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Article ; Online: Highlights of the January-March 2024 Issue.

Vitale, Giovanni

2024

Language	English
Publishing date	2024-03-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062786-2
ISSN	2724-6116
ISSN (online)	2724-6116
DOI	10.23736/S2724-6507.24.04199-X
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Zs.A 2105: Show issues

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Article ; Online: Journal title change announcement.

Vitale, Giovanni

Minerva endocrinology

2020 Volume 46, Issue 1, Page(s) 2

Language	English
Publishing date	2020-10-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062786-2
ISSN	2724-6116
ISSN (online)	2724-6116
DOI	10.23736/S2724-6507.21.03485-4
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Article ; Online: Severe Liver Injury Triggered by Sequential Use of Immune Checkpoint Blockers and Tyrosine Kinase Inhibitors: An Emerging Clinical Issue.

Gelsomino, Francesco / Vitale, Giovanni / Raschi, Emanuel / Ardizzoni, Andrea

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

2023 Volume 18, Issue 10, Page(s) e112–e113

MeSH term(s)	Humans ; Immune Checkpoint Inhibitors ; Tyrosine Kinase Inhibitors ; Lung Neoplasms ; Liver ; Antineoplastic Agents, Immunological ; Protein Kinase Inhibitors/adverse effects
Chemical Substances	Immune Checkpoint Inhibitors ; Tyrosine Kinase Inhibitors ; Antineoplastic Agents, Immunological ; Protein Kinase Inhibitors
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2432037-7
ISSN	1556-1380 ; 1556-0864
ISSN (online)	1556-1380
ISSN	1556-0864
DOI	10.1016/j.jtho.2023.07.002
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Zs.A 6664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 652: Show issues

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Article ; Online: Foreword to the special issue on advances in neuroendocrine neoplasms.

Vitale, Giovanni / Faggiano, Antongiulio

Reviews in endocrine & metabolic disorders

2021 Volume 22, Issue 3, Page(s) 493–494

MeSH term(s)	Humans ; Neuroendocrine Tumors/therapy
Language	English
Publishing date	2021-03-12
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2185718-0
ISSN	1573-2606 ; 1389-9155
ISSN (online)	1573-2606
ISSN	1389-9155
DOI	10.1007/s11154-021-09639-z
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Zs.A 6069: Show issues

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Article ; Online: Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products.

Vitale, Giovanni Andrea / Geibel, Christian / Minda, Vidit / Wang, Mingxun / Aron, Allegra T / Petras, Daniel

Natural product reports

2024

Abstract: Covering: 1995 to 2023Advances in bioanalytical methods, particularly mass spectrometry, have provided valuable molecular insights into the mechanisms of life. Non-targeted metabolomics aims to detect and (relatively) quantify all observable small ... ...

Abstract	Covering: 1995 to 2023Advances in bioanalytical methods, particularly mass spectrometry, have provided valuable molecular insights into the mechanisms of life. Non-targeted metabolomics aims to detect and (relatively) quantify all observable small molecules present in a biological system. By comparing small molecule abundances between different conditions or timepoints in a biological system, researchers can generate new hypotheses and begin to understand causes of observed phenotypes. Functional metabolomics aims to investigate the functional roles of metabolites at the scale of the metabolome. However, most functional metabolomics studies rely on indirect measurements and correlation analyses, which leads to ambiguity in the precise definition of functional metabolomics. In contrast, the field of natural products has a history of identifying the structures and bioactivities of primary and specialized metabolites. Here, we propose to expand and reframe functional metabolomics by integrating concepts from the fields of natural products and chemical biology. We highlight emerging functional metabolomics approaches that shift the focus from correlation to physical interactions, and we discuss how this allows researchers to uncover causal relationships between molecules and phenotypes.
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/d3np00050h
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Article ; Online: How to use the Contour intrasaccular device: two illustrative cases.

