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  1. Article ; Online: Gender discrepancies in bladder cancer: potential explanations.

    Viswambaram, Pravin / Hayne, Dickon

    Expert review of anticancer therapy

    2020  Volume 20, Issue 10, Page(s) 841–849

    Abstract: Introduction: Gender differences in urothelial carcinoma of the bladder (UCB) exist. Although men have a higher incidence of UCB, women tend to have poorer outcomes. We have explored and summarized the evidence for gender differences of UCB diagnosis ... ...

    Abstract Introduction: Gender differences in urothelial carcinoma of the bladder (UCB) exist. Although men have a higher incidence of UCB, women tend to have poorer outcomes. We have explored and summarized the evidence for gender differences of UCB diagnosis and prognosis, together with reasons for these disparities.
    Areas covered: The incidence of UCB is 3-4 times higher in men than women. However, women are more likely to be diagnosed with advanced disease. Women have a higher stage-for-stage mortality compared to men, and their greatest risk of death appears to be within the first 2 years of diagnosis. Survival outcomes following radical cystectomy (RC) and radiotherapy are also poorer in women. Delays in diagnosis, differences in female anatomy, as well as poorer surgical outcomes post-RC appear to contribute significantly to the disparities noted between genders. Other factors such as exposure to risk factors, differential hormone signaling, and carcinogen breakdown may also have a role.
    Expert opinion: The gender divide in UCB outcomes has to be addressed. Improved medical and patient education and centralization of RC are recommended.
    MeSH term(s) Animals ; Carcinoma, Transitional Cell/diagnosis ; Carcinoma, Transitional Cell/pathology ; Carcinoma, Transitional Cell/therapy ; Cystectomy ; Delayed Diagnosis ; Female ; Humans ; Male ; Neoplasm Staging ; Prognosis ; Risk Factors ; Sex Factors ; Survival Rate ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/therapy
    Language English
    Publishing date 2020-09-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2020.1813029
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5907: Show issues Location:
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  2. Article: Adenocarcinoma of the urethra: A rare subtype of urethral cancer.

    Viswambaram, Pravin / Oey, Oliver / Swarbrick, Nicole / Hayne, Dickon

    Urology case reports

    2021  Volume 37, Page(s) 101654

    Abstract: Urethral adenocarcinoma (UA) is a rare type of urethral cancer with a poor prognosis. We present a case of UA of intestinal subtype in a 57-year-old patient who initially had lower urinary tract symptoms and was subsequently found to have a urethral ... ...

    Abstract Urethral adenocarcinoma (UA) is a rare type of urethral cancer with a poor prognosis. We present a case of UA of intestinal subtype in a 57-year-old patient who initially had lower urinary tract symptoms and was subsequently found to have a urethral lesion in a urethral diverticulum on pelvic MRI which was confirmed on biopsy. She had neoadjuvant chemotherapy followed by open anterior pelvic exenteration, complete urethrectomy and ileal conduit urinary diversion. She required adjuvant chemotherapy for local invasion and a metastasis in the uterus but developed progressive metastatic disease and succumbed to the disease 13-months after surgery.
    Language English
    Publishing date 2021-03-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2021.101654
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  3. Article ; Online: Anterior pelvic exenteration and synchronous bilateral nephroureterectomy for BK polyoma virus induced urothelial carcinoma of the bladder: A case report.

    Oey, Oliver / Viswambaram, Pravin / Moe, Andrew / Swarbick, Nicole / Hayne, Dickon

    Folia medica

    2022  Volume 64, Issue 3, Page(s) 521–526

    Abstract: BK polyoma virus (BKV) is a known risk factor for the development of urothelial carcinoma. There is currently limited data on the management of BKV-induced urothelial carcinoma (BUC) of the bladder, with available data limited to case reports. It remains ...

