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  1. Article ; Online: Potential beneficial effect of IFN-β1a and ocrelizumab in people with MS during the COVID-19 pandemic.

    Todorović, Stefan / Vojinović, Slobodan / Savić, Dejan / Aleksić, Dejan / Danilović, Miloš

    Acta neurologica Belgica

    2023  Volume 124, Issue 2, Page(s) 447–455

    Abstract: Background/aim: Disease-modifying therapy (DMT) has led to added challenges in the management of people with multiple sclerosis (pwMS) during the COVID-19 era. It can reduce relapse in MS or slow down disease progression, but some DMTs can increased ... ...

    Abstract Background/aim: Disease-modifying therapy (DMT) has led to added challenges in the management of people with multiple sclerosis (pwMS) during the COVID-19 era. It can reduce relapse in MS or slow down disease progression, but some DMTs can increased risk of infection. The aim of study was to evaluate risk and severity of COVID-19 in pwMS.
    Methods: The examined group of pwMS were divided in group treated with IFN-β1a, group treated with ocrelizumab and untreated group. The examination included impact of age, gender, duration of MS, type of MS, vaccination status and Expanded Disability Status Scale (EDSS) on the risk and severity of COVID-19 infection. A diagnosis of COVID-19 in pwMS was confirmed by positive polymerase-chain-reaction (PCR) or antigen test.
    Results: Out of 207 pwMS, 82 patients were treated with ocrelizumab, 63 with IFN-β1a, while 62 patients were untreated pwMS. The average duration of the MS was longer in the group of patients treated with ocrelizumab than in the group treated with IFN-β1a (p < 0.05). EDSS was higher in the ocrelizumab group compared to the other two groups (p < 0.001). Untreated (more often unvaccinated) had the same COVID frequency as ocrelizumab-treated (more vaccinated, but higher EDSS). The multivariate logistic regression model indicated that administration of IFN-β1a reduces the risk of COVID-19 infection (p = 0.001, OR = 0.381, 95% CI 0.602-0.160). The use of both DMTs, driven mainly by the IFN-β1a effect, reduces the risk of moderate and severe COVID-19 (p < 0.05, OR = 0.105, 95% CI 0.011-0.968).
    Conclusion: This study provides evidence that IFN-β1a can reduce the frequency of COVID-19 infection and that two DMTs, driven mainly by the IFN-β1a effect, do not increase the risk of moderate/severe COVID-19.
    MeSH term(s) Humans ; COVID-19 ; Pandemics ; Multiple Sclerosis/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use
    Chemical Substances ocrelizumab (A10SJL62JY) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-11-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-023-02421-9
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  2. Article ; Online: Targeted RNAseq Revealed the Gene Expression Signature of Ferroptosis-Related Processes Associated with Disease Severity in Patients with Multiple Sclerosis.

    Stojkovic, Ljiljana / Jovanovic, Ivan / Dincic, Evica / Djordjevic, Ana / Kuveljic, Jovana / Djuric, Tamara / Stankovic, Aleksandra / Vojinovic, Slobodan / Zivkovic, Maja

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Detrimental molecular processes in multiple sclerosis (MS) lead to the cellular accumulation of lipid peroxidation products and iron in the CNS, which represents the main driving force for ferroptosis. Ferroptosis is an iron-dependent form of regulated ... ...

