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  1. Article: Balloon-Assisted Coil Embolization and Balloon Angioplasty for Post Subarachnoid Hemorrhage Vasospasm: Initial Experience with Scepter Mini Balloon.

    Ioannidis, Ioannis / Adamou, Antonis / Nasis, Nikolaos / Vlychou, Marianna / Poullos, Nektarios

    Neurointervention

    2022  Volume 17, Issue 2, Page(s) 110–114

    Abstract: The scope of this technical note is to report our experience with balloon remodeling for wideneck aneurysms and balloon angioplasty of post-subarachnoid hemorrhage vasospasm using the novel Scepter Mini balloon (SMB). Five cases were treated with balloon ...

    Abstract The scope of this technical note is to report our experience with balloon remodeling for wideneck aneurysms and balloon angioplasty of post-subarachnoid hemorrhage vasospasm using the novel Scepter Mini balloon (SMB). Five cases were treated with balloon remodeling for aneurysmal subarachnoid hemorrhage, 2 of which were additionally treated with angioplasty due to post-bleeding vasospasm. All patients had their aneurysm located on parent vessels with a diameter smaller than 2 mm. Complete occlusion was noted in all aneurysms, and the patients had no short-term complications attributed to the catheterization. Additionally, we confirm the previously reported smooth navigation of the balloon through vessels with tortuous anatomy without catheter-induced vasospasm. Based on our experience, the SMB can be a safe and efficient device for applying the balloon remodeling technique for distally located wide-neck aneurysms and distal balloon angioplasty.
    Language English
    Publishing date 2022-06-15
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2639823-0
    ISSN 2233-6273 ; 2093-9043
    ISSN (online) 2233-6273
    ISSN 2093-9043
    DOI 10.5469/neuroint.2022.00171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: PCaGuard: A Software Platform to Support Optimal Management of Prostate Cancer.

    Tamposis, Ioannis / Tsougos, Ioannis / Karatzas, Anastasios / Vassiou, Katerina / Vlychou, Marianna / Tzortzis, Vasileios

    Applied clinical informatics

    2022  Volume 13, Issue 1, Page(s) 91–99

    Abstract: Background and objective: Prostate cancer (PCa) is a severe public health issue and the most common cancer worldwide in men. Early diagnosis can lead to early treatment and long-term survival. The addition of the multiparametric magnetic resonance ... ...

    Abstract Background and objective: Prostate cancer (PCa) is a severe public health issue and the most common cancer worldwide in men. Early diagnosis can lead to early treatment and long-term survival. The addition of the multiparametric magnetic resonance imaging in combination with ultrasound (mpMRI-U/S fusion) biopsy to the existing diagnostic tools improved prostate cancer detection. Use of both tools gradually increases in every day urological practice. Furthermore, advances in the area of information technology and artificial intelligence have led to the development of software platforms able to support clinical diagnosis and decision-making using patient data from personalized medicine.
    Methods: We investigated the current aspects of implementation, architecture, and design of a health care information system able to handle and store a large number of clinical examination data along with medical images, and produce a risk calculator in a seamless and secure manner complying with data security/accuracy and personal data protection directives and standards simultaneously. Furthermore, we took into account interoperability support and connectivity to legacy and other information management systems. The platform was implemented using open source, modern frameworks, and development tools.
    Results: The application showed that software platforms supporting patient follow-up monitoring can be effective, productive, and of extreme value, while at the same time, aiding toward the betterment medicine clinical workflows. Furthermore, it removes access barriers and restrictions to specialized care, especially for rural areas, providing the exchange of medical images and patient data, among hospitals and physicians.
    Conclusion: This platform handles data to estimate the risk of prostate cancer detection using current state-of-the-art in eHealth systems and services while fusing emerging multidisciplinary and intersectoral approaches. This work offers the research community an open architecture framework that encourages the broader adoption of more robust and comprehensive systems in standard clinical practice.
    MeSH term(s) Artificial Intelligence ; Humans ; Male ; Precision Medicine ; Prostate/pathology ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/therapy ; Software
    Language English
    Publishing date 2022-01-19
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1869-0327
    ISSN (online) 1869-0327
    DOI 10.1055/s-0041-1741481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bone Mineral Density in Adult Patients with Type 1 Diabetes Mellitus Assessed by Both DXA and QCT.

