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  1. Article: Lipase C, Hepatic Type −250A/G (rs2070895) Variant Enhances Carotid Atherosclerosis in Normolipidemic and Asymptomatic Individuals from Brazil

    Zago, Vanessa H. S. / Parra, Eliane S. / Virgínio, Vítor W. M. / Vendrame, Felipe / Gomes, Érica I. L. / Scherrer, Daniel Z. / Marson, Fernando A. L. / de Faria, Eliana C.

    Lipids. 2020 May, v. 55, no. 3

    2020  

    Abstract: The common genetic variant in the promoter region of the hepatic lipase gene [LIPC −250G/A(rs2070895)] has an ambiguous association with cardiovascular disease. In this context, our study was performed to identify the relationships between the rs2070895 ... ...

    Abstract The common genetic variant in the promoter region of the hepatic lipase gene [LIPC −250G/A(rs2070895)] has an ambiguous association with cardiovascular disease. In this context, our study was performed to identify the relationships between the rs2070895 with carotid atherosclerosis, plasma lipids, and parameters of reverse cholesterol transport. A total of 285 normolipidemic and asymptomatic participants from an initial sample of 598,288 individuals (inclusion criteria: LDL‐C ≤130 mg/dL and triglycerides ≤150 mg/dL; age: 20–75 years, both genders; confirmation of clinical, anthropometric and laboratory data; attended all visits; DNA was achieved to perform genetic analysis) were enrolled and the rs2070895 variant was genotyped by TaqMan® OpenArray® Plataform. Carotid intima‐media thickness and the screening of atherosclerotic plaques were determined by B‐mode ultrasonography. The rs2070895 genotype frequencies were 0.44, 0.41, and 0.15 (GG, GA, and AA, respectively). Logistic regression analysis showed that the risk of having plaques was increased in participants carrying the AA or AG genotypes (OR = 3.90; 95% CI = 1.54–10.33), despite an increase in high‐density lipoprotein cholesterol levels, HDL diameter and apolipoprotein A‐I, as compared to the GG genotype. Hepatic lipase and endogenous lecithin cholesterol acyl transferase activities were reduced (38% and 19%, respectively) and lipoprotein lipase was increased by 30% (AA vs GG). Our results provide evidence that the AA or AG genotypes of the rs2070895 were associated with carotid atherosclerosis in apparently healthy participants, probably as a consequence of reduced reverse cholesterol transport and accumulation of HDL subfraction 2 rich in triglycerides and depleted in cholesteryl esters that could become dysfunctional.
    Keywords DNA ; apolipoprotein A-I ; atherosclerosis ; genes ; genetic analysis ; genotype ; genotyping ; high density lipoprotein cholesterol ; lecithins ; lipoprotein lipase ; promoter regions ; regression analysis ; risk ; ultrasonography ; Brazil
    Language English
    Dates of publication 2020-05
    Size p. 225-237.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 241539-2
    ISSN 1558-9307 ; 0024-4201
    ISSN (online) 1558-9307
    ISSN 0024-4201
    DOI 10.1002/lipd.12232
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 645: Show issues Location:
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  2. Article ; Online: Lipase C, Hepatic Type -250A/G (rs2070895) Variant Enhances Carotid Atherosclerosis in Normolipidemic and Asymptomatic Individuals from Brazil.

    Zago, Vanessa H S / Parra, Eliane S / Virgínio, Vítor W M / Vendrame, Felipe / Gomes, Érica I L / Scherrer, Daniel Z / Marson, Fernando A L / de Faria, Eliana C

    Lipids

    2020  Volume 55, Issue 3, Page(s) 225–237

    Abstract: The common genetic variant in the promoter region of the hepatic lipase gene [LIPC -250G/A(rs2070895)] has an ambiguous association with cardiovascular disease. In this context, our study was performed to identify the relationships between the rs2070895 ... ...

    Abstract The common genetic variant in the promoter region of the hepatic lipase gene [LIPC -250G/A(rs2070895)] has an ambiguous association with cardiovascular disease. In this context, our study was performed to identify the relationships between the rs2070895 with carotid atherosclerosis, plasma lipids, and parameters of reverse cholesterol transport. A total of 285 normolipidemic and asymptomatic participants from an initial sample of 598,288 individuals (inclusion criteria: LDL-C ≤130 mg/dL and triglycerides ≤150 mg/dL; age: 20-75 years, both genders; confirmation of clinical, anthropometric and laboratory data; attended all visits; DNA was achieved to perform genetic analysis) were enrolled and the rs2070895 variant was genotyped by TaqMan® OpenArray® Plataform. Carotid intima-media thickness and the screening of atherosclerotic plaques were determined by B-mode ultrasonography. The rs2070895 genotype frequencies were 0.44, 0.41, and 0.15 (GG, GA, and AA, respectively). Logistic regression analysis showed that the risk of having plaques was increased in participants carrying the AA or AG genotypes (OR = 3.90; 95% CI = 1.54-10.33), despite an increase in high-density lipoprotein cholesterol levels, HDL diameter and apolipoprotein A-I, as compared to the GG genotype. Hepatic lipase and endogenous lecithin cholesterol acyl transferase activities were reduced (38% and 19%, respectively) and lipoprotein lipase was increased by 30% (AA vs GG). Our results provide evidence that the AA or AG genotypes of the rs2070895 were associated with carotid atherosclerosis in apparently healthy participants, probably as a consequence of reduced reverse cholesterol transport and accumulation of HDL subfraction 2 rich in triglycerides and depleted in cholesteryl esters that could become dysfunctional.
    MeSH term(s) Adult ; Aged ; Asymptomatic Diseases ; Brazil ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/genetics ; Cholesterol/blood ; Female ; Genetic Association Studies ; Humans ; Lipase/genetics ; Lipids/blood ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Young Adult
    Chemical Substances LIPC protein, human ; Lipids ; Cholesterol (97C5T2UQ7J) ; Lipase (EC 3.1.1.3)
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 241539-2
    ISSN 1558-9307 ; 0024-4201
    ISSN (online) 1558-9307
    ISSN 0024-4201
    DOI 10.1002/lipd.12232
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    Zs.A 645: Show issues Location:
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  3. Article: Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity

