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Article ; Online: A comprehensive assessment of lymphocyte subsets, their prognostic significance, and changes after first-line therapy administration in patients with chronic lymphocytic leukemia.

Vodárek, Pavel / Écsiová, Dominika / Řezáčová, Vladimíra / Souček, Ondřej / Šimkovič, Martin / Vokurková, Doris / Belada, David / Žák, Pavel / Smolej, Lukáš

Cancer medicine

2022 Volume 12, Issue 6, Page(s) 6956–6970

Abstract: Background: In chronic lymphocytic leukemia (CLL), changes in the peripheral blood lymphocyte subsets play an important role in disease progression and infectious complications. The impact of chemoimmunotherapy (CIT) on these changes has not been ... ...

Abstract	Background: In chronic lymphocytic leukemia (CLL), changes in the peripheral blood lymphocyte subsets play an important role in disease progression and infectious complications. The impact of chemoimmunotherapy (CIT) on these changes has not been extensively studied METHODS: We used multi-color flow cytometry, to prospectively measure absolute and relative numbers of CD4 Conclusion: Our results indicate that naïve cell depletion and CD4
MeSH term(s)	Humans ; Leukemia, Lymphocytic, Chronic, B-Cell ; Prognosis ; CD8-Positive T-Lymphocytes ; Lymphocyte Subsets ; T-Lymphocytes, Regulatory ; T-Lymphocyte Subsets ; CD4-Positive T-Lymphocytes
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.5492
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Article ; Online: Serum Citrulline and Ornithine: Potential Markers of Coeliac Disease Activity.

Douda, Ladislav / Hyšpler, Radomír / Mžik, Martin / Vokurková, Doris / Drahošová, Marcela / Řeháček, Vít / Čermáková, Eva / Douda, Tomáš / Cyrany, Jiří / Fejfar, Tomáš / Jirkovský, Václav / Kopáčová, Marcela / Kupková, Blanka / Vašátko, Tomáš / Tachecí, Ilja / Bureš, Jan

Acta medica (Hradec Kralove)

2023 Volume 65, Issue 3, Page(s) 75–82

Abstract: Introduction: To date, there is not generally accepted and universal indicator of activity, and functional integrity of the small intestine in patients with coeliac disease. The aim of our study was to investigate whether serum concentrations of the non- ...

Abstract	Introduction: To date, there is not generally accepted and universal indicator of activity, and functional integrity of the small intestine in patients with coeliac disease. The aim of our study was to investigate whether serum concentrations of the non-essential amino acids citrulline and ornithine might have this function. Methods: We examined serum citrulline and ornithine concentrations in a subgroup of patients with proven coeliac disease and healthy controls (blood donors). Results: A total of 94 patients with coeliac disease (29 men, mean age 53 ± 18 years; 65 women, mean age 44 ± 14 years) and 35 healthy controls (blood donors) in whom coeliac disease was serologically excluded (10 men, mean age 51 ± 14 years; 25 women, mean age 46 ± 12 years) were included in the study. Significantly lower concentrations of serum ornithine were found in patients with coeliac disease (mean 65 ± 3 μmol/L; median 63 μmol/L, IQR 34 μmol/L, p < 0.001). No statistically nor clinically significant differences were found in the citrulline concentrations between the study and control group. Conclusions: Serum ornithine (but not citrulline) may be useful for assessing the functional status of the small intestine in uncomplicated coeliac disease. Further studies involving more detailed analysis of dietary and metabolic changes in patients will be needed to reach definitive conclusions.
MeSH term(s)	Male ; Humans ; Female ; Adult ; Middle Aged ; Aged ; Citrulline/metabolism ; Celiac Disease ; Ornithine/metabolism ; Diet
Chemical Substances	Citrulline (29VT07BGDA) ; Ornithine (E524N2IXA3)
Language	English
Publishing date	2023-02-03
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	1360995-6
ISSN	1805-9694 ; 1211-4286
ISSN (online)	1805-9694
ISSN	1211-4286
DOI	10.14712/18059694.2022.22
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Article ; Online: Monitoring of Lymphocyte Populations During Treatment with Interferon-β-1b to Predict Multiple Sclerosis Disability Progression.

