Article ; Online: Mild/Moderate Asthma Network in Italy (MANI): a long-term observational study.
The Journal of asthma : official journal of the Association for the Care of Asthma
2021 Volume 59, Issue 9, Page(s) 1908–1913
Abstract: Objective: The prevalence of asthma in Italy is estimated to be around 4%; it affects approximately 2,000,000 citizens, and up to 80-90% of patients have mild-to-moderate asthma. Despite the clinical relevance of mild-to-moderate asthma, longitudinal ... ...
| Abstract | Objective: The prevalence of asthma in Italy is estimated to be around 4%; it affects approximately 2,000,000 citizens, and up to 80-90% of patients have mild-to-moderate asthma. Despite the clinical relevance of mild-to-moderate asthma, longitudinal observational data are very limited, including data on disease progression (worsening vs. improvement), the response to treatment, and prognosis. Studies are needed to develop long-term, observational, real-life research in large cohorts. The primary outcomes of this study will be based on prospective observation and the epidemiological evolution of mild and moderate asthma. Secondary outcomes will include patient-reported outcomes, treatments over time, disease-related functional and inflammatory patterns, and environmental and life-style influences. Methods: This study, called the Mild/Moderate Asthma Network of Italy (MANI), is a research initiative launched by the Italian Respiratory Society and the Italian Society of Allergology, Asthma and Clinical Immunology. MANI is a cluster-based, real world, cross-sectional, prospective, observational cohort study that includes 20,000 patients with mild-to-moderate asthma. (ClinicalTrials.gov Identifier: NCT04796844). Results and conclusion: Despite advances in asthma care, several research gaps remain to be addressed through clinical research. This study will add important new knowledge about long-term disease history, the transferability of clinical research results to daily practice, the efficacy of currently recommended strategies, and their impact on the burden and evolution of the disease. Abbreviations: MANI:Mild/Moderate Asthma Network of ItalySANI:Severe Asthma Network ItalyGINA:Global Initiative for AsthmaSABA:short acting β2-agonistsICS:inhaled corticosteroidsCRF:Case Report Form. |
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| MeSH term(s) | Administration, Inhalation ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Asthma/epidemiology ; Cross-Sectional Studies ; Disease Progression ; Humans ; Prospective Studies ; Quality of Life | |||||
| Chemical Substances | Anti-Asthmatic Agents | |||||
| Language | English | |||||
| Publishing date | 2021-09-01 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 603816-5 | |||||
| ISSN | 1532-4303 ; 0277-0903 | |||||
| ISSN (online) | 1532-4303 | |||||
| ISSN | 0277-0903 | |||||
| DOI | 10.1080/02770903.2021.1968895 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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