    Abstract BK polyoma virus (BKV) is a known risk factor for the development of urothelial carcinoma. There is currently limited data on the management of BKV-induced urothelial carcinoma (BUC) of the bladder, with available data limited to case reports. It remains debatable whether radical cystectomy (RC) with removal of the native urinary tract or RC alone is the most optimal management for BUC of the bladder. BKV-induced urothelial carcinoma is rare, and its management is challenging in immunocompromised patients such as that of post-transplant patients. This case report provides additional insight into a rare disease, the management of which still lacks established guidelines and remains debatable.
    MeSH term(s) BK Virus ; Carcinoma, Transitional Cell/pathology ; Carcinoma, Transitional Cell/surgery ; Humans ; Nephroureterectomy ; Pelvic Exenteration ; Urinary Bladder/pathology ; Urinary Bladder/surgery ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/surgery
    Language English
    Publishing date 2022-07-18
    Publishing country Bulgaria
    Document type Case Reports ; Journal Article
    ZDB-ID 300275-5
    ISSN 1314-2143 ; 0430-8638 ; 0204-8043
    ISSN (online) 1314-2143
    ISSN 0430-8638 ; 0204-8043
    DOI 10.3897/folmed.64.e77713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 972: Show issues Location:
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  4. Article: Salmonella Mississippi

    Chui, William / Pan, Henry / Viswambaram, Pravin / O'Hern, Jennifer / Tan, Philip / Ilie, Victor

    Urology case reports

    2022  Volume 45, Page(s) 102197

    Abstract: Renal abscess is a rare manifestation ... ...

    Abstract Renal abscess is a rare manifestation of
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2022.102197
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  5. Article ; Online: Lymph node assessment technique matters in radical cystectomy for bladder cancer.

    Chau, Matthew / Thia, Ivan / Viswambaram, Pravin / Hawks, Cynthia / Green, William / Swarbrick, Nicole / McCombie, Steve P / Hayne, Dickon

    ANZ journal of surgery

    2023  Volume 93, Issue 3, Page(s) 675–679

    Abstract: Background: For patients undergoing radical cystectomy with pelvic lymph node dissection for urothelial cancer, a lymph node count of at least 16 is associated with improved cancer-specific and overall survival. Lymph node yield is presumed to relate ... ...

    Abstract Background: For patients undergoing radical cystectomy with pelvic lymph node dissection for urothelial cancer, a lymph node count of at least 16 is associated with improved cancer-specific and overall survival. Lymph node yield is presumed to relate directly to extent of dissection and surgical quality, however limited studies have reviewed the impact of the pathological assessment process of lymph nodes on lymph node yield.
    Method: A retrospective assessment of 139 patients who had radical cystectomy for urothelial cancer between March 2015 and July 2021 from Fiona Stanley Hospital (Perth, Australia) by a single surgeon was assessed. A change in pathological assessment process from assessment of only palpable lymph nodes to microscopic assessment of the entire submitted specimens occurred in August 2018. Patients were divided into two groups accordingly and other relevant demographic and pathological data was recorded. The impact of pathological processing technique on lymph node yield was assessed using the Student T test and logistical regression was used to assess the impact of other demographic variables.
    Results: The mean lymph node yield was 16.2 nodes (IQR 12-23) in 54 patients in the pre-process change group compared to 22.4 nodes (IQR 15-28.4) in 85 patients in the post-process change group (P < 0.0001). 53.7% had 16 or more nodes in the pre-process change group compared to 71.3% in the post-process change group (P = 0.04). Age, BMI, and gender were not significant predictors of lymph node yield.
    Conclusion: The current study demonstrates that the microscopic assessment of all lymph node tissue detects significantly more lymph nodes than only examining palpably abnormal tissue. Pathologic assessment protocols should be standardized to this technique to ensure the utility of lymph node yield as a quality metric.
    MeSH term(s) Humans ; Cystectomy/methods ; Retrospective Studies ; Pelvis/pathology ; Lymphatic Metastasis/pathology ; Urinary Bladder Neoplasms/pathology ; Carcinoma, Transitional Cell/surgery ; Carcinoma, Transitional Cell/pathology ; Lymph Node Excision/methods ; Lymph Nodes/surgery ; Lymph Nodes/pathology
    Language English
    Publishing date 2023-03-03
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18292
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    Zs.A 180: Show issues Location:
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  6. Article ; Online: Comparing fluorodeoxyglucose positron emission tomography with computed tomography in staging for nodal and distant metastasis in urothelial/bladder cancer.