Vališ, Martin / Vyšata, Oldřich / Sobíšek, Luláš / Klímová, Blanka / Andrýs, Ctirad / Vokurková, Doris / Pavelek, Zbyšek

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

2018 Volume 39, Issue 3, Page(s) 164–173

Abstract: The authors aim to understand how lymphocyte populations could predict the course of multiple sclerosis (MS) in people treated with interferon-β (IFN-β). Twenty-five male patients and 72 female patients were analyzed in the study. Peripheral blood ... ...

Abstract	The authors aim to understand how lymphocyte populations could predict the course of multiple sclerosis (MS) in people treated with interferon-β (IFN-β). Twenty-five male patients and 72 female patients were analyzed in the study. Peripheral blood samples were taken before and 5 years after the treatment with IFN-β. Lymphocyte subsets were analyzed by flow cytometry. The authors compared lymphocyte parameters between confirmed sustained progression (CSP) and non-CSP groups by using Welch's one-way analysis of means or a chi-square test of independence. A penalized (lasso) logistic regression model was fitted to identify the combination of lymphocyte parameters for potential biomarkers. The combination of lymphocyte counts, relative CD3+/CD25+ cells, absolute CD8 T cells, absolute CD8+/CD38+ cells, absolute CD38+ cells, and relative CD5+/CD19+ cells was identified as potential biomarker for the IFN-β treatment to monitor MS development in relation to CSP. The results suggest that other biomarkers aid in patient observation, predict a favorable outcome, and assist in the decision-making process for the early therapy escalation.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Interferon-beta/therapeutic use ; Lymphocyte Count ; Lymphocytes/pathology ; Male ; Middle Aged ; Multiple Sclerosis/blood ; Multiple Sclerosis/drug therapy ; Young Adult
Chemical Substances	Interferon-beta (77238-31-4)
Language	English
Publishing date	2018-12-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1226675-9
ISSN	1557-7465 ; 1079-9907
ISSN (online)	1557-7465
ISSN	1079-9907
DOI	10.1089/jir.2018.0100
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Article: Azorella compacta

Tůmová, Lenka / Dučaiová, Zuzana / Cheel, José / Vokřál, Ivan / Sepúlveda, Beatriz / Vokurková, Doris

Pharmacognosy magazine

2017 Volume 13, Issue 50, Page(s) 260–264

Abstract: Background: Azorella compacta: Materials and methods: The free radical scavenging activity of : Results: Eight polyphenols including chlorogenic acid, 6,8-di-: Conclusion: Overall, the results demonstrate the free radical scavenging and immune- ... ...

Abstract	Background: Azorella compacta Materials and methods: The free radical scavenging activity of Results: Eight polyphenols including chlorogenic acid, 6,8-di- Conclusion: Overall, the results demonstrate the free radical scavenging and immune-stimulating properties of ACI, and support, at least in part, its potential utilization as a functional herbal tea. for preventing chronic diseases and as a nonspecific immune stimulator during human immunosenescence. Summary: The total contents of phenols, flavonoids, and tannins in
Language	English
Publishing date	2017-04-18
Publishing country	India
Document type	Journal Article
ZDB-ID	2274976-7
ISSN	0976-4062 ; 0973-1296
ISSN (online)	0976-4062
ISSN	0973-1296
DOI	10.4103/0973-1296.204558
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Article: CD4+/CD45RO+: A Potential Biomarker of the Clinical Response to Glatiramer Acetate.

Vališ, Martin / Sobíšek, Lukáš / Vyšata, Oldřich / Klímová, Blanka / Andrýs, Ctirad / Vokurková, Doris / Masopust, Jiří / Pavelek, Zbyšek

Cells

2019 Volume 8, Issue 5

Abstract: ... ...