    de Lima-Junior, Jose Carlos / Virginio, Vitor W.M / Moura, Filipe A / Bertolami, Adriana / Bertolami, Marcelo / Coelho-Filho, Otavio R / Zanotti, Ilaria / Nadruz, Wilson / de Faria, Eliana Cotta / de Carvalho, Luiz Sergio F / Sposito, Andrei C

    The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University Nutrition, metabolism, and cardiovascular diseases. 2019 Sept. 16,

    2019  

    Abstract: Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. We investigated if potentially ...

    Abstract Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. We investigated if potentially other HDL protective actions may be affected with weight gain and these changes may occur even before the obesity range in a cross-sectional analysis.Lipid profile, body mass index (BMI), biochemical measurements, and carotid intima-media thickness (cIMT) were obtained in this cross-sectional study with 899 asymptomatic individuals. Lipoproteins were separated by ultracentrifugation and HDL physical-chemical characterization, CEC, antioxidant activity, anti-inflammatory activity, HDL-mediated platelet aggregation inhibition were measured in a randomly-selected subgroup (n = 101).Individuals with increased HDL-C had an attenuated increase in cIMT with elevation of BMI (interaction effect β = −0.054; CI 95% −0.0815, −0.0301). CEC, HDL-C, HDL size and HDL-antioxidant activity were negatively associated with cIMT. BMI was inversely correlated with HDL-mediated inhibition of platelet aggregation (Spearman's rho −0.157, p < 0.03) and CEC (Spearman's rho −0.32, p < 0.001), but surprisingly it was directly correlated with the antioxidant activity (Spearman's rho 0.194, p = 0.052). Thus, even in non-obese, non-diabetic individuals, increased BMI is associated with a wide change in protective functions of HDL, reducing CEC and increasing antioxidant activity. In these subjects, decreased HDL concentration, size or function are related to increased atherosclerotic burden.Our findings demonstrate that in non-obese, non-diabetic individuals, the increasing values of BMI are associated with impaired protective functions of HDL and concomitant increase in atherosclerotic burden.
    Keywords anti-inflammatory activity ; antioxidant activity ; atherogenesis ; body mass index ; cholesterol ; cross-sectional studies ; high density lipoprotein ; obesity ; patients ; platelet aggregation ; ultracentrifugation ; weight gain
    Language English
    Dates of publication 2019-0916
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 1067704-5
    ISSN 0939-4753
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2019.09.017
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3149: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity.

    de Lima-Junior, Jose Carlos / Virginio, Vitor W M / Moura, Filipe A / Bertolami, Adriana / Bertolami, Marcelo / Coelho-Filho, Otavio R / Zanotti, Ilaria / Nadruz, Wilson / de Faria, Eliana Cotta / de Carvalho, Luiz Sergio F / Sposito, Andrei C

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2019  Volume 30, Issue 2, Page(s) 254–264

    Abstract: Background and aim: Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. We ... ...