    Barmpa, Eleftheria / Karamagkiolis, Spyridon / Tigas, Stelios / Navrozidou, Parthena / Vlychou, Marianna / Fezoulidis, Ioannis / Koukoulis, Georgios N / Bargiota, Alexandra

    Journal of diabetes research

    2023  Volume 2023, Page(s) 8925956

    Abstract: Purpose: Bone mineral density (BMD) was measured in uncomplicated young adult patients with type 1 diabetes mellitus (T1DM) and sex- and age-matched controls, using both dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) to ... ...

    Abstract Purpose: Bone mineral density (BMD) was measured in uncomplicated young adult patients with type 1 diabetes mellitus (T1DM) and sex- and age-matched controls, using both dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) to investigate their diagnostic ability in detecting abnormal values in these patients.
    Methods: 118 patients with T1DM (65 females, mean age 30.12 ± 8.78 years) and 94 sex- and age-matched controls were studied. BMD was assessed in all participants by DXA and QCT at lumbar spine (LS). Biochemical markers of bone metabolism were also measured.
    Results: T1DM was associated with lower BMD at L1-L3 vertebrae measured by both DXA and QCT and lower bone turnover compared to sex- and age-matched controls. In T1DM subjects, QCT detected more patients with abnormal BMD values compared to DXA. BMI and HbA1c levels were the only determinants of BMD. Bone turnover markers were lower in patients with longer duration of diabetes.
    Conclusion: QCT provides a higher sensitivity compared to DXA in detecting abnormal BMD values in patients with uncomplicated T1DM. In these patients, the diabetes-related decreased BMD may be present early, before it is detected by DXA, the clinical gold standard for BMD measurements, and before the presence of any other diabetes complications, stressing the importance of an early intervention for fracture prevention.
    MeSH term(s) Female ; Young Adult ; Humans ; Adult ; Bone Density ; Absorptiometry, Photon/methods ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Lumbar Vertebrae/diagnostic imaging
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6753
    ISSN (online) 2314-6753
    ISSN 2314-6753
    DOI 10.1155/2023/8925956
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  4. Article ; Online: Combination of fusion guided multiparametric MRI-transrectal US with systematic biopsy of the prostate for the detection of clinically significant prostate cancer: A prospective single-center study.

    Agrotis, Georgios / Tsougos, Ioannis / Oikonomou, Athanasios / Vassiou, Katerina / Karatzas, Anastasios / Tamposis, Ioannis / Fanariotis, Michalis / Vamvakas, Alexandros / Tzortzis, Vasilis / Vlychou, Marianna

    Journal of clinical ultrasound : JCU

    2023  Volume 51, Issue 6, Page(s) 1101–1111

    Abstract: Purpose: To investigate the diagnostic efficacy of fusion guided multiparametric MRI (mpMRI)-transrectal ultrasound (TRUS) biopsy versus systematic biopsy of the prostate in patients with suspicion of prostate cancer.: Methods: A total of 185 ... ...

    Abstract Purpose: To investigate the diagnostic efficacy of fusion guided multiparametric MRI (mpMRI)-transrectal ultrasound (TRUS) biopsy versus systematic biopsy of the prostate in patients with suspicion of prostate cancer.
    Methods: A total of 185 patients with PI-RADS 3 lesions or higher underwent fusion guided targeted and systematic prostate biopsy. Histology of samples was correlated with PI-RADS score and biopsy method for each patient.
    Results: A total of 81/185 (43.8%) cases positive for cancer were detected; 23/81 (28.4%) cases with clinically insignificant prostate cancer-insPCa and 58/81 (71.6%) cases with clinically significant prostate cancer-csPCa. There was a statistically significant difference in the overall detection of adenocarcinomas between methods (p = .035, McNemar test). Moreover, there was a statistically significant difference in the detection of insPCa between the two methods (p = .004, McNemar test). Systematic biopsy detected 13 patients with insPCa more (14.4%) than the targeted biopsy method. However, there is no statistical difference in the detection rate of csPCa between the two methods (p = 1, McNemar test). When both techniques were combined more cases of csPCa were detected.
    Conclusion: The combined implementation of fusion-guided targeted mpMRI-TRUS and systematic biopsy of the prostate provides higher detection number of csPCa, compared to each method alone. The potential of fusion-guided mpMRI-TRUS biopsy of the prostate needs to be further assessed since each method has its limitations; therefore, systematic prostate biopsy still plays an important role in clinical practice.
    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/diagnostic imaging ; Prostate/diagnostic imaging ; Multiparametric Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging ; Prospective Studies ; Ultrasonography, Interventional/methods ; Image-Guided Biopsy/methods
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189393-2
    ISSN 1097-0096 ; 0091-2751
    ISSN (online) 1097-0096
    ISSN 0091-2751
    DOI 10.1002/jcu.23497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 vaccine-associated myositis: a comprehensive review of the literature driven by a case report.

