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  1. Article ; Online: What makes community health worker models for tuberculosis active case finding work? A cross-sectional study of TB REACH projects to identify success factors for increasing case notifications.

    Dam, Thu A / Forse, Rachel J / Tran, Phuong M T / Vo, Luan N Q / Codlin, Andrew J / Nguyen, Lan P / Creswell, Jacob

    Human resources for health

    2022  Volume 20, Issue 1, Page(s) 25

    Abstract: Background: In the field of tuberculosis (TB), Community Healthcare Workers (CHWs) have been engaged for advocacy, case detection, and patient support in a wide range of settings. Estimates predict large-scale shortfalls of healthcare workers in low- ... ...

    Abstract Background: In the field of tuberculosis (TB), Community Healthcare Workers (CHWs) have been engaged for advocacy, case detection, and patient support in a wide range of settings. Estimates predict large-scale shortfalls of healthcare workers in low- and middle-income settings by 2030 and strategies are needed to optimize the health workforce to achieve universal availability and accessibility of healthcare. In 2018, the World Health Organization (WHO) published guidelines on best practices for CHW engagement, and identified remaining knowledge gaps. Stop TB Partnership's TB REACH initiative has supported interventions using CHWs to deliver TB care in over 30 countries, and utilized the same primary indicator to measure project impact at the population-level for all TB active case finding projects, which makes the results comparable across multiple settings. This study compiled 10 years of implementation data from the initiative's grantee network to begin to address key knowledge gaps in CHW networks.
    Methods: We conducted a cross-sectional study analyzing the TB REACH data repository (n = 123) and primary survey responses (n = 50) of project implementers. We designed a survey based on WHO guidelines to understand projects' practices on CHW recruitment, training, activities, supervision, compensation, and sustainability. We segmented projects by TB notification impact and fitted linear random-effect regression models to identify practices associated with higher changes in notifications.
    Results: Most projects employed CHWs for advocacy alongside case finding and holding activities. Model characteristics associated with higher project impact included incorporating e-learning in training and having the prospect of CHWs continuing their responsibilities at the close of a project. Factors that trended towards being associated with higher impact were community-based training, differentiated contracts, and non-monetary incentives.
    Conclusion: In line with WHO guidelines, our findings emphasize that successful implementation approaches provide CHWs with comprehensive training, continuous supervision, fair compensation, and are integrated within the existing primary healthcare system. However, we encountered a great degree of heterogeneity in CHW engagement models, resulting in few practices clearly associated with higher notifications.
    MeSH term(s) Community Health Services ; Community Health Workers ; Cross-Sectional Studies ; Humans ; Motivation ; Tuberculosis/diagnosis
    Language English
    Publishing date 2022-03-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126923-3
    ISSN 1478-4491 ; 1478-4491
    ISSN (online) 1478-4491
    ISSN 1478-4491
    DOI 10.1186/s12960-022-00708-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Towards universal health coverage in Vietnam: a mixed-method case study of enrolling people with tuberculosis into social health insurance.

    Forse, Rachel / Yoshino, Clara Akie / Nguyen, Thanh Thi / Phan, Thi Hoang Yen / Vo, Luan N Q / Codlin, Andrew J / Nguyen, Lan / Hoang, Chi / Basu, Lopa / Pham, Minh / Nguyen, Hoa Binh / Van Dinh, Luong / Caws, Maxine / Wingfield, Tom / Lönnroth, Knut / Sidney-Annerstedt, Kristi

    Health research policy and systems

    2024  Volume 22, Issue 1, Page(s) 40

    Abstract: Background: Vietnam's primary mechanism of achieving sustainable funding for universal health coverage (UHC) and financial protection has been through its social health insurance (SHI) scheme. Steady progress towards access has been made and by 2020, ... ...

