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Article: Metabolic changes in Euphorbia palusrtis latex after fungal infection

Krstić, Gordana / Boban Anđelković / Dejan Gođevac / Tatjana Stević / Vele Tešević / Vlatka Vajs / Young Hae Choi

Phytochemistry. 2016 Nov., v. 131

2016

Abstract: The variations of metabolic profile of the latex of wild-growing Euphorbia palustris was carried out using multivariate analysis of 1H NMR spectral data. One population was infected with fungi Fusarium sporotrichioides, Fusarium proliferatum and ... ...

Abstract	The variations of metabolic profile of the latex of wild-growing Euphorbia palustris was carried out using multivariate analysis of 1H NMR spectral data. One population was infected with fungi Fusarium sporotrichioides, Fusarium proliferatum and Alternaria alternata, while the other consisted of healthy plant species. The non-polar metabolites of latex extracts such as benzoyl ingenol-laurate, amyrin decadienoate esters, cis-1,4-polyisoprene, and 24-methylenecycloartanol were identified using 1H and 2D NMR spectra. Principal component analysis of 1H NMR data provided a clear discrimination between the latex of infected and healthy plants. Minimum inhibitory concentration and minimum fungicidal concentration values of the latex extracts of healthy and infected plants were determined. The latex of infected plants was found to contain higher levels of benzoyl ingenol-laurate and 24-methylenecycloartanol, of which concentrations were strongly correlated with the antifungal activities of the latex.
Keywords	Alternaria alternata ; antifungal properties ; esters ; Euphorbia ; fungi ; Fusarium proliferatum ; Fusarium sporotrichioides ; latex ; metabolites ; minimum inhibitory concentration ; multivariate analysis ; nuclear magnetic resonance spectroscopy ; principal component analysis ; spectral analysis
Language	English
Dates of publication	2016-11
Size	p. 17-25.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2016.08.005
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Methylprednisolone and its related substances in freeze-dried powders for injections

LJILJANA SOLOMUN / SVETLANA IBRIĆ / VLATKA VAJS / IVAN VUČKOVIĆ / ZORICA VUJIĆ

Journal of the Serbian Chemical Society, Vol 75, Iss 10, Pp 1441-

2010 Volume 1452

Abstract: In this work, the behavior of the active pharmaceutical substances methylprednisolone (in a form of methylprednisolone sodium succinate) in finished pharmaceutical dosage form, i.e., freeze-dried powder for injections was examined. The goal was to ... ...

Abstract	In this work, the behavior of the active pharmaceutical substances methylprednisolone (in a form of methylprednisolone sodium succinate) in finished pharmaceutical dosage form, i.e., freeze-dried powder for injections was examined. The goal was to evaluate the chemical stabilities of methyl-prednisolone sodium succinate packaged in a dual chamber vial, as a specific container closure system. The effect of different parameters: temperature, moisture and light were monitored. The method proposed by United States Pharmacopeia was used to determine concentrations of methylprednisolone, as the sum of the concentration of methylpredisolone esters (17-hydrogen succinate and 21-hydrogen succinate) and free methylprednisolone. The HPLC method was used for stability evaluation of the active substance and determination of related substances. Four main degradation products were registered. Temperature has a major impact on the degradation process with the appearance of 3 degradation products (impurities B, C and D), while the presence of light caused an increasing content of impurity A. Identification of impurity B, C and D has been realized using mass and NMR spectroscopy. All three substances are substances related to methylprednisolone.
Keywords	methylprednisolone sodium succinate ; freeze-dried powder ; container closure system ; stability ; impurities ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2010-10-01T00:00:00Z
Publisher	Serbian Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of four lichen acids isolated from Hypogymnia physodes on viability of rat thymocytes

Pavlovic, Voja / Andrija Smelcerovic / Gordana Stojanovic / Igor Stojanovic / Iris Djordjević / Milka Jadranin / Vlatka Vajs

Food and chemical toxicology. 2013 Jan., v. 51

2013

Abstract: Four lichen acids, physodalic acid (F1), physodic acid (F2), 3-hydroxyphysodic acid (F3), and isophysodic acid (F4), were isolated from Hypogymnia physodes methanol extract using preparative reversed-phase high performance liquid chromatography and their ...

