endotoxemia and eventually platelet activation.
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: New Insight Into Platelet Activation and Thrombosis: Is There a Role for IL-37?

    Pignatelli, Pasquale / Violi, Francesco / Cammisotto, Vittoria

    Circulation research

    2023  Volume 132, Issue 9, Page(s) 1107–1109

    MeSH term(s) Humans ; Platelet Activation ; Thrombosis ; Blood Platelets/physiology ; Inflammation
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.322780
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  6. Article ; Online: Platelet defects in cirrhosis: Fact or fiction.

    Violi, Francesco / Pignatelli, Pasquale / Cammisotto, Vittoria

    Journal of hepatology

    2023  Volume 79, Issue 5, Page(s) e197–e198

    Language English
    Publishing date 2023-03-08
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.02.037
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  7. Article ; Online: COVID-19 and Long-COVID Thrombosis: From Clinical and Basic Science to Therapeutics.

    Violi, Francesco / Harenberg, Job / Pignatelli, Pasquale / Cammisotto, Vittoria

    Thrombosis and haemostasis

    2023  Volume 124, Issue 4, Page(s) 286–296

    Abstract: Coronavirus infectious disease-19 (COVID-19) is a pandemic characterized by serious lung disease and thrombotic events in the venous and circulation trees, which represent a harmful clinical sign of poor outcome. Thrombotic events are more frequent in ... ...

    Abstract Coronavirus infectious disease-19 (COVID-19) is a pandemic characterized by serious lung disease and thrombotic events in the venous and circulation trees, which represent a harmful clinical sign of poor outcome. Thrombotic events are more frequent in patients with severe disease requiring intensive care units and are associated with platelet and clotting activation. However, after resolution of acute infection, patients may still have clinical sequelae, the so-called long-COVID-19, including thrombotic events again in the venous and arterial circulation. The mechanisms accounting for thrombosis in acute and long COVID-19 have not been fully clarified; interactions of COVID-19 with angiotensin converting enzyme 2 or toll-like receptor family or infection-induced cytokine storm have been suggested to be implicated in endothelial cells, leucocytes, and platelets to elicit clotting activation in acute as well in chronic phase of the disease. In acute COVID-19, prophylactic or full doses of anticoagulants exert beneficial effects even if the dosage choice is still under investigation; however, a residual risk still remains suggesting a need for a more appropriate therapeutic approach. In long COVID-19 preliminary data provided useful information in terms of antiplatelet treatment but definition of candidates for thrombotic prophylaxis is still undefined.
    MeSH term(s) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Endothelial Cells ; SARS-CoV-2 ; Anticoagulants/therapeutic use ; Thrombosis/drug therapy ; Communicable Diseases
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-11-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0043-1776713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Waves of SARS-CoV-2 Infection and Blood Coagulation-A Link and Beyond.

    Harenberg, Job / Violi, Francesco

    Thrombosis and haemostasis

    2021  Volume 121, Issue 1, Page(s) 4–6

    MeSH term(s) Anticoagulants/therapeutic use ; Blood Coagulation/drug effects ; COVID-19/blood ; COVID-19/drug therapy ; COVID-19/mortality ; COVID-19/virology ; Host-Pathogen Interactions ; Humans ; SARS-CoV-2/pathogenicity ; Thromboembolism/blood ; Thromboembolism/mortality ; Thromboembolism/prevention & control ; Thromboembolism/virology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-01-21
    Publishing country Germany
    Document type Editorial
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0040-1721778
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  9. Article ; Online: Sharing Clinical Data.

    Violi, Francesco

    European journal of internal medicine

    2016  Volume 32, Page(s) e10

    MeSH term(s) Biomedical Research ; Humans ; Information Dissemination
    Language English
    Publishing date 2016-07
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2016.03.013
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  10. Article ; Online: Effect of severe thrombocytopenia on bleeding in chronic liver disease after low risk surgical procedures: a meta-analysis.

    Loffredo, Lorenzo / Maggio, Enrico / Vestri, Anna Rita / Di Rocco, Arianna / Pignatelli, Pasquale / Violi, Francesco

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2024  

    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Letter
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2024.02.009
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