Biondi, Alessandra / Primikiris, Panagiotis / Di Caterino, Fortunato / Vancheri, Sergio / Vitale, Giovanni / Charbonnier, Guillaume

Journal of neurointerventional surgery

2024 Volume 16, Issue 3, Page(s) 225

Abstract: Contour (Stryker, Kalamazoo, MI) is a relatively new endosaccular device for the treatment of intracranial aneurysms.1 2 Its unique cup-like shape permits treatment of most lesions, including wide-necked, irregular, and shallowed-shaped aneurysms. The ... ...

Abstract	Contour (Stryker, Kalamazoo, MI) is a relatively new endosaccular device for the treatment of intracranial aneurysms.1 2 Its unique cup-like shape permits treatment of most lesions, including wide-necked, irregular, and shallowed-shaped aneurysms. The sizing of the device only requires two parameters: neck size and equatorial plane (width). It must be positioned at the neck of the aneurysm with the device proximal marker in the parent artery. In our experience, dual antiplatelet therapy is usually not required for intrasaccular devices and this is also an advantage of the Contour device. We report two illustrative cases of wide-neck aneurysms in the anterior and posterior circulation, respectively (video 1). In this video we demonstrate the feasibility of this treatment in a middle cerebral artery bifurcation with atypical triangular shape and typical tip-basilar aneurysm. neurintsurg;16/3/225/V1F1V1Video 1 .
MeSH term(s)	Humans ; Treatment Outcome ; Embolization, Therapeutic ; Endovascular Procedures ; Middle Cerebral Artery ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Video-Audio Media ; Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/jnis-2023-021090
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Article ; Online: Minimally invasive techniques: full endoscopic inferior parietal lobule approach for an endoventricular removal of a left trigone meningioma grade I.

Gelmi, Clarissa A E / Cecchini, Giulio / Vitale, Giovanni / Di Biase, Francesco

Neurosurgical focus: Video

2023 Volume 8, Issue 2, Page(s) V9

Abstract: Intraventricular meningiomas are rare tumors, mainly localized in the lateral ventricle trigone. Several microscopic surgical approaches have been proposed according to the location of the tumors in the atrium. The authors present the case of a 68-year- ... ...

Abstract	Intraventricular meningiomas are rare tumors, mainly localized in the lateral ventricle trigone. Several microscopic surgical approaches have been proposed according to the location of the tumors in the atrium. The authors present the case of a 68-year-old woman who had an increscent medically resistant headache with a left trigone meningioma. In the video, they demonstrate the four-hands surgical technique through a minimally invasive fully endoscopic retractor-less transcortical approach. They also discuss the background of these tumors and the technical nuances of the procedure, including the differences between an endoscopic surgical and a microsurgical one. The video can be found here: https://stream.cadmore.media/r10.3171/2023.1.FOCVID2296.
Language	English
Publishing date	2023-04-01
Publishing country	United States
Document type	Journal Article
ISSN	2643-5217
ISSN (online)	2643-5217
DOI	10.3171/2023.1.FOCVID2296
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Article: Polycystic ovary syndrome and thyroid disorder: a comprehensive narrative review of the literature.

Palomba, Stefano / Colombo, Carla / Busnelli, Andrea / Caserta, Donatella / Vitale, Giovanni

Frontiers in endocrinology

2023 Volume 14, Page(s) 1251866

Abstract: Background: Published data on the relationship between polycystic ovary syndrome (PCOS) and thyroid dysfunction are sparse and confusing.: Objective: To comprehensively review data available in the literature regarding the relationship between PCOS ... ...