    Abstract Detrimental molecular processes in multiple sclerosis (MS) lead to the cellular accumulation of lipid peroxidation products and iron in the CNS, which represents the main driving force for ferroptosis. Ferroptosis is an iron-dependent form of regulated cell death, with proposed roles in neurodegeneration, oligodendrocyte loss and neuroinflammation in the pathogenesis of MS. Ferroptosis-related gene expression signature and molecular markers, which could reflect MS severity and progression, are currently understudied in humans. To tackle these challenges, we have applied a curated approach to create and experimentally analyze a comprehensive panel of ferroptosis-related genes covering a wide range of biological processes associated with ferroptosis. We performed the first ferroptosis-related targeted RNAseq on PBMCs from highly distinctive MS phenotype groups: mild relapsing-remitting (RR) (n = 24) and severe secondary progressive (SP) (n = 24), along with protein detection of GPX4 and products of lipid peroxidation (MDA and 4-HNE). Out of 138 genes, 26 were differentially expressed genes (DEGs), indicating changes in both pro- and anti-ferroptotic genes, representing a molecular signature associated with MS severity. The top three DEGs, as non-core ferroptosis genes,
    MeSH term(s) Humans ; Multiple Sclerosis ; Ferroptosis ; Transcriptome ; Neoplasm Recurrence, Local ; Patient Acuity ; Iron ; Hypoxia-Inducible Factor-Proline Dioxygenases
    Chemical Substances Iron (E1UOL152H7) ; EGLN2 protein, human (EC 1.14.11.29) ; Hypoxia-Inducible Factor-Proline Dioxygenases (EC 1.14.11.29)
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25053016
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  3. Article ; Online: Quality of sleep and fatigue in patients with the relapsing-remitting multiple sclerosis during the coronavirus disease-2019 pandemic.

    Stojanov, Aleksandar / Vojinovic, Slobodan / Stojanov, Jelena / Malobabic, Marina / Stevic, Milos / Milosevic, Vuk / Stanojevic, Goran

    Clinical neurology and neurosurgery

    2021  Volume 205, Page(s) 106640

    Abstract: ОBJECTIVE: Sleep disturbances and fatigue are frequent symptoms in multiple sclerosis patients. The aim was to assess the quality of sleep (QoS) and fatigue in patients with the relapsing-remitting multiple sclerosis (RRMS), during the coronavirus ... ...

    Abstract ОBJECTIVE: Sleep disturbances and fatigue are frequent symptoms in multiple sclerosis patients. The aim was to assess the quality of sleep (QoS) and fatigue in patients with the relapsing-remitting multiple sclerosis (RRMS), during the coronavirus disease-2019 (COVID-19) pandemic.
    Methods: The study included 67 patients with RRMS and 85 healthy control subjects. RRMS patients, who were tested in first half of 2019, were retested in April and May 2020, during the COVID-19 pandemic. We collected sociodemographic and clinical data, and also used the following questionnaires: Pittsburgh sleep quality index (PSQI), Fatigue Severity Scale (FSS), and Multiple Sclerosis Quality of Life-54 Instrument (MSQOL-54).
    Results: The FSS score and PSQI global score were significantly higher in patients with RRMS than in the control group (p < 0.01). We noticed a statistically significant difference between the results obtained a year ago and the results during the COVID-19 pandemic in PSQI global score (p < 0.01) and all subscores. Higher disability status was an independent predictor of the worse PSQI scores.
    Conclusion: During the COVID-19 outbreak worse QoS were noticed in RRMS patients than in healthy individuals. Also, QoS of RRMS patients is more affected during the COVID-19 pandemic than in regular circumstances. High levels of sleep disturbance and fatigue in RRMS patients correlates with worse life quality, female gender, lower educational level and partner status. The results of the present study provide evidence in support of regular screening and monitoring of fatigue and QoS in this patient population, especially during the pandemic states.
    Language English
    Publishing date 2021-04-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2021.106640
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  4. Article ; Online: Psychological status of patients with relapsing-remitting multiple sclerosis during coronavirus disease-2019 outbreak.

    Stojanov, Aleksandar / Malobabic, Marina / Milosevic, Vuk / Stojanov, Jelena / Vojinovic, Slobodan / Stanojevic, Goran / Stevic, Milos