    Abstract Background: Vietnam's primary mechanism of achieving sustainable funding for universal health coverage (UHC) and financial protection has been through its social health insurance (SHI) scheme. Steady progress towards access has been made and by 2020, over 90% of the population were enrolled in SHI. In 2022, as part of a larger transition towards the increased domestic financing of healthcare, tuberculosis (TB) services were integrated into SHI. This change required people with TB to use SHI for treatment at district-level facilities or to pay out of pocket for services. This study was conducted in preparation for this transition. It aimed to understand more about uninsured people with TB, assess the feasibility of enrolling them into SHI, and identify the barriers they faced in this process.
    Methods: A mixed-method case study was conducted using a convergent parallel design between November 2018 and January 2022 in ten districts of Hanoi and Ho Chi Minh City, Vietnam. Quantitative data were collected through a pilot intervention that aimed to facilitate SHI enrollment for uninsured individuals with TB. Descriptive statistics were calculated. Qualitative interviews were conducted with 34 participants, who were purposively sampled for maximum variation. Qualitative data were analyzed through an inductive approach and themes were identified through framework analysis. Quantitative and qualitative data sources were triangulated.
    Results: We attempted to enroll 115 uninsured people with TB into SHI; 76.5% were able to enroll. On average, it took 34.5 days to obtain a SHI card and it cost USD 66 per household. The themes indicated that a lack of knowledge, high costs for annual premiums, and the household-based registration requirement were barriers to SHI enrollment. Participants indicated that alternative enrolment mechanisms and greater procedural flexibility, particularly for undocumented people, is required to achieve full population coverage with SHI in urban centers.
    Conclusions: Significant addressable barriers to SHI enrolment for people affected by TB were identified. A quarter of individuals remained unable to enroll after receiving enhanced support due to lack of required documentation. The experience gained during this health financing transition is relevant for other middle-income countries as they address the provision of financial protection for the treatment of infectious diseases.
    MeSH term(s) Humans ; Universal Health Insurance ; Vietnam ; Insurance, Health ; Delivery of Health Care ; Tuberculosis/therapy
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2101196-5
    ISSN 1478-4505 ; 1478-4505
    ISSN (online) 1478-4505
    ISSN 1478-4505
    DOI 10.1186/s12961-024-01132-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluating novel engagement mechanisms, yields and acceptability of tuberculosis screening at retail pharmacies in Ho Chi Minh City, Viet Nam.

    Tran, Phuong M T / Dam, Thu A / Huynh, Huy B / Codlin, Andrew J / Forse, Rachel J / Dang, Ha M T / Truong, Vinh V / Nguyen, Lan H / Nguyen, Hoa B / Nguyen, Nhung V / Creswell, Jacob / Meralli, Farouk / Morishita, Fukushi / Dong, Thuy T T / Nguyen, Giang H / Vo, Luan N Q

    PLOS global public health

    2022  Volume 2, Issue 10, Page(s) e0000257

    Abstract: Pharmacies represent a key health system entry point for people with TB in Viet Nam, but high fragmentation hinders their broader engagement. Professional networking apps may be able to facilitate pharmacy engagement for systematic TB screening and ... ...

    Abstract Pharmacies represent a key health system entry point for people with TB in Viet Nam, but high fragmentation hinders their broader engagement. Professional networking apps may be able to facilitate pharmacy engagement for systematic TB screening and referral. Between September and December 2019, we piloted the use of a social networking app, SwipeRx, to recruit pharmacists for a TB referral scheme across four districts of Ho Chi Minh City, Viet Nam. We measured chest X-ray (CXR) referrals and TB detection yields at participating pharmacies and fielded 100 acceptability surveys, divided into pharmacists who did and did not make a CXR referral. We then fitted mixed-effect odds proportional models to explore acceptability factors that were associated with making a CXR referral. 1,816 push notifications were sent to pharmacists via the SwipeRx app and 78 indicated their interest in participating; however, only one was within the pilot's intervention area. Additional in-person outreach resulted in the recruitment of 146 pharmacists, with 54 (37.0%) making at least one CXR referral. A total of 182 pharmacy customers were referred, resulting in a total of 64 (35.2%) CXR screens and seven people being diagnosed with TB. Compared to pharmacists who did not make any CXR referrals, pharmacists making at least one CXR referral understood the pilot's objectives more clearly (aOR = 2.6, 95% CI: 1.2-5.8) and they believed that TB screening increased customer trust (aOR = 2.7, 95% CI: 1.2-5.8), benefited their business (aOR = 2.8, 95% CI: 1.3-6.2) and constituted a competitive advantage (aOR = 4.4, 95% CI: 1.9-9.9). They were also more confident in using mHealth apps (aOR = 3.1, 95 CI%: 1.4-6.8). Pharmacies can play an important role in early and increased TB case finding. It is critical to highlight the value proposition of TB referral schemes to their business during recruitment. Digital networking platforms, such as SwipeRx, can facilitate referrals for TB screening by pharmacists, but their ability to identify and recruit pharmacists requires optimization, particularly when targeting specific segments of a nation-wide digital network.
    Language English
    Publishing date 2022-10-17
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0000257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparing Catastrophic Costs: Active vs. Passive Tuberculosis Case Finding in Urban Vietnam.