Abstract	Background: Published data on the relationship between polycystic ovary syndrome (PCOS) and thyroid dysfunction are sparse and confusing. Objective: To comprehensively review data available in the literature regarding the relationship between PCOS and the thyroid function, and its abnormalities. Methods: Nine main areas of interest were identified and analyzed according to the available evidence: 1) Evaluation of thyroid function for PCOS diagnosis; 2) Epidemiology data on thyroid function/disorders in patients with PCOS, and vice versa; 3) Experimental data supporting the relationship between thyroid function/disorders and PCOS; 4) Effects of thyroid function/disorders on PCOS features, and vice versa; 5) Effect of thyroid alterations on the cardiometabolic risk in women with PCOS; 6) Effect of thyroid abnormalities on reproductive outcomes in women with PCOS; 7) Relationship between thyroid function/abnormalities in patients with PCOS who are undergoing fertility treatment; 8) Effect of treatments for thyroid diseases on PCOS; and 9) Effect of treatments for PCOS on thyroid function. An extensive literature search for specific keywords was performed for articles published from 1970 to March 2023 using PubMed and Web of Science. Data were reported in a narrative fashion. Results: PCOS is a diagnosis of exclusion for which diagnosis is possible only after excluding disorders that mimic the PCOS phenotype, including thyroid dysfunctions. However, the tests and the cutoff values used for this are not specified. Many experimental and clinical data suggest a relationship between perturbations of the thyroid function and PCOS. Direct and unequivocal evidence on the effects of thyroid function/disorders on PCOS features are lacking. High thyroid-stimulating hormone levels and subclinical hypothyroidism may be associated with significant worsening of several intermediate endpoints of cardiometabolic risk in women with PCOS. Thyroid abnormalities may worsen reproductive outcomes, especially in patients undergoing fertility treatment. To date, there are no data demonstrating the efficacy of thyroid medications on fertility and cardiometabolic risk in women with PCOS. Lifestyle modification changes, metformin, and vitamin D seem to improve thyroid function in the general population. Conclusion: PCOS and thyroid disorders are closely related, and their coexistence may identify patients with a higher reproductive and metabolic risk. Regular screening for thyroid function and thyroid-specific autoantibodies in women with PCOS, particularly before and during pregnancy, is highly recommended.
MeSH term(s)	Female ; Humans ; Pregnancy ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/diagnosis ; Thyroid Diseases/complications ; Thyroid Diseases/epidemiology ; Hypothyroidism ; Thyroid Dysgenesis ; Antibodies ; Cardiovascular Diseases
Chemical Substances	Antibodies
Language	English
Publishing date	2023-08-11
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1251866
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Article ; Online: Carvedilol as the new non-selective beta-blocker of choice in patients with cirrhosis and portal hypertension.

Turco, Laura / Reiberger, Thomas / Vitale, Giovanni / La Mura, Vincenzo

Liver international : official journal of the International Association for the Study of the Liver

2023 Volume 43, Issue 6, Page(s) 1183–1194

Abstract: Portal hypertension (PH) is the most common complication ofcirrhosis and represents the main driver of hepatic decompensation. The overarching goal of PH treatments in patients with compensated cirrhosis is to reduce the risk of hepatic decompensation (i. ...