    Multiple sclerosis and related disorders

    2020  Volume 45, Page(s) 102407

    Abstract: Background: The coronavirus disease 2019 (COVID-19) is a global health emergency. The aim was to investigate the impact of COVID-19 pandemic on the psychological status of patients with relapsing-remitting multiple sclerosis (RRMS).: Methods: Data on ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) is a global health emergency. The aim was to investigate the impact of COVID-19 pandemic on the psychological status of patients with relapsing-remitting multiple sclerosis (RRMS).
    Methods: Data on the socio-demographic and clinical characteristics of 95 RRMS patients were collected. We used a self-designed questionnaire, the Multiple Sclerosis Quality of Life-54 Instrument (MSQOL-54), Hamilton scales for the assessment of anxiety (HAM-A), and depression (HAM-D). Patients who were tested one year ago were reassessed using the same questionnaires during the COVID-19 outbreak. Group of 99 healthy individuals (HC) were tested, using the same questionnaires.
    Results: The main concerns in RRMS patients were that someone that they know could be infected with COVID-19 (78.5%), or could die due to the infection (33.8%), and the lack of specific treatment options (25.8%). The main concerns about the RRMS status were that their disease would be worse if they get infected with COVID-19 (36.4%), that they would experience some difficulties in drug availability (43.6%), that they could not go to the hospital as usual (72.4%). Results on all questionnaires were worse in RRMS patients than in HC (p<0.01). We noticed a statistically significant difference between the results obtained a year ago and the results from April 2020 in HAM-A (p<0.05).
    Conclusions: There is an impact of the COVID-19 pandemic on the psychological status of RRMS patients. Healthcare organizations need to provide professional therapeutic advice and psychosocial support for this population of patients during the pandemic.
    MeSH term(s) Adult ; Anxiety/epidemiology ; Anxiety/etiology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/psychology ; Female ; Humans ; Male ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/psychology ; Pandemics ; Pneumonia, Viral/psychology ; SARS-CoV-2 ; Surveys and Questionnaires
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2020.102407
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  5. Article ; Online: Disease relapses in multiple sclerosis can be influenced by air pollution and climate seasonal conditions

    Vojinović Slobodan / Savić Dejan / Lukić Stevo / Savić Ljiljana / Vojinović Jelena

    Vojnosanitetski Pregled, Vol 72, Iss 1, Pp 44-

    2015  Volume 49

    Abstract: Background/Aim. Environmental factors may influence the disease activity in patients with relapsing-remitting multiple sclerosis (MS). The aim of this study was to evaluate the influence of air pollution and seasonal climate factors of any on number of ... ...

    Abstract Background/Aim. Environmental factors may influence the disease activity in patients with relapsing-remitting multiple sclerosis (MS). The aim of this study was to evaluate the influence of air pollution and seasonal climate factors of any on number of relapses in MS patients during a consecutive 5 years of observation. Methods. We retrospectively analyzed data of MS patients from the town of Niš, hospitalized at the Clinic of Neurology, Clinical Center Niš, Serbia, from 2005 to 2009. Climate data: mean daily sun shining; mean monthly sun shining, mean whole daily cloudiness, daily cloudiness at 7 a.m, 2 p.m. and 9 p.m. and air pollution expressed by NSR (New Source Review) were obtained from the Meteorology Observatory Niš. Results. During a 5-year of observation there were 260 relapses in 101 MS patients. The number of relapses showed a significantly negative correlation with the number of days with NSR < 2 (ρ = -0.31; p < 0.01) and a positive correlation with the mean whole daily cloudiness (p < 0.05), mean daily cloudiness at 7 a.m. (p < 0.05) and 2 p.m. (p < 0.01). We found a significantly positive correlation (p < 0.05) between the reduced number of relapses during the period of high vitamin D season, i.e. July-October. There was a statistically significant increase (p < 0.01) of the number of relapses during spring (ґ = 6.53; SD = 3.98) compared to the other three seasons. The joint presence of lower number of days with NSR < 2 during low vitamin D season (January-April) correlated with a statistically significant increase of the number of relapses in MS patients (F = 5.06, p < 0.01). Conclusion. The obtained results confirmed the influence of air pollution and climate seasonal conditions on disease relapses in MS patients based on a long-term observation. Lower numbers of days with low air pollution during the periods with low vitamin D (January-April), especially with increased cloudiness at 2 p.m, induce a higher risk of MS relapses in southern continental parts of Europe.
    Keywords multiple sclerosis ; recurrence ; air pollution ; climate ; sunlight ; vitamin D ; Medicine (General) ; R5-920
    Subject code 333
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Military Health Department, Ministry of Defance, Serbia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Psychological status of patients with relapsing-remitting multiple sclerosis during coronavirus disease-2019 outbreak

