LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 58

Search options

  1. Article: PI(4,5)P

    Fujita, Naonobu / Girada, Shravan / Vogler, Georg / Bodmer, Rolf / Kiger, Amy A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Transverse (T)-tubules - vast, tubulated domains of the muscle plasma membrane - are critical to maintain healthy skeletal and heart contractions. How the intricate T-tubule membranes are formed is not well understood, with challenges to systematically ... ...

    Abstract Transverse (T)-tubules - vast, tubulated domains of the muscle plasma membrane - are critical to maintain healthy skeletal and heart contractions. How the intricate T-tubule membranes are formed is not well understood, with challenges to systematically interrogate in muscle. We established the use of intact Drosophila larval body wall muscles as an ideal system to discover mechanisms that sculpt and maintain the T-tubule membrane network. A muscle-targeted genetic screen identified specific phosphoinositide lipid regulators necessary for T-tubule organization and muscle function. We show that a
    Summary: T-tubules - vast, tubulated domains of the muscle plasma membrane - are critical to maintain skeletal and heart contractions. Fujita
    Key findings: PI4KIIIα
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.31.578124
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling.

    Schroeder, Analyne M / Nielsen, Tanja / Lynott, Michaela / Vogler, Georg / Colas, Alexandre R / Bodmer, Rolf

    PLoS genetics

    2022  Volume 18, Issue 10, Page(s) e1010448

    Abstract: Establishing a catalog of Congenital Heart Disease (CHD) genes and identifying functional networks would improve our understanding of its oligogenic underpinnings. Our studies identified protein biogenesis cofactors Nascent polypeptide-Associated Complex ...

    Abstract Establishing a catalog of Congenital Heart Disease (CHD) genes and identifying functional networks would improve our understanding of its oligogenic underpinnings. Our studies identified protein biogenesis cofactors Nascent polypeptide-Associated Complex (NAC) and Signal-Recognition-Particle (SRP) as disease candidates and novel regulators of cardiac differentiation and morphogenesis. Knockdown (KD) of the alpha- (Nacα) or beta-subunit (bicaudal, bic) of NAC in the developing Drosophila heart disrupted cardiac developmental remodeling resulting in a fly with no heart. Heart loss was rescued by combined KD of Nacα with the posterior patterning Hox gene Abd-B. Consistent with a central role for this interaction in cardiogenesis, KD of Nacα in cardiac progenitors derived from human iPSCs impaired cardiac differentiation while co-KD with human HOXC12 and HOXD12 rescued this phenotype. Our data suggest that Nacα KD preprograms cardioblasts in the embryo for abortive remodeling later during metamorphosis, as Nacα KD during translation-intensive larval growth or pupal remodeling only causes moderate heart defects. KD of SRP subunits in the developing fly heart produced phenotypes that targeted specific segments and cell types, again suggesting cardiac-specific and spatially regulated activities. Together, we demonstrated directed function for NAC and SRP in heart development, and that regulation of NAC function depends on Hox genes.
    MeSH term(s) Animals ; Humans ; Signal Recognition Particle/metabolism ; Ribosomes/metabolism ; Heart ; Genes, Homeobox ; Drosophila/genetics ; Drosophila/metabolism ; Peptides/metabolism
    Chemical Substances Signal Recognition Particle ; Peptides
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1010448
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book ; Online ; Thesis: Funktionelle Analyse der beiden Zinkfinger-Homöodomänentranskriptionsfaktoren Zfh-1 und Zfh-2 während der Entwicklung des Nervensystems von Drosophila melanogaster

    Vogler, Georg

    2007  

    Author's details Georg Vogler
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Mainz, 2007
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Cellular Mechanisms of Drosophila Heart Morphogenesis.

    Vogler, Georg / Bodmer, Rolf

    Journal of cardiovascular development and disease

    2015  Volume 2, Issue 1, Page(s) 2–16

    Abstract: Many of the major discoveries in the fields of genetics and developmental biology have been made using the fruit fly, ...

    Abstract Many of the major discoveries in the fields of genetics and developmental biology have been made using the fruit fly,
    Language English
    Publishing date 2015-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd2010002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Overexpression of

    Akasaka, Takeshi / Ocorr, Karen / Lin, Lizhu / Vogler, Georg / Bodmer, Rolf / Grossfeld, Paul

    Journal of cardiovascular development and disease

    2020  Volume 7, Issue 2

    Abstract: Left-sided congenital heart defects (CHDs) are among the most common forms of congenital heart disease, but a disease-causing gene has only been identified in a minority of cases. Here, we identified a candidate gene for CHDs, ...

    Abstract Left-sided congenital heart defects (CHDs) are among the most common forms of congenital heart disease, but a disease-causing gene has only been identified in a minority of cases. Here, we identified a candidate gene for CHDs,
    Language English
    Publishing date 2020-06-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd7020022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: A single DPE core promoter motif contributes to

    Sloutskin, Anna / Itzhak, Dekel / Vogler, Georg / Ideses, Diana / Alter, Hadar / Shachar, Hadar / Doniger, Tirza / Frasch, Manfred / Bodmer, Rolf / Duttke, Sascha H / Juven-Gershon, Tamar

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Transcription is initiated at the core promoter, which confers specific functions depending on the unique combination of core promoter elements. The downstream core promoter element (DPE) is found in many genes related to heart and mesodermal development. ...