Abstract	Background
MeSH term(s)	Adult ; Aged ; Antigens, Differentiation/blood ; Biomarkers ; Biomarkers, Pharmacological ; Cohort Studies ; Disease Progression ; Female ; Glatiramer Acetate/therapeutic use ; Humans ; Leukocyte Common Antigens/blood ; Lymphocyte Count/methods ; Lymphocytes/immunology ; Male ; Middle Aged ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology ; Treatment Outcome ; Young Adult
Chemical Substances	Antigens, Differentiation ; Biomarkers ; Biomarkers, Pharmacological ; Glatiramer Acetate (5M691HL4BO) ; Leukocyte Common Antigens (EC 3.1.3.48)
Language	English
Publishing date	2019-05-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409
ISSN	2073-4409
DOI	10.3390/cells8050456
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Article ; Online: Lymphocytes in the treatment with interferon beta-1 b.

Pavelek, Zbyšek / Vyšata, Oldřich / Klímová, Blanka / Andrýs, Ctirad / Vokurková, Doris / Vališ, Martin

Multiple sclerosis and related disorders

2017 Volume 18, Page(s) 29–32

Abstract: Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease affecting the central nervous system. One of the basic medications for the treatment of a clinically isolated syndrome (CIS) or relapsing-remitting ...

Abstract	Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease affecting the central nervous system. One of the basic medications for the treatment of a clinically isolated syndrome (CIS) or relapsing-remitting MS is interferon beta (INFβ). Although the exact mechanism of its effects is unknown, the medication has an anti-inflammatory and immunomodulatory effect. The goal of this study was to determine the characters which are affected in patients treated with INFβ. Methods: A total of 97 patients (25 males and 72 females) were included into the study. Patients were treated by INFβ 1-b (subcutaneous injection, 250µg, each other day). Clinical evaluations were performed by an attending neurologist. Peripheral blood samples were obtained just prior to treatment and 5 years after INFβ 1-b. Statistical analysis and processing of the obtained data were performed by using a comprehensive statistical software package MATLAB®. Results: A significant decrease of the observed parameters after 5 years' of treatment (significant at the 1% significance level) was found in the absolute and relative CD69 count, absolute cytotoxic/suppressor T lymphocyte count, absolute total leukocyte count, absolute natural killer cells count. A significant decrease of the observed parameters after 5 years' of treatment (significant at the 5% significance level) was found in the absolute lymphocyte count, relative cytotoxic/suppressor T lymphocyte count, relative CD3+CD69+ count and absolute CD8+CD38+ count. Conclusion: The treatment with interferon beta reduces clinical exacerbations in multiple sclerosis (MS) through several known immunomodulatory mechanisms. However, the exact mechanism of effect of this medication is not known. This study presents some parameters that were affected by the long-term INFβ treatment.
MeSH term(s)	Adjuvants, Immunologic/therapeutic use ; Adult ; Aged ; Female ; Follow-Up Studies ; Humans ; Injections, Subcutaneous ; Interferon beta-1b/therapeutic use ; Lymphocyte Count ; Lymphocytes/drug effects ; Lymphocytes/pathology ; Male ; Middle Aged ; Multiple Sclerosis/blood ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology ; Multiple Sclerosis/pathology ; Treatment Outcome ; Young Adult
Chemical Substances	Adjuvants, Immunologic ; Interferon beta-1b (145155-23-3)
Language	English
Publishing date	2017-11
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-0356
ISSN (online)	2211-0356
DOI	10.1016/j.msard.2017.08.020
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Article: Lymphocyte populations and their change during five-year glatiramer acetate treatment.

Pavelek, Zbyšek / Vyšata, Oldřich / Sobíšek, Lukáš / Klímová, Blanka / Andrýs, Ctirad / Vokurková, Doris / Mazurová, Radka / Štourač, Pavel / Vališ, Martin

Neurologia i neurochirurgia polska

2018 Volume 52, Issue 5, Page(s) 587–592

Abstract: Background: The goal of this study was to determine the characteristics that are affected in patients treated with glatiramer acetate (GA).: Methods: A total of 113 patients were included in this study. Patients were treated with glatiramer acetate ( ... ...