    Dinh, Luong V / Wiemers, Anja M C / Forse, Rachel J / Phan, Yen T H / Codlin, Andrew J / Annerstedt, Kristi Sidney / Dong, Thuy T T / Nguyen, Lan / Pham, Thuong H / Nguyen, Lan H / Dang, Ha M T / Tuan, Mac H / Le, Phuc Thanh / Lonnroth, Knut / Creswell, Jacob / Khan, Amera / Kirubi, Beatrice / Nguyen, Hoa B / Nguyen, Nhung V /
    Vo, Luan N Q

    Tropical medicine and infectious disease

    2023  Volume 8, Issue 9

    Abstract: Active case finding (ACF) is a strategy that aims to identify people with tuberculosis (TB) earlier in their disease. This outreach approach may lead to a reduction in catastrophic cost incurrence (costs exceeding 20% of annual household income), a main ... ...

    Abstract Active case finding (ACF) is a strategy that aims to identify people with tuberculosis (TB) earlier in their disease. This outreach approach may lead to a reduction in catastrophic cost incurrence (costs exceeding 20% of annual household income), a main target of WHO's End TB Strategy. Our study assessed the socio-economic impact of ACF by comparing patient costs in actively and passively detected people with TB. Longitudinal patient cost surveys were prospectively fielded for people with drug-sensitive pulmonary TB, with 105 detected through ACF and 107 passively detected. Data were collected in four Vietnamese cities between October 2020 and March 2022. ACF reduced pre-treatment (USD 10 vs. 101,
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed8090423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: All-oral longer regimens are effective for the management of multidrug-resistant tuberculosis in high-burden settings.

    Khan, Palwasha Y / Franke, Molly F / Hewison, Catherine / Seung, Kwonjune J / Huerga, Helena / Atwood, Sidney / Ahmed, Saman / Khan, Munira / Sultana, Tanha / Manzur-Ul-Alam, Mohammad / Vo, Luan N Q / Lecca, Leonid / Yae, Kalkidan / Kozhabekov, Serik / Tamirat, Meseret / Gelin, Alain / Vilbrun, Stalz C / Kikvidze, Marina / Faqirzai, Jamil /
    Kadyrov, Abdullaat / Skrahina, Alena / Mesic, Anita / Avagyan, Nana / Bastard, Mathieu / Rich, Michael L / Khan, Uzma / Mitnick, Carole D

    The European respiratory journal

    2022  Volume 59, Issue 1

    Abstract: Background: Recent World Health Organization guidance on drug-resistant tuberculosis treatment de-prioritised injectable agents, in use for decades, and endorsed all-oral longer regimens. However, questions remain about the role of the injectable agent, ...

    Abstract Background: Recent World Health Organization guidance on drug-resistant tuberculosis treatment de-prioritised injectable agents, in use for decades, and endorsed all-oral longer regimens. However, questions remain about the role of the injectable agent, particularly in the context of regimens using new and repurposed drugs. We compared the effectiveness of an injectable-containing regimen to that of an all-oral regimen among patients with drug-resistant tuberculosis who received bedaquiline and/or delamanid as part of their multidrug regimen.
    Methods: Patients with a positive baseline culture were included. 6-month culture conversion was defined as two consecutive negative cultures collected >15 days apart. We derived predicted probabilities of culture conversion and relative risk using marginal standardisation methods.
    Results: Culture conversion was observed in 83.8% (526 out of 628) of patients receiving an all-oral regimen and 85.5% (425 out of 497) of those receiving an injectable-containing regimen. The adjusted relative risk comparing injectable-containing regimens to all-oral regimens was 0.96 (95% CI 0.88-1.04). We found very weak evidence of effect modification by HIV status: among patients living with HIV, there was a small increase in the frequency of conversion among those receiving an injectable-containing regimen, relative to an all-oral regimen, which was not apparent in HIV-negative patients.
    Conclusions: Among individuals receiving bedaquiline and/or delamanid as part of a multidrug regimen for drug-resistant tuberculosis, there was no significant difference between those who received an injectable and those who did not regarding culture conversion within 6 months. The potential contribution of injectable agents in the treatment of drug-resistant tuberculosis among those who were HIV positive requires further study.
    MeSH term(s) Antitubercular Agents/therapeutic use ; Clinical Protocols ; Humans ; Tuberculosis, Multidrug-Resistant/drug therapy ; World Health Organization
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2022-01-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.04345-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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