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Book ; Thesis: Genomweite Genexpressionsprofile von Zahnfollikelzellen nach osteogener Differenzierung in vitro

Vollkommer, Tobias

2015

Author's details	vorgelegt vonTobias Vorkommer
Language	German ; English
Size	20 Blätter, Illustrationen
Publishing place	Regensburg
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Universität Regensburg, 2016
Note	Enthält 1 Sonderabdruck in englischer Sprache
HBZ-ID	HT019114200
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Tolerance of Human Fibroblasts to Benfo-Oxythiamine In Vitro.

Yan, Ming / Smeets, Ralf / Gosau, Martin / Vollkommer, Tobias / Fuest, Sandra / Stetzer, Eva / Kluwe, Lan / Coy, Johannes F / Burg, Simon

International journal of environmental research and public health

2022 Volume 19, Issue 7

Abstract: Objectives: To explore the potential application of B-OT in the aspiration tract.: Materials and methods: We conceived and optimized an in vitro model simulating the mouth-washing process to assess tolerance to B-OT on primary human gingival ... ...

Abstract	Objectives: To explore the potential application of B-OT in the aspiration tract. Materials and methods: We conceived and optimized an in vitro model simulating the mouth-washing process to assess tolerance to B-OT on primary human gingival fibroblasts. Cells derived from 4 unrelated donors were flushed with medium containing drugs of various concentration for one minute twice daily for 3 days. Results: No effect was seen on the cells up to 1000 µM B-OT. In addition, we treated the cells with B-OT permanently in medium, corresponding to a systemic treatment. No effect was seen by 10 µM B-OT and only a slight reduction (approximately 10%) was seen by 100 µM B-OT. Conclusions: Our results suggest good tolerance of oral cells for B-OT, favoring the further development of this antiviral reagent as a mouth-washing solution and nasal spray.
MeSH term(s)	Antiviral Agents ; Fibroblasts ; Humans ; Oxythiamine/pharmacology ; Oxythiamine/therapeutic use
Chemical Substances	Antiviral Agents ; Oxythiamine (136-16-3)
Language	English
Publishing date	2022-03-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19074112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cytocompatibility of Bone Substitute Materials and Membranes.

Schafer, Sogand / Al-Qaddo, Hayder / Gosau, Martin / Smeets, Ralf / Hartjen, Philip / Friedrich, Reinhard E / Nada, Ola A / Vollkommer, Tobias / Rashad, Ashkan

In vivo (Athens, Greece)

2021 Volume 35, Issue 4, Page(s) 2035–2040

Abstract: Background/aim: With the demographic change and associated chronic bone loss, the need for cytocompatible bone replacement materials arise in modern medicine. The aim of this in vitro study was to investigate the cytocompatibility of eleven different ... ...

Abstract	Background/aim: With the demographic change and associated chronic bone loss, the need for cytocompatible bone replacement materials arise in modern medicine. The aim of this in vitro study was to investigate the cytocompatibility of eleven different bone substitute materials and membranes. Materials and methods: Seven bone substitute materials and four membranes were assessed in vitro. The specimens were tested based on their interaction with MC3T3 pre-osteoblasts, through the utilization of viability, proliferation, and cytotoxicity assays. Cell vitality was evaluated using live-dead staining. Results: Although we found minor differences in cytocompatibility among the assessed materials, all tested materials can be considered as cytocompatible with a viability of more than 70% of the negative control, which indicates the non-toxic range as defined in current, international standards (DIN EN ISO 10993-5:2009, German Institute for Standardization, Berlin, Germany). Direct live-dead staining assays confirmed satisfactory cytocompatibility of all tested membranes. Conclusion: All examined bone substitute materials and membranes were found to be cytocompatible. In order to assess whether the observed minor differences can impact regenerative processes, further in vivo studies need to be conducted.
MeSH term(s)	Biocompatible Materials ; Bone Regeneration ; Bone Substitutes ; Germany ; Materials Testing ; Membranes, Artificial ; Osteoblasts
Chemical Substances	Biocompatible Materials ; Bone Substitutes ; Membranes, Artificial
Language	English
Publishing date	2021-06-26
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.12472
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Article ; Online: Corrigendum: DCBLD1 Overexpression is associated with a poor prognosis in head and neck squamous cell carcinoma.

Fu, Ling-Ling / Yan, Ming / Ma, Min-Xian / Luo, Yi / Shao, Min / Gosau, Martin / Friedrich, Reinhard E / Vollkommer, Tobias / Feng, Hong-Chao / Smeets, Ralf

Frontiers in immunology

2022 Volume 13, Page(s) 1099835

Abstract: This corrects the article DOI: 10.3389/fimmu.2022.939344.]. ...