Abstract	Background: The goal of this study was to determine the characteristics that are affected in patients treated with glatiramer acetate (GA). Methods: A total of 113 patients were included in this study. Patients were treated with glatiramer acetate (subcutaneous injection, 20 mg, each day). Peripheral blood samples were obtained just prior to treatment as well as 5 years after GA treatment. All the calculations were performed with the statistical system R (r-project.org). Results: After 5 years of treatment, a significant decrease was found in the absolute and relative CD3+/CD69+ counts, the absolute and relative CD69 counts, the relative CD8+/CD38+ count and the relative CD38 count. A significant increase was found in the absolute and relative CD5+/CD45RA+ counts and the absolute CD5+/CD45RO+ count after 5 years of treatment. Conclusion: This study presents some parameters that were affected by long-term GA treatment.
MeSH term(s)	Glatiramer Acetate/pharmacology ; Humans ; Lymphocytes ; Peptides
Chemical Substances	Peptides ; Glatiramer Acetate (5M691HL4BO)
Language	English
Publishing date	2018-08-18
Publishing country	Poland
Document type	Journal Article
ZDB-ID	415519-1
ISSN	1897-4260 ; 0028-3843
ISSN (online)	1897-4260
ISSN	0028-3843
DOI	10.1016/j.pjnns.2018.08.001
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Article: Sekundární humorální imunodeficience u nemocných se systémovým lupus erythematodes.

Králíčková, Pavlína / Malá, Eva / Vokurková, Doris / Souček, Ondřej / Krčmová, Irena / Hrnčíř, Zbyněk

Vnitrni lekarstvi

2015 Volume 61, Issue 9, Page(s) 778–784

Abstract: Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune multisystem disease. The aim of our study was to clarify the frequency of decreased serum immunoglobulin levels in SLE patients. There were evaluated 799 results of serum ... ...

Title translation	Secondary humoral immunodeficiency in patiens with systemic lupus erythematosus.
Abstract	Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune multisystem disease. The aim of our study was to clarify the frequency of decreased serum immunoglobulin levels in SLE patients. There were evaluated 799 results of serum immunoglobulin levels gained from 157 patients fulfilling revised ACR criteria in the retrospective study. Results: The immunoglobulin levels under the normal range were found in 29/157 (18.5 %) patients. The most frequent was isolated reduction of IgG 12/157 (7.6 %), two persons fulfilled criteria for selective IgA deficiency, and one case possible diagnosis of common variable immunodeficiency (CVID). Additionally we report two cases of SLE patients complicated by severe hypogammaglobulinaemia and infectious complications with necessity of long-term immunoglobulin substitution therapy. The diagnosis of CVID is highly probable in the first case. The second case presents sever drug-induced hypogammaglobulinaemia. This female with lymphoma history and multiorgan impairment due to acute SLE was treated with rituximab after convention therapy failure. Conclusion: Humoral immunodeficiency may occur in SLE patients. The monitoring of serum immunoglobulin levels could be a routine in these patients. The CVID diagnosis is possible in patients suffering from recurrent sinopulmonary infections, especially in combination with absence of lupus activity. Rituximab therapy could cause long-term suppression of B lymphocytes with secondary humoral deficiency requiring immunoglobulin substitution therapy.
MeSH term(s)	Acquired Immunodeficiency Syndrome/diagnosis ; Acquired Immunodeficiency Syndrome/immunology ; Adult ; Common Variable Immunodeficiency/chemically induced ; Common Variable Immunodeficiency/complications ; Female ; Humans ; Immunoglobulins/blood ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/immunology ; Retrospective Studies ; Rituximab/adverse effects ; Rituximab/therapeutic use
Chemical Substances	Immunoglobulins ; Rituximab (4F4X42SYQ6)
Language	Czech
Publishing date	2015-09
Publishing country	Czech Republic
Document type	Classical Article ; English Abstract ; Journal Article
ZDB-ID	138213-5
ISSN	1801-7592 ; 0042-773X
ISSN (online)	1801-7592
ISSN	0042-773X
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Article: Ionizing radiation sensitizes leukemic MOLT-4 cells to TRAIL-induced apoptosis.