    Stojanov, Aleksandar / Malobabic, Marina / Milosevic, Vuk / Stojanov, Jelena / Vojinovic, Slobodan / Stanojevic, Goran / Stevic, Milos

    Mult Scler Relat Disord

    Abstract: BACKGROUND: The coronavirus disease 2019 (COVID-19) is a global health emergency. The aim was to investigate the impact of COVID-19 pandemic on the psychological status of patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: Data on the ... ...

    Abstract BACKGROUND: The coronavirus disease 2019 (COVID-19) is a global health emergency. The aim was to investigate the impact of COVID-19 pandemic on the psychological status of patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: Data on the socio-demographic and clinical characteristics of 95 RRMS patients were collected. We used a self-designed questionnaire, the Multiple Sclerosis Quality of Life-54 Instrument (MSQOL-54), Hamilton scales for the assessment of anxiety (HAM-A), and depression (HAM-D). Patients who were tested one year ago were reassessed using the same questionnaires during the COVID-19 outbreak. Group of 99 healthy individuals (HC) were tested, using the same questionnaires. RESULTS: The main concerns in RRMS patients were that someone that they know could be infected with COVID-19 (78.5%), or could die due to the infection (33.8%), and the lack of specific treatment options (25.8%). The main concerns about the RRMS status were that their disease would be worse if they get infected with COVID-19 (36.4%), that they would experience some difficulties in drug availability (43.6%), that they could not go to the hospital as usual (72.4%). Results on all questionnaires were worse in RRMS patients than in HC (p<0.01). We noticed a statistically significant difference between the results obtained a year ago and the results from April 2020 in HAM-A (p<0.05). CONCLUSIONS: There is an impact of the COVID-19 pandemic on the psychological status of RRMS patients. Healthcare organizations need to provide professional therapeutic advice and psychosocial support for this population of patients during the pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #653798
    Database COVID19

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  7. Article: Disease relapses in multiple sclerosis can be influenced by air pollution and climate seasonal conditions.

    Vojinović, Slobodan / Savić, Dejan / Lukić, Stevo / Savić, Ljiljana / Vojinović, Jelena

    Vojnosanitetski pregled

    2015  Volume 72, Issue 1, Page(s) 44–49

    Abstract: Background/aim: Environmental factors may influence the disease activity in patients with relapsing-remitting multiple sclerosis (MS). The aim of this study was to evaluate the in- fluence of air pollution and seasonal climate factors of any on number ... ...