Abstract	[This corrects the article DOI: 10.3389/fimmu.2022.939344.].
Language	English
Publishing date	2022-11-25
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1099835
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Article ; Online: DCBLD1 Overexpression Is Associated With a Poor Prognosis in Head and Neck Squamous Cell Carcinoma.

Fu, Ling-Ling / Yan, Ming / Ma, Min-Xian / Luo, Yi / Shao, Min / Gosau, Martin / Friedrich, Reinhard E / Vollkommer, Tobias / Feng, Hong-Chao / Smeets, Ralf

Frontiers in immunology

2022 Volume 13, Page(s) 939344

Abstract: Background: DCBLD1 is highly expressed in several kinds of cancer and plays a potential prognostic factor. However, the prognostic value and immune infiltration in head and neck squamous cell carcinoma remain unclear and need further research.: ... ...

Abstract	Background: DCBLD1 is highly expressed in several kinds of cancer and plays a potential prognostic factor. However, the prognostic value and immune infiltration in head and neck squamous cell carcinoma remain unclear and need further research. Materials and methods: DCBLD1 expression and clinical information were obtained from the Cancer Genome Atlas (TCGA) database. The mRNA level in cell lines (SCC25 and CAL27) and gingival fibroblasts were detected using quantitative PCR. Cox regression analysis was used to evaluate the prognostic values of DCBLD1 and clinical data in HNSCC. A nomogram was also established to predict the impact of DCBLD1 on prognosis based on Cox multivariate results. The methylation level of DCBLD1 in HNSC and its prognosis were analyzed in UALACN and MethSurv. Finally, the potential biological functions of DCBLD1 were investigated using gene set enrichment analysis (GSEA) and single-sample GSEA (ssGSEA). Results: The mRNA and protein expression levels of DCBLD1 were highly expressed in HNSCC tissue and cell lines. The Cox analyses demonstrate that highly expressed DCBLD1 is an independent prognosis marker ( Conclusion: In head and neck squamous cell carcinoma, DCBLD1 is overexpressed, associated with poor patient prognosis. The detailed underlying mechanism merits further research.
MeSH term(s)	Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/genetics ; Humans ; Prognosis ; RNA, Messenger ; Squamous Cell Carcinoma of Head and Neck/genetics
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2022-07-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.939344
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Article ; Online: Tissue Adhesives in Reconstructive and Aesthetic Surgery-Application of Silk Fibroin-Based Biomaterials.

Smeets, Ralf / Tauer, Nathalie / Vollkommer, Tobias / Gosau, Martin / Henningsen, Anders / Hartjen, Philip / Früh, Leonie / Beikler, Thomas / Stürmer, Ewa K / Rutkowski, Rico / Grust, Audrey Laure Céline / Fuest, Sandra / Gaudin, Robert / Aavani, Farzaneh

International journal of molecular sciences

2022 Volume 23, Issue 14

Abstract: Tissue adhesives have been successfully used in various kind of surgeries such as oral and maxillofacial surgery for some time. They serve as a substitute for suturing of tissues and shorten treatment time. Besides synthetic-based adhesives, a number of ... ...

Abstract	Tissue adhesives have been successfully used in various kind of surgeries such as oral and maxillofacial surgery for some time. They serve as a substitute for suturing of tissues and shorten treatment time. Besides synthetic-based adhesives, a number of biological-based formulations are finding their way into research and clinical application. In natural adhesives, proteins play a crucial role, mediating adhesion and cohesion at the same time. Silk fibroin, as a natural biomaterial, represents an interesting alternative to conventional medical adhesives. Here, the most commonly used bioadhesives as well as the potential of silk fibroin as natural adhesives will be discussed.
MeSH term(s)	Biocompatible Materials/therapeutic use ; Fibroins/therapeutic use ; Silk ; Surgery, Plastic ; Tissue Adhesives/therapeutic use ; Tissue Engineering ; Tissue Scaffolds
Chemical Substances	Biocompatible Materials ; Silk ; Tissue Adhesives ; Fibroins (9007-76-5)
Language	English
Publishing date	2022-07-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23147687
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Article ; Online: Lingual Mandibular Bone Depression.