    Syrmou, Vasiliki / Liaskos, Christos / Ntavari, Niki / Mitsimponas, Konstantinos / Simopoulou, Theodora / Alexiou, Ioannis / Vlychou, Marianna / Katsiari, Christina G / Bogdanos, Dimitrios P

    Immunologic research

    2023  Volume 71, Issue 4, Page(s) 537–546

    Abstract: Several cases of vaccine-associated manifestations have been published including cases of inflammatory myositis. Herein, we comprehensively review the literature on the occasion of case of a woman with inflammatory myositis following COVID-19 vaccination. ...

    Abstract Several cases of vaccine-associated manifestations have been published including cases of inflammatory myositis. Herein, we comprehensively review the literature on the occasion of case of a woman with inflammatory myositis following COVID-19 vaccination. A 67-year-old woman presented with left arm edema, rash, and weakness after the 2
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Ad26COVS1 ; Autoantibodies ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Dermatomyositis/diagnosis ; Lung Diseases, Interstitial ; Myositis/chemically induced ; Myositis/diagnosis ; SARS-CoV-2
    Chemical Substances Ad26COVS1 (JT2NS6183B) ; Autoantibodies ; BNT162 Vaccine ; COVID-19 Vaccines
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-023-09368-2
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  6. Article ; Online: Satisfactory patient-reported outcomes in patients treated with impaction bone grafting and autologous matrix-induced chondrogenesis for osteochondral knee defects.

    Mitrousias, Vasileios / Chalatsis, Georgios / Mylonas, Theodoros / Siouras, Athanasios / Stergiadou, Stella / Panteliadou, Freideriki / Vlychou, Marianna / Hantes, Michael

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

    2023  Volume 31, Issue 12, Page(s) 5698–5706

    Abstract: Purpose: Osteochondral knee defects usually affect young, active patients and may alter knee biomechanics and progressively lead to joint degeneration. Various treatment options exist with autologous, impaction bone grafting in combination with ... ...

