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  1. Article ; Online: The genetic landscape of chromosomal aberrations in 3776 Vietnamese fetuses with clinical anomalies during pregnancy.

    Tran, Danh-Cuong / Phan, Minh Ngoc / Dao, Hong-Thuy Thi / Nguyen, Hong-Dang Luu / Nguyen, Duy-Anh / Le, Quang Thanh / Hoang, Diem-Tuyet Thi / Tran, Nhat Thang / Thi Ha, Thi Minh / Dinh, Thuy Linh / Nguyen, Canh Chuong / Thi Doan, Kim Phuong / Thi Luong, Lan Anh / Vo, Ta Son / Nhat Trinh, Thu Huong / Nguyen, Van Thong / Vo, Phuong-Anh Ngoc / Nguyen, Yen-Nhi / Dinh, My-An /
    Doan, Phuoc-Loc / Do, Thanh-Thuy Thi / Nguyen, Quynh-Tho Thi / Truong, Dinh-Kiet / Nguyen, Hoai-Nghia / Phan, Minh-Duy / Tang, Hung-Sang / Giang, Hoa

    Personalized medicine

    2024  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2299146-3
    ISSN 1744-828X ; 1741-0541
    ISSN (online) 1744-828X
    ISSN 1741-0541
    DOI 10.2217/pme-2023-0113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6549: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 73: Show issues

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  2. Article ; Online: Combined Gap-Polymerase Chain Reaction and Targeted Next-Generation Sequencing Improve α- and β-Thalassemia Carrier Screening in Pregnant Women in Vietnam.

    Lam, Tuan-Thanh / Nguyen, Doan-Tu / Le, Quang Thanh / Nguyen, Duy-Anh / Hoang, Diem-Tuyet Thi / Nguyen, Huu Du / Nguyen, Canh Chuong / Doan, Kim Phuong Thi / Tran, Nhat-Thang / Ha, Thi Minh Thi / Trinh, Thu Huong Nhat / Nguyen, Van Thong / Lam, Duc Tam / Le, Minh Tam / Nguyen, Xuan Thao / Ho, Thu-Hang Thi / Tran, Trung Hoanh / Ho, Viet Thang / Bui, Thanh Van /
    Nguyen, Van Trong / Hoang, Phuoc Ba / Nguyen, Hoai Thanh / Nguyen, Manh Hoan / Vo, Thanh-Binh / Le, Duy-Khang Nguyen / Truong, Thao Ngoc / Dao, Hong-Thuy Thi / Vo, Phuong-Anh Ngoc / Nguyen, Thien-Chi Van / Tran, Ngoc-Nhu Thi / Tran, Quynh-Nhu Thi / Van, Yen-Linh Thi / Nguyen, Thanh-Thanh Thi / Huynh, Bich-Ngoc Thi / Nguyen, Thanh-Phuong Thi / Tran, Kim-Van Thi / Nguyen, Cong-Trai / Doan, Phuoc-Loc / Nguyen, Thanh-Dat / Do, Thanh-Thuy Thi / Truong, Dinh-Kiet / Tang, Hung Sang / Cao, Ngoc-Phuong Thi / Phan, Minh-Duy / Giang, Hoa / Nguyen, Hoai-Nghia

    Hemoglobin

    2022  Volume 46, Issue 4, Page(s) 233–239

    Abstract: Vietnam has a high thalassemia burden. We collected blood samples from 5880 pregnant Vietnamese women during prenatal health checks to assess thalassemia carrier frequency using combined gap-polymerase chain reaction (gap-PCR) and targeted next- ... ...

    Abstract Vietnam has a high thalassemia burden. We collected blood samples from 5880 pregnant Vietnamese women during prenatal health checks to assess thalassemia carrier frequency using combined gap-polymerase chain reaction (gap-PCR) and targeted next-generation sequencing (NGS). Thalassemia carriers were identified with prevalence of 13.13% (772), including 7.82% (460) carriers of α-thalassemia (α-thal), 5.31% (312) carriers of β-thalassemia (β-thal), and 0.63% (37) concurrent α-/β-thal carriers. Deletional mutations (368) accounted for 80.0% of α-thal carriers, of which, --
    MeSH term(s) Female ; Humans ; Pregnancy ; beta-Thalassemia/diagnosis ; beta-Thalassemia/epidemiology ; beta-Thalassemia/genetics ; beta-Globins/genetics ; Pregnant Women ; Vietnam/epidemiology ; Gene Frequency ; alpha-Thalassemia/diagnosis ; alpha-Thalassemia/epidemiology ; alpha-Thalassemia/genetics ; Polymerase Chain Reaction ; Mutation ; Codon ; Genotype ; High-Throughput Nucleotide Sequencing
    Chemical Substances beta-Globins ; Codon
    Language English
    Publishing date 2022-08-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 750615-6
    ISSN 1532-432X ; 0363-0269
    ISSN (online) 1532-432X
    ISSN 0363-0269
    DOI 10.1080/03630269.2022.2096461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1345: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Genetic profiling of Vietnamese population from large-scale genomic analysis of non-invasive prenatal testing data.

    Tran, Ngoc Hieu / Vo, Thanh Binh / Nguyen, Van Thong / Tran, Nhat-Thang / Trinh, Thu-Huong Nhat / Pham, Hong-Anh Thi / Dao, Thi Hong Thuy / Nguyen, Ngoc Mai / Van, Yen-Linh Thi / Tran, Vu Uyen / Vu, Hoang Giang / Bui, Quynh-Tram Nguyen / Vo, Phuong-Anh Ngoc / Nguyen, Huu Nguyen / Nguyen, Quynh-Tho Thi / Do, Thanh-Thuy Thi / Lam, Nien Vinh / Ngoc, Phuong Cao Thi / Truong, Dinh Kiet /
    Nguyen, Hoai-Nghia / Giang, Hoa / Phan, Minh-Duy

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 19142

    Abstract: The under-representation of several ethnic groups in existing genetic databases and studies have undermined our understanding of the genetic variations and associated traits or diseases in many populations. Cost and technology limitations remain the ... ...

    Abstract The under-representation of several ethnic groups in existing genetic databases and studies have undermined our understanding of the genetic variations and associated traits or diseases in many populations. Cost and technology limitations remain the challenges in performing large-scale genome sequencing projects in many developing countries, including Vietnam. As one of the most rapidly adopted genetic tests, non-invasive prenatal testing (NIPT) data offers an alternative untapped resource for genetic studies. Here we performed a large-scale genomic analysis of 2683 pregnant Vietnamese women using their NIPT data and identified a comprehensive set of 8,054,515 single-nucleotide polymorphisms, among which 8.2% were new to the Vietnamese population. Our study also revealed 24,487 disease-associated genetic variants and their allele frequency distribution, especially 5 pathogenic variants for prevalent genetic disorders in Vietnam. We also observed major discrepancies in the allele frequency distribution of disease-associated genetic variants between the Vietnamese and other populations, thus highlighting a need for genome-wide association studies dedicated to the Vietnamese population. The resulted database of Vietnamese genetic variants, their allele frequency distribution, and their associated diseases presents a valuable resource for future genetic studies.
    MeSH term(s) Alleles ; Asian Continental Ancestry Group/genetics ; Female ; Gene Frequency ; Genetic Testing ; Genome-Wide Association Study ; Genotype ; Humans ; Noninvasive Prenatal Testing ; Phenotype ; Polymorphism, Single Nucleotide ; Pregnancy ; Vietnam
    Language English
    Publishing date 2020-11-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-76245-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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