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Article ; Online: Supporting GPs in the Management of Children and Young People with ADHD Through Project ECHO®

Dana Newcomb / Phil Nixon / Perrin Moss / Vishal Kapoor

International Journal of Integrated Care, Vol 22, Iss

Results from a Self-Efficacy Survey

2022 Volume 3

Abstract: Introduction: Attention Deficit Hyperactivity Disorder (ADHD) accounts for a high proportion of paediatric outpatient visits in Australia. Shared care by general practitioners (GPs) would deliver more timely care, closer to home, however GPs indicated ... ...

Abstract	Introduction: Attention Deficit Hyperactivity Disorder (ADHD) accounts for a high proportion of paediatric outpatient visits in Australia. Shared care by general practitioners (GPs) would deliver more timely care, closer to home, however GPs indicated the need for interprofessional training support. This study describes the use of Project ECHO®, a guided practice model, to support GPs with ADHD management, by connecting them virtually with an interprofessional team of paediatric specialists using a structured methodology. Methods: A retrospective pre/post-knowledge and self-efficacy survey across twenty-seven aspects of ADHD management was administered, using a seven-point Likert scale. Results: Significant improvement (p < 0.001) in provider self-efficacy was demonstrated across all tested domains. Discussion: Use of the ECHO model™ by an interprofessional team of paediatric specialists achieved an increase in GP knowledge and self-efficacy in the local management of children and young people with complex healthcare needs. Learnings indicate viability to expand the application of the ECHO model™ to address fragmentation for other priority populations across the Australian healthcare and human service sector landscape. Conclusion: Use of the ECHO model™ to support and train GPs was successful. Integration of care was achieved through strengthened partnerships between content and context experts, and the ECHO model™’s case-based learning methodology.
Keywords	project echo ; communities of practice ; virtual learning ; attention deficit hyperactivity disorder ; australia ; paediatrics ; integration ; queensland ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Ubiquity Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Uncovering the organization of neural circuits with Generalized Phase Locking Analysis.

Shervin Safavi / Theofanis I Panagiotaropoulos / Vishal Kapoor / Juan F Ramirez-Villegas / Nikos K Logothetis / Michel Besserve

PLoS Computational Biology, Vol 19, Iss 4, p e

2023 Volume 1010983

Abstract: Despite the considerable progress of in vivo neural recording techniques, inferring the biophysical mechanisms underlying large scale coordination of brain activity from neural data remains challenging. One obstacle is the difficulty to link high ... ...

Abstract	Despite the considerable progress of in vivo neural recording techniques, inferring the biophysical mechanisms underlying large scale coordination of brain activity from neural data remains challenging. One obstacle is the difficulty to link high dimensional functional connectivity measures to mechanistic models of network activity. We address this issue by investigating spike-field coupling (SFC) measurements, which quantify the synchronization between, on the one hand, the action potentials produced by neurons, and on the other hand mesoscopic "field" signals, reflecting subthreshold activities at possibly multiple recording sites. As the number of recording sites gets large, the amount of pairwise SFC measurements becomes overwhelmingly challenging to interpret. We develop Generalized Phase Locking Analysis (GPLA) as an interpretable dimensionality reduction of this multivariate SFC. GPLA describes the dominant coupling between field activity and neural ensembles across space and frequencies. We show that GPLA features are biophysically interpretable when used in conjunction with appropriate network models, such that we can identify the influence of underlying circuit properties on these features. We demonstrate the statistical benefits and interpretability of this approach in various computational models and Utah array recordings. The results suggest that GPLA, used jointly with biophysical modeling, can help uncover the contribution of recurrent microcircuits to the spatio-temporal dynamics observed in multi-channel experimental recordings.
Keywords	Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Decoding internally generated transitions of conscious contents in the prefrontal cortex without subjective reports

Vishal Kapoor / Abhilash Dwarakanath / Shervin Safavi / Joachim Werner / Michel Besserve / Theofanis I. Panagiotaropoulos / Nikos K. Logothetis

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 16

Abstract: The role of the prefrontal cortex in conscious perception is debated because of its involvement in task relevant behaviour, such as subjective perceptual reports. Here, the authors show that prefrontal activity in rhesus macaques correlates with ... ...

