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  1. Article ; Online: Expression quantitative trait locus analysis identifies novel genes for statin myopathy.

    Voora, Deepak

    Circulation. Cardiovascular genetics

    2014  Volume 7, Issue 2, Page(s) 220–221

    MeSH term(s) Amidinotransferases/genetics ; Gene Expression Regulation/drug effects ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Muscular Diseases/chemically induced ; Quantitative Trait Loci/genetics ; Simvastatin/adverse effects
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Simvastatin (AGG2FN16EV) ; Amidinotransferases (EC 2.1.4.-)
    Language English
    Publishing date 2014-04
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2477394-3
    ISSN 1942-3268 ; 1942-325X
    ISSN (online) 1942-3268
    ISSN 1942-325X
    DOI 10.1161/CIRCGENETICS.114.000611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6731: Show issues Location:
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  2. Article ; Online: Cost-effectiveness of CYP2C19-guided P2Y12 inhibitors in Veterans undergoing percutaneous coronary intervention for acute coronary syndromes.

    Dong, Olivia M / Friede, Kevin A / Chanfreau-Coffinier, Catherine / Voora, Deepak

    European heart journal. Quality of care & clinical outcomes

    2022  Volume 9, Issue 3, Page(s) 249–257

    Abstract: Aims: CYP2C19-guided P2Y12 inhibitor selection can reduce cardiovascular (CV) events and bleeding in patients with acute coronary syndromes (ACSs) post-percutaneous coronary intervention (PCI). The 12-month cost-effectiveness of CYP2C19-guided P2Y12 ... ...

    Abstract Aims: CYP2C19-guided P2Y12 inhibitor selection can reduce cardiovascular (CV) events and bleeding in patients with acute coronary syndromes (ACSs) post-percutaneous coronary intervention (PCI). The 12-month cost-effectiveness of CYP2C19-guided P2Y12 inhibitor selection for Veterans post-ACS/PCI was evaluated from the Veterans Health Administration's (VHA) perspective.
    Methods and results: Using average annualized PCI volumes and P2Y12 inhibitor use from VA data, a decision-analytic model simulated CYP2C19 testing vs. no testing outcomes in 2800 hypothetical Veterans receiving PY212 inhibitor for 12 months post-ACS/PCI (74% clopidogrel, 5% prasugrel, and 21% ticagrelor use at baseline without testing). CYP2C19 loss-of-function (LOF) carrier prevalence was 28%. Model inputs were from studies (bleeding/ischaemic events, CYP2C19-guided therapy effect, health state utilities, CYP2C19 LOF carrier prevalence) and VHA administrative data (costs of events, drugs, CYP2C19 testing; PCI volumes, and P2Y12 inhibitor prescriptions). The primary outcome was cost (2020 US${\$}$) per quality-adjusted life year (QALY) gained. Base-case scenarios, probabilistic sensitivity analyses, and scenario analyses were completed. CYP2C19-guided therapy resulted in 496 (24%) escalations (clopidogrel to prasugrel/ticagrelor) and 465 (65%) de-escalations (prasugrel/ticagrelor to clopidogrel). CYP2C19 testing averted 1 stroke, 27 myocardial infarctions, 8 CV-related deaths, and caused 3 bleeds. CYP2C19 testing (vs. no testing) was dominant in the base-case scenario (0.0027 QALYs gained, ${\$}$527 saved/person) and in 97.1% of simulations, making it cost-effective and high-value. In scenario analyses, de-escalation in conjunction with escalation is required for CYP2C19 testing to be cost-effective and high-value.
    Conclusion: In Veterans post-ACS/PCI, CYP2C19-guided P2Y12 inhibitor selection can improve CV outcomes and lower costs for the VHA within 12 months of implementation.
    MeSH term(s) Humans ; Clopidogrel/therapeutic use ; Ticagrelor/therapeutic use ; Prasugrel Hydrochloride/therapeutic use ; Platelet Aggregation Inhibitors/therapeutic use ; Cost-Benefit Analysis ; Acute Coronary Syndrome/surgery ; Cytochrome P-450 CYP2C19 Inhibitors/therapeutic use ; Percutaneous Coronary Intervention ; Cytochrome P-450 CYP2C19/genetics ; Cytochrome P-450 CYP2C19/therapeutic use ; Veterans ; Hemorrhage/chemically induced
    Chemical Substances Clopidogrel (A74586SNO7) ; Ticagrelor (GLH0314RVC) ; Prasugrel Hydrochloride (G89JQ59I13) ; Platelet Aggregation Inhibitors ; Cytochrome P-450 CYP2C19 Inhibitors ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; CYP2C19 protein, human (EC 1.14.14.1)
    Language English
    Publishing date 2022-05-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2823451-0
    ISSN 2058-1742 ; 2058-5225
    ISSN (online) 2058-1742
    ISSN 2058-5225
    DOI 10.1093/ehjqcco/qcac031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A transcriptomics-informed genetic association study identifies RHOA in simvastatin-induced low-density lipoprotein cholesterol lowering.