    Abstract Purpose: Osteochondral knee defects usually affect young, active patients and may alter knee biomechanics and progressively lead to joint degeneration. Various treatment options exist with autologous, impaction bone grafting in combination with autologous matrix-induced chondrogenesis (BG-AMIC) being a less-expensive, one-step, promising option. The purpose of this study is to evaluate the clinical and radiological mid-term outcomes of large osteochondral lesions treated with BG-AMIC, identify a possible correlation between the two and report postoperative complications and reoperation rate.
    Methods: A retrospective analysis of 25 patients treated with the BG-AMIC technique for knee osteochondral lesions was performed. Patients were assessed using the following PROMs: the IKDC, the KOOS and the Lysholm score, the Tegner activity scale and a patient acceptable symptom state (PASS). The EQ-5D-5L score was used to assess health-related quality of life. Radiological assessment was performed using the MOCART 2.0 score on a 3 T MRI.
    Results: At a mean of 3.8 (± 0.8)-year follow-up, all functional scores increased significantly (p < 0.005) when compared to the preoperative baseline. IKDC increased from 44.5 (± 15.9) to 81.4 (± 14.7), KOOS from 41.5 (± 16.1) to 91.6 (± 11.6) and Lysholm from 54.4 (± 23) to 95.2 (± 5.5) (p < 0.005). The EQ-5D-5L score also revealed a significant improvement [59.9 (± 25) to 93.4 (± 10.2), p < 0.005]. Mean Tegner score reached pre-injury levels. The PASS was positive in 100% of patients. The minimum clinically important difference was reached in all PROMs except for the KOOS Sports subscale. There were no re-operations. Morphological evaluation of the repair tissue using the MOCART 2.0 score revealed a mean total score of 52.8 (± 30.5). A statistically significant, positive correlation was found between the MOCART 2.0 score and the IKDC score, the KOOS ADL subscale and the EQ-5D-5L (p < 0.05).
    Conclusion: BG-AMIC is a safe and reliable option for treating deep, knee osteochondral lesions, providing a statistically significant and clinically important improvement in patient-reported outcomes. No complications were noticed, and no re-operations were performed after the procedure. A moderate positive correlation between the MOCART 2.0 score and the IKDC, KOOS ADL and EQ-5D-5L was noticed. However, this correlation is not necessarily clinically relevant, and excellent clinical results can be expected even in patients with low MOCART scores.
    Level of evidence: III.
    MeSH term(s) Humans ; Cartilage, Articular/surgery ; Cartilage, Articular/injuries ; Follow-Up Studies ; Bone Transplantation/methods ; Chondrogenesis ; Retrospective Studies ; Quality of Life ; Knee Joint/surgery ; Magnetic Resonance Imaging/methods ; Transplantation, Autologous/methods ; Treatment Outcome
    Language English
    Publishing date 2023-10-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1159064-6
    ISSN 1433-7347 ; 0942-2056
    ISSN (online) 1433-7347
    ISSN 0942-2056
    DOI 10.1007/s00167-023-07626-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Bursitis of the coccyx in an adult with rheumatoid arthritis mimicking a sacrococcygeal meningocele.

    Tzerefos, Christos / Koukoulis, George K / Vlychou, Marianna / Brotis, Alexandros G / Fountas, Kostas N / Paterakis, Konstantinos N

    Surgical neurology international

    2021  Volume 12, Page(s) 220

    Abstract: Background: Bursitis is a chronic inflammatory condition characterized by the deposition of cholesterol, macrophage infiltration, and bursal wall calcification. Bursitis is, however, rarely found in the sacrococcygeal region where it may present as a ... ...

    Abstract Background: Bursitis is a chronic inflammatory condition characterized by the deposition of cholesterol, macrophage infiltration, and bursal wall calcification. Bursitis is, however, rarely found in the sacrococcygeal region where it may present as a space-occupying mass.
    Case description: A 64-year-old male with rheumatoid arthritis presented with 3 years' duration of difficulty sitting and walking due to a soft-tissue mass involving the coccyx region. Once the patient's MR demonstrated a cystic lesion with erosion of the coccyx, the patient underwent gross total resection of the lesion that proved to be pathologically consistent with bursitis. Postoperatively, the patient's complaints fully resolved.
    Conclusion: Bursitis may present as a soft-tissue tumor-like lesion in the coccyx that favorably responds to gross total surgical excision.
    Language English
    Publishing date 2021-05-10
    Publishing country United States
    Document type Case Reports
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_369_2021
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  8. Article: Asymptomatic unilateral aplasia of the left parotid gland: an unusual entity and case report.

    Sgantzou, Ioanna-Konstantina / Vassiou, Katerina / Gkrinia, Eleni / Maiou, Chariklia / Agrotis, Georgios / Vlychou, Marianna

    Radiology case reports

    2021  Volume 16, Issue 11, Page(s) 3453–3456

    Abstract: Congenital agenesis of major salivary glands is considered a very infrequent condition and typically appears to be a coincidental finding. It can be present as sporadic case or may be combined with aplasia or hypoplasia of other salivary glands or the ... ...

    Abstract Congenital agenesis of major salivary glands is considered a very infrequent condition and typically appears to be a coincidental finding. It can be present as sporadic case or may be combined with aplasia or hypoplasia of other salivary glands or the lacrimal glands, or as a part of syndromes. Only 23 cases documented in the literature to date, while the youngest patient was 50 days old. Plenty of radiographic useful techniques and treatment is closely related to the clinical manifestations; therefore. We present a case of 52 year old female who was referred to our radiology department for recurrent numbness of the left upper limb, experienced over the previous three months. Complete absence of the left parotid gland was incidentally demonstrated at the brain MRI scan. Based on the patient's past medical history, physical examination and demonstrated radiographic techniques it was an asymptomatic, no-syndromic and no-familious unilateral aplasia of the parotid gland. In the present report, we aimed to underline that this rare condition may be asymptomatic and co-exist with other medical conditions and syndromes.
    Language English
    Publishing date 2021-09-06
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2021.07.096
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  9. Article ; Online: A meta-analysis evaluating contrast-enhanced intraoperative ultrasound (CE-IOUS) in the context of surgery for colorectal liver metastases.