Abstract	The role of the prefrontal cortex in conscious perception is debated because of its involvement in task relevant behaviour, such as subjective perceptual reports. Here, the authors show that prefrontal activity in rhesus macaques correlates with subjective perception and the contents of consciousness can be decoded from prefrontal population activity even without reports.
Keywords	Science ; Q
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Parallel and functionally segregated processing of task phase and conscious content in the prefrontal cortex

Vishal Kapoor / Michel Besserve / Nikos K. Logothetis / Theofanis I. Panagiotaropoulos

Communications Biology, Vol 1, Iss 1, Pp 1-

2018 Volume 12

Abstract: Vishal Kapoor et al. identify a population of cells in the lateral prefrontal cortex that exhibits ...

Abstract	Vishal Kapoor et al. identify a population of cells in the lateral prefrontal cortex that exhibits task phase-related activity during a no-report task. This cell population is functionally segregated from the population encoding conscious perception, although the two operate in parallel.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Partial Purification and Characterization of a Heat Stable α-Amylase from a Thermophilic Actinobacteria, Streptomyces sp. MSC702

Renu Singh / Vijay Kumar / Vishal Kapoor

Enzyme Research, Vol

2014 Volume 2014

Abstract: A partial purification and biochemical characterization of the α-amylase from Streptomyces sp. MSC702 were carried out in this study. The optimum operational conditions for enzyme substrate reaction for amylolytic enzyme activity from the strain were ... ...

Abstract	A partial purification and biochemical characterization of the α-amylase from Streptomyces sp. MSC702 were carried out in this study. The optimum operational conditions for enzyme substrate reaction for amylolytic enzyme activity from the strain were evaluated. The optimum pH, temperature, and incubation period for assaying the enzyme were observed to be 5.0, 55°C, and 30 min, respectively. The extracellular extract was concentrated using ammonium sulfate precipitation. It was stable in the presence of metal ions (5 mM) such as K+, Co2+, and Mo2+, whereas Pb2+, Mn2+, Mg2+, Cu2+, Zn2+, Ba2+, Ca2+, Hg2+, Sn2+, Cr3+, Al3+, Ag+, and Fe2+ were found to have inhibitory effects. The enzyme activity was also unstable in the presence of 1% Triton X-100, 1% Tween 80, 5 mM sodium lauryl sulphate, 1% glycerol, 5 mM EDTA, and 5 mM denaturant urea. At temperature 60°C and pH 5.0, the enzyme stability was maximum. α-amylase retained 100% and 34.18% stability for 1 h and 4 h, respectively, at 60°C (pH 7.0). The enzyme exhibited a half-life of 195 min at 60°C temperature. The analysis of kinetic showed that the enzyme has Km of 2.4 mg/mL and Vmax of 21853.0 μmol/min/mg for soluble potato starch. The results indicate that the enzyme reflects their potentiality towards industrial utilization.
Keywords	Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
Subject code	660
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Utilization of Agro-industrial Wastes for the Simultaneous Production of Amylase and Xylanase by Thermophilic Actinomycetes

Renu Singh / Vishal Kapoor / Vijay Kumar

Brazilian Journal of Microbiology, Vol 43, Iss 4, Pp 1545-

2012 Volume 1552

Abstract: Agro-industrial wastes such as sugarcane bagasse, wheat bran, rice bran, corn cob and wheat straw are cheapest and abundantly available natural carbon sources. The present study was aimed to production of amylase and xylanase simultaneously using agro- ... ...

Abstract	Agro-industrial wastes such as sugarcane bagasse, wheat bran, rice bran, corn cob and wheat straw are cheapest and abundantly available natural carbon sources. The present study was aimed to production of amylase and xylanase simultaneously using agro-industrial waste as the sole carbon source. Seven thermophilic strains of actinomycete were isolated from the mushroom compost. Among of these, strain designated MSC702 having high potential to utilize agro-industrial wastes for the production of amylase and xylanase. Strain MSC702 was identified as novel species of Streptomyces through morphological characterization and 16S rRNA gene sequence. Enzyme production was determined using 1% (w/v) of various agro-industrial waste in production medium containing (g/100mL): K2HPO4(0.1), (NH4)2SO4(0.1), NaCl (0.1), MgSO4(0.1) at pH 7.0 after incubation of 48 h at 50°C. The amylase activity (373.89 IU/mL) and xylanase activity (30.15 IU/mL) was maximum in rice bran. The decreasing order of amylase and xylanase activity in different type of agro-industrial wastes were found rice bran (RB) > corn cob (CC) > wheat bran (WB) > wheat straw (WS) > sugarcane bagasse (SB) and rice bran (RB) > wheat bran (WB) > wheat straw (WS) > sugarcane bagasse (SB) > corn cob (CC), respectively. Mixed effect of different agro-industrial wastes was examined in different ratios. Enzyme yield of amylase and xylanase was ~1.3 and ~2.0 fold higher with RB: WB in 1:2 ratio.
Keywords	Agro-industrial wastes ; thermophilic actinomycetes ; Streptomyces ; amylase ; xylanase ; Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	660
Language	English
Publishing date	2012-12-01T00:00:00Z
Publisher	Sociedade Brasileira de Microbiologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development of a capture sequencing assay for enhanced detection and genotyping of tick-borne pathogens