Abstract	Four lichen acids, physodalic acid (F1), physodic acid (F2), 3-hydroxyphysodic acid (F3), and isophysodic acid (F4), were isolated from Hypogymnia physodes methanol extract using preparative reversed-phase high performance liquid chromatography and their structures were determined by UV, MS, 1H NMR and 13C NMR. This is the first report on the isolation of F4 from H. physodes. Isolated rat thymocytes were cultivated with increasing F1–F4 concentrations (0.1, 1, 10μg/well) and proliferative activity, viability, ROS (reactive oxygen species) production and MMP (mitochondrial membrane potential) disturbances were evaluated. Obtained results show significantly decreased thymocytes proliferation was observed when cells were treated with F1 (1μg, p<0.05; 10μg; p<0.001), F2 (10μg, p<0.05) and F3 compound (10μg, p<0.05). Significantly increased cytotoxicity was detected when cells were incubated with F1 (1μg, p<0.05; 10μg, p<0.01), F2 (10μg, p<0.05) and F3 compound (10μg, p<0.001). Increased H2DCF-DA fluorescence intensity, when cells were treated with F1 (1μg, p<0.001; 1μg, p<0.01; 10μg, p<0.001) and F2 (1μg, p<0.05; 10μg, p<0.01) compound, indicating the increase of intracellular ROS production. Simultaneously, increased ROS levels were followed with significantly decreased MMP when thymocytes were cultivated with F1 (0.1μg, p<0.001; 1μg, p<0.001; 10μg, p<0.001) and F2 compound (10μg, p<0.001). Thymocytes exposure to increased (0.1, 1, 10μg) concentrations of F3 and F4 compounds did not result with significant alterations in MMP and intracellular ROS production. We have shown that higher F1 and F2 concentrations induce thymocytes toxicity mainly through induction of oxidative stress, while cytotoxicity effect of F3 is followed with altered antioxidant/oxidant balance. The rigid 11H-dibenzo[b,e][1,4]dioxepin-11-one ring in the depsidone structure may play a important role for the examined biological activities.
Keywords	acids ; antioxidants ; cytotoxicity ; fluorescence ; Hypogymnia physodes ; lichens ; membrane potential ; methanol ; mitochondrial membrane ; nuclear magnetic resonance spectroscopy ; oxidants ; oxidative stress ; rats ; reactive oxygen species ; reversed-phase high performance liquid chromatography ; thymocytes ; toxicology ; viability
Language	English
Dates of publication	2013-01
Size	p. 160-164.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2012.04.043
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Analysis of amphetamines illegally produced in Serbia

VLATKA VAJS / SLOBODAN PETROVIC / SONJA BANOVIC STEVIC / MARINA NEVESCANIN

Journal of the Serbian Chemical Society, Vol 73, Iss 7, Pp 691-

2008 Volume 701

Abstract: Forensic practice in the Republic of Serbia faced the illegal production of amphetamine for the first time in 2003. This paper presents the results of the chemical characterization of 32 batches of amphetamine samples from three separate cases, for the ... ...

Abstract	Forensic practice in the Republic of Serbia faced the illegal production of amphetamine for the first time in 2003. This paper presents the results of the chemical characterization of 32 batches of amphetamine samples from three separate cases, for the purpose of identification of the active components and additives. Through the profiling of impurities of all samples, using gas chromatography/mass spectrometry (GC/MS), 30 compounds associated with amphetamine were identified. The results of the analysis of powder tartrate, sulfate and phosphate salts of amphetamine, as well as variously formulated tablets are presented in this study. The analyses showed that the amphetamines were synthesized by the Leuckart method in all cases.
Keywords	amphetamine ; impurity profiling ; Leuckart synthesis ; Chemistry ; QD1-999
Language	English
Publishing date	2008-07-01T00:00:00Z
Publisher	Serbian Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Polyphenolic compounds in seeds from some grape cultivars grown in Serbia

DEJAN GOĐEVAC / VELE TEŠEVIĆ / MILOVAN VELIČKOVIĆ / LJUBODRAG VUJISIĆ / VLATKA VAJS / SLOBODAN MILOSAVLJEVI

Journal of the Serbian Chemical Society, Vol 75, Iss 12, Pp 1641-

2010 Volume 1652

Abstract: Seed extracts from eight grape cultivars (Vitis vinifera) growing in Serbia were screened for their polyphenolic composition by means of HPLC/PDA/ESI/MS analysis. The study revealed 34 phenolic compounds belonging to the following groups: flavan-3-ol ... ...