    Abstract Background/aim: Environmental factors may influence the disease activity in patients with relapsing-remitting multiple sclerosis (MS). The aim of this study was to evaluate the in- fluence of air pollution and seasonal climate factors of any on number of relapses in MS patients during a consecutive 5 years of observation.
    Methods: We retrospectively analyzed data of MS patients from the town of Niš, hospitalized at the Clinic of Neurology, Clinical Center Niš, Serbia, from 2005 to 2009. Climate data: mean daily sun shining; mean monthly sun shining, mean whole daily cloudiness, daily cloudiness at 7 a.m, 2 p.m. and 9 p.m. and air pollution expressed by NSR (New Source Review) were obtained from the Meteorology Observatory Niš.
    Results: During a 5-year of observation there were 260 relapses in 101 MS patients. The number of relapses showed a significantly negative correlation with the number of days with NSR < 2 (p = -0.31; p < 0.01) and a positive correlation with the mean whole daily cloudiness (p < 0.05), mean daily cloudiness at 7 a.m. (p < 0.05) and 2 p.m. (p < 0.01). We found a significantlly positive correlation (p < 0.05) between the reduced number of relapses during the period of high vitamin D season, i.e. July-October. There was a statistically significant increase (p < 0.01) of the number of relapses during spring (x = 6.53; SD = 3.98) compared to the other three seasons. The joint presence of lower number of days with NSR < 2 during low vitamin D season (January- April) correlated with a statistically significant increase of the number of relapses in MS patients (F = 5.06, p < 0.01). CON- CLUSION: The obtained results confirmed the influence of air pollution and climate seasonal conditions on disease relapses in MS patients based on a long-term observation. Lower numbers of days with low air pollution during the periods with low vitamin D (January-April), especially with increased cloudiness at 2 p.m, induce a higher risk of MS relapses in southern continental parts of Europe.
    MeSH term(s) Adolescent ; Adult ; Air Pollution/adverse effects ; Climate ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Multiple Sclerosis/pathology ; Recurrence ; Retrospective Studies ; Risk Factors ; Seasons ; Serbia
    Language English
    Publishing date 2015-06-02
    Publishing country Serbia
    Document type Journal Article ; Observational Study
    ZDB-ID 123795-0
    ISSN 0042-8450
    ISSN 0042-8450
    DOI 10.2298/vsp140121030v
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  8. Article ; Online: Syringomyelia in demyelinating disease of the central nervous system

    Savić Dejan / Vojinović Slobodan / Spasić Mirjana / Perić Zoran / Lukić Stevo

    Srpski Arhiv za Celokupno Lekarstvo, Vol 139, Iss 9-10, Pp 657-

    Report of two cases

    2011  Volume 660

    Abstract: Introduction. Syringomyelia is a cavitary extension inside the spinal cord which can be either symptomatic or congenitally-idiopathic. Syringomyelia during the course of the disease in patients presenting with clinically definite multiple sclerosis was ... ...

    Abstract Introduction. Syringomyelia is a cavitary extension inside the spinal cord which can be either symptomatic or congenitally-idiopathic. Syringomyelia during the course of the disease in patients presenting with clinically definite multiple sclerosis was described earlier. Syringomyelia in patients presenting with a clinically isolated syndrome suggestive of multiple sclerosis is unusual. Case Outline. We present two patients presenting with demy-elinating disease of the central nervous system with syringomyelia in the cervical and thoracic spinal cord. We did not find classical clinical signs of syringomyelia in our patients, but we disclosed syringomyelia incidentally during magnetic resonance exploration. Magnetic resonance exploration using the gadolinium contrast revealed the signs of active demyelinating lesions in the spinal cord in one patient but not in the other. Conclusion. Syringomyelia in demyelinating disease of the central nervous system opens the question whether it is a coincidental finding or a part of clinical features of the disease. Differentiation of the significance of syringomyelia finding in these patients plays a role in the choice of treatment concept in such patients.
    Keywords syringomyelia ; demyelinating disease of the central nervous system ; multiple sclerosis ; clinically isolated syndrome ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Serbian Medical Society
    Document type Article ; Online
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  9. Article ; Online: Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol.

    Stojanov, Dragan A / Aracki-Trenkic, Aleksandra / Vojinovic, Slobodan / Benedeto-Stojanov, Daniela / Ljubisavljevic, Srdjan

    European radiology

    2015  Volume 26, Issue 3, Page(s) 807–815

    Abstract: Objective: To evaluate correlation between cumulative dose of gadobutrol and signal intensity (SI) within dentate nucleus and globus pallidus on unenhanced T1-weighted images in patients with relapsing-remitting multiple sclerosis (RRMS).: Methods: ... ...