    Voora, Deepak

    Circulation. Cardiovascular genetics

    2013  Volume 6, Issue 1, Page(s) 137–138

    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2477394-3
    ISSN 1942-3268 ; 1942-325X
    ISSN (online) 1942-3268
    ISSN 1942-325X
    DOI 10.1161/CIRCGENETICS.111.000070
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  4. Article ; Online: Genetic influences on aspirin response in patients undergoing percutaneous coronary intervention.

    Friede, Kevin A / Voora, Deepak

    Cardiovascular research

    2019  Volume 115, Issue 10, Page(s) 1452–1453

    MeSH term(s) Aspirin ; Coronary Artery Disease ; Humans ; Percutaneous Coronary Intervention ; Platelet Aggregation Inhibitors ; Soluble Guanylyl Cyclase
    Chemical Substances GUCY1A1 protein, human ; Platelet Aggregation Inhibitors ; Soluble Guanylyl Cyclase (EC 4.6.1.2) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2019-04-30
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvz110
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    Zs.A 565: Show issues Location:
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  5. Article: Building the evidentiary framework for pharmacogenetic testing: is it time to move beyond randomized controlled trials?

    Voora, Deepak

    Personalized medicine

    2013  Volume 10, Issue 1, Page(s) 1–3

    Language English
    Publishing date 2013-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2299146-3
    ISSN 1744-828X ; 1741-0541
    ISSN (online) 1744-828X
    ISSN 1741-0541
    DOI 10.2217/pme.12.105
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    Zs.A 6549: Show issues Location:
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  6. Article ; Online: Workforce readiness for pharmacogenomics and key elements for sustainment within the Veterans Health Administration.

    Wu, Rebekah Ryanne / Benevent, Richelle / Sperber, Nina R / Bates, Jill S / Villa, Daniel / Weeraratne, Dilhan / Burrell, Timothy A / Voora, Deepak

    Pharmacogenomics

    2024  Volume 25, Issue 3, Page(s) 133–145

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; Pharmacogenetics/education ; Veterans Health ; Delivery of Health Care ; Surveys and Questionnaires ; Health Personnel
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2023-0193
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    Zs.A 5247: Show issues Location:
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  7. Article ; Online: Future directions in pharmacogenomics discovery in cardiovascular disease.

    Friede, Kevin A / Voora, Deepak

    Pharmacogenomics

    2018  Volume 19, Issue 5, Page(s) 375–377

    MeSH term(s) Anti-HIV Agents/adverse effects ; Anti-HIV Agents/therapeutic use ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/genetics ; Dideoxynucleosides/adverse effects ; Dideoxynucleosides/therapeutic use ; Drug Hypersensitivity/genetics ; Forecasting ; Genome-Wide Association Study ; Humans ; Pharmacogenetics/trends
    Chemical Substances Anti-HIV Agents ; Dideoxynucleosides ; abacavir (WR2TIP26VS)
    Language English
    Publishing date 2018-03-23
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2018-0002
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    Zs.A 5247: Show issues Location:
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  8. Article ; Online: Platelet inhibition by low-dose aspirin is not influenced by body mass or weight.

    Heffron, Sean P / Windheim, Joseph / Barrett, Tessa J / Voora, Deepak / Berger, Jeffrey S

    Platelets

    2022  Volume 33, Issue 8, Page(s) 1208–1213

    Abstract: Aspirin's clinical efficacy may be influenced by body weight and mass. Although inadequate platelet inhibition by aspirin is suggested as responsible, evidence for this in non-diabetic patients is sparse. We investigated the influence of body weight and ... ...

