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  1. Article ; Online: COVID-19 does not impact on outcome of myeloma patients infected while undergoing autologous stem cell transplantation.

    Masina, Lorenzo / Bianchetti, Nicola / Passi, Angela / Bottelli, Chiara / Bagnasco, Samuele / Spolzino, Angelica / Oberti, Margherita / Chiarini, Marco / Belotti, Angelo / Voltolini, Simone / Faglioni, Laura / Rossi, Giuseppe / Tucci, Alessandra / Cattaneo, Chiara

    Hematological oncology

    2023  Volume 41, Issue 3, Page(s) 555–558

    Abstract: Here we report two cases of myeloma patients who became positive for SARS-CoV-2 infection during the acute phase of autologous stem cell transplant. Both patients were promptly treated with monoclonal antibodies and remdesivir, and, despite the profound ... ...

    Abstract Here we report two cases of myeloma patients who became positive for SARS-CoV-2 infection during the acute phase of autologous stem cell transplant. Both patients were promptly treated with monoclonal antibodies and remdesivir, and, despite the profound neutropenia and lymphopenia, they did not develop respiratory failure and they remained paucisymptomatic during the entire period of aplasia. Neutrophil engraftment took place as expected and the patients were discharged quickly and did not experience adverse effects after discharge.
    MeSH term(s) Humans ; Multiple Myeloma/complications ; Multiple Myeloma/therapy ; Hematopoietic Stem Cell Transplantation ; COVID-19/complications ; SARS-CoV-2 ; Transplantation, Autologous
    Language English
    Publishing date 2023-02-17
    Publishing country England
    Document type Case Reports
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.3127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1816: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: e6a2 BCR-ABL transcript in chronic myeloid leukemia: is it associated with aggressive disease?

    Colla, Simona / Sammarelli, Gabriella / Voltolini, Simone / Crugnola, Monica / Sebastio, Paola / Giuliani, Nicola

    Haematologica

    2004  Volume 89, Issue 5, Page(s) 611–613

    Abstract: We describe the fourth case of e6a2 BCR-ABL transcript in a patient with chronic myeloid leukemia (CML), using reverse transcriptase polymerase chain reaction (RT-PCR) and sequencing analysis. The clinical and hematologic features and the aggressive ... ...

    Abstract We describe the fourth case of e6a2 BCR-ABL transcript in a patient with chronic myeloid leukemia (CML), using reverse transcriptase polymerase chain reaction (RT-PCR) and sequencing analysis. The clinical and hematologic features and the aggressive course of disease in our patient and in the others reported in literature lead us to hypothesize that this atypical rearrangement may be associated with a worse prognosis.
    MeSH term(s) Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Disease Progression ; Fusion Proteins, bcr-abl/genetics ; Humans ; Hydroxyurea/therapeutic use ; Interferon-alpha/therapeutic use ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Male ; Middle Aged ; Prognosis
    Chemical Substances Interferon-alpha ; Fusion Proteins, bcr-abl (EC 2.7.10.2) ; Hydroxyurea (X6Q56QN5QC)
    Language English
    Publishing date 2004-05
    Publishing country Italy
    Document type Case Reports ; Letter
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.76: Show issues Location:
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  3. Article ; Online: FarmaREL: An Italian pharmacovigilance project to monitor and evaluate adverse drug reactions in haematologic patients.

    Fracchiolla, Nicola S / Artuso, Silvia / Cortelezzi, Agostino / Pelizzari, Anna M / Tozzi, Paola / Bonfichi, Maurizio / Bocchio, Federica / Gargantini, Livio / De Rosa, Elisa / Vighi, Giuseppe D / Prestini, Lucia / Sammassimo, Simona / Frungillo, Niccolò / Pasquini, Maria C / Ragazzi, Alessandra / Boghi, Daniele / Pastore, Alessia / Lanzi, Eraldo / Gritti, Giuseppe /
    Quaresmini, Giulia / Voltolini, Simone / Gaiardoni, Roberta / Corti, Consuelo / Vilardo, Maria C / La Targia, Maria L / Berini, Giacomo / Magagnoli, Massimo / Bacci, Claudia / Consonni, Dario / Rivolta, Alma L / Muti, Giuliana

    Hematological oncology

    2017  

    Abstract: Adverse drug reactions (ADRs) reduce patients' quality of life, increase mortality and morbidity, and have a negative economic impact on healthcare systems. Nevertheless, the importance of ADR reporting is often underestimated. The project "FarmaREL" has ...

    Abstract Adverse drug reactions (ADRs) reduce patients' quality of life, increase mortality and morbidity, and have a negative economic impact on healthcare systems. Nevertheless, the importance of ADR reporting is often underestimated. The project "FarmaREL" has been developed to monitor and evaluate ADRs in haematological patients and to increase pharmacovigilance culture among haematology specialists. In 13 haematology units, based in Lombardy, Italy, a dedicated specialist with the task of encouraging ADRs reporting and sensitizing healthcare professionals to pharmacovigilance has been assigned. The ADRs occurring in haematological patients were collected electronically and then analysed with multiple logistic regression. Between January 2009 and December 2011, 887 reports were collected. The number of ADRs was higher in older adults (528; 59%), in male (490; 55%), and in non-Hodgkin lymphoma patients (343; 39%). Most reactions were severe (45% required or prolonged hospitalization), but in most cases, they were fully resolved at the time of reporting. According to Schumock and Thornton criteria, a percentage of ADRs as high as 7% was found to be preventable versus 2% according to reporter opinion. Patients' haematological diagnosis, not age or gender, resulted to be the variable that most influenced ADR, in particular severity and outcome. The employment of personnel specifically dedicated to pharmacovigilance is a successful strategy to improve the number and quality of ADR reports. "FarmaREL", the first programme of active pharmacovigilance in oncohaematologic patients, significantly contributed to reach the WHO "Gold Standard" for pharmacovigilance in Lombardy, Italy.
    Language English
    Publishing date 2017-08-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.2451
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1816: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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