Article: In vitro
Frontiers in veterinary science
2024 Volume 11, Page(s) 1387174
Abstract: Introduction: Canine adipose-derived mesenchymal stem cells (cAD-MSCs) hold therapeutic promise due to their regenerative potential, particularly within their secretome. However, concerns arise regarding the impact of : Methods: The study involved ... ...
Abstract | Introduction: Canine adipose-derived mesenchymal stem cells (cAD-MSCs) hold therapeutic promise due to their regenerative potential, particularly within their secretome. However, concerns arise regarding the impact of Methods: The study involved collecting abdominal adipose tissue samples from nine healthy female dogs, from which cAD-MSCs were extracted and cultured. Stem cells were validated through trilineage differentiation assays and flow cytometry immunophenotyping. Gene expression profiling using RT-qPCR array, and cAD-MSCs secretome LC-MS/MS analysis, were conducted at passages 3 and 6 to reveal gene expression and protein composition alterations during Results and discussion: The results demonstrate that the gene expression and secretome composition of cAD-MSCs were impacted by |
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Language | English |
Publishing date | 2024-03-28 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 2834243-4 |
ISSN | 2297-1769 |
ISSN | 2297-1769 |
DOI | 10.3389/fvets.2024.1387174 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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