    Abstract Aspirin's clinical efficacy may be influenced by body weight and mass. Although inadequate platelet inhibition by aspirin is suggested as responsible, evidence for this in non-diabetic patients is sparse. We investigated the influence of body weight and mass on aspirin's inhibition of platelet aggregation in healthy adults without diabetes. Cohort one (NYU, n = 84) had light transmission aggregometry (LTA) of platelet-rich plasma to submaximal adenosine diphosphate (ADP) and arachidonic acid (AA) before and following 1 week of daily 81 mg non-enteric coated aspirin. Subjects in the validation cohort (Duke, n = 66) were randomized to 81 mg or 325 mg non-enteric coated aspirin for 4 weeks, immediately followed by 4 weeks of the other dose, with LTA to submaximal collagen, ADP, and AA before and after each dosage period. Body mass index (BMI) range was 18.0-57.5 kg/m
    MeSH term(s) Adenosine Diphosphate/pharmacology ; Adult ; Arachidonic Acid/pharmacology ; Aspirin/pharmacology ; Aspirin/therapeutic use ; Blood Platelets ; Body Weight ; Collagen/pharmacology ; Humans ; Platelet Aggregation ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Function Tests
    Chemical Substances Platelet Aggregation Inhibitors ; Arachidonic Acid (27YG812J1I) ; Adenosine Diphosphate (61D2G4IYVH) ; Collagen (9007-34-5) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2022-06-29
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2022.2087868
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    Zs.A 2888: Show issues Location:
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  9. Article ; Online: Veterans Health Administration: Implementation of pharmacogenomic clinical decision support with statin medications and the SLCO1B1 gene as an exemplar.

    Tomcsanyi, Kelly M / Tran, Kelvin A / Bates, Jill / Cunningham, Francesca E / Silverman, Robert / Norris, Amy K / Moore, Von R / Voora, Deepak

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2023  Volume 80, Issue 16, Page(s) 1082–1089

    Abstract: Purpose: To describe the implementation of clinical decision support tools for alerting prescribers of actionable drug-gene interactions in the Veterans Health Administration (VHA).: Summary: Drug-gene interactions have been the focus of clinicians ... ...

    Abstract Purpose: To describe the implementation of clinical decision support tools for alerting prescribers of actionable drug-gene interactions in the Veterans Health Administration (VHA).
    Summary: Drug-gene interactions have been the focus of clinicians for years. Interactions between SCLO1B1 genotype and statin medications are of particular interest as these can inform risk for statin-associated muscle symptoms (SAMS). VHA identified approximately 500,000 new users of statin medications prescribed in VHA in fiscal year 2021, some of whom could benefit from pharmacogenomic testing for the SCLO1B1 gene. In 2019, VHA implemented the Pharmacogenomic Testing for Veterans (PHASER) program to offer panel-based, preemptive pharmacogenomic testing and interpretation. The PHASER panel includes SLCO1B1, and VHA utilized Clinical Pharmacogenomics Implementation Consortium statin guidelines to build its clinical decision support tools. The program's overarching goal is to reduce the risk of adverse drug reactions such as SAMS and improve medication efficacy by alerting practitioners of actionable drug-gene interactions. We describe the development and implementation of decision support for the SLCO1B1 gene as an example of the approach being used for the nearly 40 drug-gene interactions screened for by the panel.
    Conclusion: The VHA PHASER program identifies and addresses drug-gene interactions as an application of precision medicine to reduce veterans' risks for adverse events. The PHASER program's implementation of statin pharmacogenomics utilizes a patient's SCLO1B1 phenotype to alert providers of the risk for SAMS with the statin being prescribed and how to lower that risk through a lower dose or alternative statin selection. The PHASER program may help reduce the number of veterans who experience SAMS and may improve their adherence to statin medications.
    MeSH term(s) Pharmacogenetics ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Decision Support Systems, Clinical ; Veterans Health ; Precision Medicine
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxad111
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    Zs.A 419: Show issues Location:
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  10. Article ; Online: The need for sex-specific precision biomarkers for antiplatelet therapies.

    Friede, Kevin / Voora, Deepak

    Future cardiology

    2017  Volume 13, Issue 5, Page(s) 419–422

    Language English
    Publishing date 2017-08-23
    Publishing country England
    Document type Editorial
    ZDB-ID 2274267-0
    ISSN 1744-8298 ; 1479-6678
    ISSN (online) 1744-8298
    ISSN 1479-6678
    DOI 10.2217/fca-2017-0043
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