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  1. Artikel ; Online: Reproductive Strategies of Brazilian Lizards of the Genus Tropidurus Rodrigues, 1987 (Squamata, Tropiduridae) in the Temporal and Spatial Estrategias Reproductivas de las Lagartijas Brasileñas del Género Tropidurus Rodrigues, 1987 (Squamata, Tropiduridae) en lo Temporal y Espacial

    Adelina Ferreira / Virginia Ojeda Kihara / Mahmoud Mehanna

    International Journal of Morphology, Vol 29, Iss 4, Pp 1414-

    2011  Band 1421

    Abstract: Reproductive strategy is the set of adaptations that promote the most efficient way that the species will survive under the particular conditions of a determined environment. Understanding these adaptations is important and can help pinpoint populations ... ...

    Abstract Reproductive strategy is the set of adaptations that promote the most efficient way that the species will survive under the particular conditions of a determined environment. Understanding these adaptations is important and can help pinpoint populations indicator of environmental changes. Spermatogenesis is a measurable biological process of these adaptations in spatial and temporal scales. We analyzed the morphology of the testes and oviducts of the lizard species that comprise the genus Tropidurus, taking into account the geographical distribution and sympatric relations. For the analysis and the testes were removed from the middle part of the oviducts from Tropidurus etheridge, T. oreadicus, T. itambere, T. spinulosus and T. Guarani species, collected in different places in the Mato Grosso state, Brazil. The reproductive period is synchronous for males and females and occurs in September, October and November. Reproductive males were characterized. In the testes are seminiferous tubules with germ cells at different stages of spermatogenesis, with a high epithelium, at present light, free spermatozoa in the lumen and reduction of interstitial tissue. For females, the reproduction peak occurs when the oviduct epithelium is high with secretions and basal nucleus. These months are characterized in the sampled areas over a period of heavy rain and high temperatures. The decline of reproductive period was observed in both sexes, between April and August. Low reproduction in males is characterized by ample light, absence of sperm, only germ cells in the early stages of spermatogenesis are observed (a few spermatogonia and spermatocytes) and interstitial tissue wide. In females, the period of reproductive decline is marked by the absence of unicellular glands in the oviduct epithelium, with higher affinity with the dye. This period corresponds to low rainfall periods and lower temperatures. We propose an analysis of zoological samples; this is a proposal to facilitate the work of many researchers through access to the species, especially rare species. Estrategia reproductiva es el conjunto de adaptaciones que promueven la manera más eficiente para una población a sobrevivir en las condiciones específicas de un entorno particular. Comprender esta adaptación es importante y puede identificarse en algunas poblaciones como indicador de cambios ambientales. La espermatogénesis puede ser un proceso biológico medible de estas adaptaciones en escalas espaciales y temporales. Se analizó la morfología de los testículos y oviductos de las especies de lagartijas que componen el género Tropidurus, teniendo en cuenta la amplia distribución geográfica y las relaciones simpátricas. Para el análisis hemos eliminado los testículos de los machos y la parte media de los oviductos de hembras de las especiesTropidurus Etheridge, T. oreadicus, T. itambere, T. spinulosus y T. Guarani recolectadas en diferentes lugares en el estado de Mato Grosso, Brasil. El período reproductivo es sincrónico para machos y hembras, y se produce durante septiembre, octubre y noviembre. Se caracterizaron como machos reproductores por testículos con túbulos seminíferos con células germinales en distintas etapas de la espermatogénesis, un epitelio muy alto, un lumen reducido, numerosos espermatozoides libres en el lumen y tejido intersticial redicudo. En hembras el pico reproductivo se produce cuando los canales de conducción de gametos poseen un epitelio alto, secretor y con núcleos basales. Estos meses son caracterizados en las zonas muestreadas por fuertes lluvias y altas temperaturas. La disminución del período reproductivo se observó en ambos sexos, entre abril y agosto. La baja reproducción en machos se caracteriza por un lumen ancho, ausencia de espermatozoides, presencia de células germinales sólo en las primeras etapas de la espermatogénesis (espermatogonias y pocos espermatocitos) y tejido intersticial amplio. En las mujeres, el período de baja reproducción está marcado por la ausencia de glándulas unicelulares en el epitelio del oviducto, con mayor afinidad a la tinción. Este período corresponde al de baja precipitaciones y temperaturas más bajas. Proponemos un análisis de muestras de las colecciones zoológicas ya que esta es una propuesta para facilitar el trabajo de muchos investigadores a través del acceso a las especies, especialmente especies raras.
    Schlagwörter Ciclo reproductivo ; Lagartos ; Brasil ; Reproductive cycle ; Lizards ; Brazil ; Human anatomy ; QM1-695 ; Science ; Q ; DOAJ:Anatomy ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Sprache Englisch
    Erscheinungsdatum 2011-12-01T00:00:00Z
    Verlag Sociedad Chilena de Anatomía
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops.

    Mauricio Menacho-Márquez / Ramón García-Escudero / Virginia Ojeda / Antonio Abad / Pilar Delgado / Clotilde Costa / Sergio Ruiz / Balbino Alarcón / Jesús M Paramio / Xosé R Bustelo

    PLoS Biology, Vol 11, Iss 7, p e

    2013  Band 1001615

    Abstract: The catalytic activity of GDP/GTP exchange factors (GEFs) is considered critical to maintain the typically high activity of Rho GTPases found in cancer cells. However, the large number of them has made it difficult to pinpoint those playing proactive, ... ...

    Abstract The catalytic activity of GDP/GTP exchange factors (GEFs) is considered critical to maintain the typically high activity of Rho GTPases found in cancer cells. However, the large number of them has made it difficult to pinpoint those playing proactive, nonredundant roles in tumors. In this work, we have investigated whether GEFs of the Vav subfamily exert such specific roles in skin cancer. Using genetically engineered mice, we show here that Vav2 and Vav3 favor cooperatively the initiation and promotion phases of skin tumors. Transcriptomal profiling and signaling experiments indicate such function is linked to the engagement of, and subsequent participation in, keratinocyte-based autocrine/paracrine programs that promote epidermal proliferation and recruitment of pro-inflammatory cells. This is a pathology-restricted mechanism because the loss of Vav proteins does not cause alterations in epidermal homeostasis. These results reveal a previously unknown Rho GEF-dependent pro-tumorigenic mechanism that influences the biology of cancer cells and their microenvironment. They also suggest that anti-Vav therapies may be of potential interest in skin tumor prevention and/or treatment.
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2013-07-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets

    Ying-Bei Chen / Jianing Xu / Anders Jacobsen Skanderup / Yiyu Dong / A. Rose Brannon / Lu Wang / Helen H. Won / Patricia I. Wang / Gouri J. Nanjangud / Achim A. Jungbluth / Wei Li / Virginia Ojeda / A. Ari Hakimi / Martin H. Voss / Nikolaus Schultz / Robert J. Motzer / Paul Russo / Emily H. Cheng / Filippo G. Giancotti /
    William Lee / Michael F. Berger / Satish K. Tickoo / Victor E. Reuter / James J. Hsieh

    Nature Communications, Vol 7, Iss 1, Pp 1-

    2016  Band 10

    Abstract: A subset of renal cell carcinomas have uncertain histology and are aggressive in nature. Here, the authors examine this group of unclassified renal cancers using genomics techniques and identify further subclasses of the tumours that have differing ... ...

    Abstract A subset of renal cell carcinomas have uncertain histology and are aggressive in nature. Here, the authors examine this group of unclassified renal cancers using genomics techniques and identify further subclasses of the tumours that have differing prognoses.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2016-10-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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