    Al-Zubaidi, Mohammed / Ong, Katherine / Viswambaram, Pravin / Bangash, Haider / Boardman, Glenn / McCombie, Steve P / Oey, Oliver / Swarbrick, Nicole / Redfern, Andrew / Ong, Jeremy / Gauci, Richard / Low, Ronny / Hayne, Dickon

    BJUI compass

    2024  Volume 5, Issue 4, Page(s) 473–479

    Abstract: Objectives: We aim to assess the clinical value of : Methods: A retrospective review of 75 patients with invasive bladder cancer (≥T1) who were staged with both CT and : Results: Sensitivity, specificity, positive predictive values (PPV) and ... ...

    Abstract Objectives: We aim to assess the clinical value of
    Methods: A retrospective review of 75 patients with invasive bladder cancer (≥T1) who were staged with both CT and
    Results: Sensitivity, specificity, positive predictive values (PPV) and negative predictive value (NPV) of CT versus FDG-PET for detecting metastasis, in patients who underwent pelvic LN dissection or biopsy of lesions suspicious of metastases, were 46.6% (95% CI: 21%-70%) versus 60% (95% CI: 32%-84%), 100% (95% CI: 91%-100%) versus 83.78% (95% CI: 69%-94%), 100% (95% CI: 63%-100%) versus 60% (95% CI: 32%-84%), and 82.2% (95% CI: 68%-92%) versus 83.78% (95% CI: 69%-94%), respectively. 7/75 (9.3%) patients avoided cystectomy due to
    Conclusion: FDG-PET may be more sensitive than CT for metastases in the staging of bladder cancer, which resulted in significant avoidance of aggressive local management in cases with occult metastasis.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ISSN 2688-4526
    ISSN (online) 2688-4526
    DOI 10.1002/bco2.304
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  7. Article ; Online: Technetium-99 m-sestamibi single-photon emission computerised tomography (CT)/CT in the prediction of malignant versus benign small renal masses.

    Viswambaram, Pravin / Swarbrick, Nicole / Picardo, Alarick / Hohnen, Andrew / Pham, Kevin / Macdonald, William / Hayne, Dickon / Hamid, Akhlil

    BJU international

    2022  Volume 130 Suppl 3, Page(s) 23–31

    Abstract: Objectives: To determine the effectiveness of technetium-99m (: Patients and methods: Between June 2018 and October 2020 all patients with new indeterminate small renal masses (SRMs) underwent : Results: A total of 74 patients with SRMs were ... ...

    Abstract Objectives: To determine the effectiveness of technetium-99m (
    Patients and methods: Between June 2018 and October 2020 all patients with new indeterminate small renal masses (SRMs) underwent
    Results: A total of 74 patients with SRMs were investigated with
    Conclusion: 99m
    MeSH term(s) Humans ; Technetium Tc 99m Sestamibi ; Radiopharmaceuticals ; Tomography, Emission-Computed, Single-Photon/methods ; Tomography, X-Ray Computed ; Sensitivity and Specificity
    Chemical Substances Technetium Tc 99m Sestamibi (971Z4W1S09) ; Technetium-99 ; Radiopharmaceuticals
    Language English
    Publishing date 2022-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.15737
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  8. Article ; Online: Centralization and prospective audit of cystectomy are necessary: a commentary on the case for centralization, supported by a contemporary series utilizing the ANZUP cystectomy database.

    Viswambaram, Pravin / McCombie, Steve P / Hawks, Cynthia / Wallace, D Michael A / Sengupta, Shomik / Hayne, Dickon

    Asia-Pacific journal of clinical oncology

    2022  Volume 19, Issue 3, Page(s) 290–295

    Abstract: Bladder cancer (BC) outcomes are unacceptably poor. In Australia, BC survival is actually deteriorating. There is an urgent need to improve outcomes in BC patients, which requires a multipronged approach. One area deserving closer scrutiny is radical ... ...