    Abstract Transcription is initiated at the core promoter, which confers specific functions depending on the unique combination of core promoter elements. The downstream core promoter element (DPE) is found in many genes related to heart and mesodermal development. However, the function of these core promoter elements has thus far been studied primarily in isolated,
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.11.544490
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: The nutrient sensor CRTC & Sarcalumenin / Thinman represent a new pathway in cardiac hypertrophy.

    Dondi, Cristiana / Vogler, Georg / Gupta, Anjali / Walls, Stanley M / Kervadec, Anaïs / Romero, Michaela R / Diop, Soda B / Goode, Jason / Thomas, John B / Colas, Alexandre R / Bodmer, Rolf / Montminy, Marc / Ocorr, Karen

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Obesity and type 2 diabetes are at epidemic levels and a significant proportion of these patients are diagnosed with left ventricular hypertrophy. ...

    Abstract Obesity and type 2 diabetes are at epidemic levels and a significant proportion of these patients are diagnosed with left ventricular hypertrophy.
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.02.560407
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity.

    Birker, Katja / Ge, Shuchao / Kirkland, Natalie J / Theis, Jeanne L / Marchant, James / Fogarty, Zachary C / Missinato, Maria A / Kalvakuri, Sreehari / Grossfeld, Paul / Engler, Adam J / Ocorr, Karen / Nelson, Timothy J / Colas, Alexandre R / Olson, Timothy M / Vogler, Georg / Bodmer, Rolf

    eLife

    2023  Volume 12

    Abstract: Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited. We performed whole genome ... ...

    Abstract Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited. We performed whole genome sequencing (WGS) on 183 HLHS patient-parent trios to identify candidate genes, which were functionally tested in the
    MeSH term(s) Humans ; Hypoplastic Left Heart Syndrome/genetics ; Actomyosin ; Heart Defects, Congenital ; Computational Biology ; Adenosine Triphosphate ; Mitochondrial Proteins
    Chemical Substances Actomyosin (9013-26-7) ; Adenosine Triphosphate (8L70Q75FXE) ; CHCHD3 protein, human ; Mitochondrial Proteins
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.83385
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Genetic architecture of natural variation of cardiac performance from flies to humans.

    Saha, Saswati / Spinelli, Lionel / Castro Mondragon, Jaime A / Kervadec, Anaïs / Lynott, Michaela / Kremmer, Laurent / Roder, Laurence / Krifa, Sallouha / Torres, Magali / Brun, Christine / Vogler, Georg / Bodmer, Rolf / Colas, Alexandre R / Ocorr, Karen / Perrin, Laurent

    eLife

    2022  Volume 11

    Abstract: Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlying complexity is a major hurdle. We investigated the natural variation of cardiac performance in the sequenced inbred lines of ... ...

    Abstract Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlying complexity is a major hurdle. We investigated the natural variation of cardiac performance in the sequenced inbred lines of the
    MeSH term(s) Animals ; Humans ; Drosophila melanogaster/physiology ; Gene Regulatory Networks ; Genetic Variation ; Genome-Wide Association Study ; Phenotype ; Quantitative Trait Loci ; Heart/physiology
    Language English
    Publishing date 2022-11-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.82459
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Methods to assess Drosophila heart development, function and aging.

    Ocorr, Karen / Vogler, Georg / Bodmer, Rolf

    Methods (San Diego, Calif.)

    2014  Volume 68, Issue 1, Page(s) 265–272

    Abstract: In recent years the Drosophila heart has become an established model for many different aspects of human cardiac disease. This model has allowed identification of disease-causing mechanisms underlying congenital heart disease and cardiomyopathies and has ...

    Abstract In recent years the Drosophila heart has become an established model for many different aspects of human cardiac disease. This model has allowed identification of disease-causing mechanisms underlying congenital heart disease and cardiomyopathies and has permitted the study of underlying genetic, metabolic and age-related contributions to heart function. In this review we discuss methods currently employed in the analysis of the Drosophila heart structure and function, such as optical methods to infer heart function and performance, electrophysiological and mechanical approaches to characterize cardiac tissue properties, and conclude with histological techniques used in the study of heart development and adult structure.
    MeSH term(s) Aging/genetics ; Aging/pathology ; Animals ; Developmental Biology/methods ; Drosophila/genetics ; Drosophila/growth & development ; Drosophila Proteins/biosynthesis ; Heart/growth & development ; Humans
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2014-04-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1066584-5
    ISSN 1095-9130 ; 1046-2023
    ISSN (online) 1095-9130
    ISSN 1046-2023
    DOI 10.1016/j.ymeth.2014.03.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3239: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top