Abstract	Portal hypertension (PH) is the most common complication ofcirrhosis and represents the main driver of hepatic decompensation. The overarching goal of PH treatments in patients with compensated cirrhosis is to reduce the risk of hepatic decompensation (i.e development of ascites, variceal bleeding and/or hepatic encephalopathy). In decompensated patients, PH-directed therapies aim at avoiding further decompensation (i.e. recurrent/refractory ascites, variceal rebleeding, recurrent encephalopathy, spontaneous bacterial peritonitis or hepatorenal syndrome) and at improving survival. Carvedilol is a non-selective beta-blocker (NSBB) acting on hyperdynamic circulation/splanchnic vasodilation and on intrahepatic resistance. It has shown superior efficacy than traditional NSBBs in lowering PH in patients with cirrhosis and may be, therefore, the NSBB of choice for the treatment of clinically significant portal hypertension. In primary prophylaxis of variceal bleeding, carvedilol has been demonstrated to be more effective than endoscopic variceal ligation (EVL). In patients with compensated cirrhosis carvedilol achieves higher rate of hemodynamic response than propranolol, resulting in a decreased risk of hepatic decompensation. In secondary prophylaxis, the combination of EVL with carvedilol may prevent rebleeding and non-bleeding further decompensation better than that with propranolol. In patients with ascites and gastroesophageal varices, carvedilol is safe and may improve survival, as long as no impairment of the systemic hemodynamic or renal dysfunction occurs, with maintained arterial blood pressure as suitable safety surrogate. The target dose of carvedilol to treat PH should be 12.5 mg/day. This review summarizes the evidence behind Baveno-VII recommendations on the use of carvedilol in patients with cirrhosis.
MeSH term(s)	Humans ; Carvedilol/therapeutic use ; Propranolol ; Esophageal and Gastric Varices/etiology ; Esophageal and Gastric Varices/complications ; Ascites/etiology ; Ascites/complications ; Gastrointestinal Hemorrhage/drug therapy ; Gastrointestinal Hemorrhage/etiology ; Adrenergic beta-Antagonists/therapeutic use ; Hypertension, Portal/complications ; Hypertension, Portal/drug therapy ; Liver Cirrhosis
Chemical Substances	Carvedilol (0K47UL67F2) ; Propranolol (9Y8NXQ24VQ) ; Adrenergic beta-Antagonists
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.15559
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Article ; Online: Endosaccular flow disruption with the Contour Neurovascular System: angiographic and clinical results in a single-center study of 60 unruptured intracranial aneurysms.

Biondi, Alessandra / Primikiris, Panagiotis / Vitale, Giovanni / Charbonnier, Guillaume

Journal of neurointerventional surgery

2022 Volume 15, Issue 9, Page(s) 838–843

Abstract: Background: The Contour Neurovascular System is a novel device designed to treat intracranial aneurysms by intrasaccular flow disruption. We report our experience and mid-term follow-up in a series of patients treated with the Contour.: Methods: The ... ...

Abstract	Background: The Contour Neurovascular System is a novel device designed to treat intracranial aneurysms by intrasaccular flow disruption. We report our experience and mid-term follow-up in a series of patients treated with the Contour. Methods: The patients were divided into an intention to treat and a per protocol population, the latter defined by the successful implantation of the Contour device. The intention to treat population included 53 patients (30 women, mean age 56 years) with 60 unruptured intracranial aneurysms (53 in the anterior circulation and seven in the posterior circulation). There was clinical and angiographic follow-up immediate postoperatively and at 24 hours, 3 months and 1 year using the Raymond-Roy classification and the O'Kelly-Marotta grading scale. Results: The Contour was successfully implanted in 54/60 (90%) aneurysms. With regard to the angiographic follow-up, there was adequate occlusion (defined as complete occlusion or presence of a neck remnant) in 31.5% of 54 aneurysms immediately postoperatively, 62.3% (in 53/54 aneurysms) at 24 hours, 81.4% (in 43/54 aneurysms) at 3 months, and 89.3% (in 28/54 aneurysms) at 1 year. Technical complications in 60 aneurysms of the intention to treat population included two (3.3%) inadvertent detachments of the device. Thromboembolic events were observed in four of the 60 aneurysms (6.7%), with no clinical symptoms in three patients and transient morbidity in one (1.7%). No aneurysm bleeding was observed and no patient was retreated during the 1-year follow-up period. There was no permanent morbidity or mortality. Conclusions: The Contour device is effective and safe in the treatment of intracranial aneurysms. However, more experience and long-term follow-up are needed.
MeSH term(s)	Humans ; Female ; Middle Aged ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Intracranial Aneurysm/complications ; Treatment Outcome ; Cerebral Angiography/methods ; Embolization, Therapeutic/methods ; Endovascular Procedures/methods ; Retrospective Studies
Language	English
Publishing date	2022-08-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/jnis-2022-019271
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