Abstract	Seed extracts from eight grape cultivars (Vitis vinifera) growing in Serbia were screened for their polyphenolic composition by means of HPLC/PDA/ESI/MS analysis. The study revealed 34 phenolic compounds belonging to the following groups: flavan-3-ol monomers, proanthocyanidins, flavonols, hydroxycinnamic acid and hydroxybenzoic acid derivatives. The quantities of the main constituents were determined using PDA/HPLC. Qualitative and quantitative differences among the cultivars were observed.
Keywords	Vitis vinifera ; grape seeds ; HPLC/PDA/ESI/MS ; flavanol monomers ; proanthocyanidins ; flavonols ; hydroxycinnamic acid ; hydroxybenzoic acid derivative ; Chemistry ; QD1-999
Language	English
Publishing date	2010-12-01T00:00:00Z
Publisher	Serbian Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preliminary analysis of fatty acid chemistry of Kindbergia praelonga and Kindbergia stokesii (Brachytheciaceae)

BORIS PEJIN / LJUBODRAG VUJISIĆ / MARKO SABOVLJEVIĆ / ANETA SABOVLJEVIĆ / VELE TEŠEVIĆ / VLATKA VAJS

Journal of the Serbian Chemical Society, Vol 75, Iss 12, Pp 1637-

2010 Volume 1640

Abstract: Moss species of the family Brachytheciaceae, Kindbergia praelonga (Hedw.) Ochyra and Kindbergia stokesii (Turn.) Ochyra, were preliminarily analysed for their fatty acid composition with the aim of studying the chemical relationship of these two entities. ...

Abstract	Moss species of the family Brachytheciaceae, Kindbergia praelonga (Hedw.) Ochyra and Kindbergia stokesii (Turn.) Ochyra, were preliminarily analysed for their fatty acid composition with the aim of studying the chemical relationship of these two entities. Fatty acid methyl esters were examined by GC and GC–MS in their methanol extracts. Thirteen fatty acids were identified. It is likely that the mosses are chemically distinguishable and should be treated as separate entities. However, additional chemical constituents of various moss samples, such as phenolic acids, their derivatives and flavonoids, must be also analyzed in order to support the re-examination of the relationship between these two species.
Keywords	bryophytes ; mosses ; Kindbergia ; fatty acids ; chemotaxonomy ; Chemistry ; QD1-999
Language	English
Publishing date	2010-12-01T00:00:00Z
Publisher	Serbian Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sesquiterpene Lactones of Amphoricarpos autariatus ssp. autariatus from Montenegro - Antifungal Leaf - Surface Constituents

Milka Jadranin / Iris Đorđević / Vele Tešević / Vlatka Vajs / Nebojša Menković / Marina Soković / Jasmina Glamočlija / Slobodan Milosavljević

Records of Natural Products, Vol 7, Iss 3, Pp 234-

2013 Volume 238

Abstract: The composition of leaf cuticular neutral lipids of Amphoricarpos autariatus ssp. autariatus collected at canyon of river Tara (North Montenegro) was investigated by GC/MS (nonpolar fraction), LC-ESI TOF MS and 1H NMR spectroscopy (more polar fraction). ... ...

Abstract	The composition of leaf cuticular neutral lipids of Amphoricarpos autariatus ssp. autariatus collected at canyon of river Tara (North Montenegro) was investigated by GC/MS (nonpolar fraction), LC-ESI TOF MS and 1H NMR spectroscopy (more polar fraction). The nonpolar fraction (ca. 15% of the whole surface extract) contained C 27 - 33 n-alkanes, those with odd-number of carbons predominating. The LC-ESI MS and 1H NMR of the more polar fraction revealed 13 sesquiterpene lactones, constituting ca. 97.5% of the lactone mixture, identified as the known guaianolides, so-called amphoricarpolides, found previously in the aerial parts of the genus. The lactone fraction exhibited considerable in vitro effect against eight fungi, i.e. Aspergillus ochraceus , A. niger, A. versicolor , Penicillium funiculosum, P. ochrochloron, Trichoderma viride, Fusarium verticillioides and Fulvia fulvum.
Keywords	Amphoricarpos autariatus ssp. autariatus ; Asteraceae ; Leaf-surface sesquiterpene lactones ; Amphoricarpolides ; Antifungal activity ; Chemistry ; QD1-999 ; Organic chemistry ; QD241-441 ; Botany ; QK1-989
Language	English
Publishing date	2013-05-01T00:00:00Z
Publisher	ACG Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chemical composition and antifungal activity of the essential oil of Douglas fir (Pseudosuga menziesii Mirb. Franco) from Serbia

VELE TEŠEVIĆ / SLOBODAN MILOSAVLJEVIĆ / VLATKA VAJS / IRIS ĐORĐEVIĆ / MARINA SOKOVIĆ / VERA LAVADINOVIĆ / MIROSLAV NOVAKOVIĆ

Journal of the Serbian Chemical Society, Vol 74, Iss 10, Pp 1035-

2009 Volume 1040

Abstract: The chemical composition of the essential oil of fresh young needles with twigs of Douglas fir (Pseudosuga menziesii Mirb. Franco) obtained by hydrodistillation were analyzed by gas chromatography (GC) and gas chromatography–mass spectrometry (GC–MS). ... ...