    Abstract Bladder cancer (BC) outcomes are unacceptably poor. In Australia, BC survival is actually deteriorating. There is an urgent need to improve outcomes in BC patients, which requires a multipronged approach. One area deserving closer scrutiny is radical cystectomy. Audit is necessary to identify areas for improvement and without it, outcomes remain unknown. Evidence convincingly shows high-volume surgeons and centers improve cystectomy outcomes including overall survival, yet centralization has still not occurred. The Australia and New Zealand Urogenital and Prostate (ANZUP) Cancer Trials Group cystectomy database has been established to facilitate cystectomy audit in Australia and New Zealand. We present initial data from the ANZUP cystectomy database from a single high-volume center, discuss the benefits of centralization and its challenges in the Asia-Pacific context.
    MeSH term(s) Male ; Humans ; Cystectomy ; Treatment Outcome ; Urinary Bladder Neoplasms/surgery ; Australia ; Prostate
    Language English
    Publishing date 2022-11-09
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2187409-8
    ISSN 1743-7563 ; 1743-7555
    ISSN (online) 1743-7563
    ISSN 1743-7555
    DOI 10.1111/ajco.13883
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  9. Article ; Online: The SUB-urothelial DUrvalumab InjEction-1 (SUBDUE-1) trial: first-in-human trial in patients with bladder cancer.

    Hayne, Dickon / Ong, Katherine / Swarbrick, Nicole / McCombie, Steve P / Moe, Andrew / Hawks, Cynthia / Viswambaram, Pravin / Conduit, Ciara / Liow, Elizabeth / Spalding, Lisa / Lim, Jayne / Ferguson, Thomas / Meehan, Katie / Davis, Ian D / Redfern, Andrew D

    BJU international

    2024  

    Abstract: Objectives: To assess the safety of sub-urothelial injection of durvalumab and examine the impact on tissue and circulating immune cell populations.: Patients and methods: The patients were chemotherapy and immunotherapy naïve (bacille Calmette- ... ...

    Abstract Objectives: To assess the safety of sub-urothelial injection of durvalumab and examine the impact on tissue and circulating immune cell populations.
    Patients and methods: The patients were chemotherapy and immunotherapy naïve (bacille Calmette-Guérin allowed) with non-metastatic muscle-invasive bladder cancer or non-muscle-invasive bladder cancer planned for radical cystectomy (RC). The study was a Phase Ib 3 + 3 dose-escalation design with sub-urothelial injection of durvalumab at three pre-determined doses (25, 75, 150 mg) diluted in 25 mL normal saline, injected at 25 locations (25 × 1 mL injections), at least 2 weeks before RC.
    Results: A total of 11 patients were recruited (10 male, one female). No significant changes were reported on American Urological Association Symptom Score or O'Leary Interstitial Cystitis Scale. In all, 14 adverse events (AEs) were reported (10 Grade 1, three Grade 2, one Grade 3), none considered immune-related. No Grade 4 or 5 AEs were recorded. All the patients underwent RC. Tissue immune populations changed following durvalumab injection (P = 0.012), with a statistically significant increase in M2-macrophage (CD163) when comparing the 25-150 mg dose (P = 0.021). Basal/mixed cancers showed a larger CD163 increase than luminal cancers (P = 0.033).
    Conclusion: Sub-urothelial injection of durvalumab is feasible and safe without immune-related AEs and shows local immunological effects.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.16325
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  10. Article: Multi-route antifungal administration in the management of urinary

    Viswambaram, Pravin / Misko, Jeanie / Rawlins, Matthew / Clark, Sarah / Dyer, John / Hayne, Dickon

    Urology case reports

    2020  Volume 33, Page(s) 101275

    Abstract: A 65-year-old lady was admitted with urosepsis and imaging suggesting right sided hydronephrosis secondary to a filling defect consistent with a fungal bezoar. An indwelling urinary catheter and a right percutaneous nephrostomy tube were inserted. ... ...

    Abstract A 65-year-old lady was admitted with urosepsis and imaging suggesting right sided hydronephrosis secondary to a filling defect consistent with a fungal bezoar. An indwelling urinary catheter and a right percutaneous nephrostomy tube were inserted. Candida glabrata cultured from urine was resistant to fluconazole. Amphotericin B was instilled into the renal pelvis via the nephrostomy tube while intravenous liposomal amphotericin was administered daily along with oral flucytosine. This multi-modal antifungal administration was continued for 14 days. Clinical and biochemical improvement was achieved and repeat imaging showed complete resolution of the filling defects and hydronephrosis.
    Language English
    Publishing date 2020-05-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2020.101275
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