Komal Jain / Teresa Tagliafierro / Adriana Marques / Santiago Sanchez-Vicente / Alper Gokden / Brian Fallon / Nischay Mishra / Thomas Briese / Vishal Kapoor / Stephen Sameroff / Cheng Guo / Luis A. Marcos / Linden Hu / W. Ian Lipkin / Rafal Tokarz

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 11

Abstract: Abstract Inadequate sensitivity has been the primary limitation for implementing high-throughput sequencing for studies of tick-borne agents. Here we describe the development of TBDCapSeq, a sequencing assay that uses hybridization capture probes that ... ...

Abstract	Abstract Inadequate sensitivity has been the primary limitation for implementing high-throughput sequencing for studies of tick-borne agents. Here we describe the development of TBDCapSeq, a sequencing assay that uses hybridization capture probes that cover the complete genomes of the eleven most common tick-borne agents found in the United States. The probes are used for solution-based capture and enrichment of pathogen nucleic acid followed by high-throughput sequencing. We evaluated the performance of TBDCapSeq to surveil samples that included human whole blood, mouse tissues, and field-collected ticks. For Borrelia burgdorferi and Babesia microti, the sensitivity of TBDCapSeq was comparable and occasionally exceeded the performance of agent-specific quantitative PCR and resulted in 25 to > 10,000-fold increase in pathogen reads when compared to standard unbiased sequencing. TBDCapSeq also enabled genome analyses directly within vertebrate and tick hosts. The implementation of TBDCapSeq could have major impact in studies of tick-borne pathogens by improving detection and facilitating genomic research that was previously unachievable with standard sequencing approaches.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A common neurodynamical mechanism could mediate externally induced and intrinsically generated transitions in visual awareness.

Theofanis I Panagiotaropoulos / Vishal Kapoor / Nikos K Logothetis / Gustavo Deco

PLoS ONE, Vol 8, Iss 1, p e

2013 Volume 53833

Abstract: The neural correlates of conscious visual perception are commonly studied in paradigms of perceptual multistability that allow multiple perceptual interpretations during unchanged sensory stimulation. What is the source of this multistability in the ... ...

Abstract	The neural correlates of conscious visual perception are commonly studied in paradigms of perceptual multistability that allow multiple perceptual interpretations during unchanged sensory stimulation. What is the source of this multistability in the content of perception? From a theoretical perspective, a fine balance between deterministic and stochastic forces has been suggested to underlie the spontaneous, intrinsically driven perceptual transitions observed during multistable perception. Deterministic forces are represented by adaptation of feature-selective neuronal populations encoding the competing percepts while stochastic forces are modeled as noise-driven processes. Here, we used a unified neuronal competition model to study the dynamics of adaptation and noise processes in binocular flash suppression (BFS), a form of externally induced perceptual suppression, and compare it with the dynamics of intrinsically driven alternations in binocular rivalry (BR). For the first time, we use electrophysiological, biologically relevant data to constrain a model of perceptual rivalry. Specifically, we show that the mean population discharge pattern of a perceptually modulated neuronal population detected in electrophysiological recordings in the lateral prefrontal cortex (LPFC) during BFS, constrains the dynamical range of externally induced perceptual transitions to a region around the bifurcation separating a noise-driven attractor regime from an adaptation-driven oscillatory regime. Most interestingly, the dynamical range of intrinsically driven perceptual transitions during BR is located in the noise-driven attractor regime, where it overlaps with BFS. Our results suggest that the neurodynamical mechanisms of externally induced and spontaneously generated perceptual alternations overlap in a narrow, noise-driven region just before a bifurcation where the system becomes adaptation-driven.
Keywords	Medicine ; R ; Science ; Q
Subject code	612
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Eco-geomorphological approach for environmental flows assessment in monsoon-driven highland rivers