    Abstract Objective: To evaluate correlation between cumulative dose of gadobutrol and signal intensity (SI) within dentate nucleus and globus pallidus on unenhanced T1-weighted images in patients with relapsing-remitting multiple sclerosis (RRMS).
    Methods: Dentate nucleus-to-pons and globus pallidus-to-thalamus SI ratios, and renal and liver functions, were evaluated after multiple intravenous administrations of 0.1 mmol/kg gadobutrol at 27, 96-98, and 168 weeks. We compared SI ratios based on the number of administrations, total amount of gadobutrol administered, and time between injections.
    Results: Globus pallidus-to-thalamus (p = 0.025) and dentate nucleus-to-pons (p < 0.001) SI ratios increased after multiple gadobutrol administrations, correlated with the number of administrations (ρ = 0.263, p = 0.046, respectively) and depended on the length of administration (p = 0.017, p = 0.037, respectively). Patients receiving gadobutrol at 27 weeks showed the greatest increase in both SI ratios (p = 0.006; p = 0.014, respectively, versus 96-98 weeks). GGT increased at the end of the study (p = 0.004).
    Conclusion: In patients with RRMS, SI within the dentate nucleus and globus pallidus increased on unenhanced T1-weighted images after multiple gadobutrol injections. Administration of the same total amount of gadobutrol over a shorter period caused greater SI increase.
    Key points: Gadolinium deposition may occur within the human brain after multiple gadolinium contrast administrations. Increasing T1W signal intensity occurs within the dentate nucleus and globus pallidus. Increasing signal intensity may be a consequence of multiple administrations of gadobutrol. Administration of gadobutrol over a shorter period causes greater signal intensity increase.
    MeSH term(s) Adult ; Analysis of Variance ; Brain Diseases/pathology ; Cerebellar Nuclei/pathology ; Contrast Media/administration & dosage ; Dose-Response Relationship, Drug ; Female ; Globus Pallidus/pathology ; Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy/methods ; Male ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/pathology ; Organometallic Compounds/administration & dosage ; Retrospective Studies ; Thalamus/pathology ; Young Adult
    Chemical Substances Contrast Media ; Organometallic Compounds ; gadobutrol (1BJ477IO2L)
    Language English
    Publishing date 2015-06-25
    Publishing country Germany
    Document type Comparative Study ; Evaluation Study ; Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-015-3879-9
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  10. Article: [Syringomyelia in demyelinating disease of the central nervous system: report of two cases].

    Savić, Dejan / Vojinović, Slobodan / Spasić, Mirjana / Perič, Zoran / Lukić, Stevo

    Srpski arhiv za celokupno lekarstvo

    2011  Volume 139, Issue 9-10, Page(s) 657–660

    Abstract: Introduction: Syringomyelia is a cavitary extension inside the spinal cord which can be either symptomatic or congenitally-idiopathic. Syringomyelia during the course of the disease in patients presenting with clinically definite multiple sclerosis was ... ...

    Abstract Introduction: Syringomyelia is a cavitary extension inside the spinal cord which can be either symptomatic or congenitally-idiopathic. Syringomyelia during the course of the disease in patients presenting with clinically definite multiple sclerosis was described earlier. Syringomyelia in patients presenting with a clinically isolated syndrome suggestive of multiple sclerosis is unusual.
    Case outline: We present two patients presenting with demyelinating disease of the central nervous system with syringomyelia in the cervical and thoracic spinal cord. We did not find classical clinical signs of syringomyelia in our patients, but we disclosed syringomyelia incidentally during magnetic resonance exploration. Magnetic resonance exploration using the gadolinium contrast revealed the signs of active demyelinating lesions in the spinal cord in one patient but not in the other.
    Conclusion: Syringomyelia in demyelinating disease of the central nervous system opens the question whether it is a coincidental finding or a part of clinical features of the disease. Differentiation of the significance of syringomyelia finding in these patients plays a role in the choice of treatment concept in such patients.
    MeSH term(s) Adolescent ; Adult ; Demyelinating Diseases/complications ; Demyelinating Diseases/diagnosis ; Female ; Humans ; Multiple Sclerosis/diagnosis ; Syringomyelia/complications ; Syringomyelia/diagnosis
    Language Serbian
    Publishing date 2011-11-07
    Publishing country Serbia
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 128567-1
    ISSN 0370-8179 ; 0354-2793 ; 0049-0210
    ISSN 0370-8179 ; 0354-2793 ; 0049-0210
    DOI 10.2298/sarh1110657s
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