Rezácová, Martina / Vávrová, Jirina / Vokurková, Doris

Acta medica (Hradec Kralove)

2008 Volume 51, Issue 2, Page(s) 101–105

Abstract: One of perspective approaches in treatment of hematological malignancies is activation of death receptors for TRAIL. However, leukemia cells studied to date have shown variable susceptibility to TRAIL. Our study demonstrates that cells of acute T- ... ...

Abstract	One of perspective approaches in treatment of hematological malignancies is activation of death receptors for TRAIL. However, leukemia cells studied to date have shown variable susceptibility to TRAIL. Our study demonstrates that cells of acute T-lymphoblastic leukemia MOLT-4 are resistant to TRAIL and that ionizing radiation in the therapeutically achievable dose of 1 Gy sensitizes TRAIL-resistant cells MOLT-4 to the TRAIL-induced apoptosis by increase in death receptors for TRAIL DR5. When TRAIL is applied after the irradiation in the time of increased DR5 positivity more efficient cell killing is achieved.
MeSH term(s)	Apoptosis/drug effects ; Apoptosis/radiation effects ; Gamma Rays ; Humans ; Leukemia/metabolism ; Leukemia/pathology ; Radiation Tolerance/drug effects ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; TNF-Related Apoptosis-Inducing Ligand/pharmacology ; Tumor Cells, Cultured/drug effects ; Tumor Cells, Cultured/radiation effects
Chemical Substances	Receptors, TNF-Related Apoptosis-Inducing Ligand ; TNF-Related Apoptosis-Inducing Ligand
Language	English
Publishing date	2008-08-11
Publishing country	Czech Republic
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1360995-6
ISSN	1211-4286
ISSN	1211-4286
DOI	10.14712/18059694.2017.10
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Article ; Online: Licorice infusion: Chemical profile and effects on the activation and the cell cycle progression of human lymphocytes.

Cheel, José / Onofre, Gabriela / Vokurkova, Doris / Tůmová, Lenka / Neugebauerová, Jarmila

Pharmacognosy magazine

2010 Volume 6, Issue 21, Page(s) 26–33

Abstract: Unlabelled: A licorice infusion (LI) and its major constituents were investigated for their capacity to stimulate the activation and the cell cycle progression of human lymphocytes, measured by the CD69 expression and DNA content, respectively. The ... ...

Abstract	Unlabelled: A licorice infusion (LI) and its major constituents were investigated for their capacity to stimulate the activation and the cell cycle progression of human lymphocytes, measured by the CD69 expression and DNA content, respectively. The chemical profile of LI was determined by high-performance liquid chromatography-diode array detection (HPLC-DAD). Results: Two major components of LI were identified as liquiritin (1) and glycyrrhizin (2); total flavones and flavonols were shown as its minor constituents. The LI (100-800 mug/ml) stimulated the expression of CD69 on lymphocytes in a concentration-independent manner. Values of the activation index (AI) of total lymphocytes treated with LI (100-800 mug/ml) did not differ significantly among them (P < 0.05), but were 50% lower than the AI value exhibited by cells treated with phytohemagglutinin (PHA). The LI showed a similar effect on T cells, but on a lower scale. Compounds 1 and 2 (12-100 mug/ml) did not stimulate the CD69 expression on lymphocytes. The LI, 1 and 2 showed no meaningful effect on cell cycle progression of lymphocytes. The experimental data indicates that LI stimulates the activation of lymphocytes as a result of a proliferation-independent process. This finding suggests that LI could be considered as a potential specific immune stimulator.
Keywords	covid19
Language	English
Publishing date	2010-02-13
Publishing country	India
Document type	Journal Article
ZDB-ID	2274976-7
ISSN	0976-4062 ; 0973-1296
ISSN (online)	0976-4062
ISSN	0973-1296
DOI	10.4103/0973-1296.59963
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