    Abstract Background and aim: Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. We investigated if potentially other HDL protective actions may be affected with weight gain and these changes may occur even before the obesity range in a cross-sectional analysis.
    Methods and results: Lipid profile, body mass index (BMI), biochemical measurements, and carotid intima-media thickness (cIMT) were obtained in this cross-sectional study with 899 asymptomatic individuals. Lipoproteins were separated by ultracentrifugation and HDL physical-chemical characterization, CEC, antioxidant activity, anti-inflammatory activity, HDL-mediated platelet aggregation inhibition were measured in a randomly-selected subgroup (n = 101). Individuals with increased HDL-C had an attenuated increase in cIMT with elevation of BMI (interaction effect β = -0.054; CI 95% -0.0815, -0.0301). CEC, HDL-C, HDL size and HDL-antioxidant activity were negatively associated with cIMT. BMI was inversely correlated with HDL-mediated inhibition of platelet aggregation (Spearman's rho -0.157, p < 0.03) and CEC (Spearman's rho -0.32, p < 0.001), but surprisingly it was directly correlated with the antioxidant activity (Spearman's rho 0.194, p = 0.052). Thus, even in non-obese, non-diabetic individuals, increased BMI is associated with a wide change in protective functions of HDL, reducing CEC and increasing antioxidant activity. In these subjects, decreased HDL concentration, size or function are related to increased atherosclerotic burden.
    Conclusion: Our findings demonstrate that in non-obese, non-diabetic individuals, the increasing values of BMI are associated with impaired protective functions of HDL and concomitant increase in atherosclerotic burden.
    MeSH term(s) Adult ; Aged ; Antioxidants/analysis ; Biomarkers/blood ; Body Mass Index ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/physiopathology ; Carotid Intima-Media Thickness ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Dyslipidemias/blood ; Dyslipidemias/diagnosis ; Dyslipidemias/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Overweight/blood ; Overweight/diagnosis ; Overweight/physiopathology ; Platelet Aggregation ; Risk Assessment ; Risk Factors ; Weight Gain ; Young Adult
    Chemical Substances Antioxidants ; Biomarkers ; Cholesterol, HDL
    Language English
    Publishing date 2019-09-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2019.09.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Elevated CETP activity during acute phase of myocardial infarction is independently associated with endothelial dysfunction and adverse clinical outcome.

    Carvalho, Luiz Sergio F / Virginio, Vitor W M / Panzoldo, Natalia B / Figueiredo, Valeria N / Santos, Simone N / Modolo, Rodrigo G P / Andrade, Joalbo M / Quinaglia E Silva, Jose C / Nadruz-Junior, Wilson / de Faria, Eliana C / Sposito, Andrei C

    Atherosclerosis

    2014  Volume 237, Issue 2, Page(s) 777–783

    Abstract: Objective: Recent data suggests that cholesteryl ester transfer protein (CETP) activity may interact with acute stress conditions via inflammatory-oxidative response and thrombogenesis. We investigated this assumption in patients with ST-elevation ... ...

    Abstract Objective: Recent data suggests that cholesteryl ester transfer protein (CETP) activity may interact with acute stress conditions via inflammatory-oxidative response and thrombogenesis. We investigated this assumption in patients with ST-elevation myocardial infarction (STEMI).
    Methods: Consecutive patients with STEMI (n = 116) were enrolled <24-h of symptoms onset and were followed for 180 days. Plasma levels of C-reactive protein (CRP), interleukin-2 (IL-2), tumor necrosis factor (TNFα), 8-isoprostane, nitric oxide (NOx) and CETP activity were measured at enrollment (D1) and at fifth day (D5). Flow-mediated dilation (FMD) was assessed by ultrasound and coronary thrombus burden (CTB) was evaluated by angiography.
    Results: Neither baseline nor the change of CETP activity from D1 to D5 was associated with CRP, IL-2, TNFα, 8-isoprostane levels or CTB. The rise in NOx from D1 to D5 was inferior [3.5(-1; 10) vs. 5.5(-1; 12); p < 0.001] and FMD was lower [5.9(5.5) vs. 9.6(6.6); p = 0.047] in patients with baseline CETP activity above the median value than in their counterparts. Oxidized HDL was measured by thiobarbituric acid reactive substances (TBARS) in isolated HDL particles and increased from D1 to D5, and remaining elevated at D30. The change in TBARS content in HDL was associated with CETP activity (r = 0.72; p = 0.014) and FMD (r = -0.61; p = 0.046). High CETP activity at admission was associated with the incidence of sudden death and recurrent MI at 30 days (OR 12.8; 95% CI 1.25-132; p = 0.032) and 180 days (OR 3.3; 95% CI 1.03-10.7; p = 0.044).
    Conclusions: An enhanced CETP activity during acute phase of STEMI is independently associated with endothelial dysfunction and adverse clinical outcome.
    MeSH term(s) Aged ; Angiography ; C-Reactive Protein/metabolism ; Cholesterol Ester Transfer Proteins/blood ; Dinoprost/analogs & derivatives ; Dinoprost/blood ; Endothelium, Vascular/pathology ; Endothelium, Vascular/physiopathology ; Female ; Humans ; Interleukin-2/blood ; Lipoproteins, HDL/blood ; Male ; Middle Aged ; Myocardial Infarction/blood ; Nitric Oxide/blood ; Oxygen/chemistry ; Prospective Studies ; Registries ; Thiobarbituric Acid Reactive Substances/chemistry ; Treatment Outcome ; Tumor Necrosis Factor-alpha/blood ; Vascular Diseases/pathology
    Chemical Substances CETP protein, human ; Cholesterol Ester Transfer Proteins ; Interleukin-2 ; Lipoproteins, HDL ; Thiobarbituric Acid Reactive Substances ; Tumor Necrosis Factor-alpha ; 8-epi-prostaglandin F2alpha (27415-26-5) ; Nitric Oxide (31C4KY9ESH) ; C-Reactive Protein (9007-41-4) ; Dinoprost (B7IN85G1HY) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2014-12
    Publishing country Ireland
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2014.10.104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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