Vinod Tare / Suresh Kumar Gurjar / Haridas Mohanta / Vishal Kapoor / Ankit Modi / R.P. Mathur / Rajiv Sinha

Journal of Hydrology: Regional Studies, Vol 13, Iss C, Pp 110-

A case study of Upper Ganga, India

2017 Volume 121

Abstract: Study region: Upper Ganga reaches up to Rishikesh town, India. Study focus: Environmental Flows (E-Flows) assessment in the upper stretches of the Ganga river has been carried out by integrating ecological and geomorphological parameters with hydraulic ... ...

Abstract	Study region: Upper Ganga reaches up to Rishikesh town, India. Study focus: Environmental Flows (E-Flows) assessment in the upper stretches of the Ganga river has been carried out by integrating ecological and geomorphological parameters with hydraulic analysis to estimate the flow depths and flow volumes necessary for river ecology and channel maintenance. We have used a modified version of Building Block Method (BBM) for computing E-Flows for lean period, for monsoon period and for high floods based on the flow requirements of keystone species for different sites and geomorphic considerations. We define three flow depths, D1, D2 and D3 which correspond to the minimum flow depths required for sustenance of keystone species during lean period, for breeding and spawning of keystone species during monsoon period, and for maintaining lateral connectivity during floods respectively. New hydrological insights for the region: Annual hydrographs for E-Flows have been developed and compared with the observed flows for each site under natural flow conditions. Our computation shows that for the wet period, which is taken as the period from mid-May to mid-October, monthly E-Flows vary from ∼23% to ∼40% of the monthly natural flows at different sites. However, dry season E-Flows as percentages of natural flows, taken for the period from mid-October to mid-May, vary over a wider range of 29%–53% for these sites.
Keywords	E-Flows ; Monsoon-driven highland rivers ; Eco-geomorphology ; Stage-discharge curve ; Dams ; Keystone species ; Physical geography ; GB3-5030 ; Geology ; QE1-996.5
Subject code	333
Language	English
Publishing date	2017-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Eco-geomorphological approach for environmental flows assessment in monsoon-driven highland rivers: A case study of Upper Ganga, India

Tare, Vinod / Ankit Modi / Haridas Mohanta / R.P. Mathur / Rajiv Sinha / Suresh Kumar Gurjar / Vishal Kapoor

Journal of hydrology. 2017 Oct., v. 13

2017

Abstract: Upper Ganga reaches up to Rishikesh town, India.Environmental Flows (E-Flows) assessment in the upper stretches of the Ganga river has been carried out by integrating ecological and geomorphological parameters with hydraulic analysis to estimate the flow ...

Abstract	Upper Ganga reaches up to Rishikesh town, India.Environmental Flows (E-Flows) assessment in the upper stretches of the Ganga river has been carried out by integrating ecological and geomorphological parameters with hydraulic analysis to estimate the flow depths and flow volumes necessary for river ecology and channel maintenance. We have used a modified version of Building Block Method (BBM) for computing E-Flows for lean period, for monsoon period and for high floods based on the flow requirements of keystone species for different sites and geomorphic considerations. We define three flow depths, D1, D2 and D3 which correspond to the minimum flow depths required for sustenance of keystone species during lean period, for breeding and spawning of keystone species during monsoon period, and for maintaining lateral connectivity during floods respectively.Annual hydrographs for E-Flows have been developed and compared with the observed flows for each site under natural flow conditions. Our computation shows that for the wet period, which is taken as the period from mid-May to mid-October, monthly E-Flows vary from ∼23% to ∼40% of the monthly natural flows at different sites. However, dry season E-Flows as percentages of natural flows, taken for the period from mid-October to mid-May, vary over a wider range of 29%–53% for these sites.
Keywords	breeding ; case studies ; dry season ; ecology ; floods ; geomorphology ; hydrograph ; keystone species ; monsoon season ; rivers ; spawning ; India
Language	English
Dates of publication	2017-10
Size	p. 110-121.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2814784-4
ISSN	2214-5818
ISSN	2214-5818
DOI	10.1016/j.ejrh.2017.07.005
Database	NAL-Catalogue (AGRICOLA)

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