    Fergadi, Maria P / Magouliotis, Dimitrios E / Vlychou, Marianna / Rountas, Christos / Athanasiou, Thanos / Zacharoulis, Dimitrios

    Abdominal radiology (New York)

    2021  Volume 46, Issue 9, Page(s) 4178–4188

    Abstract: Background: This study aimed to assess the outcomes of contrast-enhanced intraoperative ultrasound (CE-IOUS) for patients with colorectal liver metastases (CRLMs) undergoing surgery.: Method: A thorough literature search was performed in PubMed, ... ...

    Abstract Background: This study aimed to assess the outcomes of contrast-enhanced intraoperative ultrasound (CE-IOUS) for patients with colorectal liver metastases (CRLMs) undergoing surgery.
    Method: A thorough literature search was performed in PubMed, Scopus, and Cochrane databases, in accordance with the PRISMA guidelines. The Odds Ratio, Weighted Mean Difference, and 95% Confidence Interval were evaluated, by means of Random-Effects model.
    Results: Eleven articles met the inclusion criteria and incorporated 497 patients. The present study shows that CE-IOUS is associated with higher sensitivity and accuracy compared with multidetector computed tomography (MDCT), magnetic resonance imaging (MRI), and intraoperative ultrasound (IOUS) in identifying CRLMs (p < 0.05). The positive predictive value was similar among the different modalities. Furthermore, new CRLMs were identified by CE-IOUS, thus affecting the surgical plan in 128 patients (51.8% of the patients with new CRLMs). Moreover, 91 patients (71%) underwent a more extensive hepatectomy and 15 patients (11.7%) were considered non-operable. Two alternative contrast agents, Sonazoid and Sonovue, were employed with similar sensitivity (p > 0.05).
    Conclusion: These outcomes suggest the superiority of the CE-IOUS over MDCT, MRI, and IOUS for the staging of patients with CRLMs undergoing surgery. However, they should be treated with caution given the small number of the included studies.
    MeSH term(s) Colorectal Neoplasms/diagnostic imaging ; Contrast Media ; Hepatectomy ; Humans ; Intraoperative Care ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/surgery ; Magnetic Resonance Imaging ; Ultrasonography
    Chemical Substances Contrast Media
    Language English
    Publishing date 2021-05-09
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-021-03096-7
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  10. Article ; Online: Facial nerve: A review of the anatomical, surgical landmarks and its iatrogenic injuries.

    Zourntou, Stamatina-Emmanouela / Makridis, Konstantinos G / Tsougos, Crysovalantis-Ioannis / Skoulakis, Charalampos / Vlychou, Marianna / Vassiou, Aikaterini

    Injury

    2021  Volume 52, Issue 8, Page(s) 2038–2048

    Abstract: Facial nerve iatrogenic injuries are serious and can negatively affect the quality of life of the patients. Due to the properties of the nerve, the complications are devastating involving the aesthetic appearance and the function of the face. Moreover, ... ...

    Abstract Facial nerve iatrogenic injuries are serious and can negatively affect the quality of life of the patients. Due to the properties of the nerve, the complications are devastating involving the aesthetic appearance and the function of the face. Moreover, the multiple branches of the nerve increase the risk of an iatrogenic injury making the detailed knowledge of the anatomical correlations around them critical. In this review, a meticulous analysis was performed including the surgical procedures posing the greater risk of an iatrogenic injury as well as the full description of all the reported anatomical landmarks involving the extracranial course of the facial nerve.
    MeSH term(s) Facial Nerve ; Facial Nerve Injuries/etiology ; Humans ; Iatrogenic Disease ; Quality of Life
    Language English
    Publishing date 2021-05-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2021.05.029
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