Friedrich, Reinhard E / Barsukov, Evgeny / Kohlrusch, Felix K / Zustin, Jozef / Hagel, Christian / Speth, Ulrike / Vollkommer, Tobias / Gosau, Martin

In vivo (Athens, Greece)

2020 Volume 34, Issue 5, Page(s) 2527–2541

Abstract: Background/aim: In the area of the jaw angle, osteolytic lesions can occur, the differential diagnosis of which can be difficult and require very different therapeutic measures. One of these lesions is lingual mandibular bone depression (LMBD). The aim ... ...

Abstract	Background/aim: In the area of the jaw angle, osteolytic lesions can occur, the differential diagnosis of which can be difficult and require very different therapeutic measures. One of these lesions is lingual mandibular bone depression (LMBD). The aim of this study was to present the characteristics of the lesion in a group of LMBD patients and to differentiate it from other lesions. Patients and methods: Radiological images of 21 patients with LMBD were examined. Results: The majority of LMBDs were located in the jaw angle. On cross-sectional images, the lesion could be distinguished from salivary tissue (n=2). One case of LMBD had an impact on the course of the fracture line in the mandibular trauma. Conclusion: LMBD is a developmental disorder of the mandible and only rarely of pathological importance. Imaging the lesion with cross-sectional images is preferable to using plain X-ray projections. In some cases, surgical exploration is essential for diagnosis.
MeSH term(s)	Cross-Sectional Studies ; Depression ; Diagnosis, Differential ; Humans ; Jaw Cysts/diagnosis ; Mandible/diagnostic imaging ; Mandibular Diseases/diagnostic imaging ; Radiography, Panoramic ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-08-29
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.12070
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Article: The Impact of a Nanocellulose-Based Wound Dressing in the Management of Thermal Injuries in Children: Results of a Retrospective Evaluation.

Cattelaens, Julia / Turco, Laura / Berclaz, Luc M / Huelsse, Birgit / Hitzl, Wolfgang / Vollkommer, Tobias / Bodenschatz, Karl J

Life (Basel, Switzerland)

2020 Volume 10, Issue 9

Abstract: The aim of this retrospective study is to evaluate for the first time the impact of a nanocellulose-based wound dressing in the treatment of pediatric patients with both partial- and deep-thickness burns. Usability and effectiveness were defined based on ...

Abstract	The aim of this retrospective study is to evaluate for the first time the impact of a nanocellulose-based wound dressing in the treatment of pediatric patients with both partial- and deep-thickness burns. Usability and effectiveness were defined based on parameters such as frequency of dressing changes under narcosis, duration of hospital stay, onset of complications, need for additional treatments, and follow up scar formation assessment. Fifty-six children who sustained burns in the year 2018 and were treated with a nanocellulose-based wound dressing were included in the trial. The mean stay in hospital was 6.7 days. Patients underwent dressing changes under narcosis 2.4 times on average, and none had wound-associated infection. In all, 82% of the patients were treated only with nanocellulose-based wound dressings, and reepithelialization occurred after ten days. The majority of patients had scars with normal pigmentation (98%), vascularization (91%), height (92%), and pliability (92%). In conclusion, using a nanocellulose-based wound dressing for the treatment of both superficial, partial-thickness and deep, full-thickness burns has several advantages. Compared with the results published in literature on other wound dressings, it requires a moderate number of dressing changes under narcosis and results in short hospital stays. Additionally, it has a low associated infection rate and promotes wound healing.
Language	English
Publishing date	2020-09-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life10090212
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Article ; Online: Symptomatic Intraosseous Vascular Malformation of Infraorbital Rim: A Case Report With Literature Survey.

Friedrich, Reinhard E / Grzyska, Ulrich / Kohlrusch, Felix K / VON Kroge, Simon / Vollkommer, Tobias / Luebke, Andreas M

Anticancer research

2020 Volume 40, Issue 6, Page(s) 3333–3343

Abstract: Background/aim: Intraosseous orbital hemangiomas or vascular malformations (VM) are rare. This report is intended to complement the experience of diagnosing and treating a rare vascular lesion at this site. Special attention is paid to three-dimensional ...

