Article ; Online: Health-related quality of life in patients with solid tumors receiving implantable venous access ports for chemotherapy: A prospective randomized controlled trial.
European journal of oncology nursing : the official journal of European Oncology Nursing Society
2023 Volume 67, Page(s) 102445
Abstract: Purpose: Implantable venous access ports are widely used in patients receiving chemotherapy, but there is still scarce evidence about any patient-reported outcome measures. This prospective randomized controlled trial examined the impact on patients' ... ...
| Abstract | Purpose: Implantable venous access ports are widely used in patients receiving chemotherapy, but there is still scarce evidence about any patient-reported outcome measures. This prospective randomized controlled trial examined the impact on patients' quality-of-life following the placement of an implantable port device for long-term chemotherapy treatment. Method: A total of 120 chemotherapy naïve adult outpatients scheduled to receive chemotherapy (duration ≥12 weeks) for solid tissue tumors in a single academic oncology unit were randomly allocated (n = 60 in each arm) between radiologically guided insertion of an implantable venous access port (PORT arm) or standard repeated peripheral venous access (Control arm). Health-related quality-of-life scores (HRQoL) were assessed with the EQ-5D-5L and the oncology-specific EORTC QLQ-C30 (version 3.0) questionnaires at baseline, 3- and 6-months post randomization. Non-parametric tests were applied and differences between medians (Δ) are reported because of skewed-left HRQoL data. Results: Baseline clinical and demographic characteristics were well balanced between the two groups. There were no complications during insertion and no infection or device failure in the PORT subjects through the 6-month follow-up. The functional and symptom scales of the EORTC QLQ-C30 questionnaire were similar between both study arms at all time intervals. The EORTC QLQ-C30 global health status was significantly improved in the PORT subjects both at 3 months (Δ: 8.3 out of 100; P = 0.04) and 6 months follow-up (Δ: 16.7 out of 100; P = 0.003). Changes in EQ-5D-5L scores were significantly improved at 6 months in the PORT arm compared to control (Δ: 0.074 out of 1; P = 0.01). Conclusions: Implantable venous access ports may confer significantly improved patient-reported quality-of-life benefits in patients receiving chemotherapy for solid tissue tumors. |
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| MeSH term(s) | Adult ; Humans ; Catheterization, Central Venous/adverse effects ; Quality of Life ; Prospective Studies ; Neoplasms/drug therapy ; Central Venous Catheters |
| Language | English |
| Publishing date | 2023-10-09 |
| Publishing country | Scotland |
| Document type | Randomized Controlled Trial ; Journal Article |
| ZDB-ID | 2017117-1 |
| ISSN | 1532-2122 ; 1462-3889 |
| ISSN (online) | 1532-2122 |
| ISSN | 1462-3889 |
| DOI | 10.1016/j.ejon.2023.102445 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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