Abstract	The chemical composition of the essential oil of fresh young needles with twigs of Douglas fir (Pseudosuga menziesii Mirb. Franco) obtained by hydrodistillation were analyzed by gas chromatography (GC) and gas chromatography–mass spectrometry (GC–MS). Ten compounds, accounting for 94.26 % of the oil, were identified. The main compounds found were bornyl acetate (34.65 %), camphene (29.82 %), a-pinene (11.65 %) and santene (5.45 %). The antifungal activity of the essential oil was tested against various fungal species. The minimum inhibitory concentration of Douglas fir essential oil ranged from 1.5 to 4 µg mL-1. The fungi most sensitive to the tested oil were Phomopsis helianthi, while Penicillium species, along with Microsporum canis, were the most resistant. Compared to the commercial fungicidal agent bifonazole, the studied essential oil demonstrated higher antifungal activity.
Keywords	antifungal activity ; bornyl acetate ; Douglas fir ; essential oil ; Chemistry ; QD1-999
Language	English
Publishing date	2009-09-01T00:00:00Z
Publisher	Serbian Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Supercritical carbon dioxide extraction of antioxidants from rosemary (Rosmarinus officinalis L.) and sage (Salvia officinalis L.)

JASNA IVANOVIĆ / SONJA ĐILAS / MILKA JADRANIN / VLATKA VAJS / NADA BABOVIĆ / SLOBODAN PETROVIĆ / IRENA ŽIŽOVIĆ

Journal of the Serbian Chemical Society, Vol 74, Iss 7, Pp 717-

2009 Volume 732

Abstract: The aim of the present study was to isolate and characterize antioxidant extracts obtained from dried leaves of rosemary (Rosmarinus officinalis L.) and sage (Salvia officinalis L.), originating from the southern Balkan Region. The antioxidant fraction ... ...

Abstract	The aim of the present study was to isolate and characterize antioxidant extracts obtained from dried leaves of rosemary (Rosmarinus officinalis L.) and sage (Salvia officinalis L.), originating from the southern Balkan Region. The antioxidant fraction was isolated from the plant material by supercritical carbon dioxide (SC-CO2) fractional extraction under a pressure of 30 MPa and at temperatures of 40 and 100 °C. In the present study, kinetic data and yields of antioxidant extracts obtained from dried leaves of rosemary and sage under different conditions were determined. Electron spin resonance (ESR) spectroscopy assay on the ability of the extracts to scavenge stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals and reactive hydroxyl radicals during the Fenton reaction trapped by 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) showed that the investigated extracts had antioxidant activity comparable to that of butylated hydroxyanisole (BHA) and commercial rosemary extract. The antioxidant fractions isolated at the higher temperature had higher antioxidant activities. A tentative analysis of the chemical composition of the antioxidant fractions obtained at the higher temperature was accomplished by LC-DAD and LC-MS analytical methods. Abietane-type diterpenoids, flavonoids and fatty acids were identified in the SC-CO2 extract of rosemary and sage.
Keywords	rosemary ; sage ; supercritical extraction ; antioxidant ; DPPH ; hydroxyl radicals ; Chemistry ; QD1-999
Language	English
Publishing date	2009-07-01T00:00:00Z
Publisher	Serbian Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Flavonoids from the aerial parts of Onobrychis montana subsp. scardica

BORIS PEJIN / DEJAN GODJEVAC / GORDANA ZDUNIC / KATARINA SAVIKIN / DANIJELA STESEVIC / VLATKA VAJS / SLOBODAN MILOSAVLJEVIC

Journal of the Serbian Chemical Society, Vol 73, Iss 5, Pp 525-

2008 Volume 529

Abstract: Rutin (1, main constituent) and two flavone C-glycosides, vitexin (2) and vitexin 2''-O-alpha-rhamnopyranoside (3) were isolated from the aerial parts of Onobrychis montana subsp. scardica. They were identified by 1H-NMR, 13C-NMR and UV–Vis spectroscopy ( ...

Abstract	Rutin (1, main constituent) and two flavone C-glycosides, vitexin (2) and vitexin 2''-O-alpha-rhamnopyranoside (3) were isolated from the aerial parts of Onobrychis montana subsp. scardica. They were identified by 1H-NMR, 13C-NMR and UV–Vis spectroscopy (procedure with shift reagents), and high resolution ESI-MS. A relatively high content of 1 (5.27 mg/g of dry plant material), measured by HPLC, indicated O. montana subsp. scardica as a new natural source of this biologically active compound. The isolated flavonoid compounds might be of value as chemotaxonomic markers.
Keywords	Onobrychis scardica ; Fabaceae ; flavonoids ; Chemistry ; QD1-999
Language	English
Publishing date	2008-05-01T00:00:00Z
Publisher	Serbian Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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