Abstract	Background/aim: Intraosseous orbital hemangiomas or vascular malformations (VM) are rare. This report is intended to complement the experience of diagnosing and treating a rare vascular lesion at this site. Special attention is paid to three-dimensional imaging and the morphological distinction between the two entities in this location. Case report: A 54-year-old female was examined and surgically treated for an exophytic firm mass of the infraorbital, which had become palpable as a hard mass due to growth in size. At first, a bone tumor, for example, an osteoma, was suspected. Intraoperatively, an osseous expansion with distinct fenestrations of the newly grown bone's surface, was detected. The lesion was firmly attaching to the orbital rim. The densely vascularized tumor was well defined to the soft tissues but had grown in continuity from the orbital floor and rim. Vascularized cavities caused the tumor to have a slightly reddish color. The histological examination confirmed the suspicion of the lesion's vascular origin. The lesion's immunohistochemical expression profile approved the final diagnosis of intraosseous VM. Conclusion: The symptoms of intraosseous vascular lesions of the orbit are determined by location and size. Modern imaging techniques facilitate the estimation of tumor-like expansion of lesions. However, the imaging characteristics of intraosseous vascular lesions are very variable. The symptoms of the patient presented herein show that growth phases of a vascular orbital malformation can occur in later stages of life and are initially indistinguishable from a neoplasm. In individual cases, patient care necessitates advanced diagnostic measures to establish the diagnosis and determine surgical therapy.
MeSH term(s)	Female ; Humans ; Immunohistochemistry ; Middle Aged ; Orbital Neoplasms/blood supply ; Orbital Neoplasms/pathology ; Vascular Malformations/etiology
Language	English
Publishing date	2020-05-30
Publishing country	Greece
Document type	Case Reports ; Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.14316
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Article ; Online: Antibacterial properties of functionalized silk fibroin and sericin membranes for wound healing applications in oral and maxillofacial surgery.

Schäfer, Sogand / Smeets, Ralf / Köpf, Marius / Drinic, Aleksander / Kopp, Alexander / Kröger, Nadja / Hartjen, Philip / Assaf, Alexandre Thomas / Aavani, Farzaneh / Beikler, Thomas / Peters, Ulrike / Fiedler, Imke / Busse, Björn / Stürmer, Ewa K / Vollkommer, Tobias / Gosau, Martin / Fuest, Sandra

Biomaterials advances

2022 Volume 135, Page(s) 212740

Abstract: Oral wounds are among the most troublesome injuries which easily affect the patients' quality of life. To date, the development of functional antibacterial dressings for oral wound healing remains a challenge. In this regard, we investigated ... ...

Abstract	Oral wounds are among the most troublesome injuries which easily affect the patients' quality of life. To date, the development of functional antibacterial dressings for oral wound healing remains a challenge. In this regard, we investigated antibacterial silk protein-based membranes for the application as wound dressings in oral and maxillofacial surgery. The present study includes five variants of casted membranes, i.e., i) membranes-silver nanoparticles (CM-Ag), ii) membranes-gentamicin (CM-G), iii) membranes-control (without functionalization) (CM-C), iv) membranes-silk sericin control (CM-SSC), and v) membranes-silk fibroin/silk sericin (CM-SF/SS), and three variants of nonwovens, i.e., i) silver nanoparticles (NW-Ag), ii) gentamicin (NW-G), iii) control (without functionalization) (NW-C). The surface structure of the samples was visualized with scanning electron microscopy. In addition, antibacterial testing was accomplished using agar diffusion assay, colony forming unit (CFU) analysis, and qrt-PCR. Following antibacterial assays, biocompatibility was evaluated by cell proliferation assay (XTT), cytotoxicity assay (LDH), and live-dead assay on L929 mouse fibroblasts. Findings indicated significantly lower bacterial colony growth and DNA counts for CM-Ag with a reduction of bacterial counts by 3log levels (99.9% reduction) in CFU and qrt-PCR assay compared to untreated control membranes (CM-C and CM-SSC) and membranes functionalized with gentamicin (CM-G and NW-G) (p < 0.001). Similarly, NW-G yielded significantly lower DNA and colony growth counts compared to NW-Ag and NW-C (p < 0.001). In conclusion, CM-Ag represented 1log level better antibacterial activity compared to NW-G, whereas NW-G showed better cytocompatibility for L929 cells. As data suggest, these two membranes have the potential of application in the field of bacteria-free oral wound healing. However, provided that loading strategy and cytocompatibility are adjusted according to the antibacterial agents' characteristic and fabrication technique of the membranes.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Fibroins/pharmacology ; Gentamicins/pharmacology ; Metal Nanoparticles/therapeutic use ; Mice ; Quality of Life ; Sericins/pharmacology ; Silk/chemistry ; Silver/pharmacology ; Surgery, Oral ; Wound Healing
Chemical Substances	Anti-Bacterial Agents ; Gentamicins ; Sericins ; Silk ; Silver (3M4G523W1G) ; Fibroins (9007-76-5)
Language	English
Publishing date	2022-03-17
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-9508
ISSN (online)	2772-9508
DOI	10.1016/j.bioadv.2022.212740
Database	MEDical Literature Analysis and Retrieval System OnLINE

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